Searching for up to 100 curated homologs for WP_011384541.1 NCBI__GCF_000009985.1:WP_011384541.1 (259 a.a.)
Found high-coverage hits (≥70%) to 69 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
O87873 cyclohexa-1,5-dienecarbonyl-CoA hydratase (EC 4.2.1.100) from Thauera aromatica (see 2 papers)
dch / CAA12246.1 cyclohexa-1,5-diene-1-carbonyl-CoA hydratase from Thauera aromatica (see paper)
69% identity, 98% coverage of query (339 bits)
D3RXI0 cyclohexa-1,5-dienecarbonyl-CoA hydratase (EC 4.2.1.100) from Ferroglobus placidus (see paper)
32% identity, 97% coverage of query (130 bits)
bamR / Q2LXU6 cyclohexa-1,5-dienecarbonyl-CoA hydratase monomer (EC 4.2.1.100) from Syntrophus aciditrophicus (strain SB) (see paper)
31% identity, 95% coverage of query (122 bits)
crt1 / A5N5C7 crotonase (EC 4.2.1.150) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) (see paper)
31% identity, 95% coverage of query (103 bits)
F4JML5 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Arabidopsis thaliana (see paper)
30% identity, 92% coverage of query (99.4 bits)
FADB_BACSU / P94549 Probable enoyl-CoA hydratase; EC 4.2.1.17 from Bacillus subtilis (strain 168) (see paper)
32% identity, 89% coverage of query (95.9 bits)
Q8GB17 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Proteus sp. (see paper)
caiD / CAD48582.1 crotonobetainyl-CoA-hydratase from Proteus sp. LE138 (see paper)
32% identity, 94% coverage of query (94.4 bits)
Msed_0399 / A4YDS4 crotonyl-CoA hydratase/(S)-3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.35; EC 4.2.1.150) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 3 papers)
A4YDS4 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Metallosphaera sedula (see 2 papers)
31% identity, 88% coverage of query (94.0 bits)
Build an alignment for WP_011384541.1 and 8 homologs with ≥ 30% identity
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Msed_2001 / A4YI89 3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 2 papers)
HPCD_METS5 / A4YI89 3-hydroxypropionyl-coenzyme A dehydratase; 3-hydroxypropionyl-CoA dehydratase; EC 4.2.1.116 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
A4YI89 3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) from Metallosphaera sedula (see 3 papers)
5zaiC / A4YI89 Crystal structure of 3-hydroxypropionyl-coa dehydratase from metallosphaera sedula (see paper)
28% identity, 92% coverage of query (91.7 bits)
3q0gD Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
31% identity, 92% coverage of query (90.5 bits)
acuH / Q5LWT8 acryloyl-CoA hydratase (EC 4.2.1.116) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (see 2 papers)
30% identity, 92% coverage of query (88.6 bits)
CRCH_SYNWW / Q0AVM1 Crotonyl-CoA hydratase; EC 4.2.1.150 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) (see paper)
30% identity, 94% coverage of query (87.8 bits)
3h81A / P9WNN9 Crystal structure of enoyl-coa hydratase from mycobacterium tuberculosis (see paper)
30% identity, 95% coverage of query (85.9 bits)
3q0jC Crystal structure of the mycobacterium tuberculosis crotonase in complex with the inhibitor acetoacetylcoa
30% identity, 94% coverage of query (85.5 bits)
3q0gC Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
30% identity, 94% coverage of query (85.5 bits)
6slbAAA / H9ZNW0 6slbAAA (see paper)
30% identity, 98% coverage of query (85.1 bits)
Q5SLK3 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase (EC 5.3.3.18) from Thermus thermophilus (see paper)
30% identity, 96% coverage of query (84.7 bits)
crt / P52046 crotonase monomer (EC 4.2.1.74; EC 4.2.1.150) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
CRT_CLOAB / P52046 Short-chain-enoyl-CoA hydratase; 3-hydroxybutyryl-CoA dehydratase; Crotonase; EC 4.2.1.150 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 2 papers)
P52046 short-chain-enoyl-CoA hydratase (EC 4.2.1.150) from Clostridium acetobutylicum (see paper)
crt 3-hydroxybutyryl-CoA dehydratase; EC 4.2.1.55 from Clostridium acetobutylicum (see paper)
27% identity, 93% coverage of query (84.3 bits)
YaaL / b0036 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
caiD / P31551 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Escherichia coli (strain K12) (see 2 papers)
CAID_ECOLI / P31551 Carnitinyl-CoA dehydratase; Crotonobetainyl-CoA hydratase; EC 4.2.1.149 from Escherichia coli (strain K12) (see paper)
P31551 crotonobetainyl-CoA hydratase (EC 4.2.1.149) from Escherichia coli (see 2 papers)
caiD carnitinyl-CoA dehydratase; EC 4.2.1.- from Escherichia coli K12 (see 5 papers)
27% identity, 95% coverage of query (83.2 bits)
H281DRAFT_05725 2,3-dehydroadipyl-CoA hydratase / enoyl-CoA hydratase (EC 4.2.1.17) from Paraburkholderia bryophila 376MFSha3.1
29% identity, 95% coverage of query (83.2 bits)
6slaAAA Enoyl-CoA hydratase/carnithine racemase
29% identity, 96% coverage of query (82.8 bits)
BPHYT_RS17335 2,3-dehydroadipyl-CoA hydratase / enoyl-CoA hydratase (EC 4.2.1.17) from Burkholderia phytofirmans PsJN
29% identity, 95% coverage of query (82.0 bits)
YdbR / b1393 putative 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
PAAF_ECOLI / P76082 2,3-dehydroadipyl-CoA hydratase; Enoyl-CoA hydratase; EC 4.2.1.17 from Escherichia coli (strain K12) (see 4 papers)
P76082 enoyl-CoA hydratase (EC 4.2.1.17) from Escherichia coli (see paper)
29% identity, 95% coverage of query (81.6 bits)
echA mitochondrial enoyl-CoA hydratase from Emericella nidulans (see paper)
30% identity, 91% coverage of query (80.9 bits)
A0A0H3C585 fructokinase (EC 2.7.1.4) from Halothermothrix orenii (see paper)
29% identity, 90% coverage of query (80.1 bits)
Psest_2437 Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) from Pseudomonas stutzeri RCH2
28% identity, 95% coverage of query (79.7 bits)
ECH_THET8 / Q5SKU3 Putative enoyl-CoA hydratase; TtECH; EC 4.2.1.17 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
31% identity, 87% coverage of query (79.0 bits)
DPGD_AMYOR / G4V4T7 Enoyl-CoA-hydratase; EC 4.2.1.17 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
27% identity, 95% coverage of query (78.6 bits)
Q1D5Y4 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Myxococcus xanthus (see paper)
28% identity, 90% coverage of query (75.9 bits)
badK / O07453 BadK from Rhodopseudomonas palustris (see paper)
30% identity, 96% coverage of query (75.9 bits)
5jbxB / Q1D5Y4 Crystal structure of liuc in complex with coenzyme a and malonic acid (see paper)
28% identity, 90% coverage of query (75.5 bits)
D3RXI4 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) from Ferroglobus placidus (see paper)
31% identity, 71% coverage of query (73.6 bits)
acuK / C8YX87 acryloyl-CoA hydratase/3-hydroxypropanoyl-CoA hydrolase (EC 3.1.2.4; EC 4.2.1.116) from Halomonas sp. HTNK1 (see paper)
29% identity, 91% coverage of query (72.8 bits)
1mj3A Crystal structure analysis of rat enoyl-coa hydratase in complex with hexadienoyl-coa
27% identity, 92% coverage of query (72.4 bits)
ECHS1 / Q58DM8 short chain enoyl-CoA hydratase subunit (EC 4.2.1.150) from Bos taurus (see 5 papers)
26% identity, 95% coverage of query (72.0 bits)
ECHM_MOUSE / Q8BH95 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Mus musculus (Mouse) (see paper)
27% identity, 92% coverage of query (71.6 bits)
CLAC_PENCR / A0A481WNM8 Enoyl-CoA isomerase/hydratase claC; Clavatol biosynthesis cluster protein C; EC 4.2.1.- from Penicillium crustosum (Blue mold fungus) (see 2 papers)
27% identity, 91% coverage of query (71.6 bits)
2dubA Enoyl-coa hydratase complexed with octanoyl-coa
26% identity, 92% coverage of query (71.2 bits)
1dubA / P14604 2-enoyl-coa hydratase, data collected at 100 k, ph 6.5 (see paper)
27% identity, 92% coverage of query (70.9 bits)
Q9I5I4 enoyl-CoA hydratase (EC 4.2.1.17) from Pseudomonas aeruginosa (see paper)
26% identity, 96% coverage of query (70.5 bits)
1ey3A Structure of enoyl-coa hydratase complexed with the substrate dac-coa
27% identity, 92% coverage of query (70.5 bits)
ECHM_RAT / P14604 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus (Rat) (see 6 papers)
P14604 enoyl-CoA hydratase (EC 4.2.1.17); DELTA3,5-DELTA2,4-dienoyl-CoA isomerase (EC 5.3.3.21) from Rattus norvegicus (see 6 papers)
27% identity, 92% coverage of query (70.1 bits)
SM_b21126 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Sinorhizobium meliloti 1021
27% identity, 97% coverage of query (70.1 bits)
H16_A3593 / Q0K5S0 enoyl-CoA hydratase (EC 4.2.1.17) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
28% identity, 92% coverage of query (70.1 bits)
dmdD / Q5LLW6 methylthioacryloyl-CoA hydrolase (EC 4.2.1.155) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (see paper)
DMDD_RUEPO / Q5LLW6 Methylthioacryloyl-CoA hydratase; EC 4.2.1.155 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see 2 papers)
Q5LLW6 (methylthio)acryloyl-CoA hydratase (EC 4.2.1.155) from Ruegeria pomeroyi (see 2 papers)
28% identity, 93% coverage of query (70.1 bits)
Fer4 / Q4PEN0 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Ustilago maydis (strain 521 / FGSC 9021) (see 2 papers)
FER4_USTMA / Q4PEN0 Enoyl-CoA isomerase/hydratase fer4; Fe-regulated protein 4; Ferrichrome A biosynthesis protein fer4; EC 4.2.1.17 from Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) (see 2 papers)
26% identity, 87% coverage of query (69.7 bits)
ECHS1 / P30084 short-chain enoyl-CoA hydratase monomer (EC 4.2.1.17) from Homo sapiens (see 7 papers)
ECHM_HUMAN / P30084 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Homo sapiens (Human) (see 6 papers)
P30084 enoyl-CoA hydratase (EC 4.2.1.17) from Homo sapiens (see 3 papers)
26% identity, 92% coverage of query (68.9 bits)
bbsH / Q9KJE7 (2S)-2-[(R)-hydroxybenzyl]succinyl-CoA monomer (EC 4.2.1.180) from Thauera aromatica (see 2 papers)
BBSH_THAAR / Q9KJE7 (E)-benzylidenesuccinyl-CoA hydratase; EC 4.2.1.180 from Thauera aromatica (see 2 papers)
29% identity, 89% coverage of query (68.6 bits)
paaF / Q845K2 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) from Pseudomonas sp. Y2 (see paper)
32% identity, 89% coverage of query (68.2 bits)
2hw5C / P30084 The crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1
26% identity, 92% coverage of query (68.2 bits)
3omeC / A0R1R4 Crystal structure of a probable enoyl-coa hydratase from mycobacterium smegmatis (see paper)
26% identity, 81% coverage of query (68.2 bits)
ECHD3_HUMAN / Q96DC8 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial from Homo sapiens (Human) (see 2 papers)
24% identity, 90% coverage of query (67.8 bits)
7borA / Q9HW71 Structure of pseudomonas aeruginosa coa-bound odaa (see paper)
26% identity, 93% coverage of query (67.4 bits)
4izcB / Q5LLW6 Crystal structure of dmdd e121a in complex with mta-coa (see paper)
28% identity, 93% coverage of query (67.0 bits)
SIDH_ASPFU / Q4WF54 Mevalonyl-coenzyme A hydratase sidH; Siderophore biosynthesis protein H; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 6 papers)
30% identity, 92% coverage of query (66.6 bits)
4emlA Synechocystis sp. Pcc 6803 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase (menb) in complex with bicarbonate
27% identity, 92% coverage of query (66.2 bits)
4i52A Scmenb im complex with 1-hydroxy-2-naphthoyl-coa
25% identity, 92% coverage of query (61.6 bits)
menB / P73495 naphthoyl-CoA synthase (EC 4.1.3.36) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
P73495 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) from Synechocystis sp. (see 2 papers)
4i4zA / P73495 Synechocystis sp. Pcc 6803 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase (menb) in complex with salicylyl-coa (see paper)
25% identity, 92% coverage of query (61.6 bits)
AUH / Q13825 methylglutaconyl-CoA hydratase subunit (EC 4.2.1.18) from Homo sapiens (see 4 papers)
AUHM_HUMAN / Q13825 Methylglutaconyl-CoA hydratase, mitochondrial; 3-MG-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; AU-binding protein/enoyl-CoA hydratase; Itaconyl-CoA hydratase; EC 4.2.1.18; EC 4.2.1.56 from Homo sapiens (Human) (see 5 papers)
Q13825 methylglutaconyl-CoA hydratase (EC 4.2.1.18) from Homo sapiens (see 4 papers)
28% identity, 88% coverage of query (58.9 bits)
ECH19_MYCTU / O53561 Enoyl-CoA hydratase EchA19; EC 4.2.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
26% identity, 95% coverage of query (57.4 bits)
2uzfA / Q5HH38 Crystal structure of staphylococcus aureus 1,4-dihydroxy-2-naphthoyl coa synthase (menb) in complex with acetoacetyl coa (see paper)
25% identity, 90% coverage of query (56.2 bits)
ECH1_RAT / Q62651 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; EC 5.3.3.- from Rattus norvegicus (Rat) (see 3 papers)
Q62651 DELTA3,5-DELTA2,4-dienoyl-CoA isomerase (EC 5.3.3.21) from Rattus norvegicus (see paper)
21% identity, 92% coverage of query (55.1 bits)
MENB_STAAC / Q5HH38 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Staphylococcus aureus (strain COL) (see 2 papers)
25% identity, 90% coverage of query (51.6 bits)
MENB_ARATH / Q8GYN9 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal; DHNS; Enoyl-CoA hydratase/isomerase D; ECHID; Naphthoate synthase; EC 4.1.3.36 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
23% identity, 91% coverage of query (50.8 bits)
1q51B Crystal structure of mycobacterium tuberculosis menb in complex with acetoacetyl-coenzyme a, a key enzyme in vitamin k2 biosynthesis
27% identity, 92% coverage of query (49.7 bits)
1q51A Crystal structure of mycobacterium tuberculosis menb in complex with acetoacetyl-coenzyme a, a key enzyme in vitamin k2 biosynthesis
25% identity, 92% coverage of query (48.5 bits)
3p85A / A0A0H2ZUQ2 Crystal structure enoyl-coa hydratase from mycobacterium avium (see paper)
27% identity, 75% coverage of query (48.1 bits)
1rjnB / P9WNP5 The crystal structure of menb (rv0548c) from mycobacterium tuberculosis in complex with the coa portion of naphthoyl coa (see paper)
25% identity, 92% coverage of query (48.1 bits)
AKT31_ALTAL / Q9P4U9 Enoyl-CoA hydratase AKT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 4 papers)
24% identity, 87% coverage of query (43.5 bits)
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