Searching for up to 100 curated homologs for WP_011606083.1 NCBI__GCF_000058485.1:WP_011606083.1 (267 a.a.)
Found high-coverage hits (≥70%) to 38 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
A1KJ27 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis variant bovis BCG (see paper)
A5U2W7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis H37Ra (see paper)
P9WFX7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis (see paper)
63% identity, 98% coverage of query (301 bits)
3t44A / P9WFX7 Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with indole glycerol phosphate (igp) amd anthranilate
64% identity, 96% coverage of query (296 bits)
3t55A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with phenoxymethyl benzoic acid (pmba)
64% identity, 96% coverage of query (295 bits)
3t78A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) in complex with 5-fluoroanthranilate
63% identity, 96% coverage of query (289 bits)
3t40A Crystal structure of mycobacterium tuberculosis indole glycerol phosphate synthase (igps) complex with n-2-carboxyphenyl glycine (cpg)
60% identity, 98% coverage of query (273 bits)
trpC / AAB39010.1 indole-3-glycerol-phosphate synthase from Bradyrhizobium japonicum (see paper)
42% identity, 90% coverage of query (171 bits)
TRPC_ARATH / P49572 Indole-3-glycerol phosphate synthase, chloroplastic; IGPS; EC 4.1.1.48 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
40% identity, 96% coverage of query (165 bits)
trpC anthranilate synthase component 2; EC 4.1.3.27 from Emericella nidulans (see 4 papers)
44% identity, 90% coverage of query (160 bits)
TRPG_YEAST / P00937 Multifunctional tryptophan biosynthesis protein; EC 4.1.3.27; EC 4.1.1.48 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
43% identity, 83% coverage of query (157 bits)
6y88B / P20577 Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp (see paper)
43% identity, 92% coverage of query (155 bits)
P84126 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Thermus thermophilus (see paper)
1vc4B / P84126 Crystal structure of indole-3-glycerol phosphate synthase (trpc) from thermus thermophilus at 1.8 a resolution (see paper)
51% identity, 77% coverage of query (149 bits)
trpC / AAD09119.1 indole-3-glycerol phosphate synthase from Rhodobacter sphaeroides (see paper)
41% identity, 89% coverage of query (147 bits)
6y88G Igps (indole-3-glycerol phosphate synthase) from pseudomonas aeruginosa in complex with substrate inhibitor rcdrp
46% identity, 76% coverage of query (147 bits)
P24920 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Phytophthora parasitica (see paper)
39% identity, 95% coverage of query (144 bits)
trpC / BAC65125.1 indole-3-glycerol phosphate synthase from Burkholderia multivorans (see paper)
44% identity, 91% coverage of query (142 bits)
1piiA / P00909 Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
37% identity, 92% coverage of query (134 bits)
TrpC / b1262 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24) from Escherichia coli K-12 substr. MG1655 (see 17 papers)
trpC / P00909 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24) from Escherichia coli (strain K12) (see 16 papers)
P00909 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Escherichia coli (see 2 papers)
37% identity, 92% coverage of query (134 bits)
1lbfA Crystal structure of indole-3-glycerol phosphate syntase (igps)with reduced 1-(o-caboxyphenylamino)-1-deoxyribulose 5-phosphate (rcdrp)
36% identity, 86% coverage of query (134 bits)
1jukA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus in a trigonal crystal form
36% identity, 86% coverage of query (134 bits)
1igsA Indole-3-glycerolphosphate synthase from sulfolobus solfataricus at 2.0 a resolution
36% identity, 86% coverage of query (134 bits)
1a53A Complex of indole-3-glycerolphosphate synthase from sulfolobus solfataricus with indole-3-glycerolphosphate at 2.0 a resolution
36% identity, 86% coverage of query (134 bits)
1jcmP Trpc stability mutant containing an engineered disulphide bridge and in complex with a cdrp-related substrate
36% identity, 92% coverage of query (131 bits)
trpC / Q9YGB5 indole-3-glycerol phosphate synthase (EC 4.1.1.48) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
Q9YGB5 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Thermococcus kodakarensis (see paper)
39% identity, 77% coverage of query (121 bits)
4iwwA Computational design of an unnatural amino acid metalloprotein with atomic level accuracy
33% identity, 88% coverage of query (119 bits)
trpC / Q56319 indole-3-glycerol phosphate synthase (EC 4.1.1.48) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
36% identity, 79% coverage of query (112 bits)
3uz5A Designed protein ke59 r13 3/11h (see paper)
33% identity, 87% coverage of query (108 bits)
3uzjA Designed protein ke59 r13 3/11h with benzotriazole
33% identity, 87% coverage of query (108 bits)
3uxdA Designed protein ke59 r1 7/10h with dichlorobenzotriazole (dbt)
32% identity, 88% coverage of query (108 bits)
4ou1A Crystal structure of a computationally designed retro-aldolase covalently bound to folding probe 1 [(6-methoxynaphthalen-2-yl) (oxiran-2-yl)methanol]
32% identity, 88% coverage of query (108 bits)
7etxA / P06560 Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum (see paper)
34% identity, 82% coverage of query (103 bits)
7etyA Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum in complex with reduced 1-(o-carboxyphenylamino)-1- deoxyribulose 5-phosphate (rcdrp)
34% identity, 82% coverage of query (103 bits)
3nz1A / Q06121 Crystal structure of kemp elimination catalyst 1a53-2 complexed with transition state analog 5-nitro benzotriazole (see paper)
32% identity, 83% coverage of query (101 bits)
4a2rA / Q06121 Structure of the engineered retro-aldolase ra95.5-5 (see paper)
30% identity, 88% coverage of query (100 bits)
5k7jA Structure of designed zinc binding protein ze2 bound to zn2+
32% identity, 83% coverage of query (100 bits)
3ud6A Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design
31% identity, 81% coverage of query (100 bits)
6nw4A Evolution of a computationally designed kemp eliminase
30% identity, 83% coverage of query (98.6 bits)
8xynA retro-aldolase RA95.5-8
32% identity, 73% coverage of query (94.4 bits)
Build an alignment for WP_011606083.1 and 37 homologs with ≥ 30% identity
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5an7A Structure of the engineered retro-aldolase ra95.5-8f with a bound 1,3- diketone inhibitor
28% identity, 88% coverage of query (90.5 bits)
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Lawrence Berkeley National Laboratory