Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011382485.1 NCBI__GCF_000009985.1:WP_011382485.1 (318 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

wreQ / Q6TP29 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see 2 papers)
Q6TP29 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Rhizobium etli (see paper)
    49% identity, 96% coverage of query (259 bits)

wbpV / Q9RHC9 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (EC 1.1.1.426) from Pseudomonas aeruginosa (see paper)
    46% identity, 99% coverage of query (244 bits)

wbiG / GI|3135686 putative epimerase/dehydratase WbiG from Burkholderia pseudomallei (see paper)
    45% identity, 99% coverage of query (242 bits)

ORF35x7 / CAA69124.1 ORF35x7 from Vibrio cholerae (see paper)
    40% identity, 100% coverage of query (219 bits)

wbpK / P72144 UDP-N-acetyl-α-D-fucosamine dehydrogenase from Pseudomonas aeruginosa (see 2 papers)
    39% identity, 99% coverage of query (190 bits)

Build an alignment

Build an alignment for WP_011382485.1 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

gnu / Q8X7P7 N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase (EC 5.1.3.26) from Escherichia coli O157:H7 (see 2 papers)
GNU_ECO57 / Q8X7P7 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase; GlcNAc-P-P-Und 4-epimerase; EC 5.1.3.26 from Escherichia coli O157:H7 (see paper)
gne UDP-N-acetylglucosamine 4-epimerase; EC 5.1.3.7 from Escherichia coli O157:H7 (see paper)
    25% identity, 98% coverage of query (88.6 bits)

5u4qA 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
    23% identity, 99% coverage of query (68.9 bits)

rmd / AAK53475.1 putative NDP-hexose epimerase/oxydoreductase from Xanthomonas campestris pv. campestris (see 4 papers)
    29% identity, 87% coverage of query (66.2 bits)

Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
    24% identity, 99% coverage of query (64.7 bits)

5u4qB 1.5 angstrom resolution crystal structure of NAD-dependent epimerase from klebsiella pneumoniae in complex with NAD.
    25% identity, 99% coverage of query (63.9 bits)

3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
    27% identity, 98% coverage of query (63.5 bits)

JF740056 / F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Magnaporthe oryzae (see paper)
F8U969 UDP-glucose 4,6-dehydratase (EC 4.2.1.76) from Pyricularia grisea (see paper)
    26% identity, 98% coverage of query (63.5 bits)

graE / AAA99939.1 dTDP-glucose dehydratase from Streptomyces violaceoruber (see paper)
    27% identity, 99% coverage of query (63.2 bits)

RHM2 / Q9LPG6 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM2 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM2_ARATH / Q9LPG6 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2; NDP-rhamnose synthase; Protein MUCILAGE-MODIFIED 4; Protein RHAMNOSE BIOSYNTHESIS 2; Rhamnose biosynthetic enzyme 2; AtRHM2; UDP-L-rhamnose synthase MUM4; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    24% identity, 98% coverage of query (63.2 bits)

YbjT / b0869 putative NAD(P)-dependent oxidoreductase YbjT from Escherichia coli K-12 substr. MG1655 (see paper)
    25% identity, 92% coverage of query (62.0 bits)

tylA2 / Q54144 dTDP-glucose 4,6-dehydratase monomer (EC 4.2.1.46) from Streptomyces fradiae (see 2 papers)
    26% identity, 100% coverage of query (61.6 bits)

galE / CAA89986.1 UDP-galactose 4-epimease from Corynebacterium glutamicum (see paper)
    26% identity, 95% coverage of query (61.2 bits)

LPSL_RHIME / O54067 Probable UDP-glucuronate 4-epimerase; UDP-glucuronic acid epimerase; EC 5.1.3.6 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    24% identity, 98% coverage of query (60.5 bits)

Q7MH46 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Vibrio vulnificus (see paper)
    23% identity, 99% coverage of query (60.1 bits)

WBIB_BURTA / Q2SYH7 dTDP-L-rhamnose 4-epimerase; EC 5.1.3.25 from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CCUG 48851 / CIP 106301 / E264) (see paper)
Q2SYH7 dTDP-L-rhamnose 4-epimerase (EC 5.1.3.25) from Burkholderia thailandensis (see paper)
    25% identity, 98% coverage of query (59.3 bits)

epsS / BAC55147.1 UDP-glucose 4-epimerase EpsS from Methylobacillus sp. 12S (see paper)
    23% identity, 99% coverage of query (59.3 bits)

RMD_PSEAE / Q9HTB6 GDP-6-deoxy-D-mannose reductase; EC 1.1.1.281 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HTB6 GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) from Pseudomonas aeruginosa (see paper)
    28% identity, 99% coverage of query (59.3 bits)

A0A024CBV5 dihydroflavonol 4-reductase (EC 1.1.1.219) from Viola x wittrockiana (see paper)
    27% identity, 76% coverage of query (58.9 bits)

GALE_LACHE / Q7WTB1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
    23% identity, 99% coverage of query (58.9 bits)

RHM1 / Q9SYM5 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM1 (EC 4.2.1.76) from Arabidopsis thaliana (see 3 papers)
RHM1_ARATH / Q9SYM5 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; Protein REPRESSOR OF LRX1 1; Rhamnose biosynthetic enzyme 1; AtRHM1; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    25% identity, 98% coverage of query (58.5 bits)

6x3bA / Q9HTB6 Structure of rmd from pseudomonas aeruginosa complexed with NADPH
    28% identity, 99% coverage of query (57.8 bits)

A3MUJ4 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrobaculum calidifontis (see paper)
    27% identity, 98% coverage of query (57.8 bits)

6x3bB Structure of rmd from pseudomonas aeruginosa complexed with NADPH
    28% identity, 99% coverage of query (57.8 bits)

RHM3 / Q9LH76 trifunctional UDP-glucose 4,6-dehydratase/UDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase/UDP-4-dehydro-L-rhamnose-reductase RHM3 (EC 4.2.1.76) from Arabidopsis thaliana (see 2 papers)
RHM3_ARATH / Q9LH76 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3; Probable rhamnose biosynthetic enzyme 3; AtRHM3; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    24% identity, 98% coverage of query (57.4 bits)

GALE_MYCS2 / A0R5C5 UDP-glucose 4-epimerase; UDP-galactose 4-epimerase; Uridine diphosphate galactose 4-epimerase; EC 5.1.3.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    27% identity, 99% coverage of query (56.6 bits)

3BHD_KLEAE / P0DX23 3-beta-hydroxysteroid dehydrogenase; 3beta-HSD; EC 1.1.1.51 from Klebsiella aerogenes (Enterobacter aerogenes) (see paper)
    24% identity, 99% coverage of query (56.2 bits)

YbjS / b0868 putative epimerase YbjS from Escherichia coli K-12 substr. MG1655 (see paper)
    24% identity, 99% coverage of query (56.2 bits)

jadT / Q939Q5 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
    26% identity, 81% coverage of query (56.2 bits)

O73960 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrococcus horikoshii (see paper)
    28% identity, 71% coverage of query (55.8 bits)

2q1sA / O87989 Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with nadh (see paper)
    26% identity, 81% coverage of query (54.3 bits)

2q1tA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with NAD+ and udp
    26% identity, 81% coverage of query (54.3 bits)

2pzjA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with NAD+
    26% identity, 81% coverage of query (53.9 bits)

Q2LC81 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Hordeum vulgare (see paper)
    21% identity, 98% coverage of query (53.5 bits)

GalD / b0759 UDP-glucose 4-epimerase (EC 5.1.3.2) from Escherichia coli K-12 substr. MG1655 (see 42 papers)
galE / P09147 UDP-glucose 4-epimerase (EC 5.1.3.2) from Escherichia coli (strain K12) (see 38 papers)
GALE_ECOLI / P09147 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Escherichia coli (strain K12) (see 13 papers)
    24% identity, 98% coverage of query (53.5 bits)

RMLD_MYCS2 / A0QTF8 dTDP-4-dehydrorhamnose reductase; dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase; EC 1.1.1.133 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    28% identity, 81% coverage of query (53.5 bits)

2udpA Udp-galactose 4-epimerase complexed with udp-phenol
    24% identity, 98% coverage of query (53.5 bits)

1udcA Structure of udp-galactose-4-epimerase complexed with udp-mannose
    24% identity, 98% coverage of query (53.5 bits)

6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
    23% identity, 80% coverage of query (53.1 bits)

6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
    23% identity, 80% coverage of query (53.1 bits)

6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
    23% identity, 80% coverage of query (53.1 bits)

A0A0A0PTJ7 dihydroflavonol 4-reductase (EC 1.1.1.219) from Fragaria x ananassa (see paper)
    25% identity, 94% coverage of query (52.8 bits)

1udaA Structure of udp-galactose-4-epimerase complexed with udp-4-deoxy-4- fluoro-alpha-d-galactose
    24% identity, 98% coverage of query (52.8 bits)

1naiA Udp-galactose 4-epimerase from escherichia coli, oxidized
    24% identity, 98% coverage of query (52.8 bits)

1lrjA Crystal structure of e. Coli udp-galactose 4-epimerase complexed with udp-n-acetylglucosamine
    24% identity, 98% coverage of query (52.8 bits)

1kvrA Udp-galactose 4-epimerase complexed with udp-phenol
    23% identity, 98% coverage of query (52.4 bits)

6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
    23% identity, 80% coverage of query (51.6 bits)

1a9yA / P09147 Udp-galactose 4-epimerase mutant s124a/y149f complexed with udp- glucose (see paper)
    23% identity, 98% coverage of query (50.8 bits)

8vr2B / Q1QD53 Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
    23% identity, 98% coverage of query (49.7 bits)

5l3zA / G9VYV4 Polyketide ketoreductase simc7 - binary complex with NADP+ (see paper)
    26% identity, 81% coverage of query (48.9 bits)

4twrA / Q2YKG6 Structure of udp-glucose 4-epimerase from brucella abortus
    26% identity, 78% coverage of query (47.8 bits)

5l4lA Polyketide ketoreductase simc7 - ternary complex with NADP+ and 7-oxo- sd8
    26% identity, 81% coverage of query (46.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory