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Searching for up to 100 curated homologs for WP_011650292.1 NCBI__GCF_000009265.1:WP_011650292.1 (308 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

frk / GB|AAB52373.1 fructokinase; EC 2.7.1.4 from Rhizobium leguminosarum bv. trifolii (see paper)
    98% identity, 91% coverage of query (561 bits)

4wjmA / Q2YNY7 Crystal structure of fructokinase from brucella abortus 2308 with bound amppnp
    63% identity, 99% coverage of query (393 bits)

Dshi_2797 Fructokinase (EC 2.7.1.4) from Dinoroseobacter shibae DFL-12
    54% identity, 99% coverage of query (311 bits)

AO353_25910 Fructokinase (EC 2.7.1.4) from Pseudomonas fluorescens FW300-N2E3
    34% identity, 99% coverage of query (185 bits)

PfGW456L13_3036 Fructokinase (EC 2.7.1.4) from Pseudomonas fluorescens GW456-L13
    35% identity, 100% coverage of query (184 bits)

O04897 fructokinase (EC 2.7.1.4) from Solanum lycopersicum (see paper)
    33% identity, 97% coverage of query (137 bits)

Q9FLH8 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see 2 papers)
    33% identity, 97% coverage of query (137 bits)

SCRK2_ORYSI / A2YQL4 Fructokinase-2; Fructokinase II; OsFKII; EC 2.7.1.4 from Oryza sativa subsp. indica (Rice) (see paper)
SCRK2_ORYSJ / Q0J8G4 Fructokinase-2; Fructokinase II; OsFKII; EC 2.7.1.4 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
A2YQL4 fructokinase (EC 2.7.1.4) from Oryza sativa (see paper)
    32% identity, 97% coverage of query (136 bits)

Q9C524 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see 2 papers)
    33% identity, 97% coverage of query (135 bits)

O82616 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    33% identity, 97% coverage of query (131 bits)

SCRK2_MAIZE / Q6XZ78 Fructokinase-2; ZmFRK2; EC 2.7.1.4 from Zea mays (Maize)
    33% identity, 97% coverage of query (130 bits)

Q42896 fructokinase (EC 2.7.1.4) from Solanum lycopersicum (see paper)
    33% identity, 99% coverage of query (128 bits)

Q9SID0 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    33% identity, 97% coverage of query (126 bits)

SCRK1_ORYSJ / Q0JGZ6 Fructokinase-1; Fructokinase I; OsFKI; EC 2.7.1.4 from Oryza sativa subsp. japonica (Rice) (see paper)
    31% identity, 99% coverage of query (125 bits)

SCRK1_ORYSI / A2WXV8 Fructokinase-1; Fructokinase I; OsFKI; EC 2.7.1.4 from Oryza sativa subsp. indica (Rice) (see paper)
    31% identity, 99% coverage of query (125 bits)

Q42645 fructokinase (EC 2.7.1.4) from Beta vulgaris (see paper)
    31% identity, 97% coverage of query (124 bits)

7fcaD / B2HEF4 Pfkb(mycobacterium marinum) (see paper)
    33% identity, 96% coverage of query (122 bits)

Q9LNE4 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    32% identity, 99% coverage of query (122 bits)

Q9M1B9 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see paper)
    31% identity, 97% coverage of query (120 bits)

SCRK1_MAIZE / Q6XZ79 Fructokinase-1; ZmFRK1; EC 2.7.1.4 from Zea mays (Maize)
    31% identity, 99% coverage of query (119 bits)

P37829 fructokinase (EC 2.7.1.4) from Solanum tuberosum (see 2 papers)
    32% identity, 99% coverage of query (111 bits)

ABZR86_RS11105 Fructokinase (EC 2.7.1.4) from Dyella japonica UNC79MFTsu3.2
    30% identity, 96% coverage of query (111 bits)

A0A0H3AER7 fructokinase (EC 2.7.1.4) from Vibrio cholerae (see paper)
    30% identity, 84% coverage of query (110 bits)

5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
    30% identity, 84% coverage of query (109 bits)

Build an alignment

Build an alignment for WP_011650292.1 and 24 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

scrK / GB|AAA08602.1 fructokinase; EC 2.7.1.4 from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
scrK / CAA43323.1 fructokinase from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    29% identity, 99% coverage of query (108 bits)

5yggA / A0A0H3AER7 Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
    30% identity, 83% coverage of query (106 bits)

3ih0A / O59128 Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
    29% identity, 84% coverage of query (106 bits)

3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
    29% identity, 84% coverage of query (106 bits)

Sama_0561 Fructokinase (EC 2.7.1.4) from Shewanella amazonensis SB2B
    29% identity, 97% coverage of query (103 bits)

Pf6N2E2_1965 Fructokinase (EC 2.7.1.4) from Pseudomonas fluorescens FW300-N2E2
    32% identity, 99% coverage of query (103 bits)

AO356_00035 Fructokinase (EC 2.7.1.4) from Pseudomonas fluorescens FW300-N2C3
    32% identity, 99% coverage of query (103 bits)

cscK / GB|CAA57218.2 fructokinase; EC 2.7.1.4 from Escherichia coli (see paper)
    30% identity, 95% coverage of query (100 bits)

Ac3H11_3034 Fructokinase (EC 2.7.1.4) from Acidovorax sp. GW101-3H11
    28% identity, 99% coverage of query (100 bits)

3lkiB / Q87CC0 Crystal structure of fructokinase with bound atp from xylella fastidiosa
    30% identity, 96% coverage of query (100 bits)

scrK / P26420 fructokinase (EC 2.7.1.4) from Klebsiella pneumoniae (see paper)
SCRK_KLEPN / P26420 Fructokinase; EC 2.7.1.4 from Klebsiella pneumoniae (see paper)
scrK / GB|CAA43322.1 fructokinase; EC 2.7.1.4 from Klebsiella pneumoniae (see paper)
scrK / CAA43322.1 fructokinase from Klebsiella pneumoniae (see paper)
    32% identity, 84% coverage of query (97.4 bits)

Shewana3_0069 Fructokinase (EC 2.7.1.4) from Shewanella sp. ANA-3
    28% identity, 97% coverage of query (97.4 bits)

KDGK_THET8 / Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    30% identity, 88% coverage of query (95.5 bits)

1v1aA / Q53W83 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
    30% identity, 88% coverage of query (95.5 bits)

1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp
    30% identity, 88% coverage of query (95.5 bits)

scrK / Q9ZHJ6 fructokinase (EC 2.7.1.4) from Clostridium beijerinckii (see paper)
    27% identity, 96% coverage of query (94.0 bits)

KDGK_BACSU / P50845 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Bacillus subtilis (strain 168) (see paper)
    29% identity, 80% coverage of query (92.4 bits)

PFKB_THETC / D9TT10 ATP-dependent 6-phosphofructokinase; ATP-PFK; Phosphofructokinase; EC 2.7.1.11 from Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium thermosaccharolyticum) (see paper)
    27% identity, 96% coverage of query (90.5 bits)

BPHYT_RS02045 Fructokinase (EC 2.7.1.4) from Burkholderia phytofirmans PsJN
    32% identity, 84% coverage of query (89.7 bits)

STM4066 / Q8ZKR2 aminoimidazole riboside kinase (EC 2.7.1.223) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
AIRSK_SALTY / Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
Q8ZKR2 aminoimidazole riboside kinase (EC 2.7.1.223) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    29% identity, 92% coverage of query (85.5 bits)

1tz3A / Q8ZKR2 Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
    29% identity, 92% coverage of query (81.6 bits)

1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog
    29% identity, 92% coverage of query (81.6 bits)

Q4KD57 2-ketogluconokinase (EC 2.7.1.13) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    30% identity, 77% coverage of query (80.5 bits)

SM_b21374 tagatose kinase (EC 2.7.1.101) from Sinorhizobium meliloti 1021
    28% identity, 82% coverage of query (77.8 bits)

Q0K080 dehydrogluconokinase (EC 2.7.1.13); 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) from Cupriavidus necator (see paper)
    26% identity, 96% coverage of query (76.6 bits)

1gqtB / P0A9J6 Activation of ribokinase by monovalent cations (see paper)
    28% identity, 90% coverage of query (73.9 bits)

RbsK / b3752 ribokinase (EC 2.7.1.15) from Escherichia coli K-12 substr. MG1655 (see 20 papers)
rbsK / P0A9J6 ribokinase (EC 2.7.1.15) from Escherichia coli (strain K12) (see 19 papers)
RBSK_ECOLI / P0A9J6 Ribokinase; RK; EC 2.7.1.15 from Escherichia coli (strain K12) (see 5 papers)
rbsK / RF|NP_418208 ribokinase from Escherichia coli K12 (see 4 papers)
    28% identity, 90% coverage of query (73.6 bits)

1rk2A E. Coli ribokinase complexed with ribose and adp, solved in space group p212121
    28% identity, 90% coverage of query (73.6 bits)

3iq0B / A0A0H2VDX9 Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
    26% identity, 84% coverage of query (69.3 bits)

4ebuA / Q2CIP5 Crystal structure of a sugar kinase (target efi-502312) from oceanicola granulosus, with bound amp/adp crystal form i
    29% identity, 84% coverage of query (68.6 bits)

iolC / P42414 5-dehydro-2-deoxy-D-gluconate kinase (EC 2.7.1.92) from Bacillus subtilis (strain 168) (see 2 papers)
IOLC_BACSU / P42414 5-dehydro-2-deoxygluconokinase; 2-deoxy-5-keto-D-gluconate kinase; DKG kinase; EC 2.7.1.92 from Bacillus subtilis (strain 168) (see paper)
    22% identity, 99% coverage of query (68.6 bits)

Q9YG89 6-phosphofructokinase (EC 2.7.1.11) from Aeropyrum pernix (see 2 papers)
    28% identity, 90% coverage of query (68.2 bits)

4eumA Crystal structure of a sugar kinase (target efi-502132) from oceanicola granulosus with bound amp, crystal form ii
    28% identity, 84% coverage of query (66.6 bits)

RBSK_STAAC / A0A0H2WZY4 Ribokinase; RK; EC 2.7.1.15 from Staphylococcus aureus (strain COL) (see paper)
A0A0H2WZY4 ribokinase (EC 2.7.1.15) from Staphylococcus aureus (see paper)
    25% identity, 95% coverage of query (65.9 bits)

RR42_RS28860 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) from Cupriavidus basilensis FW507-4G11
    28% identity, 84% coverage of query (62.0 bits)

BWI76_RS00290 Ribokinase (EC 2.7.1.15) from Klebsiella michiganensis M5al
    25% identity, 95% coverage of query (61.6 bits)

Atu3166 / A9CES5 tagatose kinase (EC 2.7.1.101) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
TAGK_AGRFC / A9CES5 Tagatose kinase; EC 2.7.1.101 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    28% identity, 87% coverage of query (60.8 bits)

KDGK_ECOLW / E0J5J4 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / LMG 11080 / NBRC 13500 / NCIMB 8666 / NRRL B-766 / W) (see paper)
    28% identity, 83% coverage of query (60.8 bits)

YhjI / b3526 2-dehydro-3-deoxygluconokinase (EC 2.7.1.178; EC 2.7.1.45) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
kdgK / P37647 2-dehydro-3-deoxygluconokinase (EC 2.7.1.178) from Escherichia coli (strain K12) (see 4 papers)
KDGK_ECOLI / P37647 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Escherichia coli (strain K12) (see paper)
    28% identity, 83% coverage of query (60.5 bits)

CCNA_01356 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Caulobacter crescentus NA1000
iolC-DUF2090 / A0A0H3C6B4 bifunctional 5-dehydro-2-deoxygluconokinase/5-dehydro-2-deoxyphosphogluconate aldolase (EC 2.7.1.92; EC 4.1.2.29) from Caulobacter vibrioides (strain NA1000 / CB15N) (see 3 papers)
    24% identity, 90% coverage of query (60.5 bits)

3in1A / P77493 Crystal structure of a putative ribokinase in complex with adp from e.Coli
    24% identity, 96% coverage of query (60.1 bits)

YdjH / b1772 L-glycero-L-galacto-octuluronate kinase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ydjH / P77493 L-glycero-L-galacto-octuluronate kinase from Escherichia coli (strain K12) (see 2 papers)
    24% identity, 96% coverage of query (59.7 bits)

Q8NQR0 ribokinase (EC 2.7.1.15) from Corynebacterium glutamicum (see paper)
    27% identity, 94% coverage of query (59.7 bits)

AO356_00950 Ribokinase (EC 2.7.1.15) from Pseudomonas fluorescens FW300-N2C3
    30% identity, 94% coverage of query (57.4 bits)

BT2804 ribokinase (EC 2.7.1.15) from Bacteroides thetaiotaomicron VPI-5482
    27% identity, 97% coverage of query (57.0 bits)

AO353_21335 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2E3
    23% identity, 83% coverage of query (55.5 bits)

Pf6N2E2_512 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2E2
    24% identity, 85% coverage of query (55.5 bits)

6ul7A Structure of human ketohexokinasE-C in complex with fructose, no3, and osthole
    25% identity, 87% coverage of query (55.1 bits)

8ug1B / P50053 Crystal structure of khk-c and compound 13 (see paper)
    25% identity, 87% coverage of query (55.1 bits)

3qa2A X-ray structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2
    25% identity, 87% coverage of query (55.1 bits)

8ug3A Crystal structure of khk-c and compound 23
    25% identity, 87% coverage of query (55.1 bits)

8omkA Hkhk-c in complex with adp & fructose 1-phosphate
    25% identity, 87% coverage of query (55.1 bits)

8omjA Hkhk-c in complex with compound 28
    25% identity, 87% coverage of query (55.1 bits)

8omfA Crystal structure of hkhk-c in complex with compound-4
    25% identity, 87% coverage of query (55.1 bits)

6w0zA Structure of khk in complex with compound 8 (2-[(1~{s},5~{r})-3-[2- [(2~{s})-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3- azabicyclo[3.1.0]hexan-6-yl]ethanoic acid)
    25% identity, 87% coverage of query (55.1 bits)

6w0yA Structure of khk in complex with compound 6 (2-[(1~{r},5~{s})-3-[5- cyano-6-[(2~{s},3~{r})-2-methyl-3-oxidanyl-azetidin-1-yl]-4- (trifluoromethyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexan-6-yl]ethanoic acid)
    25% identity, 87% coverage of query (55.1 bits)

6w0xA Structure of khk in complex with compound 4 (6-[(1~{s},5~{r})-6- (hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-[(2~{s},3~{r})-2- methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3- carbonitrile)
    25% identity, 87% coverage of query (55.1 bits)

6w0wA Structure of khk in complex with compound 3
    25% identity, 87% coverage of query (55.1 bits)

6w0nA Structure of khk in complex with compound 2
    25% identity, 87% coverage of query (55.1 bits)

5wbzA Structure of human ketohexokinase complexed with hits from fragment screening
    25% identity, 87% coverage of query (55.1 bits)

5wbrA Structure of human ketohexokinase complexed with hits from fragment screening
    25% identity, 87% coverage of query (55.1 bits)

5wbqA Structure of human ketohexokinase complexed with hits from fragment screening
    25% identity, 87% coverage of query (55.1 bits)

5wbpA Structure of human ketohexokinase complexed with hits from fragment screening
    25% identity, 87% coverage of query (55.1 bits)

5wboA Structure of human ketohexokinase complexed with hits from fragment screening
    25% identity, 87% coverage of query (55.1 bits)

5wbmA Structure of human ketohexokinase complexed with hits from fragment screening
    25% identity, 87% coverage of query (55.1 bits)

3ro4A X-ray structure of ketohexokinase in complex with an indazole compound derivative
    25% identity, 87% coverage of query (55.1 bits)

3qaiA X-ray structure of ketohexokinase in complex with a pyrimidopyrimidine analog 3
    25% identity, 87% coverage of query (55.1 bits)

3q92A X-ray structure of ketohexokinase in complex with a pyrimidopyrimidine analog 1
    25% identity, 87% coverage of query (55.1 bits)

3ncaA X-ray structure of ketohexokinase in complex with a thieno pyridinol compound
    25% identity, 87% coverage of query (55.1 bits)

3nc9A X-ray structure of ketohexokinase complexed with an indazole compound
    25% identity, 87% coverage of query (55.1 bits)

3nc2A X-ray structure of ketohexokinase with a quinazoline
    25% identity, 87% coverage of query (55.1 bits)

3nbwA X-ray structure of ketohexokinase in complex with a pyrazole compound
    25% identity, 87% coverage of query (55.1 bits)

3nbvA X-ray structure of ketohexokinase in complex with amp-pnp and fructose
    25% identity, 87% coverage of query (55.1 bits)

KHK / P50053 Ketohexokinase (EC 2.7.1.3) from Homo sapiens (see 8 papers)
KHK_HUMAN / P50053 Ketohexokinase; Hepatic fructokinase; EC 2.7.1.3 from Homo sapiens (Human) (see 4 papers)
P50053 ketohexokinase (EC 2.7.1.3) from Homo sapiens (see 6 papers)
    25% identity, 87% coverage of query (55.1 bits)

kdgK / Q97U29 2-dehydro-3-deoxyglucono/2-dehydro-3-deoxygalactonokinase monomer (EC 2.7.1.178) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see 3 papers)
KDGK_SACS2 / Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
Q97U29 2-dehydro-3-deoxyglucono/galactono-kinase (EC 2.7.1.178) from Saccharolobus solfataricus (see 5 papers)
    25% identity, 77% coverage of query (53.9 bits)

2varA / Q97U29 Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
    25% identity, 77% coverage of query (53.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory