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Searching for up to 100 curated homologs for WP_011365992.1 NCBI__GCF_000012925.1:WP_011365992.1 (162 a.a.)

Found high-coverage hits (≥70%) to 12 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q8RCQ6 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    40% identity, 85% coverage of query (95.9 bits)

Build an alignment

Build an alignment for WP_011365992.1 and 1 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

mcee / A9WGS0 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    28% identity, 70% coverage of query (53.1 bits)

MCE_PYRHO / O58010 Methylmalonyl-CoA epimerase; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 2 papers)
    30% identity, 78% coverage of query (52.8 bits)

6wf7A / Q9L2C2 Methylmalonyl-coa epimerase in complex with methylmalonyl-coa and nh4+ (see paper)
    27% identity, 86% coverage of query (48.9 bits)

6xbqA Streptomyces coelicolor methylmalonyl-coa epimerase in complex with carboxy-carba(dethia)-coa
    27% identity, 86% coverage of query (48.9 bits)

6wfiA Methylmalonyl-coa epimerase in complex with 2-nitronate-propionyl-coa
    27% identity, 86% coverage of query (48.9 bits)

6wf6A Streptomyces coelicolor methylmalonyl-coa epimerase
    27% identity, 86% coverage of query (48.5 bits)

6wfhA Streptomyces coelicolor methylmalonyl-coa epimerase substrate complex
    27% identity, 86% coverage of query (48.5 bits)

6xbtA Streptomyces coelicolor methylmalonyl-coa epimerase (q60a) in complex with 2-nitronate-propionyl-coa
    27% identity, 86% coverage of query (47.4 bits)

6qh4C / Q96PE7 Crystal structure of human methylmalonyl-coa epimerase (mcee) p.Arg143cys variant
    26% identity, 88% coverage of query (47.0 bits)

MCEE / Q96PE7 methylmalonyl CoA epimerase (EC 5.1.99.1) from Homo sapiens (see 4 papers)
MCEE_HUMAN / Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Homo sapiens (Human) (see 2 papers)
    27% identity, 83% coverage of query (46.2 bits)

Msed_0639 / A4YEG2 methylmalonyl-CoA epimerase monomer (EC 5.1.99.1) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 2 papers)
A4YEG2 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Metallosphaera sedula (see paper)
    24% identity, 74% coverage of query (45.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory