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Searching for up to 100 curated homologs for WP_011385301.1 NCBI__GCF_000009985.1:WP_011385301.1 (416 a.a.)

Found high-coverage hits (≥70%) to 85 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

8c0zE / Q5P142 Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
    49% identity, 99% coverage of query (381 bits)

padH / Q8L3B0 phenylglyoxylate dehydrogenase (acylating) subunit PadH (EC 1.2.1.58) from Aromatoleum evansii (see 2 papers)
PADH_AROEV / Q8L3B0 NADH-dependent phenylglyoxylate dehydrogenase subunit epsilon; Phenylglyoxylate:NAD oxidoreductase; Phenylglyoxylate:acceptor oxidoreductase; EC 1.2.1.58 from Aromatoleum evansii (Azoarcus evansii) (see paper)
    33% identity, 96% coverage of query (198 bits)

Build an alignment

Build an alignment for WP_011385301.1 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6pfzA / O29847 Structure of a NAD-dependent persulfide reductase from a. Fulgidus (see paper)
    28% identity, 91% coverage of query (140 bits)

ahpH / CAH04397.1 ferredoxin reductase from Mycobacterium sp. HXN-1500 (see paper)
    33% identity, 73% coverage of query (139 bits)

NASB_BACSU / P42433 Assimilatory nitrate reductase electron transfer subunit from Bacillus subtilis (strain 168) (see 3 papers)
    29% identity, 90% coverage of query (136 bits)

NASD_BACSU / P42435 Nitrite reductase [NAD(P)H]; EC 1.7.1.4 from Bacillus subtilis (strain 168) (see 4 papers)
    30% identity, 92% coverage of query (134 bits)

Q5JFZ8 NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) from Thermococcus kodakarensis (see 2 papers)
    27% identity, 83% coverage of query (131 bits)

3cgbA / A0A6L7HMK7 Pyridine nucleotide complexes with bacillus anthracis coenzyme a- disulfide reductase: a structural analysis of dual NAD(p)h specificity (see paper)
    30% identity, 78% coverage of query (127 bits)

3cgeA Pyridine nucleotide complexes with bacillus anthracis coenzyme a- disulfide reductase: a structural analysis of dual NAD(p)h specificity
    30% identity, 78% coverage of query (127 bits)

3cgdA Pyridine nucleotide complexes with bacillus anthracis coenzyme a- disulfide reductase: a structural analysis of dual NAD(p)h specificity
    30% identity, 78% coverage of query (127 bits)

AZOBR_RS18565 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Azospirillum brasilense Sp245
    30% identity, 91% coverage of query (125 bits)

CCNA_00651 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Caulobacter crescentus NA1000
    30% identity, 89% coverage of query (123 bits)

narC nitrate reductase, NADH oxidase subunit from Clostridium perfringens (see paper)
    28% identity, 93% coverage of query (123 bits)

Psest_1928 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Pseudomonas stutzeri RCH2
    28% identity, 90% coverage of query (119 bits)

GB|AAB98641.1 NADH oxidase; EC 1.-.-.- from Methanocaldococcus jannaschii DSM 2661 (see paper)
    27% identity, 75% coverage of query (119 bits)

Q58065 NADH oxidase (H2O2-forming) (EC 1.6.3.3) from Methanocaldococcus jannaschii (see paper)
    27% identity, 75% coverage of query (119 bits)

Q6WRS9 nitrite reductase (NADH) (EC 1.7.1.15) from Rhodobacter capsulatus (see paper)
    29% identity, 91% coverage of query (119 bits)

4h4wA Crystal structure of ferredoxin reductase, bpha4 e175c/t176r/q177g mutant (reduced form)
    30% identity, 91% coverage of query (117 bits)

andAa / Q84BZ0 anthranilate dioxygenase reductase component (EC 1.14.12.1) from Burkholderia cepacia (see paper)
ANDAA_BURCE / Q84BZ0 Anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase component; EC 1.18.1.3 from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    32% identity, 92% coverage of query (116 bits)

Dshi_1667 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Dinoroseobacter shibae DFL-12
    29% identity, 93% coverage of query (115 bits)

NSR_THEKO / Q5JGP4 NAD(P)H sulfur oxidoreductase (CoA-dependent); NSR; NAD(P)H oxidase (H2O-forming); NOX; EC 1.8.1.18; EC 1.6.3.2 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 2 papers)
Q5JGP4 NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1); NAD(P)H oxidase (H2O-forming) (EC 1.6.3.2); NAD(P)H sulfur oxidoreductase (CoA-dependent) (EC 1.8.1.18) from Thermococcus kodakarensis (see 2 papers)
    30% identity, 79% coverage of query (115 bits)

8pxkA / Q52437 Structure of nadh-dependent ferredoxin reductase, bpha4, solved at wavelength 5.76 a (see paper)
    30% identity, 91% coverage of query (114 bits)

SM_b20984 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Sinorhizobium meliloti 1021
    28% identity, 97% coverage of query (114 bits)

BPHA4_RHOJR / Q0S032 Biphenyl 2,3-dioxygenase, ferredoxin reductase component; Biphenyl 2,3-dioxygenase, electron transfer component BphA4; Biphenyl dioxygenase system, ferredoxin--NAD(+) reductase component; BDO, ferredoxin reductase component; EC 1.18.1.3 from Rhodococcus jostii (strain RHA1) (see paper)
    28% identity, 90% coverage of query (114 bits)

2yvjA Crystal structure of the ferredoxin-ferredoxin reductase (bpha3-bpha4)complex
    30% identity, 91% coverage of query (114 bits)

1f3pA Ferredoxin reductase (bpha4)-nadh complex
    30% identity, 91% coverage of query (114 bits)

2gr2A Crystal structure of ferredoxin reductase, bpha4 (oxidized form)
    30% identity, 91% coverage of query (114 bits)

2gr0A Crystal structure of ferredoxin reductase, bpha4 (oxidized form, NAD+ complex)
    30% identity, 91% coverage of query (114 bits)

4h4uA Crystal structure of ferredoxin reductase, bpha4 t176r mutant (reduced form)
    30% identity, 91% coverage of query (114 bits)

AO353_00805 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Pseudomonas fluorescens FW300-N2E3
    28% identity, 89% coverage of query (112 bits)

PfGW456L13_4101 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Pseudomonas fluorescens GW456-L13
    28% identity, 89% coverage of query (112 bits)

Pf6N2E2_2378 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Pseudomonas fluorescens FW300-N2E2
    28% identity, 89% coverage of query (111 bits)

bphA4 / BAA06871.1 biphenyl dioxygenase from Rhodococcus jostii RHA1 (see paper)
    28% identity, 90% coverage of query (111 bits)

AIFM3_HUMAN / Q96NN9 Apoptosis-inducing factor 3; Apoptosis-inducing factor-like protein; EC 1.-.-.- from Homo sapiens (Human) (see paper)
    30% identity, 73% coverage of query (110 bits)

bphAd / BAM76239.1 biphenyl 2,3-dioxygenase, ferredoxin reductase from Janibacter sp. TYM3221 (see paper)
    29% identity, 75% coverage of query (104 bits)

Q5JJB9 NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) from Thermococcus kodakarensis (see paper)
    28% identity, 74% coverage of query (103 bits)

8a56B / Q82ZQ9 Coenzyme a-persulfide reductase (coapr) from enterococcus faecalis (see paper)
    27% identity, 80% coverage of query (103 bits)

CA265_RS09995 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Pedobacter sp. GW460-11-11-14-LB5
    26% identity, 79% coverage of query (102 bits)

CA265_RS10015 Nitrate reductase (EC 1.7.99.4) from Pedobacter sp. GW460-11-11-14-LB5
    25% identity, 94% coverage of query (102 bits)

RR42_RS31785 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Cupriavidus basilensis FW507-4G11
    26% identity, 93% coverage of query (102 bits)

Q72HK3 NADH:ubiquinone reductase (H+-translocating) (EC 7.1.1.2) from Thermus thermophilus (see paper)
6ruzA / Q72HK3 Nadh-dependent coenzyme a disulfide reductase (see paper)
    27% identity, 71% coverage of query (102 bits)

6rvhA Nadh-dependent coenzyme a disulfide reductase soaked with menadione
    27% identity, 71% coverage of query (102 bits)

6rvbA Nadh-dependent coenzyme a disulfide reductase soaked with nadh
    27% identity, 71% coverage of query (102 bits)

2v3aA / Q9HTK9 Crystal structure of rubredoxin reductase from pseudomonas aeruginosa. (see paper)
    28% identity, 71% coverage of query (99.8 bits)

RURE_PSEAE / Q9HTK9 Rubredoxin-NAD(+) reductase; RdxR; EC 1.18.1.1 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
    28% identity, 71% coverage of query (99.4 bits)

AIFM1_DICDI / Q9GRX6 Apoptosis-inducing factor 1, mitochondrial; Ddaif; EC 1.6.99.- from Dictyostelium discoideum (Social amoeba) (see paper)
    27% identity, 74% coverage of query (99.4 bits)

2cduA / Q9F1X5 The crystal structure of water-forming NAD(p)h oxidase from lactobacillus sanfranciscensis (see paper)
    24% identity, 83% coverage of query (97.8 bits)

alkT / P17052 rubredoxin-NAD(+) reductase (EC 1.18.1.1) from Pseudomonas oleovorans (see paper)
RURE_PSEOL / P17052 Rubredoxin-NAD(+) reductase; RdxR; EC 1.18.1.1 from Pseudomonas oleovorans (see 3 papers)
alkT / CAB54063.1 rubredoxin reductase from Pseudomonas putida (see 6 papers)
    26% identity, 92% coverage of query (97.8 bits)

picB2 / A0A1X9WE60 6-hydroxypicolinate 3-monooxygenase subunit 2 from Alcaligenes faecalis (see paper)
    28% identity, 92% coverage of query (97.8 bits)

cmtAa / Q51973 p-cumate 2,3-dioxygenase system, ferredoxin--NAD+ reductase component (EC 1.14.12.25) from Pseudomonas putida (see paper)
CMTAA_PSEPU / Q51973 p-cumate 2,3-dioxygenase system, ferredoxin--NAD(+) reductase component; EC 1.18.1.3 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
Q51973 p-cumate 2,3-dioxygenase (subunit 4/4) (EC 1.14.12.25) from Pseudomonas putida (see paper)
cmtAa / AAB62284.1 p-cumate dioxygenase ferredoxin reductase subunit from Pseudomonas putida (see 3 papers)
    28% identity, 98% coverage of query (96.7 bits)

Echvi_1912 Nitrate reductase (EC 1.7.99.4) from Echinicola vietnamensis KMM 6221, DSM 17526
    24% identity, 96% coverage of query (95.9 bits)

3fg2P / Q6N3B2 Crystal structure of ferredoxin reductase for the cyp199a2 system from rhodopseudomonas palustris (see paper)
    28% identity, 75% coverage of query (95.5 bits)

nasB / GB|AAA25099.1 nitrite reductase [NAD(P)H], large subunit from Klebsiella oxytoca (see 2 papers)
    28% identity, 82% coverage of query (95.1 bits)

BWI76_RS17365 Nitrite reductase (NAD(P)H) (EC 1.7.1.4) from Klebsiella michiganensis M5al
    27% identity, 93% coverage of query (93.6 bits)

NAOX_LACLM / A2RIB7 NADH oxidase; NOXase; EC 1.6.3.4 from Lactococcus lactis subsp. cremoris (strain MG1363)
A2RIB7 NADH oxidase (H2O-forming) (EC 1.6.3.4) from Lactococcus cremoris (see 4 papers)
    24% identity, 80% coverage of query (93.2 bits)

5vohA Crystal structure of engineered water-forming NADPH oxidase (tpnox) bound to NADPH. The g159a, d177a, a178r, m179s, p184r mutant of lbnox.
    24% identity, 85% coverage of query (91.7 bits)

3lxdA / Q2GBV9 Crystal structure of ferredoxin reductase arr from novosphingobium aromaticivorans (see paper)
    28% identity, 71% coverage of query (90.5 bits)

NROR_CLOAB / Q9AL95 NADH-rubredoxin oxidoreductase; NROR; NADH:rubredoxin oxidoreductase; EC 1.18.1.1 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 7 papers)
Q9AL95 rubredoxin-NAD+ reductase (EC 1.18.1.1) from Clostridium acetobutylicum (see 2 papers)
    24% identity, 85% coverage of query (89.4 bits)

3kljA / Q9AL95 Crystal structure of nadh:rubredoxin oxidoreductase from clostridium acetobutylicum (see paper)
    24% identity, 85% coverage of query (89.4 bits)

5er0A / Q03Q85 Water-forming nadh oxidase from lactobacillus brevis (lbnox) (see paper)
    24% identity, 85% coverage of query (86.3 bits)

5vn0A Water-forming nadh oxidase from lactobacillus brevis (lbnox) bound to nadh.
    24% identity, 85% coverage of query (86.3 bits)

camA / P16640 NADH-putidaredoxin reductase (EC 1.18.1.5) from Pseudomonas putida (see 4 papers)
CAMA_PSEPU / P16640 Putidaredoxin reductase CamA; Pdr; Putidaredoxin--NAD(+) reductase; EC 1.18.1.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 4 papers)
P16640 putidaredoxin-NAD+ reductase (EC 1.18.1.5) from Pseudomonas putida (see 9 papers)
    29% identity, 74% coverage of query (82.8 bits)

1q1wA / P16640 Crystal structure of putidaredoxin reductase from pseudomonas putida (see paper)
    29% identity, 74% coverage of query (82.8 bits)

4em4A Crystal structure of staphylococcus aureus bound with the covalent inhibitor pethyl-vs-coa
    23% identity, 76% coverage of query (78.6 bits)

4em3A / Q2FIA5 Crystal structure of staphylococcus aureus bound with the covalent inhibitor mevs-coa (see paper)
    23% identity, 76% coverage of query (78.6 bits)

1yqzA Structure of coenzyme a-disulfide reductase from staphylococcus aureus refined at 1.54 angstrom resolution
    23% identity, 76% coverage of query (78.6 bits)

4emwA Crystal structure of staphylococcus aureus bound with the covalent inhibitor etvc-coa
    23% identity, 76% coverage of query (78.6 bits)

CDR_STAA8 / O52582 Coenzyme A disulfide reductase; CoA-disulfide reductase; CoADR; EC 1.8.1.14 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
    23% identity, 76% coverage of query (77.8 bits)

NROR_PYRFU / Q8U1K9 NAD(P)H:rubredoxin oxidoreductase; NROR; Rubredoxin--NAD(P)(+) reductase; EC 1.18.1.4 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 3 papers)
Q8U1K9 rubredoxin-NAD(P)+ reductase (EC 1.18.1.4) from Pyrococcus furiosus (see paper)
    25% identity, 88% coverage of query (75.5 bits)

1xhcA / Q8U1K9 Nadh oxidase /nitrite reductase from pyrococcus furiosus pfu-1140779- 001
    26% identity, 75% coverage of query (75.1 bits)

2npxA Nadh binding site and catalysis of nadh peroxidase
    23% identity, 72% coverage of query (72.4 bits)

8d3gA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with 6-chloroquinolin-4-amine
    24% identity, 76% coverage of query (70.9 bits)

3ictA / A0A6L7H7X4 Crystal structure of reduced bacillus anthracis coadr-rhd (see paper)
    23% identity, 71% coverage of query (70.5 bits)

3icsB Crystal structure of partially reduced bacillus anthracis coadr-rhd
    23% identity, 71% coverage of query (70.5 bits)

5fs9B / O95831 Crystal structure of the g338e mutant of human apoptosis inducing factor (see paper)
    22% identity, 88% coverage of query (68.6 bits)

3gd4A Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor
    22% identity, 88% coverage of query (63.5 bits)

3gd4B Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor
    23% identity, 88% coverage of query (63.5 bits)

6krtA Monodehydroascorbate reductase, mdhar, from antarctic hairgrass deschampsia antarctica
    25% identity, 90% coverage of query (60.5 bits)

P37061 NADH oxidase; NOXase; EC 1.6.3.4 from Enterococcus faecalis (strain ATCC 700802 / V583)
    24% identity, 74% coverage of query (56.6 bits)

7btjC Crystal structure of pennisetum glaucum monodehydroascorbate reductase in complex with fadh2
    25% identity, 82% coverage of query (55.5 bits)

LPDA_MYCTU / P9WHH7 NAD(P)H dehydrogenase (quinone); NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase; EC 1.6.5.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    25% identity, 75% coverage of query (55.1 bits)

1xdiA / P9WHH7 Crystal structure of lpda (rv3303c) from mycobacterium tuberculosis (see paper)
    25% identity, 74% coverage of query (54.3 bits)

6zk7AAAA / Q8WU10 structure of human pyroxd1/fad complex (see paper)
    20% identity, 80% coverage of query (50.4 bits)

4gcmB / P66011 Crystal structure of a thioredoxine reductase (trxb) from staphylococcus aureus subsp. Aureus mu50 at 1.80 a resolution
    28% identity, 72% coverage of query (50.4 bits)

7jypA / B7ICV3 Structure of thioredoxin reductase from the thermophilic eubacterium thermosipho africanus tcf52b
    26% identity, 71% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory