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Searching for up to 100 curated homologs for WP_011188851.1 NCBI__GCF_000025945.1:WP_011188851.1 (395 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ARAT1_THELN / H3ZPL1 Aromatic-amino-acid aminotransferase 1; ARAT-I; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
    40% identity, 97% coverage of query (295 bits)

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp. (see paper)
    40% identity, 97% coverage of query (295 bits)

O57946 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Pyrococcus horikoshii (see paper)
    38% identity, 97% coverage of query (287 bits)

3aovA / O57946 Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with plp
    38% identity, 97% coverage of query (287 bits)

3wx9A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, gla, 4ad, 2og, glu and kya
    38% identity, 97% coverage of query (287 bits)

3av7A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, kyn as substrates and kya as products
    38% identity, 97% coverage of query (287 bits)

3aowC Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with akg
    38% identity, 97% coverage of query (287 bits)

AZOBR_RS06555 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Azospirillum brasilense Sp245
    41% identity, 97% coverage of query (283 bits)

1wstA / Q9V2W5 Crystal structure of multiple substrate aminotransferase (msat) from thermococcus profundus
    39% identity, 97% coverage of query (282 bits)

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
    43% identity, 92% coverage of query (279 bits)

BWI76_RS24235 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Klebsiella michiganensis M5al
    38% identity, 97% coverage of query (275 bits)

lysN / Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    39% identity, 98% coverage of query (273 bits)

3cbfA Crystal structure of lysn, alpha-aminoadipate aminotransferase, from thermus thermophilus hb27
    39% identity, 98% coverage of query (272 bits)

2egyA Crystal structure of lysn, alpha-aminoadipate aminotransferase (substrate free form), from thermus thermophilus hb27
    39% identity, 98% coverage of query (272 bits)

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus (see paper)
2zyjA / Q72LL6 Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-glutamate), from thermus thermophilus hb27 (see paper)
    39% identity, 98% coverage of query (271 bits)

Ac3H11_1015 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Acidovorax sp. GW101-3H11
    38% identity, 96% coverage of query (270 bits)

2z1yA Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-leucine), from thermus thermophilus hb27
    38% identity, 98% coverage of query (263 bits)

1vp4A / Q9X0L5 Crystal structure of a putative aminotransferase (tm1131) from thermotoga maritima msb8 at 1.82 a resolution
    38% identity, 94% coverage of query (257 bits)

2zc0A / Q9C4M4 Crystal structure of an archaeal alanine:glyoxylate aminotransferase (see paper)
    32% identity, 92% coverage of query (189 bits)

YdcR / b1439 fused putative DNA-binding transcriptional regulator/putative aminotransferase YdcR from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydcR / MB|P77730 uncharacterized HTH-type transcriptional regulator ydcR from Escherichia coli K12 (see 3 papers)
    31% identity, 90% coverage of query (170 bits)

Build an alignment

Build an alignment for WP_011188851.1 and 20 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

YdfD/YisV / VIMSS6924547 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Paenibacillus sp. JDR-2
    29% identity, 97% coverage of query (169 bits)

DVU0030 / VIMSS7454265 DVU0030 regulator of Amino acid transport from Desulfohalobium retbaense DSM 5692
    29% identity, 93% coverage of query (166 bits)

YdfD/YisV / VIMSS63013 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Bacillus halodurans C-125
    28% identity, 94% coverage of query (162 bits)

2vgzA Crystal structure of human kynurenine aminotransferase ii
    29% identity, 88% coverage of query (157 bits)

4ge4A Kynurenine aminotransferase ii inhibitors
    29% identity, 87% coverage of query (156 bits)

4gdyB / Q8N5Z0 Kynurenine aminotransferase ii inhibitors
    29% identity, 87% coverage of query (155 bits)

AADAT / Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (EC 2.6.1.7; EC 2.6.1.39) from Homo sapiens (see 5 papers)
AADAT_HUMAN / Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Homo sapiens (Human) (see 4 papers)
Q8N5Z0 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Homo sapiens (see 16 papers)
    29% identity, 87% coverage of query (155 bits)

4gebA Kynurenine aminotransferase ii inhibitors
    29% identity, 87% coverage of query (155 bits)

4ge9A Kynurenine aminotransferase ii inhibitors
    29% identity, 87% coverage of query (155 bits)

4ge7A Kynurenine aminotransferase ii inhibitors
    29% identity, 87% coverage of query (155 bits)

2xh1A Crystal structure of human kat ii-inhibitor complex
    29% identity, 88% coverage of query (155 bits)

6t8qA Hkatii in complex with ligand (2r)-n-benzyl-1-[6-methyl-5-(oxan-4-yl)- 7-oxo-6h,7h-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2- carboxamide
    29% identity, 87% coverage of query (155 bits)

5tf5A Crystal structure of human kat-2 in complex with a reversible inhibitor
    29% identity, 87% coverage of query (155 bits)

2r2nA The crystal structure of human kynurenine aminotransferase ii in complex with kynurenine
    29% identity, 87% coverage of query (155 bits)

3ue8A Kynurenine aminotransferase ii inhibitors
    29% identity, 91% coverage of query (154 bits)

6t8pA Hkatii in complex with ligand (2r)-n-benzyl-1-[6-methyl-5-(oxan-4-yl)- 7-oxo-6h,7h-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2- carboxamide
    29% identity, 87% coverage of query (153 bits)

DVU0030 / VIMSS7533539 DVU0030 regulator of Amino acid transport from Desulfomicrobium baculatum DSM 4028
    28% identity, 89% coverage of query (150 bits)

YjiR / b4340 fused putative DNA-binding transcriptional regulator/putative aminotransferase YjiR from Escherichia coli K-12 substr. MG1655 (see 5 papers)
yjiR / RF|NP_418760 uncharacterized HTH-type transcriptional regulator yjiR from Escherichia coli K12 (see 2 papers)
    27% identity, 93% coverage of query (149 bits)

YdfD/YisV / VIMSS822665 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Bacillus clausii KSM-K16
    30% identity, 92% coverage of query (149 bits)

DVU0030 / VIMSS8501445 DVU0030 regulator of Amino acid transport from Desulfovibrio vulgaris str. Miyazaki F
    28% identity, 93% coverage of query (147 bits)

DVU0030 / VIMSS8508254 DVU0030 regulator of Amino acid transport from Desulfovibrio salexigens DSM 2638
    29% identity, 88% coverage of query (145 bits)

Aadat / Q64602 α-aminoadipate aminotransferase subunit (EC 2.6.1.39) from Rattus norvegicus (see paper)
AADAT_RAT / Q64602 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Rattus norvegicus (Rat) (see paper)
Q64602 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Rattus norvegicus (see 2 papers)
    28% identity, 89% coverage of query (144 bits)

DVU0030 / VIMSS408289 DVU0030 regulator of Amino acid transport from Desulfovibrio vulgaris Hildenborough
    28% identity, 96% coverage of query (140 bits)

AADAT_MOUSE / Q9WVM8 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Mus musculus (Mouse) (see paper)
Q9WVM8 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Mus musculus (see paper)
    28% identity, 91% coverage of query (139 bits)

NORG_STAA8 / Q2G1P1 HTH-type transcriptional regulator NorG from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    25% identity, 92% coverage of query (135 bits)

DVU0030 / VIMSS393253 DVU0030 regulator of Amino acid transport from Desulfovibrio desulfuricans G20
    26% identity, 94% coverage of query (135 bits)

DVU0030 / VIMSS7650531 DVU0030 regulator of Amino acid transport from Desulfovibrio magneticus RS-1
    27% identity, 94% coverage of query (134 bits)

tdiD / A7XRY8 L-tryptophan:phenylpyruvate aminotransferase (EC 2.6.1.28) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see 3 papers)
TDID_EMENI / A7XRY8 Aminotransferase tdiD; Terrequinone biosynthesis protein D; EC 2.6.1.28 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 5 papers)
A7XRY8 tryptophan-phenylpyruvate transaminase (EC 2.6.1.28) from Aspergillus nidulans (see 2 papers)
    28% identity, 96% coverage of query (134 bits)

A0A0D1E3F3 tryptophan transaminase (EC 2.6.1.27) from Ustilago maydis (see paper)
    27% identity, 94% coverage of query (129 bits)

tdiD putative aminotransferase from Emericella nidulans (see paper)
    27% identity, 96% coverage of query (118 bits)

AATR1_SCHPO / O14192 Aromatic amino acid aminotransferase C56E4.03; EC 2.6.1.57 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    26% identity, 83% coverage of query (118 bits)

S4UF58 tryptophan transaminase (EC 2.6.1.27) from Malassezia furfur (see paper)
    26% identity, 98% coverage of query (117 bits)

8tn3A / Q643B9 Structure of s. Hygroscopicus aminotransferase mppq complexed with pyridoxamine 5'-phosphate (pmp) (see paper)
    28% identity, 91% coverage of query (117 bits)

HPGT_AMYOR / O52815 (S)-3,5-dihydroxyphenylglycine transaminase; p-hydroxyphenylglycine transaminase; EC 2.6.1.103 from Amycolatopsis orientalis (Nocardia orientalis) (see 2 papers)
    28% identity, 81% coverage of query (108 bits)

AATR3_SCHPO / Q9Y7S6 Aromatic amino acid aminotransferase C569.07; EC 2.6.1.57 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    23% identity, 93% coverage of query (107 bits)

6s8wC / Q4X0F7 Aromatic aminotransferase aroh (aro8) form aspergillus fumigatus in complex with plp (internal aldimine)
    24% identity, 91% coverage of query (107 bits)

BAD06364.1 aminotransferase from Thermus thermophilus (see paper)
    27% identity, 83% coverage of query (102 bits)

1v2eA / Q75WK2 Crystal structure of t.Th hb8 glutamine aminotransferase complex with a-keto-g-methylthiobutyrate (see paper)
    27% identity, 82% coverage of query (102 bits)

1v2fA Crystal structure of t.Th hb8 glutamine aminotransferase complex with 3-phenylpropionate
    27% identity, 82% coverage of query (102 bits)

6s8wB / Q4X0F7 Aromatic aminotransferase aroh (aro8) form aspergillus fumigatus in complex with plp (internal aldimine)
    24% identity, 94% coverage of query (101 bits)

PP_3721 arginine:pyruvate transaminase AruH (EC 2.6.1.84) from Pseudomonas putida KT2440
    29% identity, 83% coverage of query (99.8 bits)

patA / P16524 N-acetyl-L,L-diaminopimelate aminotransferase from Bacillus subtilis (strain 168) (see 3 papers)
DAPX_BACSU / P16524 Probable N-acetyl-LL-diaminopimelate aminotransferase; Putative aminotransferase A; EC 2.6.1.- from Bacillus subtilis (strain 168) (see paper)
    27% identity, 97% coverage of query (99.4 bits)

Q9RAT0 aromatic-amino-acid transaminase (EC 2.6.1.57) from Lactococcus lactis (see paper)
    24% identity, 95% coverage of query (97.1 bits)

aruH / Q9HUI9 L-arginine:pyruvate transaminase subunit (EC 2.6.1.84) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
ARUH_PSEAE / Q9HUI9 Arginine--pyruvate transaminase AruH; EC 2.6.1.84 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HUI9 arginine-pyruvate transaminase (EC 2.6.1.84) from Pseudomonas aeruginosa (see paper)
    27% identity, 86% coverage of query (95.5 bits)

A0A1D8PPA8 aromatic-amino-acid transaminase (EC 2.6.1.57) from Candida albicans (see paper)
    25% identity, 89% coverage of query (94.4 bits)

6hnuB / C4YJ02 Crystal structure of the aminotransferase aro8 from c. Albicans with ligands (see paper)
    25% identity, 77% coverage of query (92.0 bits)

AATR2_SCHPO / O94570 Aromatic amino acid aminotransferase C1773.13; EC 2.6.1.57 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    24% identity, 94% coverage of query (91.7 bits)

6uxzB (S)-4-amino-5-phenoxypentanoate as a selective agonist of the transcription factor gabr
    26% identity, 91% coverage of query (89.4 bits)

5x03B / P94426 Crystal structure of thE C-terminal domain of bacillus subtilis gabr reveals a closed conformation by the binding of gamma-aminobutyric acid, inducing the transcriptional activation (see paper)
    25% identity, 91% coverage of query (89.0 bits)

5t4kA Plp and gaba trigger gabr-mediated transcription regulation in bacillus subsidies via external aldimine formation
    26% identity, 91% coverage of query (88.6 bits)

5t4jB Plp and gaba trigger gabr-mediated transcription regulation in bacillus subsidies via external aldimine formation
    26% identity, 91% coverage of query (88.6 bits)

6hnvB Crystal structure of aminotransferase aro9 from c. Albicans with ligands
    23% identity, 87% coverage of query (87.4 bits)

6hnvA Crystal structure of aminotransferase aro9 from c. Albicans with ligands
    23% identity, 87% coverage of query (87.4 bits)

6hndB / A0A1D8PMC5 Crystal structure of the aromatic aminotransferase aro9 from c. Albicans (see paper)
    25% identity, 80% coverage of query (86.7 bits)

4je5B / P53090 Crystal structure of the aromatic aminotransferase aro8, a putative alpha-aminoadipate aminotransferase in saccharomyces cerevisiae (see paper)
    22% identity, 96% coverage of query (83.6 bits)

4je5A Crystal structure of the aromatic aminotransferase aro8, a putative alpha-aminoadipate aminotransferase in saccharomyces cerevisiae
    23% identity, 92% coverage of query (83.2 bits)

7pq9AAA PLP-dependent aminotransferase family protein
    23% identity, 78% coverage of query (83.2 bits)

7zn5B / Q5WKW3 Cryo-em structure of holo-pdxr from bacillus clausii bound to its target DNA in the closed conformation, c2 symmetry. (see paper)
    23% identity, 78% coverage of query (82.8 bits)

7zlaB / Q5WKW3 Cryo-em structure of holo-pdxr from bacillus clausii bound to its target DNA in the half-closed conformation (see paper)
    23% identity, 78% coverage of query (82.4 bits)

1o4sB / Q9X0Y2 Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
    25% identity, 94% coverage of query (80.9 bits)

1gdeA Crystal structure of pyrococcus protein a-1 e-form
    23% identity, 97% coverage of query (80.5 bits)

1gd9A / O59096 Crystall structure of pyrococcus protein-a1 (see paper)
    23% identity, 97% coverage of query (80.5 bits)

mfnC / Q58097 2-furaldehyde phosphate aminotransferase (EC 2.6.1.108) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
MFNC_METJA / Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase; 4-HFC-P:alanine aminotransferase; EC 2.6.1.108 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
Q58097 (5-formylfuran-3-yl)methyl phosphate transaminase (EC 2.6.1.108) from Methanocaldococcus jannaschii (see paper)
    26% identity, 84% coverage of query (77.4 bits)

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate
    23% identity, 82% coverage of query (75.9 bits)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan
    23% identity, 82% coverage of query (75.9 bits)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate
    23% identity, 82% coverage of query (75.9 bits)

1bjwA Aspartate aminotransferase from thermus thermophilus
    23% identity, 82% coverage of query (75.9 bits)

AAPAT_THET8 / Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 5 papers)
Q56232 aspartate-prephenate aminotransferase (EC 2.6.1.78) from Thermus thermophilus (see paper)
aspC / RF|YP_143312.1 aspartate transaminase; EC 2.6.1.1 from Thermus thermophilus HB8 (see 2 papers)
    23% identity, 82% coverage of query (75.5 bits)

1b5oA / Q56232 Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
    23% identity, 82% coverage of query (75.1 bits)

2o1bA / Q2FV61 Structure of aminotransferase from staphylococcus aureus
    24% identity, 80% coverage of query (74.7 bits)

3eleA / D0VX02 Crystal structure of amino transferase (rer070207001803) from eubacterium rectale at 2.10 a resolution
    23% identity, 96% coverage of query (74.3 bits)

6l1oB Product bound bacf structure from bacillus subtillis
    26% identity, 82% coverage of query (72.4 bits)

6l1nA Substrate bound bacf structure from bacillus subtillis
    26% identity, 82% coverage of query (72.4 bits)

6l1lB / P39643 Apo-bacf structure from bacillus subtillis (see paper)
    26% identity, 82% coverage of query (72.4 bits)

1j32A / Q8RR70 Aspartate aminotransferase from phormidium lapideum
aspC / BAB86290.1 aspartate aminotransferase from Phormidium lapideum (see paper)
    23% identity, 90% coverage of query (70.9 bits)

5wmhA Arabidopsis thaliana prephenate aminotransferase
    23% identity, 82% coverage of query (70.1 bits)

5wmiA Arabidopsis thaliana prephenate aminotransferase mutant- t84v
    23% identity, 82% coverage of query (69.7 bits)

4m2jA / G9MBV4 Crystal structure of plp-dependent cyclase orfr in complex with au (see paper)
    23% identity, 96% coverage of query (67.8 bits)

4m2mA Crystal structure of plp-dependent cyclase orfr in complex with plp-l- arg
    23% identity, 94% coverage of query (67.4 bits)

5wmlA / Q9SIE1 Arabidopsis thaliana prephenate aminotransferase mutant- k306a (see paper)
    22% identity, 82% coverage of query (67.4 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory