Searching for up to 100 curated homologs for WP_011023935.1 NCBI__GCF_000007345.1:WP_011023935.1 (390 a.a.)
Found high-coverage hits (≥70%) to 54 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
mvaE / A0A384E138 acetyl-CoA C-acetyltransferase (EC 2.3.1.16) from Methanothermococcus thermolithotrophicus (see paper)
A0A384E138 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Methanothermococcus thermolithotrophicus (see paper)
6esqA / A0A384E138 Structure of the acetoacetyl-coa thiolase/hmg-coa synthase complex from methanothermococcus thermolithotrophicus soaked with acetyl-coa (see paper)
53% identity, 100% coverage of query (406 bits)
I3R3D1 acetyl-CoA C-acetyltransferase (subunit 2/2) (EC 2.3.1.9) from Haloferax mediterranei (see paper)
43% identity, 100% coverage of query (288 bits)
I3RA72 acetyl-CoA C-acetyltransferase (subunit 2/2) (EC 2.3.1.9) from Haloferax mediterranei (see paper)
39% identity, 98% coverage of query (263 bits)
4yzoC / Q976U3 Crystal structure analysis of thiolase-like protein, st0096 from sulfolobus tokodaii
34% identity, 99% coverage of query (220 bits)
SCP2_MOUSE / P32020 Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; Sterol carrier protein X; SCP-X; EC 2.3.1.155; EC 2.3.1.176; EC 2.3.1.16 from Mus musculus (Mouse) (see 4 papers)
P32020 propanoyl-CoA C-acyltransferase (EC 2.3.1.176) from Mus musculus (see 2 papers)
34% identity, 98% coverage of query (216 bits)
Scp2 / P11915 sterol carrier protein 2 (EC 2.3.1.176) from Rattus norvegicus (see 5 papers)
SCP2_RAT / P11915 Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; Sterol carrier protein X; SCP-X; EC 2.3.1.155; EC 2.3.1.176; EC 2.3.1.16 from Rattus norvegicus (Rat) (see 5 papers)
34% identity, 97% coverage of query (212 bits)
SCP2_CHICK / Q07598 Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCPX; Sterol carrier protein X; SCP-X; EC 2.3.1.155; EC 2.3.1.176; EC 2.3.1.16 from Gallus gallus (Chicken) (see paper)
33% identity, 98% coverage of query (209 bits)
SCP2 / P22307 Non-specific lipid-transfer protein (EC 2.3.1.16) from Homo sapiens (see 17 papers)
SCP2_HUMAN / P22307 Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCPX; Sterol carrier protein X; SCP-X; EC 2.3.1.155; EC 2.3.1.176; EC 2.3.1.16 from Homo sapiens (Human) (see 6 papers)
P22307 propanoyl-CoA C-acyltransferase (EC 2.3.1.176) from Homo sapiens (see 3 papers)
34% identity, 98% coverage of query (206 bits)
SCP2_RABIT / O62742 Sterol carrier protein 2; SCP-2; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCPX; Sterol carrier protein X; SCP-X; EC 2.3.1.155; EC 2.3.1.176; EC 2.3.1.16 from Oryctolagus cuniculus (Rabbit) (see paper)
33% identity, 97% coverage of query (205 bits)
5lnqA / E9AW84 Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with acetoacetyl-coa. (see paper)
35% identity, 98% coverage of query (204 bits)
5lotA Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with acetyl-coa.
35% identity, 98% coverage of query (204 bits)
3zbnA Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with coenzyme a.
35% identity, 98% coverage of query (204 bits)
6hsjB / Q6P4V5 Crystal structure of the zebrafish peroxisomal scp2-thiolase (type-1) in complex with coa (see paper)
33% identity, 97% coverage of query (195 bits)
6hspB Crystal structure of the zebrafish peroxisomal scp2-thiolase (type-1) in complex with coa and octanoyl-coa
33% identity, 97% coverage of query (195 bits)
Q66Q58 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Spodoptera littoralis (see paper)
34% identity, 98% coverage of query (192 bits)
NLTP2_CAEEL / G5EDP2 Non-specific lipid-transfer protein-like 2; NSL-TP2; 3-keto-acyl-CoA thiolase; Abnormal dauer formation protein 22; Propanoyl-CoA C-acyltransferase; Protein P-44; EC 2.3.1.176 from Caenorhabditis elegans (see 3 papers)
32% identity, 95% coverage of query (190 bits)
K7NSY9 propanoyl-CoA C-acyltransferase (EC 2.3.1.176) from Helicoverpa armigera (see 3 papers)
35% identity, 98% coverage of query (190 bits)
7pytB / Q39VG1 Benzoylsuccinyl-coa thiolase with coenzyme a (see paper)
34% identity, 99% coverage of query (189 bits)
7pytD Benzoylsuccinyl-coa thiolase with coenzyme a
34% identity, 99% coverage of query (189 bits)
D8VD26 propanoyl-CoA C-acyltransferase (EC 2.3.1.176) from Manduca sexta (see paper)
33% identity, 98% coverage of query (187 bits)
bbsB / Q9KJF3 benzoylsuccinyl-CoA thiolase subunit (EC 2.3.1.310) from Thauera aromatica (see 6 papers)
35% identity, 96% coverage of query (185 bits)
tioL / Q5P8S8 3-oxoacyl CoA thiolase (EC 2.3.1.16) from Aromatoleum aromaticum (strain EbN1) (see paper)
33% identity, 97% coverage of query (162 bits)
CH_124180 putative sterol carrier protein [Aspergillus fumigatus Af293] from Magnaporthe grisea 70-15 (see paper)
30% identity, 97% coverage of query (161 bits)
LTP2_MYCTU / I6Y3T7 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase; Retro-aldolase Ltp2; EC 4.1.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
31% identity, 93% coverage of query (137 bits)
Build an alignment for WP_011023935.1 and 24 homologs with ≥ 30% identity
Or download the sequences
LTP2_THECD / D1AB74 Steroid side-chain-cleaving aldolase; 3-oxo-23,24-bisnorchol-4-en-17-ol-22-oyl-CoA lyase; EC 4.1.3.- from Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9) (see paper)
29% identity, 87% coverage of query (131 bits)
5mg5L / Q4K420 A multi-component acyltransferase phlabc from pseudomonas protegens soaked with the monoacetylphloroglucinol (mapg) (see paper)
27% identity, 99% coverage of query (121 bits)
5ab7A Crystal structure of trypanosoma brucei scp2-thiolase like protein (tbslp) in complex with malonyl-coa.
28% identity, 92% coverage of query (112 bits)
5ab6D / C9ZUV7 Crystal structure of trypanosoma brucei scp2-thiolase like protein (tbslp) in complex with acetoacetyl-coa. (see paper)
28% identity, 92% coverage of query (109 bits)
fadA6 / I6XHJ3 3-oxo-acyl CoA thiolase (EC 2.3.1.16) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
FADA6_MYCTU / I6XHJ3 Steroid 3-ketoacyl-CoA thiolase FadA6; Acetyl-CoA acetyltransferase FadA6; EC 2.3.1.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
23% identity, 92% coverage of query (64.3 bits)
fadA / Q5P5K2 3-keto-acyl-CoA-thiolase (EC 2.3.1.16) from Aromatoleum aromaticum (strain EbN1) (see paper)
24% identity, 93% coverage of query (64.3 bits)
ECHB_RAT / Q60587 Trifunctional enzyme subunit beta, mitochondrial; TP-beta; EC 2.3.1.155; EC 2.3.1.16 from Rattus norvegicus (Rat) (see paper)
26% identity, 74% coverage of query (63.5 bits)
4c2jD / P42765 Crystal structure of human mitochondrial 3-ketoacyl-coa thiolase in complex with coa (see paper)
23% identity, 98% coverage of query (63.2 bits)
8gqnA / G3XD40 X-ray structure of thiolase with coa
26% identity, 77% coverage of query (61.6 bits)
HP15_1513 Acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Marinobacter adhaerens HP15
25% identity, 75% coverage of query (61.2 bits)
ECHB_MOUSE / Q99JY0 Trifunctional enzyme subunit beta, mitochondrial; TP-beta; EC 2.3.1.155; EC 2.3.1.16 from Mus musculus (Mouse) (see paper)
25% identity, 74% coverage of query (61.2 bits)
5bz4K / A0QUH3 Crystal structure of a t1-like thiolase (coa-complex) from mycobacterium smegmatis (see paper)
25% identity, 95% coverage of query (60.1 bits)
pcaF / AAC37148.1 beta-ketoadipyl CoA thiolase from Acinetobacter baylyi (see 11 papers)
25% identity, 77% coverage of query (59.7 bits)
catF / AAC46434.1 beta-ketoadipyl CoA thiolase from Acinetobacter baylyi (see 8 papers)
25% identity, 77% coverage of query (58.5 bits)
ACAA2 / P42765 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) from Homo sapiens (see paper)
THIM_HUMAN / P42765 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Homo sapiens (Human) (see 2 papers)
P42765 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Homo sapiens (see 2 papers)
22% identity, 98% coverage of query (58.5 bits)
D2IH11 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Helianthus annuus (see paper)
25% identity, 98% coverage of query (58.5 bits)
phbA / P14611 acetyl-CoA acetyltransferase subunit (EC 2.3.1.16) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see 4 papers)
THIL_CUPNH / P14611 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see 4 papers)
P14611 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Cupriavidus necator (see paper)
24% identity, 93% coverage of query (58.2 bits)
Q8BWT1 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Mus musculus (see paper)
23% identity, 98% coverage of query (58.2 bits)
G3CH53 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Ovis aries (see paper)
23% identity, 98% coverage of query (57.4 bits)
thlA1 / A5N3I5 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see 3 papers)
24% identity, 98% coverage of query (57.0 bits)
2d3tC / P28790 Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form v (see paper)
24% identity, 72% coverage of query (55.8 bits)
4o9cC / P14611 Crystal structure of beta-ketothiolase (phaa) from ralstonia eutropha h16 (see paper)
24% identity, 93% coverage of query (53.9 bits)
6bn2A / A0A077EEP0 Crystal structure of acetyl-coa acetyltransferase from elizabethkingia anophelis nuhp1
23% identity, 90% coverage of query (53.5 bits)
4xl4A / A0A0R4I970 Crystal structure of thiolase from clostridium acetobutylicum in complex with coa (see paper)
23% identity, 98% coverage of query (52.0 bits)
6bjaA / F1L3N8 Crystal structure of acat5 thiolase from ascaris suum in complex with coenzyme a (see paper)
23% identity, 70% coverage of query (51.6 bits)
thl / P45359 acetoacetyl-CoA thiolase monomer (EC 2.3.1.16) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
THLA_CLOAB / P45359 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; CaTHL; EC 2.3.1.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W) (see 2 papers)
P45359 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Clostridium acetobutylicum (see paper)
23% identity, 98% coverage of query (50.8 bits)
2f2sA Human mitochondrial acetoacetyl-coa thiolase
23% identity, 90% coverage of query (49.7 bits)
PED1 / Q56WD9 3-ketoacyl-CoA thiolase 2, peroxisomal (EC 2.3.1.16) from Arabidopsis thaliana (see 2 papers)
THIK2_ARATH / Q56WD9 3-ketoacyl-CoA thiolase 2, peroxisomal; Acetyl-CoA acyltransferase 2; Beta-ketothiolase 2; Peroxisomal 3-oxoacyl-CoA thiolase 2; Peroxisome defective protein 1; EC 2.3.1.16 from Arabidopsis thaliana (Mouse-ear cress) (see 13 papers)
Q56WD9 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Arabidopsis thaliana (see 4 papers)
21% identity, 96% coverage of query (44.3 bits)
2ib8D / P24752 Crystallographic and kinetic studies of human mitochondrial acetoacetyl-coa thiolase (t2): the importance of potassium and chloride for its structure and function (see paper)
23% identity, 98% coverage of query (43.9 bits)
ACAT1 / P24752 acetyl-CoA acetyltransferase monomer (EC 2.3.1.16) from Homo sapiens (see 11 papers)
THIL_HUMAN / P24752 Acetyl-CoA acetyltransferase, mitochondrial; Acetoacetyl-CoA thiolase; T2; EC 2.3.1.9 from Homo sapiens (Human) (see 6 papers)
23% identity, 98% coverage of query (43.9 bits)
Or start over
Lawrence Berkeley National Laboratory