Searching for up to 100 curated homologs for WP_011606295.1 NCBI__GCF_000058485.1:WP_011606295.1 (504 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

argH / CAA88927.2 argininosuccinate lyase from Streptomyces clavuligerus (see 3 papers)
    61% identity, 93% coverage of query (540 bits)

P9WPY7 argininosuccinate lyase (EC 4.3.2.1) from Mycobacterium tuberculosis (see 2 papers)
    59% identity, 91% coverage of query (466 bits)

6ienB / P9WPY7 Substrate/product bound argininosuccinate lyase from mycobacterium tuberculosis (see paper)
    58% identity, 89% coverage of query (444 bits)

6ienA Substrate/product bound argininosuccinate lyase from mycobacterium tuberculosis
    57% identity, 89% coverage of query (436 bits)

6ienC Substrate/product bound argininosuccinate lyase from mycobacterium tuberculosis
    54% identity, 89% coverage of query (409 bits)

ARLY_NOSS1 / Q8YQE6 Argininosuccinate lyase; ASAL; Arginosuccinase; NoArgH; EC 4.3.2.1 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see paper)
    47% identity, 89% coverage of query (407 bits)

ARLY_NOSP7 / Q9LAE5 Argininosuccinate lyase; ASAL; ASL; Arginosuccinase; EC 4.3.2.1 from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see paper)
Q9LAE5 argininosuccinate lyase (EC 4.3.2.1) from Nostoc sp. (see paper)
    47% identity, 90% coverage of query (406 bits)

Q8DVX5 argininosuccinate lyase (EC 4.3.2.1) from Streptococcus mutans (see paper)
    43% identity, 90% coverage of query (401 bits)

ARLY_MOUSE / Q91YI0 Argininosuccinate lyase; ASAL; Arginosuccinase; EC 4.3.2.1 from Mus musculus (Mouse) (see paper)
    46% identity, 90% coverage of query (400 bits)

ARLY_ANSAN / P33110 Argininosuccinate lyase; ASAL; Arginosuccinase; Delta crystallin; EC 4.3.2.1 from Anser anser anser (Western greylag goose) (see 2 papers)
    44% identity, 91% coverage of query (400 bits)

ARLY2_ANAPL / P24058 Argininosuccinate lyase; ASAL; Arginosuccinase; Delta crystallin II; Delta-2 crystallin; EC 4.3.2.1 from Anas platyrhynchos (Mallard) (Anas boschas) (see 6 papers)
    43% identity, 91% coverage of query (400 bits)

ASL / P04424 argininosuccinate lyase (EC 4.3.2.1) from Homo sapiens (see 5 papers)
ARLY_HUMAN / P04424 Argininosuccinate lyase; ASAL; Arginosuccinase; EC 4.3.2.1 from Homo sapiens (Human) (see 11 papers)
    46% identity, 91% coverage of query (397 bits)

ARLY_ARTPN / P0DXD4 Argininosuccinate lyase; ASAL; ArArgH; Arginosuccinase; EC 4.3.2.1 from Arthrospira platensis (strain NIES-39 / UTEX 3086 / IAM M-135) (Spirulina platensis) (see paper)
    46% identity, 89% coverage of query (396 bits)

ARLY1_ANAPL / P24057 Delta-1 crystallin; Delta crystallin I from Anas platyrhynchos (Mallard) (Anas boschas) (see 4 papers)
    43% identity, 91% coverage of query (394 bits)

ARLY_COLLI / Q01592 Argininosuccinate lyase; ASAL; Arginosuccinase; Delta crystallin; EC 4.3.2.1 from Columba livia (Rock dove) (see 2 papers)
    44% identity, 91% coverage of query (391 bits)

argH / BAC65282.1 argininosuccinate lyase from Burkholderia multivorans (see paper)
    47% identity, 88% coverage of query (389 bits)

ARLY_SYNY3 / P73257 Argininosuccinate lyase; ASAL; Arginosuccinase; SyArgH; EC 4.3.2.1 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    45% identity, 90% coverage of query (384 bits)

1k7wD / P24058 Crystal structure of s283a duck delta 2 crystallin mutant (see paper)
    43% identity, 88% coverage of query (384 bits)

1hy0A Crystal structure of wild type duck delta 1 crystallin (eye lens protein)
    43% identity, 88% coverage of query (382 bits)

ARLY1_CHICK / P02521 Delta-1 crystallin; Delta crystallin I from Gallus gallus (Chicken) (see 2 papers)
    42% identity, 91% coverage of query (377 bits)

Q9P870 argininosuccinate lyase (EC 4.3.2.1) from Agaricus bisporus (see paper)
    44% identity, 90% coverage of query (375 bits)

ARLY1_MELGA / Q7SIE0 Delta-1 crystallin; Delta crystallin I from Meleagris gallopavo (Wild turkey) (see paper)
    41% identity, 91% coverage of query (374 bits)

arg7 / RF|NP_595129.1 argininosuccinate lyase; EC 4.3.2.1 from Schizosaccharomyces pombe (see paper)
    42% identity, 90% coverage of query (373 bits)

2e9fB / Q5SLL0 Crystal structure of t.Th.Hb8 argininosuccinate lyase complexed with l-arginine
    48% identity, 87% coverage of query (359 bits)

ArgH / b3960 argininosuccinate lyase (EC 4.3.2.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
argH / P11447 argininosuccinate lyase (EC 4.3.2.1) from Escherichia coli (strain K12) (see 2 papers)
    43% identity, 89% coverage of query (357 bits)

ARG7 / CAA09001.1 argininosuccinate lyase from Chlamydomonas reinhardtii (see paper)
    43% identity, 90% coverage of query (352 bits)

argH(A) / CAB95024.1 argininosuccinase and n-acetylglutamate synthase from Moritella abyssi (see paper)
    42% identity, 88% coverage of query (346 bits)

1tj7B / P11447 Structure determination and refinement at 2.44 a resolution of argininosuccinate lyase from e. Coli (see paper)
    43% identity, 88% coverage of query (345 bits)

ARG4 argininosuccinate lyase from Candida albicans (see paper)
    39% identity, 90% coverage of query (339 bits)

ARLY_YEAST / P04076 Argininosuccinate lyase; ASAL; Arginosuccinase; EC 4.3.2.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    41% identity, 90% coverage of query (337 bits)

AN2914 arginosuccinate lyase (Eurofung) from Emericella nidulans (see paper)
    40% identity, 90% coverage of query (336 bits)

6g3fA / Q11KV9 Crystal structure of edds lyase in complex with fumarate (see paper)
    34% identity, 86% coverage of query (204 bits)

6g3iA Crystal structure of edds lyase in complex with n-(2-aminoethyl) aspartic acid (aeaa)
    34% identity, 86% coverage of query (204 bits)

6g3hA Crystal structure of edds lyase in complex with ss-edds
    34% identity, 86% coverage of query (204 bits)

6g3gA Crystal structure of edds lyase in complex with succinate
    34% identity, 86% coverage of query (204 bits)

Echvi_3852 arginosuccinate lyase (EC 4.3.2.1) from Echinicola vietnamensis KMM 6221, DSM 17526
    34% identity, 77% coverage of query (201 bits)

BT3733 arginosuccinate lyase (EC 4.3.2.1) from Bacteroides thetaiotaomicron VPI-5482
    36% identity, 72% coverage of query (192 bits)

CA265_RS18485 arginosuccinate lyase (EC 4.3.2.1) from Pedobacter sp. GW460-11-11-14-LB5
    32% identity, 73% coverage of query (189 bits)

ABZR86_RS08695 arginosuccinate lyase (EC 4.3.2.1) from Dyella japonica UNC79MFTsu3.2
    33% identity, 71% coverage of query (147 bits)

Build an alignment

Build an alignment for WP_011606295.1 and 39 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

5hw2A Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
    22% identity, 70% coverage of query (48.1 bits)

4eeiB / Q5NIQ1 Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with amp and succinate
    22% identity, 70% coverage of query (47.4 bits)

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