Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011386171.1 AMB_RS19325 NAD(P)/FAD-dependent oxidoreductase (374 a.a.)

Found high-coverage hits (≥70%) to 14 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3dmeA / Q7VU70 Crystal structure of conserved exported protein from bordetella pertussis. Northeast structural genomics target ber141
    60% identity, 94% coverage of query (419 bits)

L2HDH_ACHAE / A0A0M7LBC1 L-2-hydroxyglutarate dehydrogenase; EC 1.1.99.2 from Achromobacter aegrifaciens (see paper)
    59% identity, 94% coverage of query (411 bits)

L2HDH_ACCRE / A0A011QK89 L-2-hydroxyglutarate dehydrogenase; EC 1.1.99.2 from Accumulibacter regalis (see paper)
    57% identity, 94% coverage of query (391 bits)

L2HDH_ARATH / Q9LES4 L-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    47% identity, 96% coverage of query (339 bits)

8w7fB / Q9VJ28 Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase bound with fad and a sulfate ion (see paper)
    31% identity, 91% coverage of query (138 bits)

8w78A Structure of drosophila melanogaster l-2-hydroxyglutarate dehydrogenase in complex with fad and 2-oxoglutarate
    31% identity, 91% coverage of query (137 bits)

Build an alignment

Build an alignment for WP_011386171.1 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

LhgD / b2660 L-2-hydroxyglutarate dehydrogenase (EC 1.1.5.13) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
lhgD / P37339 L-2-hydroxyglutarate dehydrogenase (EC 1.1.5.13) from Escherichia coli (strain K12) (see 7 papers)
LHGD_ECOLI / P37339 L-2-hydroxyglutarate dehydrogenase; L2HG dehydrogenase; L2HG:quinone oxidoreductase; EC 1.1.5.13 from Escherichia coli (strain K12) (see 3 papers)
ygaF / RF|NP_417146 uncharacterized protein ygaF from Escherichia coli K12 (see 2 papers)
    27% identity, 90% coverage of query (119 bits)

LHGD_ECOLU / B7N6P4 L-2-hydroxyglutarate dehydrogenase; L2HG dehydrogenase; L2HG:quinone oxidoreductase; EC 1.1.5.13 from Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) (see paper)
    27% identity, 89% coverage of query (117 bits)

lhgO / Q88IT9 (S)-2-hydroxyglutarate oxidase from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    26% identity, 90% coverage of query (116 bits)

LHGD_SALHO / A0A5Y6MCT2 L-2-hydroxyglutarate dehydrogenase; L2HG dehydrogenase; L2HG:quinone oxidoreductase; EC 1.1.5.13 from Salmonella houtenae (see paper)
    28% identity, 89% coverage of query (115 bits)

GLPDH_CALMK / A0A0R3K2G2 Glycerol 3-phosphate dehydrogenase; EC 1.1.99.- from Caloramator mitchellensis (see paper)
    27% identity, 96% coverage of query (109 bits)

GLPO_MYCPN / P75063 Glycerol 3-phosphate oxidase; GlpO; L-alpha-glycerophosphate oxidase; EC 1.1.3.21 from Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae) (see 3 papers)
4x9mA / P75063 Oxidized l-alpha-glycerophosphate oxidase from mycoplasma pneumoniae with fad bound (see paper)
    26% identity, 97% coverage of query (80.5 bits)

Q70GP9 glycerol-3-phosphate oxidase (EC 1.1.3.21) from Mycoplasma mycoides subsp. mycoides (see paper)
glpO glycerol-3-phosphate oxidase; EC 1.1.3.21 from Mycoplasma mycoides subsp. mycoides SC (see paper)
    26% identity, 87% coverage of query (66.6 bits)

ooxB / Q59159 octopine oxidase subunit B from Agrobacterium tumefaciens (strain Ach5) (see paper)
    26% identity, 91% coverage of query (56.6 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory