Searching for up to 100 curated homologs for WP_010961231.1 NCBI__GCF_000008325.1:WP_010961231.1 (246 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PA3004 / Q9HZK1 S-methyl-5'-thioinosine phosphorylase monomer (EC 2.4.2.44) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
MTIP_PSEAE / Q9HZK1 S-methyl-5'-thioinosine phosphorylase; 5'-methylthioinosine phosphorylase; MTI phosphorylase; MTIP; EC 2.4.2.44 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9HZK1 S-methyl-5'-thioinosine phosphorylase (EC 2.4.2.44) from Pseudomonas aeruginosa (see paper)
63% identity, 98% coverage of query (297 bits)
3ozbA / Q9HZK1 Crystal structure of 5'-methylthioinosine phosphorylase from psedomonas aeruginosa in complex with hypoxanthine (see paper)
62% identity, 98% coverage of query (287 bits)
PNPH_PYRFU / Q8U2I1 6-oxopurine nucleoside phosphorylase; Purine nucleoside phosphorylase; PNP; PfPNP; EC 2.4.2.1 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 2 papers)
Q8U2I1 purine-nucleoside phosphorylase (EC 2.4.2.1) from Pyrococcus furiosus (see 2 papers)
45% identity, 97% coverage of query (204 bits)
TK1482 / Q5JJB8 guanosine phosphorylase (EC 2.4.2.15) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
PNPH_THEKO / Q5JJB8 Probable 6-oxopurine nucleoside phosphorylase; Purine nucleoside phosphorylase; PNP; EC 2.4.2.1 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
44% identity, 99% coverage of query (203 bits)
MTAP_MYCS2 / A0QR54 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; EC 2.4.2.28 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
42% identity, 96% coverage of query (162 bits)
1wtaA / Q9YAQ8 Crystal structure of 5'-deoxy-5'-methylthioadenosine from aeropyrum pernix (r32 form)
42% identity, 90% coverage of query (162 bits)
MTAP_SACS2 / Q97W94 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPII; EC 2.4.2.28 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
Q97W94 purine-nucleoside phosphorylase (EC 2.4.2.1); S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Saccharolobus solfataricus (see 3 papers)
3t94A / Q97W94 Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (mtap) ii complexed with 5'-deoxy-5'-methylthioadenosine and sulfate (see paper)
38% identity, 95% coverage of query (160 bits)
MTAP_MYCTU / O06401 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; EC 2.4.2.28 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O06401 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Mycobacterium tuberculosis (see paper)
43% identity, 88% coverage of query (156 bits)
salT / B0L7E7 chloro-purine nucleoside phosphorylase (EC 2.4.2.1) from Salinispora tropica (see paper)
B0L7E7 purine-nucleoside phosphorylase (EC 2.4.2.1) from Salinispora tropica (see paper)
43% identity, 92% coverage of query (155 bits)
MTAP_PYRFU / Q8U4Q8 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; PfMTAP; EC 2.4.2.28 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 3 papers)
Q8U4Q8 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Pyrococcus furiosus (see paper)
36% identity, 98% coverage of query (154 bits)
flB / Q1EMV9 5'-fluoro-5'-deoxy-adenosine phosphorylase (EC 2.4.2.1) from Streptantibioticus cattleyicolor (see paper)
flB / CAJ20005.1 5'-fluoro-5'-deoxy-adenosine phosphorylase from Streptomyces cattleya (see paper)
46% identity, 83% coverage of query (154 bits)
5f7jB / I0B503 Crystal structure of mutant n87t of adenosine/methylthioadenosine phosphorylase from schistosoma mansoni in complex with adenine (see paper)
37% identity, 87% coverage of query (147 bits)
1sd2A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with 5'-methylthiotubercidin
37% identity, 89% coverage of query (147 bits)
I0B503 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Schistosoma mansoni (see paper)
37% identity, 87% coverage of query (146 bits)
pnp / Q5JEQ6 adenosine phosphorylase (EC 2.4.2.1) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
MTAP_THEKO / Q5JEQ6 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; Nucleoside phosphorylase; EC 2.4.2.28 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
37% identity, 85% coverage of query (146 bits)
C6KFA4 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from uncultured bacterium (see paper)
38% identity, 84% coverage of query (145 bits)
4gljA / C6KFA4 Crystal structure of methylthioadenosine phosphorylase in complex with rhodamine b (see paper)
38% identity, 84% coverage of query (145 bits)
Q9CQ65 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Mus musculus (see paper)
37% identity, 87% coverage of query (144 bits)
MTAP / Q13126 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Homo sapiens (see 5 papers)
MTAP_HUMAN / Q13126 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; EC 2.4.2.28 from Homo sapiens (Human) (see 6 papers)
Q13126 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Homo sapiens (see 8 papers)
36% identity, 87% coverage of query (144 bits)
5tc5A / Q13126 Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-dadme-immucillin-a and chloride
36% identity, 87% coverage of query (144 bits)
4l5aA Methylthioadenosine phosphorylase from schistosoma mansoni in complex with tubercidin
37% identity, 85% coverage of query (144 bits)
6dz0A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3- ol
36% identity, 87% coverage of query (144 bits)
6dz3A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1h-1,2,3-triazol-4-yl) propyl)thio)methyl)pyrrolidin-3-ol
36% identity, 87% coverage of query (144 bits)
6dyzA Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3- ol
36% identity, 87% coverage of query (144 bits)
5tc8A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-dadme-immucillin-a
36% identity, 87% coverage of query (144 bits)
5tc6A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-a
36% identity, 87% coverage of query (144 bits)
3ozcA Crystal structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pcl-phenylthiodadmeimma
36% identity, 87% coverage of query (144 bits)
5eubA Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-mta and sulfate
36% identity, 87% coverage of query (143 bits)
5f76A Crystal structure of mutant s12t of adenosine/methylthioadenosine phosphorylase from schistosoma mansoni in complex with methylthioadenosine
37% identity, 85% coverage of query (143 bits)
MTAP_RHORT / Q2RXH9 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; EC 2.4.2.28 from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) (see 2 papers)
38% identity, 83% coverage of query (142 bits)
1sd1A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with formycin a
36% identity, 89% coverage of query (142 bits)
1cg6A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with 5'-deoxy-5'-methylthioadenosine and sulfate at 1.7 a resolution
36% identity, 89% coverage of query (142 bits)
1cb0A Structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 a resolution
36% identity, 89% coverage of query (142 bits)
1k27A Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with a transition state analogue
37% identity, 83% coverage of query (142 bits)
MTAP_DROME / Q9V813 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; EC 2.4.2.28 from Drosophila melanogaster (Fruit fly) (see paper)
33% identity, 96% coverage of query (138 bits)
6dz2A Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3r,4s)-1-((4-amino-5h-pyrrolo[3,2- d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1h-1,2,3-triazol-4-yl) propyl)thio)methyl)pyrrolidin-3-ol
36% identity, 87% coverage of query (137 bits)
MTAP_BOVIN / Q3MHF7 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; EC 2.4.2.28 from Bos taurus (Bovine) (see paper)
36% identity, 87% coverage of query (133 bits)
MTAP_YEAST / Q07938 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; Multicopy enhancer of UAS2; EC 2.4.2.28 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
34% identity, 89% coverage of query (124 bits)
MTAP_SCHPO / Q09816 S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase; EC 2.4.2.28 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
32% identity, 93% coverage of query (122 bits)
3khsB / Q5YBA4 Crystal structure of grouper iridovirus purine nucleoside phosphorylase (see paper)
30% identity, 86% coverage of query (68.9 bits)
Build an alignment for WP_010961231.1 and 40 homologs with ≥ 30% identity
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PUNA_GEOSE / P77834 Purine nucleoside phosphorylase 1; PNP 1; Inosine phosphorylase; Inosine-guanosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; Pu-NPase I; EC 2.4.2.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 2 papers)
P77834 purine-nucleoside phosphorylase (EC 2.4.2.1) from Geobacillus stearothermophilus (see paper)
27% identity, 87% coverage of query (68.2 bits)
4uc0A / B9JYS2 Crystal structure of a purine nucleoside phosphorylase (psi-nysgrc- 029736) from agrobacterium vitis
28% identity, 93% coverage of query (65.5 bits)
3fazA Crystal structure of schistosoma mansoni purine nucleoside phosphorylase in complex with inosine
27% identity, 87% coverage of query (64.7 bits)
1tcuA Crystal structure of the purine nucleoside phosphorylase from schistosoma mansoni in complex with phosphate and acetate
27% identity, 87% coverage of query (64.7 bits)
3e9zA Crystal structure of purine nucleoside phosphorylase from schistosoma mansoni in complex with 6-chloroguanine
27% identity, 87% coverage of query (64.3 bits)
3djfA Crystal structure of schistosoma mansoni purine nucleoside phosphorylase in a complex with bcx-34
27% identity, 87% coverage of query (64.3 bits)
3fb1A Crystal structure of purine nucleoside phosphorylase in complex with ribose-1-phosphate
27% identity, 87% coverage of query (64.3 bits)
3fnqA Crystal structure of schistosoma purine nucleoside phosphorylase in complex with hypoxanthine
27% identity, 87% coverage of query (64.3 bits)
3f8wA Crystal structure of schistosoma mansoni purine nucleoside phosphorylase in complex with adenosine
27% identity, 87% coverage of query (64.3 bits)
1tcvA Crystal structure of the purine nucleoside phosphorylase from schistosoma mansoni in complex with non-detergent sulfobetaine 195 and acetate
27% identity, 87% coverage of query (63.9 bits)
1yqqA / P45563 Escherichia coli purine nucleoside phosphorylase ii, the product of the xapa gene (see paper)
26% identity, 88% coverage of query (62.4 bits)
1yr3A Escherichia coli purine nucleoside phosphorylase ii, the product of the xapa gene
26% identity, 88% coverage of query (62.4 bits)
PndA / b2407 xanthosine phosphorylase (EC 2.4.2.1; EC 2.4.2.15) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
xapA / P45563 xanthosine phosphorylase (EC 2.4.2.1; EC 2.4.2.15) from Escherichia coli (strain K12) (see 15 papers)
XAPA_ECOLI / P45563 Purine nucleoside phosphorylase 2; Inosine-guanosine phosphorylase; Purine nucleoside phosphorylase II; PNP II; Xanthosine phosphorylase; EC 2.4.2.1 from Escherichia coli (strain K12) (see 7 papers)
26% identity, 88% coverage of query (62.0 bits)
3e9rB Crystal structure of purine nucleoside phosphorylase from schistosoma mansoni in complex with adenine
27% identity, 87% coverage of query (62.0 bits)
8swuA / A0A0H2YR30 Structure of clostridium perfringens pnp bound to transition state analog immucillin h and sulfate (see paper)
25% identity, 89% coverage of query (61.6 bits)
A0A3G5E8S8 purine-nucleoside phosphorylase (EC 2.4.2.1) from Aneurinibacillus migulanus (see paper)
28% identity, 77% coverage of query (60.5 bits)
3e0qC / Q9BMI9 Crystal structure of schistosoma mansoni purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor (see paper)
27% identity, 79% coverage of query (59.7 bits)
Q9BMI9 purine-nucleoside phosphorylase (EC 2.4.2.1) from Schistosoma mansoni (see 2 papers)
27% identity, 79% coverage of query (59.7 bits)
3iexA Schistosoma purine nucleoside phosphorylase in complex with guanosine
27% identity, 87% coverage of query (59.3 bits)
8swtA / Q5LAA3 Structure of bacteroides fragilis pnp bound to transition state analog immucillin h and sulfate (see paper)
26% identity, 91% coverage of query (58.9 bits)
2ai2A Purine nucleoside phosphorylase from calf spleen
25% identity, 96% coverage of query (58.5 bits)
2ai1A Purine nucleoside phosphorylase from calf spleen
25% identity, 96% coverage of query (58.5 bits)
3lbaA / Q8DTU4 The crystal structure of smu.1229 from streptococcus mutans ua159 bound to hypoxanthine
28% identity, 84% coverage of query (56.6 bits)
3fucC Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'- phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit
26% identity, 96% coverage of query (56.2 bits)
3fucA Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'- phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit
26% identity, 96% coverage of query (56.2 bits)
1fxuA Purine nucleoside phosphorylase from calf spleen in complex with n(7)- acycloguanosine inhibitor and a phosphate ion
26% identity, 96% coverage of query (56.2 bits)
2ai3A Purine nucleoside phosphorylase from calf spleen
25% identity, 96% coverage of query (56.2 bits)
2qplA Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue
26% identity, 96% coverage of query (56.2 bits)
1a9oA / P55859 Bovine purine nucleoside phosphorylase complexed with phosphate (see paper)
25% identity, 96% coverage of query (55.1 bits)
P55859 purine-nucleoside phosphorylase (EC 2.4.2.1) from Bos taurus (see 13 papers)
25% identity, 96% coverage of query (55.1 bits)
1a9pA Bovine purine nucleoside phosphorylase complexed with 9-deazainosine and phosphate
25% identity, 96% coverage of query (55.1 bits)
P55859 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Bos taurus (Bovine)
25% identity, 96% coverage of query (55.1 bits)
1b8nA Purine nucleoside phosphorylase
25% identity, 96% coverage of query (55.1 bits)
1a9sA Bovine purine nucleoside phosphorylase complexed with inosine and sulfate
25% identity, 96% coverage of query (55.1 bits)
1a9qA Bovine purine nucleoside phosphorylase complexed with inosine
25% identity, 96% coverage of query (55.1 bits)
1a9tA Bovine purine nucleoside phosphorylase complexed with 9-deazainosine and phosphate
25% identity, 96% coverage of query (55.1 bits)
1b8oA Purine nucleoside phosphorylase
25% identity, 96% coverage of query (55.1 bits)
3odgA / Q66D48 Crystal structure of xanthosine phosphorylase bound with xanthine from yersinia pseudotuberculosis
24% identity, 86% coverage of query (54.7 bits)
7zslA Human purine nucleoside phosphorylase in complex with js-196
26% identity, 84% coverage of query (54.7 bits)
1v48A Calf spleen purine nucleoside phosphorylase (pnp) binary complex with 9-(5,5-difluoro-5-phosphonopenthyl)guanine
24% identity, 96% coverage of query (54.3 bits)
4earA Crystal structure of purine nucleoside phosphorylase (w16y, w94y, w178y, h257w) mutant from human complexed with dadme-immg and phosphate
25% identity, 96% coverage of query (53.9 bits)
3k8qA Crystal structure of human purine nucleoside phosphorylase in complex with serme-immucillin h
25% identity, 84% coverage of query (52.0 bits)
3k8oE Crystal structure of human purine nucleoside phosphorylase in complex with datme-immh
25% identity, 84% coverage of query (52.0 bits)
1rszA Structure of human purine nucleoside phosphorylase in complex with dadme-immucillin-h and sulfate
25% identity, 84% coverage of query (52.0 bits)
7zspA Human purine nucleoside phosphorylase in complex with js-555
25% identity, 84% coverage of query (52.0 bits)
3d1vA / P00491 Crystal structure of human pnp complexed with 2-mercapto(3h) quinazolinone (see paper)
25% identity, 84% coverage of query (51.6 bits)
PNP / P00491 purine nucleoside phosphorylase subunit (EC 2.4.2.1; EC 2.4.2.15) from Homo sapiens (see 9 papers)
PNPH_HUMAN / P00491 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Homo sapiens (Human) (see 6 papers)
P00491 purine-nucleoside phosphorylase (EC 2.4.2.1) from Homo sapiens (see 29 papers)
25% identity, 84% coverage of query (51.6 bits)
PNPH_MOUSE / P23492 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Mus musculus (Mouse) (see 2 papers)
26% identity, 84% coverage of query (51.6 bits)
7zsoA Human purine nucleoside phosphorylase in complex with js-554
25% identity, 84% coverage of query (51.6 bits)
3inyA Crystal structure of human purine nucleoside phosphorylase in complex with 7-deazaguanine
25% identity, 84% coverage of query (51.6 bits)
1yryE Crystal structure of human pnp complexed with mesg
25% identity, 84% coverage of query (51.6 bits)
1v45E Crystal structure of human pnp complexed with 3-deoxyguanosine
25% identity, 84% coverage of query (51.6 bits)
1v41E Crystal structure of human pnp complexed with 8-azaguanine
25% identity, 84% coverage of query (51.6 bits)
1v3qE Structure of human pnp complexed with ddi
25% identity, 84% coverage of query (51.6 bits)
1v2hE Crystal structure of human pnp complexed with guanine
25% identity, 84% coverage of query (51.6 bits)
1rfgE Crystal structure of human purine nucleoside phosphorylase complexed with guanosine
25% identity, 84% coverage of query (51.6 bits)
1rctE Crystal structure of human purine nucleoside phosphorylase complexed with inosine
25% identity, 84% coverage of query (51.6 bits)
1pwyE Crystal structure of human pnp complexed with acyclovir
25% identity, 84% coverage of query (51.6 bits)
1pf7E Crystal structure of human pnp complexed with immucillin h
25% identity, 84% coverage of query (51.6 bits)
3phbE Crystal structure of human purine nucleoside phosphorylase in complex with dadme-immg
25% identity, 84% coverage of query (51.6 bits)
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Lawrence Berkeley National Laboratory