Searching for up to 100 curated homologs for WP_011188572.1 NCBI__GCF_000025945.1:WP_011188572.1 (449 a.a.)
Found high-coverage hits (≥70%) to 76 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Tss / b0930 asparagine—tRNA ligase (EC 6.1.1.22) from Escherichia coli K-12 substr. MG1655 (see 13 papers)
asnS / P0A8M0 asparagine—tRNA ligase (EC 6.1.1.22) from Escherichia coli (strain K12) (see 14 papers)
SYN_ECOLI / P0A8M0 Asparagine--tRNA ligase; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Escherichia coli (strain K12) (see 2 papers)
59% identity, 95% coverage of query (527 bits)
SYNO_ARATH / O48593 Asparagine--tRNA ligase, chloroplastic/mitochondrial; Asparaginyl-tRNA synthetase; AsnRS; AtNS1; Protein OVULE ABORTION 8; EC 6.1.1.22 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
57% identity, 96% coverage of query (520 bits)
SYNM_MOUSE / Q8BGV0 Asparaginyl-tRNA synthetase; AsnRS; NARS2; Asparagine--tRNA ligase, mitochondrial; EC 6.1.1.22 from Mus musculus (Mouse) (see paper)
50% identity, 97% coverage of query (445 bits)
SYNM_HUMAN / Q96I59 Asparaginyl-tRNA synthetase; AsnRS; NARS2; Asparagine--tRNA ligase, mitochondrial; EC 6.1.1.22 from Homo sapiens (Human) (see 4 papers)
Q96I59 asparagine-tRNA ligase (EC 6.1.1.22) from Homo sapiens (see 2 papers)
50% identity, 96% coverage of query (439 bits)
SYNM_SCHPO / Q9P6I0 Asparagine--tRNA ligase, mitochondrial; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 96% coverage of query (320 bits)
SYNM_YEAST / P25345 Asparagine--tRNA ligase, mitochondrial; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
36% identity, 98% coverage of query (308 bits)
P54263 asparagine-tRNA ligase (EC 6.1.1.22) from Thermus thermophilus (see paper)
38% identity, 96% coverage of query (279 bits)
asnS / CAA62491.1 asparaginyl-tRNA synthetase from Thermus thermophilus (see paper)
38% identity, 96% coverage of query (278 bits)
1x54A / O57980 Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate (see paper)
38% identity, 95% coverage of query (264 bits)
1x55A Crystal structure of asparaginyl-tRNA synthetase from pyrococcus horikoshii complexed with asparaginyl-adenylate analogue
38% identity, 95% coverage of query (264 bits)
SYNC_CAEEL / Q19722 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Caenorhabditis elegans (see paper)
32% identity, 96% coverage of query (211 bits)
1b8aA / Q52428 Aspartyl-tRNA synthetase (see paper)
33% identity, 95% coverage of query (206 bits)
SYD_THEKO / Q52428 Aspartate--tRNA(Asp) ligase; Aspartyl-tRNA synthetase; AspRS; Discriminating aspartyl-tRNA synthetase; D-AspRS; EC 6.1.1.12 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 4 papers)
Q52428 aspartate-tRNA ligase (EC 6.1.1.12) from Thermococcus kodakarensis (see 4 papers)
32% identity, 95% coverage of query (205 bits)
3nemB Aspartyl-tRNA synthetase complexed with aspartyl adenylate
32% identity, 95% coverage of query (205 bits)
3nemA Aspartyl-tRNA synthetase complexed with aspartyl adenylate
32% identity, 95% coverage of query (205 bits)
3nelA Aspartyl-tRNA synthetase complexed with aspartic acid
32% identity, 95% coverage of query (205 bits)
2xgtB Asparaginyl-tRNA synthetase from brugia malayi complexed with the sulphamoyl analogue of asparaginyl-adenylate (see paper)
30% identity, 97% coverage of query (192 bits)
SYDND_METTH / O26328 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see paper)
O26328 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Methanothermobacter thermautotrophicus (see paper)
31% identity, 95% coverage of query (192 bits)
SYNC_YEAST / P38707 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
30% identity, 96% coverage of query (191 bits)
2xtiA Asparaginyl-tRNA synthetase from brugia malayi complexed with atp:mg and l-asp-beta-noh adenylate:ppi:mg
30% identity, 97% coverage of query (190 bits)
2xtiB Asparaginyl-tRNA synthetase from brugia malayi complexed with atp:mg and l-asp-beta-noh adenylate:ppi:mg
30% identity, 97% coverage of query (185 bits)
8h53A Human asparaginyl-tRNA synthetase in complex with asparagine-amp
30% identity, 95% coverage of query (183 bits)
SYNC_HUMAN / O43776 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; Asparaginyl-tRNA synthetase 1; EC 6.1.1.22 from Homo sapiens (Human) (see 6 papers)
O43776 asparagine-tRNA ligase (EC 6.1.1.22) from Homo sapiens (see 2 papers)
30% identity, 95% coverage of query (181 bits)
8tc8A / O43776 Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate (see paper)
30% identity, 95% coverage of query (181 bits)
8tc9A Human asparaginyl-tRNA synthetase bound to osm-s-106
30% identity, 95% coverage of query (181 bits)
Build an alignment for WP_011188572.1 and 25 homologs with ≥ 30% identity
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3m4pA / C4LWW8 Entamoeba histolytica asparaginyl-tRNA synthetase (asnrs) in complex with asparaginyl-adenylate
29% identity, 96% coverage of query (180 bits)
SYNC_SCHPO / O94567 Probable asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; EC 6.1.1.22 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
30% identity, 95% coverage of query (176 bits)
SYNC_BRUMA / P10723 Asparagine--tRNA ligase, cytoplasmic; Asparaginyl-tRNA synthetase; AsnRS; Potentially protective 63 kDa antigen; EC 6.1.1.22 from Brugia malayi (Filarial nematode worm) (see paper)
P10723 asparagine-tRNA ligase (EC 6.1.1.22) from Brugia malayi (see paper)
28% identity, 97% coverage of query (174 bits)
SYDND_HALSA / O07683 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
O07683 aspartate-tRNAAsn ligase (EC 6.1.1.23) from Halobacterium salinarum (see paper)
31% identity, 95% coverage of query (172 bits)
SYDND_THET8 / Q5SIC2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 4 papers)
Q5SIC2 aspartate-tRNA ligase (EC 6.1.1.12) from Thermus thermophilus (see paper)
31% identity, 95% coverage of query (163 bits)
1asyA / P04802 Class ii aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA asp (see paper)
29% identity, 99% coverage of query (153 bits)
1aszA The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction
29% identity, 99% coverage of query (153 bits)
SYDC_YEAST / P04802 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 99% coverage of query (152 bits)
SYDC_HUMAN / P14868 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; Cell proliferation-inducing gene 40 protein; EC 6.1.1.12 from Homo sapiens (Human) (see 4 papers)
P14868 aspartate-tRNA ligase (EC 6.1.1.12) from Homo sapiens (see 2 papers)
29% identity, 98% coverage of query (151 bits)
SYDND_METMA / Q8Q0R2 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase; AspRS; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) (see paper)
26% identity, 95% coverage of query (151 bits)
SYDC_RAT / P15178 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Rattus norvegicus (Rat) (see paper)
29% identity, 98% coverage of query (148 bits)
SYDC_MOUSE / Q922B2 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Mus musculus (Mouse) (see paper)
Q922B2 aspartate-tRNA ligase (EC 6.1.1.12) from Mus musculus (see paper)
30% identity, 98% coverage of query (148 bits)
aspS2 / Q9RVH4 aspartyl-tRNA synthetase, non-discriminating (EC 6.1.1.23) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 2 papers)
SYDND_DEIRA / Q9RVH4 Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase 2; AspRS2; Non-discriminating aspartyl-tRNA synthetase; ND-AspRS; EC 6.1.1.23 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see 2 papers)
29% identity, 96% coverage of query (139 bits)
C4LZN0 aspartate-tRNA ligase (EC 6.1.1.12); aspartate-tRNAAsn ligase (EC 6.1.1.23) from Entamoeba histolytica (see paper)
30% identity, 72% coverage of query (136 bits)
SYDC2_ARATH / Q9M084 Aspartate--tRNA ligase 2, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; Protein IMPAIRED IN BABA-INDUCED DISEASE IMMUNITY 1; EC 6.1.1.12 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 71% coverage of query (135 bits)
Q8I2B1 aspartate-tRNA ligase (EC 6.1.1.12) from Plasmodium falciparum (see paper)
26% identity, 94% coverage of query (135 bits)
SYDC_SCHPO / O74407 Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase; AspRS; EC 6.1.1.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 97% coverage of query (130 bits)
Q585M3 aspartate-tRNA ligase (EC 6.1.1.12) from Trypanosoma brucei (see paper)
25% identity, 96% coverage of query (125 bits)
slgZ / CBA11568.1 asparaginyl-tRNA synthetase-like from Streptomyces lydicus (see paper)
29% identity, 71% coverage of query (122 bits)
3kfuC / Q5SIC2 Crystal structure of the transamidosome (see paper)
27% identity, 95% coverage of query (119 bits)
erdS / Q4WKG3 aspartate--tRNA ligase/ergosteryl-3β-O-L-aspartate synthase (EC 6.1.1.23; EC 2.3.2.37) from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (see paper)
30% identity, 73% coverage of query (110 bits)
SYK_STAAU / Q53638 Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Staphylococcus aureus (see paper)
26% identity, 98% coverage of query (98.2 bits)
1e1tA / P0A8N5 Lysyl-tRNA synthetase (lysu) hexagonal form complexed with the lysyl_adenylate intermediate (see paper)
24% identity, 94% coverage of query (93.6 bits)
5yzxA Crystal structure of e.Coli lysu t146d mutant
24% identity, 94% coverage of query (93.6 bits)
1e24A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and atp and mn2+
24% identity, 94% coverage of query (93.6 bits)
1e22A Lysyl-tRNA synthetase (lysu) hexagonal form complexed with lysine and the non-hydrolysable atp analogue amp-pcp
24% identity, 94% coverage of query (93.6 bits)
1e1oA Lysyl-tRNA synthetase (lysu) hexagonal form, complexed with lysine
24% identity, 94% coverage of query (93.2 bits)
LysU / b4129 lysine—tRNA ligase/Ap4A synthetase/Ap3A synthetase (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 70 papers)
lysU / P0A8N5 lysyl-tRNA synthetase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 73 papers)
P0A8N5 lysine-tRNA ligase (EC 6.1.1.6) from Escherichia coli (see paper)
lysU / RF|NP_418553 lysyl-tRNA synthetase, heat inducible; EC 6.1.1.6 from Escherichia coli K12 (see 10 papers)
24% identity, 94% coverage of query (91.7 bits)
P0A8N5 Lysine--tRNA ligase, heat inducible; Lysyl-tRNA synthetase; LysRS; EC 6.1.1.6 from Escherichia coli (strain K12)
24% identity, 94% coverage of query (91.7 bits)
1bbuA / P0A8N3 Lysyl-tRNA synthetase (lyss) complexed with lysine (see paper)
24% identity, 94% coverage of query (88.6 bits)
HerC / b2890 lysine—tRNA ligase, constitutive (EC 6.1.1.6) from Escherichia coli K-12 substr. MG1655 (see 53 papers)
lysS / P0A8N3 lysine—tRNA ligase (EC 6.1.1.6) from Escherichia coli (strain K12) (see 53 papers)
lysS lysine--tRNA ligase; EC 6.1.1.6 from Escherichia coli K12 (see paper)
25% identity, 94% coverage of query (87.0 bits)
Q9V228 asparagine-tRNA ligase (EC 6.1.1.22); aspartate-ammonia ligase (EC 6.3.1.1) from Pyrococcus abyssi (see paper)
3p8vA / Q9V228 Crystal structure of the archaeal asparagine synthetase a complexed with l-aspartic acid (see paper)
24% identity, 71% coverage of query (82.8 bits)
3rexA Crystal structure of the archaeal asparagine synthetase a complexed with adenosine monophosphate
24% identity, 71% coverage of query (82.8 bits)
3reuA Crystal structure of the archaeal asparagine synthetase a complexed with l-aspartic acid and adenosine triphosphate
24% identity, 71% coverage of query (82.8 bits)
3p8yA Crystal structure of the archaeal asparagine synthetase a complexed with l-asparagine
24% identity, 71% coverage of query (82.8 bits)
Q9RHV9 lysine-tRNA ligase (EC 6.1.1.6) from Geobacillus stearothermophilus (see 3 papers)
23% identity, 96% coverage of query (81.3 bits)
Q04LI2 lysine-tRNA ligase (EC 6.1.1.6) from Streptococcus pneumoniae (see paper)
23% identity, 95% coverage of query (80.1 bits)
3a74A / Q9RHV9 Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with diadenosine tetraphosphate (ap4a)
23% identity, 96% coverage of query (79.0 bits)
3e9iA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysine hydroxamate-amp
23% identity, 96% coverage of query (79.0 bits)
3e9hA Lysyl-tRNA synthetase from bacillus stearothermophilus complexed with l-lysylsulfamoyl adenosine
23% identity, 96% coverage of query (79.0 bits)
6wbdB / B2FQ84 Crystal structure of lysyl-tRNA synthetase from stenotrophomonas maltophilia with bound l-lysine
24% identity, 94% coverage of query (75.5 bits)
7qi8A Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine and inhibitor
23% identity, 97% coverage of query (74.3 bits)
4ex5A / Q2SXD6 Crystal structure of lysyl-tRNA synthetase lysrs from burkholderia thailandensis bound to lysine (see paper)
23% identity, 97% coverage of query (70.1 bits)
7qh8A / P9WFU9 Crystal structure of lysyl-tRNA synthetase from mycobacterium tuberculosis complexed with l-lysine (see paper)
23% identity, 97% coverage of query (67.8 bits)
4up7A / C4M7X2 Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate (see paper)
23% identity, 96% coverage of query (65.9 bits)
6aqgC / A0PV47 Crystal structure of lysyl-tRNA synthetase from mycobacterium ulcerans complexed with l-lysine and cladosporin
23% identity, 98% coverage of query (64.3 bits)
4up9A Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with atp
21% identity, 96% coverage of query (63.9 bits)
4upaA Crystal structure of entamoeba histolytica lysyl-tRNA synthetase in complex with amppnp
21% identity, 96% coverage of query (62.4 bits)
5hgqB Loa loa lysyl-tRNA synthetase in complex with cladosporin. (see paper)
22% identity, 95% coverage of query (62.0 bits)
5zh2A / W7JP72 Crystal structure of pfkrs with inhibitor clado-5 (see paper)
20% identity, 95% coverage of query (57.8 bits)
6kcnA Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4
20% identity, 95% coverage of query (57.4 bits)
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Lawrence Berkeley National Laboratory