Searching for up to 100 curated homologs for WP_011649609.1 NCBI__GCF_000009265.1:WP_011649609.1 (356 a.a.)
Found high-coverage hits (≥70%) to 72 curated proteins.
Removed hits that are identical to the query, leaving 71
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Ac3H11_792 ABC transporter for Glycerol, ATPase component 2 from Acidovorax sp. GW101-3H11
55% identity, 94% coverage of query (380 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
42% identity, 81% coverage of query (226 bits)
TC 3.A.1.1.46 / P77481 Putative uncharacterized ABC transporter ATP-binding protein YcjV, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
39% identity, 81% coverage of query (223 bits)
TC 3.A.1.1.22 / Q9X103 MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
41% identity, 81% coverage of query (223 bits)
MSMX_BACSU / P94360 Oligosaccharides import ATP-binding protein MsmX; Maltodextrin import ATP-binding protein MsmX; Melibiose/raffinose/stachyose import ATP-binding protein MsmX; EC 7.5.2.- from Bacillus subtilis (strain 168) (see 5 papers)
TC 3.A.1.1.26 / TC 3.A.1.1.34 / P94360 MsmX, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 3 papers)
39% identity, 81% coverage of query (221 bits)
SM_b21216 ABC transporter for D-Glucosamine, ATPase component from Sinorhizobium meliloti 1021
37% identity, 97% coverage of query (220 bits)
Pf6N2E2_1960 ABC transporter for D-sorbitol, ATPase component from Pseudomonas fluorescens FW300-N2E2
37% identity, 91% coverage of query (219 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
36% identity, 97% coverage of query (219 bits)
AO356_00010 ABC transporter for D-Sorbitol, ATPase component from Pseudomonas fluorescens FW300-N2C3
37% identity, 91% coverage of query (217 bits)
TC 3.A.1.1.12 / Q9AI63 PalK, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
39% identity, 82% coverage of query (217 bits)
mtlK / Q4KC54 polyol ABC-type transporterATP-binding component MtlK from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
39% identity, 81% coverage of query (216 bits)
TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
37% identity, 91% coverage of query (216 bits)
HSERO_RS17020 ABC transporter for D-sorbitol/xylitol, ATPase component from Herbaspirillum seropedicae SmR1
36% identity, 92% coverage of query (216 bits)
PfGW456L13_1897 ABC transporter for D-Galactose and D-Glucose, ATPase component from Pseudomonas fluorescens GW456-L13
35% identity, 97% coverage of query (214 bits)
Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
39% identity, 76% coverage of query (213 bits)
1g291 / Q9YGA6 Malk (see paper)
39% identity, 82% coverage of query (213 bits)
PS417_12700 ABC transporter for D-Mannitol and D-Sorbitol, ATPase component from Pseudomonas simiae WCS417
38% identity, 80% coverage of query (213 bits)
SMc03065 ABC transporter for D-maltose/D-trehalose/sucrose, ATPase component (AglK) from Sinorhizobium meliloti 1021
TC 3.A.1.1.8 / Q9Z3R9 AglK aka R00699 aka SMC03065, component of Sucrose/maltose/trehalose porter (sucrose-inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
36% identity, 95% coverage of query (212 bits)
TC 3.A.1.1.49 / O30494 MtlK, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
39% identity, 80% coverage of query (212 bits)
TC 3.A.1.1.4 / Q01937 LacK, component of Lactose porter from Agrobacterium radiobacter (see paper)
38% identity, 88% coverage of query (211 bits)
TC 3.A.1.1.10 / Q9KWT9 AlgS, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
algS / BAB03314.1 AlgS from Sphingomonas sp (see paper)
39% identity, 86% coverage of query (211 bits)
TC 3.A.1.1.30 / Q88P35 GtsD (GLcK), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
38% identity, 85% coverage of query (211 bits)
MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
39% identity, 82% coverage of query (210 bits)
TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
38% identity, 81% coverage of query (210 bits)
SM_b20002 ABC transporter for Lactose, ATPase component from Sinorhizobium meliloti 1021
36% identity, 97% coverage of query (209 bits)
BPHYT_RS16095 ABC transporter for D-Sorbitol, ATPase component from Burkholderia phytofirmans PsJN
36% identity, 91% coverage of query (209 bits)
UgpC / b3450 sn-glycerol 3-phosphate ABC transporter ATP binding subunit (EC 7.6.2.10) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
UgpC / P10907 sn-glycerol 3-phosphate ABC transporter ATP binding subunit (EC 7.6.2.10) from Escherichia coli (strain K12) (see 2 papers)
UGPC_ECOLI / P10907 sn-glycerol-3-phosphate import ATP-binding protein UgpC; EC 7.6.2.10 from Escherichia coli (strain K12) (see 9 papers)
TC 3.A.1.1.3 / P10907 UgpC aka B3450, component of Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P from Escherichia coli (see 12 papers)
34% identity, 90% coverage of query (208 bits)
8hprD Lpqy-sugabc in state 4
40% identity, 81% coverage of query (208 bits)
8hprC Lpqy-sugabc in state 4
40% identity, 81% coverage of query (208 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
40% identity, 81% coverage of query (207 bits)
PS417_22130 glucose/xylose ABC transporter, ATPase component from Pseudomonas simiae WCS417
35% identity, 97% coverage of query (207 bits)
Q70HW1 ABC-type maltose transporter (EC 7.5.2.1) from Alicyclobacillus acidocaldarius (see paper)
malK / CAE45698.1 ATP-binding MalK protein from Alicyclobacillus acidocaldarius subsp. acidocaldarius (see paper)
38% identity, 80% coverage of query (207 bits)
TC 3.A.1.1.34 / O32151 Uncharacterized ABC transporter ATP-binding protein YurJ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (strain 168)
38% identity, 71% coverage of query (207 bits)
TC 3.A.1.1.5 / P54933 SmoK aka POLK, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
38% identity, 82% coverage of query (207 bits)
SMc02869 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Sinorhizobium meliloti 1021
40% identity, 81% coverage of query (207 bits)
Pf1N1B4_5115 sucrose ABC transporter, ATPase component from Pseudomonas fluorescens FW300-N1B4
37% identity, 88% coverage of query (207 bits)
smoE / Q7CS28 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter ATP-binding subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
34% identity, 97% coverage of query (206 bits)
SMc04256 ABC transporter for D-Cellobiose and D-Salicin, ATPase component from Sinorhizobium meliloti 1021
37% identity, 90% coverage of query (204 bits)
Q8NMV1 ABC-type maltose transporter (EC 7.5.2.1) from Corynebacterium glutamicum (see paper)
TC 3.A.1.1.45 / Q8NMV1 ABC-type sugar transport system, ATPase component, component of Maltose transporter, MusEFGKI from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
35% identity, 89% coverage of query (203 bits)
TC 3.A.1.1.28 / Q00752 MsmK aka SMU.882, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
36% identity, 81% coverage of query (202 bits)
TC 3.A.1.1.20 / Q7WWQ6 ATP-binding protein MsmK aka ABC transporter nucleotide binding protein, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
38% identity, 73% coverage of query (201 bits)
XACK_HALVD / D4GP39 Xylose/arabinose import ATP-binding protein XacK; EC 7.5.2.13 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
35% identity, 89% coverage of query (201 bits)
TC 3.A.1.1.24 / TC 3.A.1.1.25 / Q72L52 Sugar-binding transport ATP-binding protein aka MalK1 aka TT_C0211, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
36% identity, 87% coverage of query (201 bits)
TC 3.A.1.1.27 / Q8DT25 MalK, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) from Streptococcus mutans (see paper)
37% identity, 81% coverage of query (200 bits)
TC 3.A.1.1.23 / P96483 MsiK protein, component of The cellobiose/cellotriose (and possibly higher cellooligosaccharides), CebEFGMsiK [MsiK functions to energize several ABC transporters including those for maltose/maltotriose and trehalose] from Streptomyces reticuli (see paper)
34% identity, 86% coverage of query (200 bits)
Psest_0871 maltose ABC transporter, ATPase component MalK from Pseudomonas stutzeri RCH2
38% identity, 80% coverage of query (199 bits)
SM_b21106 ABC transporter for L-Fucose, ATPase component from Sinorhizobium meliloti 1021
35% identity, 88% coverage of query (197 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
32% identity, 97% coverage of query (197 bits)
B9J850 pterin deaminase (EC 3.5.4.11) from Agrobacterium tumefaciens (see paper)
35% identity, 89% coverage of query (196 bits)
PGA1_c27970 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Phaeobacter inhibens BS107
38% identity, 75% coverage of query (196 bits)
MSIK_STRCO / Q9L0Q1 Diacetylchitobiose uptake system ATP-binding protein MsiK; EC 7.5.2.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
TC 3.A.1.1.33 / TC 3.A.1.1.36 / Q9L0Q1 ABC transporter ATP-binding protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces coelicolor (see paper)
36% identity, 80% coverage of query (196 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
33% identity, 91% coverage of query (189 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
33% identity, 91% coverage of query (189 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
33% identity, 91% coverage of query (187 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
33% identity, 91% coverage of query (187 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
33% identity, 91% coverage of query (187 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
33% identity, 91% coverage of query (187 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
33% identity, 91% coverage of query (187 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
34% identity, 84% coverage of query (186 bits)
2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
33% identity, 84% coverage of query (173 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
30% identity, 82% coverage of query (157 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
30% identity, 82% coverage of query (157 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
30% identity, 82% coverage of query (157 bits)
Build an alignment for WP_011649609.1 and 63 homologs with ≥ 30% identity
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2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
29% identity, 91% coverage of query (137 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
32% identity, 74% coverage of query (119 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
23% identity, 83% coverage of query (82.0 bits)
3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
25% identity, 85% coverage of query (72.4 bits)
4fwiB / Q8RDH4 Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
25% identity, 73% coverage of query (70.1 bits)
8j5qD / P9WQJ5 Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- translocation state (see paper)
22% identity, 76% coverage of query (64.7 bits)
8j5tD Cryo-em structure of mycobacterium tuberculosis oppabcd in the catalytic intermediate state
22% identity, 76% coverage of query (63.2 bits)
8j5sD Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- catalytic intermediate state
22% identity, 76% coverage of query (63.2 bits)
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Lawrence Berkeley National Laboratory