Searching for up to 100 curated homologs for WP_011386821.1 NCBI__GCF_000009985.1:WP_011386821.1 (453 a.a.)
Found high-coverage hits (≥70%) to 49 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
49% identity, 98% coverage of query (449 bits)
TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
50% identity, 96% coverage of query (417 bits)
PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
35% identity, 88% coverage of query (238 bits)
genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
39% identity, 85% coverage of query (236 bits)
MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
35% identity, 95% coverage of query (231 bits)
PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
34% identity, 95% coverage of query (228 bits)
proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
32% identity, 96% coverage of query (223 bits)
NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
31% identity, 93% coverage of query (209 bits)
GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
35% identity, 88% coverage of query (206 bits)
TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
30% identity, 97% coverage of query (188 bits)
TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
31% identity, 98% coverage of query (187 bits)
TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
30% identity, 86% coverage of query (172 bits)
YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
32% identity, 87% coverage of query (159 bits)
Build an alignment for WP_011386821.1 and 13 homologs with ≥ 30% identity
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TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
27% identity, 96% coverage of query (140 bits)
TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
28% identity, 90% coverage of query (140 bits)
NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
27% identity, 90% coverage of query (138 bits)
SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
25% identity, 94% coverage of query (133 bits)
SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
26% identity, 85% coverage of query (128 bits)
TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
27% identity, 96% coverage of query (121 bits)
YaaU / b0045 putative transporter YaaU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
25% identity, 90% coverage of query (117 bits)
NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
NANX_ECOLI / P39352 Sialic acid transporter NanX from Escherichia coli (strain K12) (see 3 papers)
25% identity, 81% coverage of query (116 bits)
SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
25% identity, 85% coverage of query (114 bits)
TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
25% identity, 85% coverage of query (113 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
26% identity, 78% coverage of query (110 bits)
NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT. N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli. It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
25% identity, 86% coverage of query (104 bits)
YgcS / b2771 putative transporter YgcS from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 2.A.1.1.95 / Q46909 Inner membrane metabolite transport protein YgcS from Escherichia coli (strain K12) (see 3 papers)
28% identity, 84% coverage of query (103 bits)
TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
24% identity, 91% coverage of query (92.4 bits)
S22A6_RAT / O35956 Solute carrier family 22 member 6; Organic anion transporter 1; rOAT1; renal organic anion transporter 1; rROAT1 from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.1.19.4 / O35956 The polyspecific organic anion, cation and neutral molecule transporter, Oat1 (Slc22a6) (transports neutral compounds such as cardiac glycosides [i.e., ouabain] and steroids [i.e., aldosterone; cortisol; dexamethasone]; cationic compounds such as N-propylajmalinium, and anionic compounds such as p-aminohippurate, dicarboxylates, cyclic nucleotides, prostaglandins, urate, β-lactam antibiotics, nonsteroidal anti-inflammatory drugs, diuretics, bile salts and steroid conjugates [i.e., estrone-3-sulfate and estradiol-17-glucuronide]) transporter (H+ symporter or uniporter) Probably catalyzes organic anion (uptake):dicarboxylate (efflux) antiport in the basolateral membrane of kidney proximal tubules) (Eraly et al., 2003a,b). A 3-dimensional model of OAT1 has led to the identification of residues involved in differential transport of substrates such as p-aminohippurate and cidofovir (Perry et al., 2006). Oat1 transports many antiviral agents from Rattus norvegicus (Rat) (see 7 papers)
Slc22a6 / RF|NP_058920.1 solute carrier family 22 member 6 from Rattus norvegicus (see paper)
25% identity, 84% coverage of query (88.6 bits)
S22AO_RABIT / G1SZD9 Steroid transmembrane transporter SLC22A24; Solute carrier family 22 member 24 from Oryctolagus cuniculus (Rabbit) (see paper)
27% identity, 72% coverage of query (87.8 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
25% identity, 84% coverage of query (87.0 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
25% identity, 84% coverage of query (87.0 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
25% identity, 84% coverage of query (86.7 bits)
S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
24% identity, 84% coverage of query (84.7 bits)
S22A6_MACFA / Q4W8A3 Solute carrier family 22 member 6; Organic anion transporter 1; mkOAT1; Renal organic anion transporter 1 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
24% identity, 86% coverage of query (83.6 bits)
OCT7_ARATH / Q940M4 Organic cation/carnitine transporter 7; AtOCT7 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 87% coverage of query (81.6 bits)
S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
24% identity, 83% coverage of query (81.3 bits)
S22AD_HUMAN / Q9Y226 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3; ORCTL3 from Homo sapiens (Human) (see 5 papers)
TC 2.A.1.19.17 / Q9Y226 Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate) from Homo sapiens (Human) (see 4 papers)
26% identity, 78% coverage of query (80.5 bits)
TC 2.A.1.1.116 / C4B4V9 Arabinose/xylose transporter, AraE from Corynebacterium glutamicum
25% identity, 86% coverage of query (80.1 bits)
S22A8_MACFA / Q4W8A2 Organic anion transporter 3; mKOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
23% identity, 93% coverage of query (80.1 bits)
TC 2.A.1.19.36 / Q9VCA2 Organic cation transporter-like protein, OrcT, of 548 aas and 12 TMSs from Drosophila melanogaster (see 5 papers)
27% identity, 79% coverage of query (79.3 bits)
Q9VCA2 Organic cation transporter protein from Drosophila melanogaster (Fruit fly)
27% identity, 79% coverage of query (79.3 bits)
S22A6_PSEAM / O57379 Solute carrier family 22 member 6; Organic anion transporter 1; Renal organic anion transporter 1; ROAT1; fROAT1 from Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) (see paper)
25% identity, 77% coverage of query (76.3 bits)
S22A8_HUMAN / Q8TCC7 Organic anion transporter 3; hOAT3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8 from Homo sapiens (Human) (see 15 papers)
TC 2.A.1.19.34 / Q8TCC7 Multispecific drug transporter, solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3) from Homo sapiens (see 9 papers)
23% identity, 94% coverage of query (76.3 bits)
S22AB_HUMAN / Q9NSA0 Solute carrier family 22 member 11; Organic anion transporter 4; OAT4; Organic anion:dicarboxylate exchanger OAT4 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.10 / Q9NSA0 The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta from Homo sapiens (Human) (see 7 papers)
SLC22A11 / GB|BAA95316.1 solute carrier family 22 member 11 from Homo sapiens
25% identity, 72% coverage of query (73.9 bits)
GLCP_STAES / A0A0H2VG78 Glucose transporter GlcP; Glucose/H(+) symporter from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) (see paper)
22% identity, 88% coverage of query (61.2 bits)
S22AE_MOUSE / Q497L9 Solute carrier family 22 member 14 from Mus musculus (Mouse) (see 2 papers)
23% identity, 72% coverage of query (57.8 bits)
S22A7_HUMAN / Q9Y694 Solute carrier family 22 member 7; Novel liver transporter; NLT; Organic anion transporter 2; hOAT2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.19.25 / Q9Y694 Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports cyclic nucleotodes and the anti-viral drug, acyclovir (Dahlin et al. 2013). Expressed in liver, kidney, brain and red blood cells from Homo sapiens (see 9 papers)
28% identity, 76% coverage of query (57.8 bits)
S22AE_HUMAN / Q9Y267 Solute carrier family 22 member 14; Organic cation transporter-like 4; ORCTL-4 from Homo sapiens (Human) (see 2 papers)
TC 2.A.1.19.22 / Q9Y267 solute carrier family 22, member 14, Slc22a14, is crucial for sperm motility and male fertility in mice. It is expressed specifically in male germ cells, and mice lacking the Slc22a14 gene show severe male infertility as well as sperm morphological changes from Homo sapiens (see 5 papers)
22% identity, 72% coverage of query (46.2 bits)
7zh6A Structure of human oct3 in complex with inhibitor corticosterone
22% identity, 85% coverage of query (44.7 bits)
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Lawrence Berkeley National Laboratory