Searching for up to 100 curated homologs for WP_011612989.1 NCBI__GCF_000014265.1:WP_011612989.1 (816 a.a.)

Found high-coverage hits (≥70%) to 22 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

F6BL85 glucosylceramidase (EC 3.2.1.45) from Thermoanaerobacterium xylanolyticum (see paper)
AEF18218.1 β-glucosidase (TxGH116;Thexy_2211) (EC 3.2.1.21) (see protein)
    41% identity, 98% coverage of query (624 bits)

8r06A Crystal structure of thermoanaerobacterium xylanolyticum gh116 beta- glucosidase with a covalently bound cyclophellitol aziridine
    41% identity, 98% coverage of query (624 bits)

5ncxA Crystal structure of thermoanaerobacterium xylolyticum gh116 beta- glucosidase with an covalent inhibitor
    41% identity, 98% coverage of query (624 bits)

7w2tA / F6BL85 Crystal structure of txgh116 e730q mutant from thermoanaerobacterium xylanolyticum with glucose
    41% identity, 98% coverage of query (623 bits)

8jboA Crystal structure of txgh116 from thermoanaerobacterium xylanolyticum with isofagomine
    41% identity, 98% coverage of query (623 bits)

5bx4A Crystal structure of thermoanaerobacterium xylanolyticum gh116 beta- glucosidase with glucoimidazole
    41% identity, 98% coverage of query (623 bits)

5bx3A Crystal structure of thermoanaerobacterium xylanolyticum gh116 beta- glucosidase with deoxynojirimycin
    41% identity, 98% coverage of query (623 bits)

5bx2A Crystal structure of thermoanaerobacterium xylanolyticum gh116 beta- glucosidase with 2-deoxy-2-fluoroglucoside
    41% identity, 98% coverage of query (623 bits)

7w2wA Crystal structure of txgh116 r786k mutant from thermoanaerobacterium xylanolyticum with glucose
    41% identity, 98% coverage of query (622 bits)

5npfA Crystal structure of txgh116 (beta-glucosidase from thermoanaerobacterium xylolyticum) in complex with beta cyclophellitol cyclosulfate probe me594
    41% identity, 98% coverage of query (622 bits)

8i5sA Crystal structure of txgh116 d593n acid/base mutant from thermoanaerobacterium xylanolyticum with 2-deoxy-2-fluoroglucoside
    41% identity, 98% coverage of query (621 bits)

5o0sA Crystal structure of txgh116 (beta-glucosidase from thermoanaerobacterium xylolyticum) in complex with unreacted beta cyclophellitol cyclosulfate probe me711
    41% identity, 98% coverage of query (621 bits)

7dktA Crystal structure of txgh116 e441a nucleophile mutant from thermoanaerobacterium xylanolyticum with alpha-glucosyl fluoride
    41% identity, 98% coverage of query (621 bits)

7dksA Crystal structure of txgh116 e441a nucleophile mutant from thermoanaerobacterium xylanolyticum
    41% identity, 98% coverage of query (621 bits)

5ostA Beta-glucosidase from thermoanaerobacterium xylolyticum gh116 in complex with gluco-1h-imidazole
    41% identity, 98% coverage of query (620 bits)

5fjsA / F6BL85 Bacterial beta-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (gba2) (see paper)
    41% identity, 98% coverage of query (579 bits)

5fjsB / F6BL85 Bacterial beta-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (gba2) (see paper)
    40% identity, 98% coverage of query (552 bits)

GBA2_HUMAN / Q9HCG7 Non-lysosomal glucosylceramidase; NLGase; Beta-glucocerebrosidase 2; Beta-glucosidase 2; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; Glucosylceramidase 2; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glycosylceramidase; EC 3.2.1.45; EC 2.4.1.-; EC 3.2.1.-; EC 3.2.1.46 from Homo sapiens (Human) (see 10 papers)
Q9HCG7 glucosylceramidase (EC 3.2.1.45) from Homo sapiens (see 4 papers)
NP_065995.1 acid β-glucosidase 2 / β-glucosylceramidase 2 (Gba2) (ER;non-lysosomal;bile) (EC 3.2.1.45) (see protein)
    35% identity, 94% coverage of query (400 bits)

GBA2_MOUSE / Q69ZF3 Non-lysosomal glucosylceramidase; NLGase; Beta-glucocerebrosidase 2; Beta-glucosidase 2; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; Glucosylceramidase 2; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glycosylceramidase; EC 3.2.1.45; EC 2.4.1.-; EC 3.2.1.-; EC 3.2.1.46 from Mus musculus (Mouse) (see 6 papers)
Q69ZF3 glucosylceramidase (EC 3.2.1.45) from Mus musculus (see paper)
CAM17042.1 acid β-glucosidase 2 / glucosylceramidase 2 (Gba2;Kiaa1605) (non-lysosomal;cytosolic;bile) (EC 3.2.1.45) (see protein)
    34% identity, 94% coverage of query (393 bits)

Q7KT91 Non-lysosomal glucosylceramidase; NLGase; EC 3.2.1.45 from Drosophila melanogaster (Fruit fly)
    31% identity, 85% coverage of query (366 bits)

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Build an alignment for WP_011612989.1 and 20 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

AAK41589.1 aryl β-glucosidase/β-xylosidase (SSO1353) (EC 3.2.1.21|3.2.1.37) (see protein)
    22% identity, 73% coverage of query (76.6 bits)

Q97UH8 beta-glucosidase (EC 3.2.1.21); beta-N-acetylhexosaminidase (EC 3.2.1.52) from Saccharolobus solfataricus (see paper)
AAK43141.1 bifunctional β-glucosidase / β-N-acetylglucosaminidase (sso3039;SSO3039) (EC 3.2.1.21|3.2.1.52) (see protein)
    20% identity, 89% coverage of query (64.3 bits)

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