Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011605773.1 NCBI__GCF_000058485.1:WP_011605773.1 (394 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

DAPE_MYCS2 / A0R2G4 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    45% identity, 89% coverage of query (268 bits)

P9WHS9 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Mycobacterium tuberculosis (see 2 papers)
    46% identity, 89% coverage of query (263 bits)

Q59284 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Corynebacterium glutamicum (see paper)
    40% identity, 89% coverage of query (234 bits)

Q92Y75 acetylornithine deacetylase (EC 3.5.1.16) from Sinorhizobium meliloti (see paper)
    31% identity, 77% coverage of query (90.5 bits)

Build an alignment

Build an alignment for WP_011605773.1 and 4 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

DAPE_SALTY / Q8ZN75 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; Aspartyl peptidase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    28% identity, 86% coverage of query (82.4 bits)

CA265_RS18500 N-succinylcitrulline desuccinylase (EC 3.5.1.-) from Pedobacter sp. GW460-11-11-14-LB5
    28% identity, 87% coverage of query (80.9 bits)

7lgpB / P0AED8 Dape enzyme from shigella flexneri
    27% identity, 86% coverage of query (80.5 bits)

MsgB / b2472 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
dapE / P0AED7 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Escherichia coli (strain K12) (see paper)
DAPE_ECOLI / P0AED7 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Escherichia coli (strain K12) (see paper)
dapE / RF|NP_416967 succinyl-diaminopimelate desuccinylase; EC 3.5.1.18 from Escherichia coli K12 (see 7 papers)
    27% identity, 86% coverage of query (80.1 bits)

Echvi_3851 N-succinylcitrulline desuccinylase (EC 3.5.1.-) from Echinicola vietnamensis KMM 6221, DSM 17526
    27% identity, 85% coverage of query (77.4 bits)

5vo3A / P44514 Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
    22% identity, 89% coverage of query (70.1 bits)

DAPE_HELPY / O25002 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
O25002 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Helicobacter pylori (see paper)
    23% identity, 86% coverage of query (70.1 bits)

dapE / P44514 N-succinyl-L,L-diaminopimelate desuccinylase subunit (EC 3.5.1.18) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
DAPE_HAEIN / P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 7 papers)
P44514 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Haemophilus influenzae (see 3 papers)
    22% identity, 89% coverage of query (69.7 bits)

DAPE_NEIMB / Q9JYL2 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
Q9JYL2 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Neisseria meningitidis (see paper)
    28% identity, 91% coverage of query (69.7 bits)

4o23A / Q9JYL2 Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
    28% identity, 89% coverage of query (68.2 bits)

4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril
    28% identity, 89% coverage of query (68.2 bits)

2f7vA / Q8P8J5 Structure of acetylcitrulline deacetylase complexed with one co (see paper)
    28% identity, 79% coverage of query (65.5 bits)

argE / Q8P8J5 acetylcitrulline deacetylase subunit (EC 3.5.1.16) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
ACDAS_XANCP / Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 3 papers)
    28% identity, 79% coverage of query (63.2 bits)

lysK / Q8VUS5 [L-2-aminoadipate carrier protein]-L-lysine lysine-hydrolase monomer (EC 3.5.1.130) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
LYSK_THET2 / Q8VUS5 [LysW]-lysine hydrolase; EC 3.5.1.130 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
Q8VUS5 [amino group carrier protein]-lysine hydrolase (EC 3.5.1.130) from Thermus thermophilus (see 3 papers)
    28% identity, 86% coverage of query (62.4 bits)

dapE / CAA08876.1 DapE from Bordetella pertussis (see paper)
    28% identity, 89% coverage of query (61.6 bits)

7uoiA / A0A1S8KJG1 Crystallographic structure of dape from enterococcus faecium (see paper)
    24% identity, 86% coverage of query (58.5 bits)

5xoyA / Q8VUS5 Crystal structure of lysk from thermus thermophilus in complex with lysine (see paper)
    27% identity, 86% coverage of query (57.8 bits)

argE / CAB95019.1 acetylornithinase (n2-acetyl-l-ornithine amidohydrolase) from Moritella abyssi (see paper)
    23% identity, 74% coverage of query (56.6 bits)

ABZR86_RS08710 N-acetylcitrulline deacetylase (EC 3.5.1.-) from Dyella japonica UNC79MFTsu3.2
    25% identity, 86% coverage of query (53.1 bits)

8uw6B / P23908 Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
    23% identity, 85% coverage of query (50.4 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory