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Searching for up to 100 curated homologs for WP_010959665.1 NCBI__GCF_000008325.1:WP_010959665.1 (496 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

LysU / b4129 lysine—tRNA ligase/Ap4A synthetase/Ap3A synthetase (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 70 papers)
lysU / P0A8N5 lysyl-tRNA synthetase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 73 papers)
P0A8N5 lysine-tRNA ligase (EC 6.1.1.6) from Escherichia coli (see paper)
lysU / RF|NP_418553 lysyl-tRNA synthetase, heat inducible; EC 6.1.1.6 from Escherichia coli K12 (see 10 papers)
    63% identity, 100% coverage of query (648 bits)

HerC / b2890 lysine—tRNA ligase, constitutive (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 53 papers)
lysS / P0A8N3 lysine—tRNA ligase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 53 papers)
lysS lysine--tRNA ligase; EC 6.1.1.6 from Escherichia coli K12 (see paper)
    64% identity, 99% coverage of query (648 bits)

P0A8N5 Lysine--tRNA ligase, heat inducible; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Escherichia coli (strain K12)
    63% identity, 100% coverage of query (648 bits)

1bbuA / P0A8N3 Lysyl-tRNA synthetase (lyss) complexed with lysine (see paper)
    63% identity, 99% coverage of query (630 bits)

1e1tA / P0A8N5 Lysyl-tRNA synthetase (lysu) hexagonal form complexed with the lysyl_adenylate intermediate (see paper)
    62% identity, 99% coverage of query (628 bits)

1e24A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and atp and mn2+
    62% identity, 99% coverage of query (628 bits)

1e22A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and the non-hydrolysable atp analogue amp-pcp
    62% identity, 99% coverage of query (628 bits)

5yzxA Crystal structure of e.Coli lysu t146d mutant
    62% identity, 99% coverage of query (625 bits)

1e1oA Lysyl-tRNA synthetase (lysu) hexagonal form, complexed with lysine
    62% identity, 99% coverage of query (622 bits)

6wbdB / B2FQ84 Crystal structure of lysyl-tRNA synthetase from stenotrophomonas maltophilia with bound l-lysine
    63% identity, 99% coverage of query (608 bits)

4ex5A / Q2SXD6 Crystal structure of lysyl-tRNA synthetase lysrs from burkholderia thailandensis bound to lysine (see paper)
    57% identity, 98% coverage of query (572 bits)

Q9RHV9 lysine-tRNA ligase (EC 6.1.1.6) from Geobacillus stearothermophilus (see 3 papers)
    54% identity, 98% coverage of query (528 bits)

SYK_STAAU / Q53638 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Staphylococcus aureus (see paper)
    53% identity, 99% coverage of query (522 bits)

3a74A / Q9RHV9 Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with diadenosine tetraphosphate (ap4a)
    53% identity, 98% coverage of query (514 bits)

3e9iA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysine hydroxamate-amp
    53% identity, 98% coverage of query (514 bits)

3e9hA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysylsulfamoyl adenosine
    53% identity, 98% coverage of query (514 bits)

Q1D380 lysine-tRNA ligase (EC 6.1.1.6) from Myxococcus xanthus (see 2 papers)
    51% identity, 98% coverage of query (501 bits)

Q04LI2 lysine-tRNA ligase (EC 6.1.1.6) from Streptococcus pneumoniae (see paper)
    50% identity, 99% coverage of query (477 bits)

SYKM_ARATH / Q9LJE2 Lysine--tRNA ligase, chloroplastic/mitochondrial; Lysyl-tRNA synthetase; LysRS; Lysyl-tRNA synthetase 2; AtKRS-2; Protein OVULE ABORTION 5; EC 6.1.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    42% identity, 98% coverage of query (408 bits)

SYK_MOUSE / Q99MN1 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Mus musculus (Mouse) (see paper)
Q99MN1 lysine-tRNA ligase (EC 6.1.1.6) from Mus musculus (see paper)
    43% identity, 99% coverage of query (389 bits)

SYK_HUMAN / Q15046 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Homo sapiens (Human) (see 25 papers)
Q15046 lysine-tRNA ligase (EC 6.1.1.6) from Homo sapiens (see 12 papers)
    43% identity, 99% coverage of query (386 bits)

6chdA / Q15046 Crystal structure of human lysyl-tRNA synthetase complexed with l- lysylsulfamoyl adenosine
    43% identity, 99% coverage of query (386 bits)

4ycuA Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase
    43% identity, 99% coverage of query (386 bits)

SYK_CRIGR / P37879 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
    42% identity, 99% coverage of query (383 bits)

SYK_RAT / Q5XIM7 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 2.7.7.-; EC 6.1.1.6 from Rattus norvegicus (Rat) (see 5 papers)
    42% identity, 99% coverage of query (382 bits)

3bjuA Crystal structure of tetrameric form of human lysyl-tRNA synthetase
    42% identity, 99% coverage of query (380 bits)

4dpgA Crystal structure of human lysrs: p38/aimp2 complex i
    42% identity, 99% coverage of query (378 bits)

P15180 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    42% identity, 99% coverage of query (376 bits)

4ycwA Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant
    42% identity, 99% coverage of query (376 bits)

6ildB Crystal structure of human lysrs: p38/aimp2 complex ii
    42% identity, 99% coverage of query (376 bits)

CLA4_CLACD / A0A120HYZ1 Lysine--tRNA ligase cla4; Cladosporin biosynthesis cluster protein 4; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Cladosporium cladosporioides (see paper)
    40% identity, 99% coverage of query (374 bits)

7f6wA / P15180 Crystal structure of saccharomyces cerevisiae lysyl-tRNA synthetase (see paper)
    42% identity, 99% coverage of query (369 bits)

4up7A / C4M7X2 Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate (see paper)
    40% identity, 94% coverage of query (360 bits)

Q580G3 lysine-tRNA ligase (EC 6.1.1.6) from Trypanosoma brucei (see paper)
    39% identity, 95% coverage of query (357 bits)

Q8IDJ8 lysine-tRNA ligase (EC 6.1.1.6) from Plasmodium falciparum (see 2 papers)
    40% identity, 94% coverage of query (353 bits)

6aqgC / A0PV47 Crystal structure of lysyl-tRNA synthetase from mycobacterium ulcerans complexed with l-lysine and cladosporin
    43% identity, 97% coverage of query (353 bits)

6agtB / Q8IDJ8 Crystal structure of pfkrs complexed with chromone inhibitor (see paper)
    40% identity, 94% coverage of query (351 bits)

6kbfA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
    40% identity, 94% coverage of query (351 bits)

6kctA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 5
    40% identity, 94% coverage of query (351 bits)

6kabA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2
    40% identity, 94% coverage of query (351 bits)

6bniA / Q5CR27 Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and adenosine
    46% identity, 77% coverage of query (349 bits)

SYKC_ARATH / Q9ZPI1 Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase; LysRS; Lysyl-tRNA synthetase 1; AtKRS-1; EC 6.1.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    41% identity, 87% coverage of query (349 bits)

6hcwA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and a difluoro cyclohexyl chromone ligand
    41% identity, 94% coverage of query (349 bits)

6c86A Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysylsulfamoyl adenosine
    41% identity, 94% coverage of query (349 bits)

5eloA Crystal structure of lysyl-tRNA synthetase from cryptosporidium parvum complexed with l-lysine and cladosporin
    46% identity, 77% coverage of query (349 bits)

J5K1T7 lysine-tRNA ligase (EC 6.1.1.6) from Beauveria bassiana (see paper)
    37% identity, 98% coverage of query (346 bits)

A0QHC4 lysyltransferase (EC 2.3.2.3) from Mycobacterium avium (see paper)
    42% identity, 88% coverage of query (345 bits)

4upaA Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with amppnp
    40% identity, 94% coverage of query (344 bits)

4up9A Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with atp
    40% identity, 94% coverage of query (343 bits)

A0R577 lysine-tRNA ligase (EC 6.1.1.6) from Mycolicibacterium smegmatis (see paper)
    43% identity, 97% coverage of query (339 bits)

SYK_CAEEL / Q22099 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Caenorhabditis elegans (see paper)
    40% identity, 94% coverage of query (338 bits)

6kcnA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4
    40% identity, 94% coverage of query (338 bits)

7zogA Crystal structure of cryptosporidium parvum -plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
    41% identity, 94% coverage of query (336 bits)

LYSX_MYCTU / P9WFU7 Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX; EC 6.1.1.6; EC 2.3.2.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
A5U2Z7 [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Mycobacterium tuberculosis (see paper)
P9WFU7 lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Mycobacterium tuberculosis (see 2 papers)
    40% identity, 98% coverage of query (335 bits)

6aqhB / G7CF12 Crystal structure of lysyl-tRNA synthetase from mycobacterium thermoresistibile complexed with l-lysine and cladosporin
    43% identity, 97% coverage of query (335 bits)

6m0tA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and cladosporin derivative (cl-2)
    40% identity, 94% coverage of query (333 bits)

6nrzA / B0BAN6 Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and adenosine
6nrzB / B0BAN6 Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and adenosine
    39% identity, 99% coverage of query (331 bits)

6o3fA Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis with complexed with l-lysine and a difluoro cyclohexyl chromone ligand
    39% identity, 99% coverage of query (331 bits)

6ns0A Crystal structure of lysyl-tRNA synthetase from chlamydia trachomatis complexed with l-lysine and cladosporin
    39% identity, 99% coverage of query (331 bits)

A0QYV1 lysine-tRNA ligase (EC 6.1.1.6) from Mycolicibacterium smegmatis (see paper)
    41% identity, 90% coverage of query (330 bits)

8k9vA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 3 (adki3)
    39% identity, 94% coverage of query (329 bits)

8k9sA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 1 (adki1)
    39% identity, 94% coverage of query (329 bits)

6l4qA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-b
    39% identity, 94% coverage of query (329 bits)

7qi8A Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and inhibitor
    40% identity, 96% coverage of query (328 bits)

7qh8A / P9WFU9 Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine (see paper)
    42% identity, 96% coverage of query (327 bits)

6ka6A Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
    39% identity, 94% coverage of query (327 bits)

5hgqB Loa loa lysyl-tRNA synthetase in complex with cladosporin. (see paper)
    40% identity, 97% coverage of query (326 bits)

4pg3A Crystal structure of krs complexed with inhibitor
    39% identity, 94% coverage of query (324 bits)

8k9uA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 2 (adki2)
    38% identity, 94% coverage of query (323 bits)

5zh4A Crystal structure of pfkrs with inhibitor clado-7
    39% identity, 94% coverage of query (321 bits)

5zh2A / W7JP72 Crystal structure of pfkrs with inhibitor clado-5 (see paper)
    39% identity, 94% coverage of query (320 bits)

7bt5A Crystal structure of plasmodium lysrs complexing with an antitumor compound
    39% identity, 94% coverage of query (318 bits)

8k9xA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 5 (adki5)
    39% identity, 94% coverage of query (318 bits)

6hcuA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
    38% identity, 94% coverage of query (317 bits)

6l3yA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with l-lysine and clado-c
    39% identity, 94% coverage of query (317 bits)

8k9wA Crystal structure of plasmodium lysrs complexing with asp3026 derived lysrs inhibitor 4 (adki4)
    38% identity, 94% coverage of query (313 bits)

5zh5A Crystal structure of pfkrs with inhibitor clado-2
    38% identity, 94% coverage of query (312 bits)

5zh3B Crystal structure of pfkrs with inhibitor clado-6
    38% identity, 94% coverage of query (311 bits)

6hcvA Crystal structure of lysyl-tRNA synthetase from plasmodium falciparum complexed with a chromone ligand
    38% identity, 94% coverage of query (310 bits)

5zh4B Crystal structure of pfkrs with inhibitor clado-7
    38% identity, 94% coverage of query (310 bits)

7qhnA Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and an inhibitor
    40% identity, 96% coverage of query (305 bits)

5zh3A Crystal structure of pfkrs with inhibitor clado-6
    37% identity, 94% coverage of query (303 bits)

SYKM_SCHPO / O74858 Lysine--tRNA ligase, mitochondrial; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    33% identity, 97% coverage of query (258 bits)

SYKM_YEAST / P32048 Lysine--tRNA ligase, mitochondrial; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P32048 lysine-tRNA ligase (EC 6.1.1.6) from Saccharomyces cerevisiae (see paper)
    31% identity, 71% coverage of query (175 bits)

Build an alignment

Build an alignment for WP_010959665.1 and 84 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

SYDND_METMA / Q8Q0R2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) (see paper)
    28% identity, 92% coverage of query (138 bits)

1b8aA / Q52428 Aspartyl-tRNA synthetase (see paper)
    27% identity, 91% coverage of query (131 bits)

SYD_THEKO / Q52428 Aspartate--tRNA(Asp) ligase; Aspartyl-tRNA synthetase; AspRS; Discriminating aspartyl-tRNA synthetase; D-AspRS; EC 6.1.1.12 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 4 papers)
Q52428 aspartate-tRNA ligase (EC 6.1.1.12) from Thermococcus kodakarensis (see 4 papers)
    27% identity, 91% coverage of query (131 bits)

3nemB Aspartyl-tRNA synthetase complexed with aspartyl adenylate
    27% identity, 91% coverage of query (131 bits)

3nemA Aspartyl-tRNA synthetase complexed with aspartyl adenylate
    27% identity, 91% coverage of query (131 bits)

3nelA Aspartyl-tRNA synthetase complexed with aspartic acid
    27% identity, 91% coverage of query (131 bits)

SYDND_METTH / O26328 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
O26328 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Methanothermobacter thermautotrophicus (see paper)
    26% identity, 88% coverage of query (121 bits)

SYDND_HALSA / O07683 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
O07683 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Halobacterium salinarum (see paper)
    26% identity, 86% coverage of query (109 bits)

erdS / Q4WKG3 aspartate--tRNA ligase/ergosteryl-3β-O-L-aspartate synthase (EC 6.1.1.23; EC 2.3.2.37) from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (see paper)
    25% identity, 93% coverage of query (103 bits)

SYDC_RAT / P15178 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Rattus norvegicus (Rat) (see paper)
    23% identity, 90% coverage of query (102 bits)

SYDC_MOUSE / Q922B2 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Mus musculus (Mouse) (see paper)
Q922B2 aspartate-tRNA ligase (EC 6.1.1.12) from Mus musculus (see paper)
    23% identity, 87% coverage of query (100 bits)

SYDND_THET8 / Q5SIC2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 4 papers)
Q5SIC2 aspartate-tRNA ligase (EC 6.1.1.12) from Thermus thermophilus (see paper)
    27% identity, 88% coverage of query (99.4 bits)

1x55A Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate analogue
    24% identity, 87% coverage of query (84.3 bits)

1x54A / O57980 Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate (see paper)
    24% identity, 87% coverage of query (84.3 bits)

3kfuC / Q5SIC2 Crystal structure of the transamidosome (see paper)
    26% identity, 87% coverage of query (83.6 bits)

3m4pA / C4LWW8 Entamoeba histolytica asparaginyl-tRNA synthetase (asnrs) in complex with asparaginyl-adenylate
    23% identity, 77% coverage of query (73.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory