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Searching for up to 100 curated homologs for WP_011372650.1 NCBI__GCF_000012965.1:WP_011372650.1 (349 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AROB_HELPY / P56081 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
    53% identity, 96% coverage of query (366 bits)

3clhA / P56081 Crystal structure of 3-dehydroquinate synthase (dhqs)from helicobacter pylori (see paper)
    48% identity, 96% coverage of query (307 bits)

Q3M4V2 3-dehydroquinate synthase (EC 4.2.3.4) from Trichormus variabilis (see paper)
    44% identity, 96% coverage of query (285 bits)

3zokA / U3KRF2 Structure of 3-dehydroquinate synthase from actinidia chinensis in complex with NAD (see paper)
    44% identity, 97% coverage of query (276 bits)

DHQS_ACTCC / U3KRF2 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Actinidia chinensis var. chinensis (Chinese soft-hair kiwi) (see paper)
    44% identity, 97% coverage of query (276 bits)

DHQS_SOLLC / Q8RU74 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
    43% identity, 91% coverage of query (273 bits)

Q9KNV2 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    43% identity, 94% coverage of query (271 bits)

3okfA / Q9KNV2 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase (arob) from vibrio cholerae
    43% identity, 94% coverage of query (265 bits)

aroB / CAA05722.1 3-dehydroquinate synthetase from Neisseria gonorrhoeae (see paper)
    44% identity, 94% coverage of query (263 bits)

Q5NFS1 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    46% identity, 86% coverage of query (263 bits)

5eksA / V5V8R5 Structure of 3-dehydroquinate synthase from acinetobacter baumannii in complex with NAD
    40% identity, 95% coverage of query (253 bits)

5hvnA / Q5NFS1 3.0 angstrom crystal structure of 3-dehydroquinate synthase (arob) from francisella tularensis in complex with NAD.
    45% identity, 86% coverage of query (247 bits)

AroB / b3389 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
aroB / P07639 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli (strain K12) (see 8 papers)
AROB_ECOLI / P07639 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Escherichia coli (strain K12) (see paper)
P07639 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli (see paper)
    42% identity, 90% coverage of query (242 bits)

6llaB Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+ and NAD (see paper)
    42% identity, 90% coverage of query (233 bits)

6lk2A Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+, NAD and chlorogenic acid
    42% identity, 90% coverage of query (228 bits)

Q8U0A8 3-dehydroquinate synthase (EC 4.2.3.4) from Pyrococcus furiosus (see paper)
    38% identity, 94% coverage of query (195 bits)

P9WPX9 3-dehydroquinate synthase (EC 4.2.3.4) from Mycobacterium tuberculosis (see 3 papers)
    36% identity, 91% coverage of query (194 bits)

P9WPX9 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    36% identity, 91% coverage of query (194 bits)

3qbeA / P9WPX9 Crystal structure of the 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis
    35% identity, 91% coverage of query (184 bits)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans (see paper)
aromA pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans (see 4 papers)
    37% identity, 78% coverage of query (181 bits)

6c5cA / Q5AME2 Crystal structure of the 3-dehydroquinate synthase (dhqs) domain of aro1 from candida albicans sc5314 in complex with nadh (see paper)
    38% identity, 71% coverage of query (178 bits)

rifG / G0FS62 aminodehydroquinate synthase from Amycolatopsis mediterranei (strain S699) (see 2 papers)
RIFG_AMYMS / G0FS62 Putative aminodehydroquinate synthase; aDHQS; EC 4.2.3.- from Amycolatopsis mediterranei (strain S699) (Nocardia mediterranei) (see paper)
    35% identity, 94% coverage of query (176 bits)

3qbdA 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis in complex with NAD
    36% identity, 83% coverage of query (176 bits)

EVS_STIAD / Q08VU0 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Stigmatella aurantiaca (strain DW4/3-1) (see paper)
Q08VU0 2-epi-valiolone synthase (EC 4.2.3.155) from Stigmatella aurantiaca (see paper)
    32% identity, 87% coverage of query (174 bits)

Amir_2000 / C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) (see paper)
EVS_ACTMD / C6WFL3 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) (see paper)
C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum (see paper)
    35% identity, 91% coverage of query (173 bits)

1xagA / Q6GGU4 Crystal structure of staphlyococcus aureus 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD+ and carbaphosphonate (see paper)
    36% identity, 80% coverage of query (166 bits)

ARO1 / P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    33% identity, 82% coverage of query (164 bits)

Q6GGU4 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Staphylococcus aureus (strain MRSA252)
    36% identity, 80% coverage of query (164 bits)

EEVS_STIAD / E3FKM2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Stigmatella aurantiaca (strain DW4/3-1) (see paper)
    32% identity, 88% coverage of query (161 bits)

4p53A / H2K887 Vala (2-epi-5-epi-valiolone synthase) from streptomyces hygroscopicus subsp. Jinggangensis 5008 with NAD+ and zn2+ bound (see paper)
    30% identity, 92% coverage of query (155 bits)

valA / H2K887 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) (see 3 papers)
VALA_STRHJ / H2K887 2-epi-5-epi-valiolone synthase; EEVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.152 from Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) (see 2 papers)
H2K887 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces hygroscopicus (see paper)
valA / AAW88569.1 ValA from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
valA / ABA41506.1 2-epi-5-epi-valiolone synthase from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
    30% identity, 91% coverage of query (151 bits)

EEVS_STRGA / B0B0T7 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Streptomyces glaucescens (see paper)
    31% identity, 83% coverage of query (145 bits)

SALQ_STRA4 / A8D7K2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858) (see paper)
A8D7K2 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces albus (see paper)
    33% identity, 71% coverage of query (136 bits)

Build an alignment

Build an alignment for WP_011372650.1 and 33 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

CETA_ACTSX / A1YPR2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Actinomyces sp. (see paper)
A1YPR2 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Actinomyces sp. (see paper)
cetA / ABL74381.1 2-epi-5-epi-valiolone synthase from Actinomyces sp. Lu 9419 (see paper)
    29% identity, 78% coverage of query (129 bits)

DDGS_TRIV2 / Q3M6C3 Demethyl-4-deoxygadusol synthase; DDGS; EC 4.2.3.154 from Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis) (see 2 papers)
Q3M6C3 demethyl-4-deoxygadusol synthase (EC 4.2.3.154) from Trichormus variabilis (see paper)
    29% identity, 80% coverage of query (129 bits)

5tprA / Q3M6C3 Desmethyl-4-deoxygadusol synthase from anabaena variabilis (ava_3858) with NAD+ and zn2+ bound (see paper)
    29% identity, 80% coverage of query (129 bits)

eevs / E7EXW6 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Danio rerio (see paper)
    29% identity, 83% coverage of query (127 bits)

acbC / CAA77208.2 2-epi-5-epi-valiolone synthase AcbC from Actinoplanes sp. SE50/110 (see 5 papers)
    29% identity, 87% coverage of query (125 bits)

ACBC_ACTS5 / Q9ZAE9 2-epi-5-epi-valiolone synthase; EEVS; C7-cyclitol synthase; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.152 from Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) (see paper)
Q9ZAE9 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Actinoplanes sp. (see paper)
    29% identity, 87% coverage of query (124 bits)

DOIS_MICEC / Q70KD0 2-deoxy-scyllo-inosose synthase; DOI synthase; DOIS; EC 4.2.3.124 from Micromonospora echinospora (Micromonospora purpurea) (see paper)
gtmA / CAE06511.1 2-deoxy-scyllo-inosose synthase from Micromonospora echinospora (see paper)
    31% identity, 74% coverage of query (119 bits)

Nos2 / B2J6X9 desmethyl-4-deoxygadusol synthase (EC 4.2.3.154) from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see 2 papers)
DDGS_NOSP7 / B2J6X9 Demethyl-4-deoxygadusol synthase; DDGS; EC 4.2.3.154 from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see 2 papers)
    29% identity, 79% coverage of query (114 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory