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Searching for up to 100 curated homologs for WP_010876512.1 NCBI__GCF_000008645.1:WP_010876512.1 (224 a.a.)

Found high-coverage hits (≥70%) to 54 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2bmuB / Q8U122 Ump kinase from pyrococcus furiosus complexed with its substrate ump and its substrate analog amppnp (see paper)
    43% identity, 100% coverage of query (175 bits)

PYRH_PYRFU / Q8U122 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 2 papers)
Q8U122 UMP kinase (EC 2.7.4.22) from Pyrococcus furiosus (see paper)
    43% identity, 100% coverage of query (175 bits)

2ji5A Structure of ump kinase from pyrococcus furiosus complexed with utp
    43% identity, 100% coverage of query (166 bits)

PYRH_SACS2 / Q97ZE2 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q97ZE2 UMP kinase (EC 2.7.4.22) from Saccharolobus solfataricus (see paper)
    39% identity, 82% coverage of query (130 bits)

2j4jF / Q97ZE2 Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with ump and amppcp to 2.1 angstrom resolution (see paper)
    39% identity, 82% coverage of query (130 bits)

2j4jA Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with ump and amppcp to 2.1 angstrom resolution
    37% identity, 82% coverage of query (115 bits)

2j4lA Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with utp to 2.8 angstrom resolution
    37% identity, 82% coverage of query (112 bits)

2j4kC / Q97ZE2 Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with ump to 2.2 angstrom resolution (see paper)
    35% identity, 82% coverage of query (101 bits)

2j4lH Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with utp to 2.8 angstrom resolution
    33% identity, 82% coverage of query (84.3 bits)

PYRH_SALTY / P65933 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
P65933 UMP kinase (EC 2.7.4.22) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    30% identity, 83% coverage of query (67.0 bits)

PYRH_ENTFA / Q831V1 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
    31% identity, 88% coverage of query (66.2 bits)

Umk / b0171 UMP kinase (EC 2.7.4.22; EC 2.7.4.14) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
pyrH / P0A7E9 UMP kinase (EC 2.7.4.22) from Escherichia coli (strain K12) (see 16 papers)
PYRH_ECOLI / P0A7E9 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Escherichia coli (strain K12) (see 5 papers)
A7ZWB7 UMP kinase (EC 2.7.4.22) from Escherichia coli (see paper)
P0A7E9 UMP kinase (EC 2.7.4.22) from Escherichia coli (see 10 papers)
pyrH / SP|P0A7F0 uridylate kinase; EC 2.7.4.22 from Shigella flexneri (see 10 papers)
    30% identity, 83% coverage of query (66.2 bits)

Build an alignment

Build an alignment for WP_010876512.1 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PUMPK_ARATH / Q9LSA9 Uridylate kinase PUMPKIN, chloroplastic; Plastid UMP kinase; Protein DEFECT IN PSAA/B TRANSCRIPT ACCUMULATION 1; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    27% identity, 83% coverage of query (65.5 bits)

P56106 UMP kinase (EC 2.7.4.22) from Helicobacter pylori (see 2 papers)
    29% identity, 78% coverage of query (65.5 bits)

4a7wA Crystal structure of uridylate kinase from helicobacter pylori
    29% identity, 78% coverage of query (65.5 bits)

4a7xC / P56106 Crystal structure of uridylate kinase from helicobacter pylori (see paper)
    29% identity, 78% coverage of query (65.1 bits)

MOSB_AZOVD / P84253 Molybdenum storage protein subunit beta; Mo storage protein subunit beta; MoSto subunit beta from Azotobacter vinelandii (strain DJ / ATCC BAA-1303) (see paper)
mosB molybdenum storage protein subunit beta from Azotobacter vinelandii DJ (see 2 papers)
    29% identity, 97% coverage of query (65.1 bits)

7z5jB The molybdenum storage protein loaded with tungstate
    29% identity, 97% coverage of query (65.1 bits)

6rkeB Molybdenum storage protein - p212121, adp, molybdate
    29% identity, 97% coverage of query (65.1 bits)

6rkdB Molybdenum storage protein under turnover conditions
    29% identity, 97% coverage of query (65.1 bits)

6h8hB Molybdenum storage protein - in a recombinant and in vivo-like form
    29% identity, 97% coverage of query (65.1 bits)

6h8bB Molybdenum storage protein prepared under in vivo-like conditions and incubated with atp and molybdate at 303 k
    29% identity, 97% coverage of query (65.1 bits)

6gx4B The molybdenum storage protein: with atp/mn2+ and with pom clusters formed under in vitro conditions
    29% identity, 97% coverage of query (65.1 bits)

4f6tB The crystal structure of the molybdenum storage protein (mosto) from azotobacter vinelandii loaded with various polyoxometalates
    29% identity, 97% coverage of query (65.1 bits)

6rj4B Molybdenum storage protein - p6422, adp
    29% identity, 97% coverage of query (65.1 bits)

2bneB / P0A7E9 The structure of e. Coli ump kinase in complex with ump (see paper)
    30% identity, 83% coverage of query (64.7 bits)

PYRH_UREPA / Q9PPX6 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Ureaplasma parvum serovar 3 (strain ATCC 700970) (see 2 papers)
    25% identity, 100% coverage of query (64.7 bits)

2v4yA The structure of e. Coli ump kinase in complex with its allosteric regulator gtp
    30% identity, 83% coverage of query (64.7 bits)

6yt3B / P84253 Structure of the mostonano fusion protein (see paper)
    29% identity, 97% coverage of query (64.3 bits)

2bnfA The structure of e. Coli ump kinase in complex with utp
    29% identity, 83% coverage of query (63.5 bits)

2bndA The structure of e. Coli ump kinase in complex with udp
    29% identity, 83% coverage of query (63.2 bits)

3ek5A / P59009 Unique gtp-binding pocket and allostery of ump kinase from a gram- negative phytopathogen bacterium (see paper)
    30% identity, 94% coverage of query (62.0 bits)

2va1B / Q9PPX6 Crystal structure of ump kinase from ureaplasma parvum (see paper)
    24% identity, 100% coverage of query (55.1 bits)

PYRH_STRPN / Q97R83 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see 2 papers)
Q97R83 UMP kinase (EC 2.7.4.22) from Streptococcus pneumoniae (see paper)
    29% identity, 98% coverage of query (54.7 bits)

pyrH / CAB38122.1 UMP-kinase from Lactococcus lactis (see paper)
    27% identity, 98% coverage of query (53.1 bits)

P9WHK5 UMP kinase (EC 2.7.4.22) from Mycobacterium tuberculosis (see 2 papers)
    27% identity, 98% coverage of query (52.4 bits)

PYRH_STAA8 / Q2FZ22 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    28% identity, 83% coverage of query (49.3 bits)

PYRH_NEIMB / P65932 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
pyrH UMP kinase; EC 2.7.4.22 from Neisseria meningitidis serogroup B (see 2 papers)
    27% identity, 75% coverage of query (49.3 bits)

ipkA / Q9HLX1 isopentenyl phosphate kinase subunit (EC 2.7.4.26) from Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) (see 3 papers)
IPK_THEAC / Q9HLX1 Isopentenyl phosphate kinase; IPK; EC 2.7.4.26 from Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) (see 2 papers)
Q9HLX1 isopentenyl phosphate kinase (EC 2.7.4.26) from Thermoplasma acidophilum (see 5 papers)
    25% identity, 96% coverage of query (47.8 bits)

8u0mA Crystal structure of isopentenyl phosphate kinase from thermococcus paralvinellae bound to (e)-2-methylbut-2-en-1-yl monophosphate and atp
    28% identity, 97% coverage of query (46.6 bits)

6rkeA / P84308 Molybdenum storage protein - p212121, adp, molybdate (see paper)
    26% identity, 97% coverage of query (46.2 bits)

MOSA_AZOVD / P84308 Molybdenum storage protein subunit alpha; Mo storage protein subunit alpha; MoSto subunit alpha from Azotobacter vinelandii (strain DJ / ATCC BAA-1303) (see paper)
mosA molybdenum storage protein subunit alpha from Azotobacter vinelandii DJ (see 2 papers)
    26% identity, 97% coverage of query (46.2 bits)

6rkdA Molybdenum storage protein under turnover conditions
    26% identity, 97% coverage of query (46.2 bits)

7z5jA The molybdenum storage protein loaded with tungstate
    26% identity, 97% coverage of query (46.2 bits)

6h8bA Molybdenum storage protein prepared under in vivo-like conditions and incubated with atp and molybdate at 303 k
    26% identity, 97% coverage of query (46.2 bits)

6h73A Molybdenum storage protein - recombinantly produced and loaded with molybdate under in vitro conditions
    26% identity, 97% coverage of query (46.2 bits)

6gx4A The molybdenum storage protein: with atp/mn2+ and with pom clusters formed under in vitro conditions
    26% identity, 97% coverage of query (46.2 bits)

6risA The kb42s variant of the molybdenum storage protein
    26% identity, 97% coverage of query (46.2 bits)

6h8hA Molybdenum storage protein - in a recombinant and in vivo-like form
    26% identity, 97% coverage of query (46.2 bits)

6h74A The molybdenum storage protein - l131h
    26% identity, 97% coverage of query (46.2 bits)

3nwyB / P9WHK5 Structure and allosteric regulation of the uridine monophosphate kinase from mycobacterium tuberculosis (see paper)
    27% identity, 98% coverage of query (45.8 bits)

7besA Cryoem structure of mycobacterium tuberculosis ump kinase (umpk) in complex with udp and utp
    27% identity, 98% coverage of query (45.8 bits)

7lnwA I146a mutant of the isopentenyl phosphate kinase from candidatus methanomethylophilus alvus
    24% identity, 99% coverage of query (44.3 bits)

3ll5A Crystal structure of t. Acidophilum isopentenyl phosphate kinase product complex
    25% identity, 96% coverage of query (43.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory