Searching for up to 100 curated homologs for WP_010442163.1 NCBI__GCF_000192475.1:WP_010442163.1 (360 a.a.)
Found high-coverage hits (≥70%) to 45 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TMBP_NOSS1 / Q8YSQ6 Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
TC 2.A.56.3.3 / Q8YSQ6 Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
40% identity, 82% coverage of query (233 bits)
5cm6A Crystal structure of a trap periplasmic solute binding protein from pseudoalteromonas atlantica t6c(patl_2292, target efi-510180) with bound sodium and pyruvate
43% identity, 79% coverage of query (231 bits)
4petA / Q48AL6 Crystal structure of a trap periplasmic solute binding protein from colwellia psychrerythraea (cps_0129, target efi-510097) with bound calcium and pyruvate (see paper)
38% identity, 89% coverage of query (220 bits)
7ug8B / Q0I6F8 Crystal structure of a solute receptor from synechococcus cc9311 in complex with alpha-ketovaleric and calcium
41% identity, 79% coverage of query (215 bits)
TC 2.A.56.3.4 / D5ALT6 TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
35% identity, 99% coverage of query (210 bits)
4yicA / A0A0J9X284 Crystal structure of a trap transporter solute binding protein (ipr025997) from bordetella bronchiseptica rb50 (bb0280, target efi- 500035) with bound picolinic acid
36% identity, 87% coverage of query (203 bits)
TAKP_CERS4 / Q3J1R2 Alpha-keto acid-binding periplasmic protein TakP; Extracytoplasmic solute receptor protein TakP; TRAP transporter alpha-keto acid-binding subunit P; TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
33% identity, 98% coverage of query (201 bits)
2hzlB / Q3J1R2 Crystal structures of a sodium-alpha-keto acid binding subunit from a trap transporter in its closed forms (see paper)
32% identity, 89% coverage of query (196 bits)
SMc04251 dctP-like component of a pyruvate transporter from Sinorhizobium meliloti 1021
34% identity, 93% coverage of query (184 bits)
Build an alignment for WP_010442163.1 and 9 homologs with ≥ 30% identity
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TLBP_THET8 / Q5SK82 Lactate-binding periplasmic protein TTHA0766; ABC transporter, solute-binding protein; Extracytoplasmic solute receptor protein TTHA0766; TRAP transporter lactate-binding subunit P from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
29% identity, 84% coverage of query (116 bits)
2zzvA / Q5SK82 Crystal structure of a periplasmic substrate binding protein in complex with calcium and lactate (see paper)
28% identity, 73% coverage of query (105 bits)
2zzwA Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate
28% identity, 73% coverage of query (105 bits)
HP15_3028 TRAP-type D-lactate transporter, periplasmic component from Marinobacter adhaerens HP15
26% identity, 83% coverage of query (101 bits)
4pe3A Crystal structure of a trap periplasmic solute binding protein from rhodobacter sphaeroides (rsph17029_3620, target efi-510199), apo open structure (see paper)
27% identity, 80% coverage of query (90.5 bits)
4xf5A / Q1QZR9 Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound (s)-(+)-2-amino-1-propanol.
23% identity, 75% coverage of query (66.2 bits)
4uabA Crystal structure of a trap periplasmic solute binding protein from chromohalobacter salexigens dsm 3043 (csal_0678), target efi-501078, with bound ethanolamine
23% identity, 75% coverage of query (66.2 bits)
7nrrBBB / Q1R0W5 7nrrBBB (see paper)
28% identity, 73% coverage of query (61.6 bits)
7nrrAAA / Q1R0W5 7nrrAAA (see paper)
28% identity, 73% coverage of query (61.2 bits)
7nswBBB TRAP dicarboxylate transporter-DctP subunit
28% identity, 73% coverage of query (61.2 bits)
7ntdAAA TRAP dicarboxylate transporter-DctP subunit
28% identity, 73% coverage of query (61.2 bits)
4p8bA / Q0KC03 Crystal structure of a trap periplasmic solute binding protein from ralstonia eutropha h16 (h16_a1328), target efi-510189, with bound (s)-2-hydroxy-2-methyl-3-oxobutanoate ((s)-2-acetolactate) (see paper)
26% identity, 80% coverage of query (60.8 bits)
4n6kA / C6BWG5 Crystal structure of a trap periplasmic solute binding protein from desulfovibrio salexigens dsm2638, target efi-510113 (desal_0342), complex with diglycerolphosphate (see paper)
26% identity, 78% coverage of query (60.5 bits)
DCTP2_POLSJ / Q122C7 Solute-binding protein Bpro_4736 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
24% identity, 86% coverage of query (60.1 bits)
4mncA / Q122C7 Crystal structure of a trap periplasmic solute binding protein from polaromonas sp. Js666 (bpro_4736), target efi-510156, with bound benzoyl formate, space group p21 (see paper)
25% identity, 79% coverage of query (59.3 bits)
4x8rA Crystal structure of a trap periplasmic solute binding protein from rhodobacter sphaeroides (rsph17029_2138, target efi-510205) with bound glucuronate
24% identity, 77% coverage of query (58.5 bits)
DCTP2_OLEA2 / Q315G1 Solute-binding protein Dde_0634 from Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) (see paper)
25% identity, 73% coverage of query (56.2 bits)
4napD / Q315G1 Crystal structure of a trap periplasmic solute binding protein from desulfovibrio alaskensis g20 (dde_0634), target efi-510102, with bound d-tryptophan (see paper)
25% identity, 73% coverage of query (55.8 bits)
4pgpA Crystal structure of a trap periplasmic solute binding protein from desulfovibrio alaskensis g20 (dde_0634, target efi-510120) with bound 3-indole acetic acid
25% identity, 73% coverage of query (55.8 bits)
4pgnA Crystal structure of a trap periplasmic solute binding protein from desulfovibrio alaskensis g20 (dde_0634, target efi-510120) with bound indole pyruvate
25% identity, 73% coverage of query (55.8 bits)
SIAP_HAEIN / P44542 Sialic acid-binding periplasmic protein SiaP; Extracytoplasmic solute receptor protein SiaP; N-acetylneuraminic-binding protein; Neu5Ac-binding protein from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 4 papers)
TC 2.A.56.1.3 / P44542 SiaP. AKA Sialic acid-binding periplasmic protein, component of Na+-dependent (smf-driven) sialic acid (N-acetyl neuraminic acid) transporter, SiaTP (Allen et al., 2005; Severi et al., 2005; Johnston et al., 2008). SiaT is also called SiaQM from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 4 papers)
25% identity, 72% coverage of query (55.5 bits)
2cexA Structure of a sialic acid binding protein (siap) in the presence of the sialic acid acid analogue neu5ac2en
25% identity, 72% coverage of query (55.5 bits)
3b50A / P44542 Structure of h. Influenzae sialic acid binding protein bound to neu5ac. (see paper)
25% identity, 72% coverage of query (55.1 bits)
2cexB Structure of a sialic acid binding protein (siap) in the presence of the sialic acid acid analogue neu5ac2en
25% identity, 72% coverage of query (55.1 bits)
2wx9A Crystal structure of the sialic acid binding periplasmic protein siap
25% identity, 72% coverage of query (55.1 bits)
SIAP_VIBCH / Q9KR64 Sialic acid-binding periplasmic protein SiaP from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 2 papers)
TC 2.A.56.1.6 / Q9KR64 C4-dicarboxylate-binding periplasmic protein, component of The Na+-dependent sialic acid uptake porter, SiaPQM. SiaQ and SiaM form a 1:1 stoichiometric complex from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
24% identity, 87% coverage of query (54.7 bits)
2v4cA Structure of sialic acid binding protein (siap) in the presence of kdn
25% identity, 72% coverage of query (54.7 bits)
Psest_2125 D-gluconate TRAP transporter, periplasmic component from Pseudomonas stutzeri RCH2
26% identity, 78% coverage of query (54.3 bits)
4x04A / A8AR30 Crystal structure of a trap periplasmic solute binding protein from citrobacter koseri (cko_04899, target efi-510094) with bound d- glucuronate
23% identity, 70% coverage of query (52.8 bits)
4magA Crystal structure of the periplasmic sialic acid binding protein from vibrio cholerea (see paper)
23% identity, 78% coverage of query (52.8 bits)
7a5qB Crystal structure of vcsiap bound to sialic acid
23% identity, 78% coverage of query (52.8 bits)
7a5qA Crystal structure of vcsiap bound to sialic acid
23% identity, 78% coverage of query (52.8 bits)
DCTP_ALBFT / Q21XD7 Solute-binding protein Rfer_1840 from Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens) (see paper)
24% identity, 84% coverage of query (52.4 bits)
2xwoA Siap r147e mutant in complex with sialylamide
25% identity, 72% coverage of query (52.0 bits)
DCTP_RHOCA / P37735 C4-dicarboxylate-binding periplasmic protein DctP from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see 3 papers)
TC 2.A.56.1.1 / P37735 DctP, component of Tripartite dicarboxylate:H+ symporter (substrates include: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate and mesaconate) from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (see paper)
26% identity, 93% coverage of query (46.6 bits)
7t3eA / Q6LPV9 Structure of the sialic acid bound tripartite atp-independent periplasmic (trap) periplasmic component siap from photobacterium profundum (see paper)
24% identity, 79% coverage of query (46.2 bits)
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Lawrence Berkeley National Laboratory