Searching for up to 100 curated homologs for WP_011382757.1 NCBI__GCF_000009985.1:WP_011382757.1 (665 a.a.)
Found high-coverage hits (≥70%) to 46 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ECM_CERS4 / Q3IZ90 Ethylmalonyl-CoA mutase; EC 5.4.99.63 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
Q3IZ90 ethylmalonyl-CoA mutase (EC 5.4.99.63) from Cereibacter sphaeroides (see paper)
70% identity, 98% coverage of query (905 bits)
ECM_METEA / Q49115 Ethylmalonyl-CoA mutase; EC 5.4.99.63 from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (Methylobacterium extorquens) (see 3 papers)
68% identity, 96% coverage of query (893 bits)
C7C6S9 ethylmalonyl-CoA mutase (EC 5.4.99.63) from Methylorubrum extorquens (see paper)
68% identity, 96% coverage of query (893 bits)
mcm / CAJ91090.1 methylmalonyl-CoA mutase from Sorangium cellulosum (see paper)
39% identity, 94% coverage of query (415 bits)
Q23381 methylmalonyl-CoA mutase (EC 5.4.99.2) from Caenorhabditis elegans (see paper)
36% identity, 94% coverage of query (403 bits)
Caur_2508 / A9WI23 methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
38% identity, 94% coverage of query (402 bits)
mcmA / Q3J4D7 methylmalonyl-CoA mutase (EC 5.4.99.2) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (see paper)
MCM_CERS4 / Q3J4D7 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see 2 papers)
37% identity, 94% coverage of query (399 bits)
O74009 methylmalonyl-CoA mutase (subunit 2/2) (EC 5.4.99.2) from Pyrococcus horikoshii (see paper)
43% identity, 74% coverage of query (395 bits)
YliK / b2917 methylmalonyl-CoA mutase (EC 5.4.99.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
scpA / P27253 methylmalonyl-CoA mutase (EC 5.4.99.2) from Escherichia coli (strain K12) (see 4 papers)
SCPA_ECOLI / P27253 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Escherichia coli (strain K12) (see 3 papers)
38% identity, 94% coverage of query (394 bits)
6oxdA / P9WJK5 Structure of mycobacterium tuberculosis methylmalonyl-coa mutase with adenosyl cobalamin (see paper)
38% identity, 94% coverage of query (392 bits)
Dsui_0519 Methylmalonyl-CoA mutase (EC 5.4.99.2) from Dechlorosoma suillum PS
36% identity, 94% coverage of query (392 bits)
mutB / AAA03041.1 methylmalonyl-CoA large subunit from Streptomyces cinnamonensis (see paper)
37% identity, 94% coverage of query (390 bits)
MUTA_MOUSE / P16332 Methylmalonyl-CoA mutase, mitochondrial; MCM; Methylmalonyl-CoA isomerase; EC 5.4.99.2 from Mus musculus (Mouse) (see paper)
35% identity, 94% coverage of query (387 bits)
F1KUP0 methylmalonyl-CoA mutase subunit (EC 5.4.99.2) from Ascaris suum (see paper)
34% identity, 94% coverage of query (385 bits)
2xiqA / P22033 Crystal structure of human methylmalonyl-coa mutase in complex with adenosylcobalamin and malonyl-coa (see paper)
35% identity, 94% coverage of query (385 bits)
MUT / P22033 Methylmalonyl-CoA mutase, mitochondrial (EC 5.4.99.2) from Homo sapiens (see 4 papers)
MUTA_HUMAN / P22033 Methylmalonyl-CoA mutase, mitochondrial; MCM; Methylmalonyl-CoA isomerase; EC 5.4.99.2 from Homo sapiens (Human) (see 31 papers)
P22033 methylmalonyl-CoA mutase (EC 5.4.99.2) from Homo sapiens (see 6 papers)
35% identity, 94% coverage of query (385 bits)
8dyjB Crystal structure of human methylmalonyl-coa mutase in complex with adp and cob(ii)alamin
35% identity, 94% coverage of query (384 bits)
MCM_RHIME / O86028 Methylmalonyl-CoA mutase; MCM; EC 5.4.99.2 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 2 papers)
35% identity, 94% coverage of query (382 bits)
mutB / P11653 methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) from Propionibacterium freudenreichii subsp. shermanii (see 8 papers)
MUTB_PROFR / P11653 Methylmalonyl-CoA mutase large subunit; MCM-alpha; EC 5.4.99.2 from Propionibacterium freudenreichii subsp. shermanii (see 4 papers)
P11653 methylmalonyl-CoA mutase (EC 5.4.99.2) from Propionibacterium freudenreichii subsp. shermanii (see paper)
36% identity, 94% coverage of query (375 bits)
4reqA Methylmalonyl-coa mutase substrate complex
36% identity, 94% coverage of query (375 bits)
6reqA Methylmalonyl-coa mutase, 3-carboxypropyl-coa inhibitor complex
36% identity, 94% coverage of query (375 bits)
7reqA Methylmalonyl-coa mutase, 2-carboxypropyl-coa inhibitor complex
36% identity, 94% coverage of query (375 bits)
3reqA Methylmalonyl-coa mutase, substrate-free state (poor quality structure)
36% identity, 94% coverage of query (375 bits)
2reqA Methylmalonyl-coa mutase, non-productive coa complex, in open conformation representing substrate-free state
36% identity, 94% coverage of query (375 bits)
5reqA Methylmalonyl-coa mutase, y89f mutant, substrate complex
36% identity, 94% coverage of query (373 bits)
1e1cA / P11653 Methylmalonyl-coa mutase h244a mutant (see paper)
36% identity, 94% coverage of query (371 bits)
Q8MI68 methylmalonyl-CoA mutase (EC 5.4.99.2) from Sus scrofa (see paper)
34% identity, 94% coverage of query (369 bits)
8gjuJ / P22033 Crystal structure of human methylmalonyl-coa mutase (mmut) in complex with methylmalonic acidemia type a protein (mmaa), coenzyme a, and gdp (see paper)
34% identity, 94% coverage of query (366 bits)
Q84FZ1 methylmalonyl-CoA mutase (EC 5.4.99.2) from Methylorubrum extorquens (see paper)
37% identity, 94% coverage of query (365 bits)
A4YEG1 methylmalonyl-CoA mutase (subunit 2/2) (EC 5.4.99.2) from Metallosphaera sedula (see paper)
37% identity, 73% coverage of query (315 bits)
icmA / CAB40912.1 isobutyryl-CoA mutase A from Streptomyces coelicolor (see paper)
35% identity, 74% coverage of query (290 bits)
4r3uA / I3VE77 Crystal structure of 2-hydroxyisobutyryl-coa mutase (see paper)
31% identity, 73% coverage of query (270 bits)
hcmA / I3VE77 2-hydroxyisobutanoyl-CoA mutase large subunit (EC 5.4.99.64) from Aquincola tertiaricarbonis (see 3 papers)
HCMA_AQUTE / I3VE77 2-hydroxyisobutanoyl-CoA mutase large subunit; 2-hydroxyisobutyryl-CoA mutase large subunit; HCM large subunit; EC 5.4.99.64 from Aquincola tertiaricarbonis (see 2 papers)
I3VE77 2-hydroxyisobutanoyl-CoA mutase (subunit 2/2) (EC 5.4.99.64) from Aquincola tertiaricarbonis (see 3 papers)
31% identity, 73% coverage of query (270 bits)
D5WTR7 2-hydroxyisobutanoyl-CoA mutase (subunit 2/2) (EC 5.4.99.64) from Kyrpidia tusciae DSM 2912 (see paper)
31% identity, 73% coverage of query (247 bits)
PCMA_XANP2 / A7IQE5 Pivalyl-CoA mutase large subunit; PCM large subunit; Pivalyl-CoA mutase, substrate-binding subunit; EC 5.4.99.- from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see paper)
31% identity, 72% coverage of query (191 bits)
Build an alignment for WP_011382757.1 and 35 homologs with ≥ 30% identity
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ICMF_CUPMC / Q1LRY0 Fused isobutyryl-CoA mutase; EC 5.4.99.13; EC 3.6.5.- from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans) (see 3 papers)
Q1LRY0 isobutyryl-CoA mutase (EC 5.4.99.13) from Cupriavidus metallidurans (see 3 papers)
26% identity, 72% coverage of query (147 bits)
4xc6A / Q1LRY0 Isobutyryl-coa mutase fused with bound adenosylcobalamin, gdp, and mg (holo-icmf/gdp) (see paper)
26% identity, 72% coverage of query (147 bits)
5cjtA Isobutyryl-coa mutase fused with bound adenosylcobalamin, gdp, mg (holo-icmf/gdp), and substrate isobutyryl-coenzyme a
26% identity, 72% coverage of query (147 bits)
5cjvA Isobutyryl-coa mutase fused with bound adenosylcobalamin, gdp, mg (holo-icmf/gdp), and substrate isovaleryl-coenzyme a
26% identity, 72% coverage of query (146 bits)
4xc7A Isobutyryl-coa mutase fused with bound butyryl-coa and without cobalamin or gdp (apo-icmf)
25% identity, 72% coverage of query (146 bits)
5cjwA Isobutyryl-coa mutase fused with bound adenosylcobalamin, gdp, mg (holo-icmf/gdp), and substrate pivalyl-coenzyme a
26% identity, 72% coverage of query (146 bits)
ICMF_GEOKA / Q5KUG0 Fused isobutyryl-CoA mutase; EC 5.4.99.13; EC 3.6.5.- from Geobacillus kaustophilus (strain HTA426) (see 2 papers)
25% identity, 72% coverage of query (145 bits)
ICMF_PARXL / Q146L7 Fused isobutyryl-CoA mutase; EC 5.4.99.13; EC 3.6.5.- from Paraburkholderia xenovorans (strain LB400) (see paper)
26% identity, 73% coverage of query (141 bits)
Q8Y2U5 methylmalonyl-CoA mutase (EC 5.4.99.2) from Ralstonia solanacearum (see paper)
25% identity, 72% coverage of query (137 bits)
ICMF_NOCFA / Q5Z110 Fused isobutyryl-CoA mutase; EC 5.4.99.13; EC 3.6.5.- from Nocardia farcinica (strain IFM 10152) (see paper)
24% identity, 72% coverage of query (130 bits)
Caur_2509 / A9WI24 methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
24% identity, 80% coverage of query (103 bits)
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Lawrence Berkeley National Laboratory