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Searching for up to 100 curated homologs for WP_009126907.1 NCBI__GCF_000195635.1:WP_009126907.1 (321 a.a.)

Found high-coverage hits (≥70%) to 63 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GlsA / b0485 glutaminase 1 (EC 3.5.1.38; EC 3.5.1.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
glsA / P77454 glutaminase 1 (EC 3.5.1.38) from Escherichia coli (strain K12) (see 5 papers)
GLSA1_ECOLI / P77454 Glutaminase 1; EC 3.5.1.2 from Escherichia coli (strain K12) (see paper)
P77454 glutaminase (EC 3.5.1.2) from Escherichia coli (see paper)
glsA1 / MB|P77454 glutaminase 1 from Escherichia coli K12 (see 3 papers)
    45% identity, 97% coverage of query (281 bits)

Q8YSZ5 glutaminase (EC 3.5.1.2) from Anabaena sp. (see paper)
    37% identity, 96% coverage of query (206 bits)

SMc00486 Glutaminase (EC 3.5.1.2) from Sinorhizobium meliloti 1021
    34% identity, 97% coverage of query (189 bits)

GlsB / b1524 glutaminase 2 (EC 3.5.1.38; EC 3.5.1.2) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
glsB / P0A6W0 glutaminase 2 (EC 3.5.1.38) from Escherichia coli (strain K12) (see 2 papers)
GLSA2_ECOLI / P0A6W0 Glutaminase 2; EC 3.5.1.2 from Escherichia coli (strain K12) (see paper)
P0A6W0 glutaminase (EC 3.5.1.2) from Escherichia coli (see paper)
glsA2 / RF|NP_416041 glutaminase 2 from Escherichia coli K12 (see paper)
    33% identity, 89% coverage of query (184 bits)

5w2jB Crystal structure of dimeric form of mouse glutaminasE C
    35% identity, 94% coverage of query (183 bits)

glsA / GB|ABC91091.1 thermolabile glutaminase; EC 3.5.1.2 from Rhizobium etli CFN 42 (see paper)
    35% identity, 89% coverage of query (182 bits)

GLSK_MOUSE / D3Z7P3 Glutaminase kidney isoform, mitochondrial; GLS; EC 3.5.1.2 from Mus musculus (Mouse) (see 6 papers)
    35% identity, 94% coverage of query (182 bits)

GLSK_RAT / P13264 Glutaminase kidney isoform, mitochondrial; GLS; K-glutaminase; L-glutamine amidohydrolase; EC 3.5.1.2 from Rattus norvegicus (Rat) (see 6 papers)
P13264 glutaminase (EC 3.5.1.2) from Rattus norvegicus (see paper)
    35% identity, 94% coverage of query (181 bits)

5uqeD / O94925 Multidomain structure of human kidney-type glutaminase(kga/gls) (see paper)
    34% identity, 94% coverage of query (181 bits)

8gwrB Near full length kidney type glutaminase in complex with 2,2-dimethyl- 2,3-dihydrobenzo[a] phenanthridin-4(1h)-one (ddp)
    34% identity, 94% coverage of query (181 bits)

6umdB Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (181 bits)

6ul9B Crystal structure of human gac in complex with inhibitor upgl00023
    34% identity, 94% coverage of query (181 bits)

O94925 glutaminase kidney isoform small subunit (EC 3.5.1.38) from Homo sapiens (see 6 papers)
GLSK_HUMAN / O94925 Glutaminase kidney isoform, mitochondrial; GLS; K-glutaminase; L-glutamine amidohydrolase; EC 3.5.1.2 from Homo sapiens (Human) (see 13 papers)
O94925 glutaminase (EC 3.5.1.2) from Homo sapiens (see 4 papers)
    34% identity, 94% coverage of query (180 bits)

6loxA Crystal structure of human glutaminase with macrocyclic inhibitor
    34% identity, 94% coverage of query (180 bits)

8jueA Crystal structure of glutaminasE C in complex with compound 11
    34% identity, 94% coverage of query (180 bits)

8jubA Crystal structure of glutaminasE C in complex with compound 27
    34% identity, 94% coverage of query (180 bits)

5fi7A Crystal structure of human gac in complex with inhibitor upgl_00015: 2-phenyl-~{n}-[5-[(3~{s})-3-[[5-(2-phenylethanoylamino)-1,3,4- thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide
    34% identity, 94% coverage of query (180 bits)

5fi6A Crystal structure of human gac in complex with inhibitor upgl_00011: 2-phenyl-~{n}-[5-[[(3~{s})-1-[5-(2-phenylethanoylamino)-1,3,4- thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2- yl]ethanamide
    34% identity, 94% coverage of query (180 bits)

5fi2A Crystal structure of human gac in complex with inhibitor upgl_00009: 2-phenyl-~{n}-[5-[[(3~{r})-1-[5-(2-phenylethanoylamino)-1,3,4- thiadiazol- 2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2- yl]ethanamide
    34% identity, 94% coverage of query (180 bits)

6umfA Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (180 bits)

6uljA Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (180 bits)

6ulaA Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (180 bits)

6ukbA Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (180 bits)

6ujmA Crystal structure of human gac in complex with inhibitor upgl00013
    34% identity, 94% coverage of query (180 bits)

6umcB Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (179 bits)

6ujgA Crystal structure of human gac in complex with inhibitor upgl00012
    34% identity, 94% coverage of query (179 bits)

5wj6A Crystal structure of glutaminasE C in complex with inhibitor 2-phenyl- n-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino) piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (upgl-00004)
    34% identity, 94% coverage of query (179 bits)

5i94A Crystal structure of human glutaminasE C in complex with the inhibitor upgl-00019
    34% identity, 94% coverage of query (179 bits)

8bsnA Human gls in complex with compound 27
    34% identity, 94% coverage of query (179 bits)

4o7dA Crystal structure of human glutaminase in complex don
    34% identity, 93% coverage of query (179 bits)

Q66V97 glutaminase (EC 3.5.1.2) from Aspergillus oryzae (see paper)
    31% identity, 95% coverage of query (176 bits)

3ss4A Crystal structure of mouse glutaminasE C, phosphate-bound form
    34% identity, 94% coverage of query (174 bits)

3vp0A Crystal structure of human glutaminase in complex with l-glutamine
    33% identity, 93% coverage of query (172 bits)

3czdA Crystal structure of human glutaminase in complex with l-glutamate
    33% identity, 93% coverage of query (172 bits)

3vp3A Crystal structure of human glutaminase in complex with inhibitor 3
    34% identity, 93% coverage of query (172 bits)

3vp2A Crystal structure of human glutaminase in complex with inhibitor 2
    34% identity, 93% coverage of query (172 bits)

3vp4A Crystal structure of human glutaminase in complex with inhibitor 4
    34% identity, 93% coverage of query (172 bits)

8bslA Human gls in complex with compound 12
    34% identity, 94% coverage of query (172 bits)

6uk6A Crystal structure of human gac in complex with inhibitor upgl00018
    34% identity, 94% coverage of query (171 bits)

5jypA Allosteric inhibition of kidney isoform of glutaminase
    33% identity, 93% coverage of query (170 bits)

GLSL_MOUSE / Q571F8 Glutaminase liver isoform, mitochondrial; GLS; L-glutaminase; L-glutamine amidohydrolase; LGA; EC 3.5.1.2 from Mus musculus (Mouse) (see 2 papers)
    33% identity, 99% coverage of query (169 bits)

8t0zA / Q9UI32 Human liver-type glutaminase (k253a) with l-gln, filamentous form (see paper)
    33% identity, 92% coverage of query (169 bits)

Gls2 / P28492 glutaminase subunit (EC 3.5.1.38) from Rattus norvegicus (see paper)
    33% identity, 99% coverage of query (167 bits)

GLSL_HUMAN / Q9UI32 Glutaminase liver isoform, mitochondrial; GLS; L-glutaminase; L-glutamine amidohydrolase; EC 3.5.1.2 from Homo sapiens (Human) (see 3 papers)
    33% identity, 92% coverage of query (167 bits)

Q4U1A6 glutaminase (EC 3.5.1.2) from Micrococcus luteus (see paper)
    32% identity, 91% coverage of query (166 bits)

3ihbA / Q4U1A6 Crystal structure analysis of mglu in its tris and glutamate form (see paper)
    32% identity, 91% coverage of query (166 bits)

Build an alignment

Build an alignment for WP_009126907.1 and 46 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q9I387 glutaminase (EC 3.5.1.2) from Pseudomonas aeruginosa (see paper)
    29% identity, 94% coverage of query (165 bits)

GLSA2_BACSU / O07637 Glutaminase 2; EC 3.5.1.2 from Bacillus subtilis (strain 168) (see paper)
O07637 glutaminase (EC 3.5.1.2) from Bacillus subtilis (see paper)
    34% identity, 89% coverage of query (164 bits)

5hl1A Crystal structure of glutaminasE C in complex with inhibitor cb-839
    33% identity, 94% coverage of query (164 bits)

Sama_2487 Glutaminase (EC 3.5.1.2) from Shewanella amazonensis SB2B
    31% identity, 89% coverage of query (161 bits)

SO3365 Glutaminase (EC 3.5.1.2) from Shewanella oneidensis MR-1
    31% identity, 89% coverage of query (160 bits)

Shewana3_1184 Glutaminase (EC 3.5.1.2) from Shewanella sp. ANA-3
    31% identity, 89% coverage of query (159 bits)

Q65NY1 glutaminase (EC 3.5.1.2) from Bacillus licheniformis (see paper)
    31% identity, 90% coverage of query (154 bits)

GLSA1_BACSU / O31465 Glutaminase 1; EC 3.5.1.2 from Bacillus subtilis (strain 168) (see paper)
O31465 glutaminase (EC 3.5.1.2); pyridoxal 5'-phosphate synthase (glutamine hydrolysing) (EC 4.3.3.6) from Bacillus subtilis (see 2 papers)
glsA1 / GB|BAA33141.1 glutaminase 1; EC 3.5.1.2 from Bacillus subtilis (see paper)
    30% identity, 89% coverage of query (153 bits)

2osuA / O31465 Probable glutaminase from bacillus subtilis complexed with 6-diazo-5-oxo-l-norleucine
    29% identity, 89% coverage of query (141 bits)

Psest_4081 Glutaminase (EC 3.5.1.2) from Pseudomonas stutzeri RCH2
    29% identity, 94% coverage of query (137 bits)

Pf6N2E2_2102 Glutaminase (EC 3.5.1.2) from Pseudomonas fluorescens FW300-N2E2
    30% identity, 89% coverage of query (134 bits)

AO356_21690 Glutaminase (EC 3.5.1.2) from Pseudomonas fluorescens FW300-N2C3
    30% identity, 89% coverage of query (133 bits)

AO353_26790 Glutaminase (EC 3.5.1.2) from Pseudomonas fluorescens FW300-N2E3
    29% identity, 89% coverage of query (132 bits)

3brmA Crystal structure of the covalent complex between the bacillus subtilis glutaminase ybgj and 5-oxo-l-norleucine formed by reaction of the protein with 6-diazo-5-oxo-l- norleucine
    29% identity, 88% coverage of query (132 bits)

Q8YMZ9 glutaminase (EC 3.5.1.2) from Anabaena sp. (see paper)
    30% identity, 88% coverage of query (129 bits)

PGA1_c09550 Glutaminase (EC 3.5.1.2) from Phaeobacter inhibens BS107
    28% identity, 95% coverage of query (105 bits)

P73903 glutaminase (EC 3.5.1.2) from Synechocystis sp. PCC 6803 (see paper)
    27% identity, 86% coverage of query (90.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory