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Searching for up to 100 curated homologs for WP_011382698.1 NCBI__GCF_000009985.1:WP_011382698.1 (342 a.a.)

Found high-coverage hits (≥70%) to 34 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

proH / Q9AQI1 subunit of 4-oxalomesaconate hydratase (EC 4.2.1.83) from Pseudomonas straminea (see 3 papers)
proH / BAB21455.1 4-Oxalomesaconate hydratase from Pseudomonas straminea (see 2 papers)
    83% identity, 100% coverage of query (620 bits)

pmdE / Q93PS9 4-carboxy-2-hydroxymuconate hydratase (EC 4.2.1.83) from Comamonas testosteroni (see paper)
Q93PS9 4-oxalomesaconate hydratase (EC 4.2.1.83) from Comamonas testosteroni (see paper)
    83% identity, 100% coverage of query (618 bits)

2gwgA / Q6N0R4 Crystal structure of 4-oxalomesaconate hydratase, ligj, from rhodopseudomonas palustris, northeast structural genomics target rpr66.
    82% identity, 100% coverage of query (590 bits)

LIGJ_SPHSK / G2IQQ5 2-keto-4-carboxy-3-hexenedioate hydratase; KCH hydratase; EC 4.2.1.- from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see 3 papers)
ligJ / BAA97116.1 4-oxalomesaconate hydratase from Sphingomonas paucimobilis (see 3 papers)
ligJ / BAB88741.1 4-oxalomesaconate hydratase from Sphingomonas paucimobilis (see 5 papers)
    65% identity, 100% coverage of query (465 bits)

6dxsA / G2IQQ5 Crystal structure of the ligj hydratase e284q mutant substrate complex with (3z)-2-keto-4-carboxy-3-hexenedioate (see paper)
    64% identity, 100% coverage of query (464 bits)

6dxqA Crystal structure of the ligj hydratase product complex with 4- carboxy-4-hydroxy-2-oxoadipate
    65% identity, 100% coverage of query (462 bits)

ligY / Q9Z9I9 OH-DDVA meta-cleavage compound hydrolase from Sphingomonas paucimobilis (see paper)
    32% identity, 96% coverage of query (176 bits)

5vn5C / G2IN02 Crystal structure of ligy from sphingobium sp. Strain syk-6 (see paper)
    32% identity, 96% coverage of query (175 bits)

6e6iA Crystal structure of 4-methyl hopda bound to ligy from sphingobium sp. Strain syk-6
    32% identity, 96% coverage of query (175 bits)

Build an alignment

Build an alignment for WP_011382698.1 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ACMSD_RAT / Q8R5M5 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase; EC 4.1.1.45 from Rattus norvegicus (Rat) (see 2 papers)
Q8R5M5 aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) from Rattus norvegicus (see 3 papers)
    25% identity, 95% coverage of query (82.8 bits)

ACMSD_MOUSE / Q8R519 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase; EC 4.1.1.45 from Mus musculus (Mouse) (see paper)
Q8R519 aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) from Mus musculus (see paper)
    25% identity, 95% coverage of query (79.0 bits)

4qrnA / Q2GA79 High-resolution crystal structure of 5-carboxyvanillate decarboxylase (target efi-505250) from novosphingobium aromaticivorans dsm 12444 complexed with manganese and 4-hydroxy-3-methoxy-5-nitrobenzoic acid
    24% identity, 88% coverage of query (77.8 bits)

4infA Crystal structure of amidohydrolase saro_0799 (target efi-505250) from novosphingobium aromaticivorans dsm 12444 with bound calcium
    24% identity, 88% coverage of query (77.4 bits)

nbaD / A4IT47 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) from Geobacillus thermodenitrificans (strain NG80-2) (see paper)
    24% identity, 81% coverage of query (76.6 bits)

7pwyC / Q8TDX5 Structure of human dimeric acmsd in complex with the inhibitor tes- 1025 (see paper)
    23% identity, 95% coverage of query (74.7 bits)

4ofcA / Q8TDX5 2.0 angstroms x-ray crystal structure of human 2-amino-3- carboxymuconate-6-semialdehye decarboxylase (see paper)
    24% identity, 95% coverage of query (74.7 bits)

4ih3A 2.5 angstroms x-ray crystal structure of of human 2-amino-3- carboxymuconate-6-semialdehyde decarboxylase in complex with dipicolinic acid
    24% identity, 95% coverage of query (74.7 bits)

2wm1A The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis
    24% identity, 95% coverage of query (74.7 bits)

ACMSD / Q8TDX5 aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) from Homo sapiens (see 2 papers)
ACMSD_HUMAN / Q8TDX5 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase; EC 4.1.1.45 from Homo sapiens (Human) (see 2 papers)
Q8TDX5 aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) from Homo sapiens (see 5 papers)
    24% identity, 95% coverage of query (74.3 bits)

7pwyA Structure of human dimeric acmsd in complex with the inhibitor tes- 1025
    23% identity, 95% coverage of query (73.2 bits)

GRDC_POLSJ / Q12BV1 Gamma-resorcylate decarboxylase; Gamma-RSD; 2,6-dihydroxybenzoate decarboxylase; 2,6-DHBD; EC 4.1.1.103 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
Q12BV1 gamma-resorcylate decarboxylase (EC 4.1.1.103) from Polaromonas sp. JS666 (see paper)
    26% identity, 84% coverage of query (68.6 bits)

4qroA / Q12BV1 Crystal structure of dihydroxybenzoic acid decarbboxylase bpro_2061 (target efi-500288) from polaromonas sp. Js666 with bound manganese and an inhibitor, 2-nitroresorcinol
    26% identity, 84% coverage of query (68.2 bits)

ligW2 / Q84IP8 5-carboxyvanillate decarboxylase from Sphingomonas paucimobilis (see 2 papers)
    21% identity, 95% coverage of query (65.1 bits)

graF / Q60GU1 γ-resorcylate decarboxylase monomer (EC 4.1.1.103) from Rhizobium sp. (strain MTP-10005) (see 2 papers)
GRDC_RHIS5 / Q60GU1 Gamma-resorcylate decarboxylase; GRDC; Gamma-RDC; 2,6-dihydroxybenzoate decarboxylase; EC 4.1.1.103 from Rhizobium sp. (strain MTP-10005) (see 3 papers)
Q60GU1 gamma-resorcylate decarboxylase (EC 4.1.1.103) from Rhizobium sp. (see 3 papers)
    26% identity, 84% coverage of query (60.1 bits)

2dvtA / Q60GU1 Crystal structure of 2,6-dihydroxybenzoate decarboxylase from rhizobium
    26% identity, 82% coverage of query (58.2 bits)

3ij6A / Q5FK79 Crystal structure of an uncharacterized metal-dependent hydrolase from lactobacillus acidophilus
    23% identity, 72% coverage of query (58.2 bits)

2dvxA Crystal structure of 2,6-dihydroxybenzoate decarboxylase complexed with inhibitor 2,3-dihydroxybenzaldehyde
    26% identity, 82% coverage of query (58.2 bits)

2dvuA Crystal structure of 2,6-dihydroxybenzoate decarboxylase complexed with 2,6-dihydroxybenzoate
    26% identity, 82% coverage of query (58.2 bits)

GRDC_RHIRD / Q60FX6 Gamma-resorcylate decarboxylase; 2,6-dihydroxybenzoate decarboxylase; Reversible gamma-RA decarboxylase; EC 4.1.1.103 from Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) (see paper)
Q60FX6 gamma-resorcylate decarboxylase (EC 4.1.1.103) from Agrobacterium tumefaciens (see paper)
    26% identity, 82% coverage of query (56.6 bits)

7a19A / P80402 2,3-dihydroxybenzoate decarboxylase of aspergillus oryzae (see paper)
    23% identity, 72% coverage of query (53.9 bits)

7wjrA Crystal structure of dihydroxybenzoate decarboxylase mutant a63s from aspergillus oryzae in complex with catechol
    23% identity, 72% coverage of query (53.9 bits)

T1PRE6 6-methylsalicylate decarboxylase (EC 4.1.1.52) from Aspergillus clavatus (see paper)
    22% identity, 73% coverage of query (52.4 bits)

patG / A1CFL4 6-methylsalicylate decarboxylase (EC 4.1.1.52) from Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) (see 2 papers)
PATG_ASPCL / A1CFL4 6-methylsalicylic acid decarboxylase; Patulin synthesis protein G; EC 4.1.1.52 from Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) (see 4 papers)
    23% identity, 73% coverage of query (52.4 bits)

praH / C4TP08 5-carboxy-2-hydroxymuconate-6-semialdehyde decarboxylase from Paenibacillus sp. JJ-1b (see 3 papers)
praH / BAH79106.1 5-carboxy-2-hydroxymuconate-6-semialdehyde decarboxylase from Paenibacillus sp. JJ-1b (see paper)
    22% identity, 82% coverage of query (50.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory