Searching for up to 100 curated homologs for WP_011383051.1 NCBI__GCF_000009985.1:WP_011383051.1 (406 a.a.)
Found high-coverage hits (≥70%) to 95 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
idhA / AAC43640.1 isocitrate dehydrogenase from Sphingobium yanoikuyae (see paper)
76% identity, 99% coverage of query (667 bits)
B7GQR3 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Bifidobacterium longum subsp. infantis (see paper)
72% identity, 99% coverage of query (611 bits)
icd1 / P9WKL1 isocitrate dehydrogenase subunit (EC 1.1.1.42) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
A5U813 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
P9WKL1 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mycobacterium tuberculosis (see paper)
72% identity, 99% coverage of query (609 bits)
4hcxA / P9WKL1 Structure of icdh-1 from m.Tuberculosis complexed with NADPH & mn2+ (see paper)
73% identity, 98% coverage of query (608 bits)
IDHP_PIG / P33198 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Sus scrofa (Pig) (see 2 papers)
69% identity, 99% coverage of query (590 bits)
Q4E4L7 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Trypanosoma cruzi (see paper)
69% identity, 99% coverage of query (589 bits)
6ajcA / Q4E4L7 Crystal structure of trypanosoma cruzi cytosolic isocitrate dehydrogenase in complex with NADP+, isocitrate and ca2+
69% identity, 98% coverage of query (587 bits)
IDH2 / P48735 mitochondrial isocitrate dehydrogenase monomer (EC 1.1.1.42) from Homo sapiens (see 14 papers)
IDHP_HUMAN / P48735 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Homo sapiens (Human) (see 5 papers)
P48735 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Homo sapiens (see 9 papers)
69% identity, 99% coverage of query (586 bits)
cICDH / Q9SRZ6 NADP+-dependent isocitrate dehydrogenase (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
ICDHC_ARATH / Q9SRZ6 Cytosolic isocitrate dehydrogenase [NADP]; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SRZ6 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
70% identity, 99% coverage of query (585 bits)
IDHP_MOUSE / P54071 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Mus musculus (Mouse) (see 2 papers)
P54071 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mus musculus (see 5 papers)
69% identity, 99% coverage of query (584 bits)
6adiA / P48735 Crystal structures of idh2 r140q in complex with ag-881 (see paper)
68% identity, 99% coverage of query (584 bits)
5i96A Crystal structure of human mitochondrial isocitrate dehydrogenase (idh2) r140q mutant homodimer in complex with ag-221 (enasidenib) inhibitor.
68% identity, 99% coverage of query (584 bits)
4ja8A Complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor
68% identity, 99% coverage of query (584 bits)
5svoA Structure of idh2 mutant r140q
68% identity, 99% coverage of query (584 bits)
5i95A Crystal structure of human mitochondrial isocitrate dehydrogenase r140q mutant homodimer bound to NADPH and alpha-ketoglutaric acid
68% identity, 99% coverage of query (583 bits)
5h3eB Crystal structure of mouse isocitrate dehydrogenases 2 k256q mutant complexed with isocitrate
68% identity, 99% coverage of query (583 bits)
IDHP_RAT / P56574 Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Rattus norvegicus (Rat)
P56574 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Rattus norvegicus (see 2 papers)
68% identity, 99% coverage of query (582 bits)
idpA mitochondrial NADP-dependent isocitrate dehydrogenase; EC 1.1.1.42 from Emericella nidulans (see paper)
67% identity, 99% coverage of query (579 bits)
A0A2G2Y555 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Capsicum annuum (see paper)
68% identity, 99% coverage of query (577 bits)
A0AR16 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Pinus pinaster (see paper)
69% identity, 99% coverage of query (576 bits)
IDHC_SOYBN / Q06197 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Glycine max (Soybean) (Glycine hispida) (see paper)
67% identity, 99% coverage of query (572 bits)
O65853 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Nicotiana tabacum (see paper)
66% identity, 100% coverage of query (572 bits)
Q6C2Y4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Yarrowia lipolytica (see 2 papers)
69% identity, 99% coverage of query (571 bits)
Q6R6M7 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Pisum sativum (see 2 papers)
67% identity, 99% coverage of query (571 bits)
IDHC_MOUSE / O88844 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Mus musculus (Mouse) (see 2 papers)
O88844 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Mus musculus (see 3 papers)
66% identity, 100% coverage of query (570 bits)
ICDHX_ARATH / Q9SLK0 Peroxisomal isocitrate dehydrogenase [NADP]; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SLK0 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Arabidopsis thaliana (see paper)
67% identity, 99% coverage of query (569 bits)
J9Q6L4 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Capsicum annuum (see paper)
69% identity, 97% coverage of query (569 bits)
5yziA Crystal structure of mouse cytosolic isocitrate dehydrogenase complexed with cadmium
67% identity, 98% coverage of query (569 bits)
IDHC_RAT / P41562 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Rattus norvegicus (Rat) (see 2 papers)
P41562 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Rattus norvegicus (see 2 papers)
67% identity, 98% coverage of query (568 bits)
ICDHP_ARATH / Q8LPJ5 Isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial; EC 1.1.1.42 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
67% identity, 98% coverage of query (568 bits)
IDH1 / O75874 cytosolic NADP(+)-dependent isocitrate dehydrogenase monomer (EC 1.1.1.42) from Homo sapiens (see 13 papers)
IDHC_HUMAN / O75874 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Homo sapiens (Human) (see 5 papers)
O75874 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Homo sapiens (see 8 papers)
66% identity, 100% coverage of query (564 bits)
1t0lA Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP, isocitrate, and calcium(2+)
66% identity, 100% coverage of query (564 bits)
1t09A Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex NADP
66% identity, 100% coverage of query (564 bits)
5l57A Crystal structure of iso-citrate dehydrogenase r132h in complex with a novel inhibitor (compound 13a)
67% identity, 98% coverage of query (564 bits)
5yfnA / O75874 Human isocitrate dehydrogenase 1 bound with isocitrate
66% identity, 99% coverage of query (563 bits)
A0A4X1UZU9 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Sus scrofa (see paper)
67% identity, 98% coverage of query (563 bits)
6bkxA Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd1
67% identity, 98% coverage of query (563 bits)
6bl2A Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd15
67% identity, 98% coverage of query (563 bits)
6bl1A Novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd13
67% identity, 98% coverage of query (563 bits)
6bl0A Novel modes of inhibition of wild-type idh1:direct covalent modification of his315 with cmpd11
67% identity, 98% coverage of query (563 bits)
6bkyA Novel binding modes of inhibition of wild-type idh1: allosteric inhibition with cmpd2
67% identity, 98% coverage of query (563 bits)
6bkzA Novel modes of inhibition of wild-type idh1: non-equivalent allosteric inhibition with cmpd3
67% identity, 98% coverage of query (562 bits)
IDHC_BOVIN / Q9XSG3 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDH1; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Bos taurus (Bovine) (see paper)
67% identity, 98% coverage of query (561 bits)
6u4jA Crystal structure of idh1 r132h mutant in complex with ft-2102
67% identity, 98% coverage of query (561 bits)
6o2yA Crystal structure of idh1 r132h mutant in complex with compound 24
67% identity, 98% coverage of query (560 bits)
6vg0A Crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with NADPH and agi-15056
67% identity, 98% coverage of query (560 bits)
6veiA Crystal structure of human cytosolic isocitrate dehydrogenase (idh1) r132h mutant in complex with NADPH and ag-881 (vorasidenib) inhibitor
67% identity, 98% coverage of query (560 bits)
6adgA Crystal structures of idh1 r132h in complex with ag-881
67% identity, 98% coverage of query (560 bits)
4umxA Idh1 r132h in complex with cpd 1
67% identity, 98% coverage of query (560 bits)
3inmA Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase r132h mutant in complex with NADPH, alpha-ketoglutarate and calcium(2+)
67% identity, 97% coverage of query (560 bits)
8bayA Crystal structure of idh1 variant r132c s280f in complex with NADPH, ca2+ and 3-butyl-2-oxoglutarate
67% identity, 98% coverage of query (557 bits)
5lgeA Crystal structure of human idh1 mutant (r132h) in complex with NADP+ and an inhibitor related to bay 1436032
67% identity, 98% coverage of query (557 bits)
P21954 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Saccharomyces cerevisiae (see 2 papers)
66% identity, 99% coverage of query (556 bits)
2qfyA / P21954 Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with a-ketoglutarate (see paper)
66% identity, 99% coverage of query (555 bits)
2qfxA Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with NADPH, a- ketoglutarate and ca(2+)
66% identity, 99% coverage of query (555 bits)
2qfvA Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)- dependent isocitrate dehydrogenase in complex with NADP(+)
66% identity, 99% coverage of query (555 bits)
6o2zA Crystal structure of idh1 r132h mutant in complex with compound 32
67% identity, 98% coverage of query (552 bits)
IDP2 / P41939 NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 4 papers)
IDHC_YEAST / P41939 Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P41939 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Saccharomyces cerevisiae (see paper)
64% identity, 100% coverage of query (550 bits)
6aj6A / Q387G0 Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+
64% identity, 99% coverage of query (550 bits)
6ajbA Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with nadh, alpha-ketoglutarate and ca2+
64% identity, 99% coverage of query (550 bits)
6aj8B Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
64% identity, 99% coverage of query (550 bits)
6aj8A Crystal structure of trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
64% identity, 99% coverage of query (550 bits)
IDHP_SCHPO / O14254 Probable isocitrate dehydrogenase [NADP], mitochondrial; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
63% identity, 99% coverage of query (545 bits)
7pjnA Crystal structure of ivosidenib-resistant idh1 variant r132c s280f in complex with NADPH and inhibitor ds-1001b
66% identity, 98% coverage of query (545 bits)
5tqhA Idh1 r132h mutant in complex with idh889
65% identity, 98% coverage of query (530 bits)
6q6fA Crystal structure of idh1 r132h in complex with hms101
63% identity, 100% coverage of query (530 bits)
8hb9AAA Isocitrate dehydrogenase [NADP] cytoplasmic
65% identity, 98% coverage of query (527 bits)
5svfA Idh1 r132h in complex with idh125
65% identity, 98% coverage of query (526 bits)
6b0zA Idh1 r132h mutant in complex with idh305
65% identity, 98% coverage of query (526 bits)
6io0A Human idh1 r132c mutant complexed with compound a.
64% identity, 98% coverage of query (523 bits)
5de1A Crystal structure of human idh1 in complex with gsk321a
64% identity, 98% coverage of query (521 bits)
Q4DG65 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Trypanosoma cruzi (see paper)
61% identity, 99% coverage of query (513 bits)
6adgC / O75874 Crystal structures of idh1 r132h in complex with ag-881 (see paper)
63% identity, 98% coverage of query (512 bits)
3marA / O75874 Crystal structure of homodimeric r132h mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP (see paper)
63% identity, 98% coverage of query (504 bits)
4xrxA Crystal structure of a metabolic reductase with (e)-5-((1-methyl-5- oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
62% identity, 98% coverage of query (503 bits)
5sunA Idh1 r132h in complex with idh146
62% identity, 98% coverage of query (499 bits)
5l58A / O75874 Crystal structure of iso-citrate dehydrogenase 1 [idh1 (r132h)] in complex with a novel inhibitor (compound 2) (see paper)
63% identity, 98% coverage of query (497 bits)
4xs3A Crystal structure of a metabolic reductase with (e)-1-benzyl-5-((1- methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1h)-one
61% identity, 98% coverage of query (488 bits)
4aouA / A3DC45 Ctidh bound to NADP. The complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism (see paper)
57% identity, 97% coverage of query (465 bits)
4i3kA / O75874 Crystal structure of a metabolic reductase with 1-hydroxy-6-(4- hydroxybenzyl)-4-methylpyridin-2(1h)-one (see paper)
59% identity, 97% coverage of query (461 bits)
Q6AQ66 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Desulfotalea psychrophila (see paper)
2uxqA / Q6AQ66 Isocitrate dehydrogenase from the psychrophilic bacterium desulfotalea psychrophila: biochemical properties and crystal structure analysis (see paper)
51% identity, 98% coverage of query (425 bits)
4aovA Dpidh-NADP. The complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
51% identity, 98% coverage of query (425 bits)
IDH_OSTTA / A0A096P8D3 Isocitrate dehydrogenase (NAD(+)), mitochondrial; OtIDH; EC 1.1.1.41 from Ostreococcus tauri (see paper)
33% identity, 97% coverage of query (168 bits)
6ixnA / A0A096P8D3 Crystal structure of isocitrate dehydrogenase from ostreococcus tauri in complex with NAD+ and citrate (see paper)
33% identity, 97% coverage of query (167 bits)
6ixtA Crystal structure of isocitrate dehydrogenase from ostreococcus tauri in complex with NAD+ and mg2+
33% identity, 97% coverage of query (167 bits)
A4SBK5 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Ostreococcus sp. 'lucimarinus' (see paper)
31% identity, 97% coverage of query (154 bits)
C1E5X2 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Micromonas commoda (see paper)
33% identity, 97% coverage of query (154 bits)
IDH1_PHATC / B7G620 Isocitrate dehydrogenase [NAD(+)] 1, mitochondrial; PtIDH1; EC 1.1.1.41 from Phaeodactylum tricornutum (strain CCAP 1055/1) (see paper)
30% identity, 99% coverage of query (149 bits)
Build an alignment for WP_011383051.1 and 88 homologs with ≥ 30% identity
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icd / Q5UXA4 isocitrate dehydrogenase, NADP (EC 1.1.1.42) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see 4 papers)
24% identity, 88% coverage of query (64.7 bits)
IDH_HALVD / D4GU92 Isocitrate dehydrogenase [NADP]; IDH; ICDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
24% identity, 88% coverage of query (55.1 bits)
icdh / CAC80860.2 NADP-isocitrate dehydrogenase from Haloferax volcanii (see paper)
24% identity, 88% coverage of query (51.6 bits)
2iv0A / O29610 Thermal stability of isocitrate dehydrogenase from archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers (see paper)
26% identity, 83% coverage of query (50.8 bits)
Q9HLV8 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Thermoplasma acidophilum (see paper)
24% identity, 88% coverage of query (49.3 bits)
2d1cA / P33197 Crystal structure of tt0538 protein from thermus thermophilus hb8
24% identity, 87% coverage of query (47.0 bits)
1groA Regulatory and catalytic mechanisms in escherichia coli isocitrate dehydrogenase: multiple roles for n115
24% identity, 71% coverage of query (43.5 bits)
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Lawrence Berkeley National Laboratory