Searching for up to 100 curated homologs for WP_011734398.1 NCBI__GCF_000015045.1:WP_011734398.1 (470 a.a.)
Found high-coverage hits (≥70%) to 52 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
IDH_BACSU / P39126 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Bacillus subtilis (strain 168) (see paper)
icd / GB|CAB14873.1 isocitrate dehydrogenase; EC 1.1.1.42 from Bacillus subtilis (see 2 papers)
62% identity, 98% coverage of query (574 bits)
A8YGS2 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Microcystis aeruginosa (see paper)
54% identity, 100% coverage of query (527 bits)
IDH_PSEAB / Q02NB5 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
56% identity, 100% coverage of query (515 bits)
D0Z8Y6 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Edwardsiella tarda (see paper)
57% identity, 98% coverage of query (508 bits)
IcdE / b1136 isocitrate dehydrogenase (EC 1.1.1.42) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
icd / P08200 isocitrate dehydrogenase (EC 1.1.1.42) from Escherichia coli (strain K12) (see 3 papers)
IDH_ECOLI / P08200 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Escherichia coli (strain K12) (see 7 papers)
P08200 [Isocitrate dehydrogenase (NADP+)] kinase (EC 2.7.11.5) from Escherichia coli (see paper)
4aj3A / P08200 3d structure of e. Coli isocitrate dehydrogenase in complex with isocitrate, calcium(ii) and NADP - the pseudo-michaelis complex (see paper)
57% identity, 99% coverage of query (508 bits)
4ajaA 3d structure of e. Coli isocitrate dehydrogenase in complex with isocitrate, calcium(ii) and thionadp
57% identity, 99% coverage of query (508 bits)
1bl5A Isocitrate dehydrogenase from e. Coli single turnover laue structure of rate-limited product complex, 10 msec time resolution
57% identity, 99% coverage of query (508 bits)
1ai3A Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences
57% identity, 99% coverage of query (508 bits)
1ai2A Isocitrate dehydrogenase complexed with isocitrate, NADP+, and calcium (flash-cooled)
57% identity, 99% coverage of query (508 bits)
1hj6A Isocitrate dehydrogenase s113e mutant complexed with isopropylmalate, NADP+ and magnesium (flash-cooled)
56% identity, 99% coverage of query (507 bits)
Q1XIQ8 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Colwellia psychrerythraea (see paper)
56% identity, 99% coverage of query (506 bits)
4ajcA 3d structure of e. Coli isocitrate dehydrogenase k100m mutant in complex with alpha-ketoglutarate, calcium(ii) and adenine nucleotide phosphate
56% identity, 99% coverage of query (506 bits)
1cw4A Crystal structure of k230m isocitrate dehydrogenase in complex with alpha-ketoglutarate
56% identity, 99% coverage of query (506 bits)
1cw1A Crystal structure of isocitrate dehydrogenase mutant k230m bound to isocitrate and mn2+
56% identity, 99% coverage of query (506 bits)
1idcA Isocitrate dehydrogenase from e.Coli (mutant k230m), steady-state intermediate complex determined by laue crystallography
56% identity, 99% coverage of query (506 bits)
6c0eA / Q5ZXB6 Crystal structure of isocitrate dehydrogenase from legionella pneumophila with bound NADPH with an alpha-ketoglutarate adduct
56% identity, 100% coverage of query (505 bits)
1groA Regulatory and catalytic mechanisms in escherichia coli isocitrate dehydrogenase: multiple roles for n115
56% identity, 99% coverage of query (503 bits)
1isoA Isocitrate dehydrogenase: structure of an engineered NADP+--> NAD+ specificity-reversal mutant
56% identity, 99% coverage of query (498 bits)
IDH_COXBU / Q9ZH99 Isocitrate dehydrogenase [NADP]; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I) (see paper)
56% identity, 100% coverage of query (494 bits)
icd / B2ZP83 isocitrate dehydrogenase subunit (EC 1.1.1.42) from Helicobacter pylori (see 4 papers)
55% identity, 98% coverage of query (488 bits)
icd / BAA03135.1 isocitrate dehydrogenase isozyme IDH-I from Colwellia maris (see paper)
55% identity, 98% coverage of query (487 bits)
Q8GAX0 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Acidithiobacillus thiooxidans (see paper)
54% identity, 96% coverage of query (470 bits)
2d4vA / Q8GAX0 Crystal structure of NAD dependent isocitrate dehydrogenase from acidithiobacillus thiooxidans (see paper)
54% identity, 96% coverage of query (470 bits)
Q1GZD1 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Methylobacillus flagellatus (see paper)
51% identity, 99% coverage of query (455 bits)
IDH_HALVD / D4GU92 Isocitrate dehydrogenase [NADP]; IDH; ICDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
49% identity, 100% coverage of query (433 bits)
icdh / CAC80860.2 NADP-isocitrate dehydrogenase from Haloferax volcanii (see paper)
49% identity, 100% coverage of query (431 bits)
icd / Q5UXA4 isocitrate dehydrogenase, NADP (EC 1.1.1.42) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see 4 papers)
50% identity, 100% coverage of query (431 bits)
2iv0A / O29610 Thermal stability of isocitrate dehydrogenase from archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers (see paper)
48% identity, 100% coverage of query (417 bits)
Q9HLV8 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Thermoplasma acidophilum (see paper)
49% identity, 97% coverage of query (405 bits)
Q9YE81 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Aeropyrum pernix (see 4 papers)
44% identity, 98% coverage of query (358 bits)
1tyoA / Q9YE81 Isocitrate dehydrogenase from the hyperthermophile aeropyrum pernix in complex with etheno-NADP (see paper)
44% identity, 98% coverage of query (358 bits)
P96318 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Caldococcus noboribetus (see 2 papers)
43% identity, 98% coverage of query (350 bits)
Q4J6C9 isocitrate-homoisocitrate dehydrogenase (EC 1.1.1.286) from Sulfolobus acidocaldarius (see paper)
42% identity, 98% coverage of query (349 bits)
1xkdA Ternary complex of isocitrate dehydrogenase from the hyperthermophile aeropyrum pernix
43% identity, 98% coverage of query (349 bits)
2e5mA / Q96YK6 Crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii strain 7 (see paper)
42% identity, 99% coverage of query (345 bits)
Q8U488 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Pyrococcus furiosus (see 2 papers)
41% identity, 98% coverage of query (311 bits)
icd / Q76LM6 oxalosuccinate reductase subunit from Hydrogenobacter thermophilus (see 3 papers)
40% identity, 94% coverage of query (309 bits)
6m3sB / A0A0H2XBX7 Dimeric isocitrate dehydrogenase from xanthomonas campestris pv. Campestris 8004
31% identity, 88% coverage of query (147 bits)
Build an alignment for WP_011734398.1 and 38 homologs with ≥ 30% identity
Or download the sequences
IDH2 / P28241 isocitrate dehydrogenase [NAD] β subunit (EC 1.1.1.286) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
IDH2_YEAST / P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; Isocitric dehydrogenase; NAD(+)-specific ICDH; EC 1.1.1.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P28241 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Saccharomyces cerevisiae (see paper)
28% identity, 93% coverage of query (139 bits)
IDH1_SCHPO / O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; Isocitric dehydrogenase; NAD(+)-specific ICDH; EC 1.1.1.41 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
idh1 / RF|NP_594397.1 isocitrate dehydrogenase (NAD+) subunit 1 Idh1; EC 1.1.1.41 from Schizosaccharomyces pombe (see 3 papers)
29% identity, 88% coverage of query (138 bits)
3blwF / P28241 Yeast isocitrate dehydrogenase with citrate and amp bound in the regulatory subunits (see paper)
27% identity, 93% coverage of query (128 bits)
IDH6_ARATH / Q8LG77 Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial; IDH-VI; Isocitric dehydrogenase 6; NAD(+)-specific ICDH 6; EC 1.1.1.41 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8LG77 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana (see paper)
28% identity, 87% coverage of query (127 bits)
IDH1_ARATH / Q8LFC0 Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; IDH-I; Isocitric dehydrogenase 1; NAD(+)-specific ICDH 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8LFC0 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana (see 2 papers)
28% identity, 88% coverage of query (125 bits)
IDH3_ARATH / O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial; IDH-III; Isocitric dehydrogenase 3; NAD(+)-specific ICDH 3 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O81796 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana (see paper)
29% identity, 88% coverage of query (124 bits)
IDH-II / P93032 NAD+-dependent isocitrate dehydrogenase regulatory subunit (EC 1.1.1.286) from Arabidopsis thaliana (see paper)
IDH2_ARATH / P93032 Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial; IDH-II; Isocitric dehydrogenase 2; NAD(+)-specific ICDH 2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
P93032 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana (see 2 papers)
29% identity, 90% coverage of query (124 bits)
hicdh / Q5SIJ1 homoisocitrate dehydrogenase subunit (EC 1.1.1.87) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
HICDH_THET8 / Q5SIJ1 Isocitrate/homoisocitrate dehydrogenase; Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.286 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
HICDH_THET2 / Q72IW9 Isocitrate/homoisocitrate dehydrogenase; Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.286 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 4 papers)
Q5SIJ1 homoisocitrate dehydrogenase (EC 1.1.1.87) from Thermus thermophilus (see paper)
28% identity, 89% coverage of query (121 bits)
3asjA / Q5SIJ1 Crystal structure of homoisocitrate dehydrogenase in complex with a designed inhibitor (see paper)
28% identity, 89% coverage of query (121 bits)
4yb4A Crystal structure of homoisocitrate dehydrogenase from thermus thermophilus in complex with homoisocitrate, magnesium ion (ii) and nadh
28% identity, 89% coverage of query (121 bits)
3asjB Crystal structure of homoisocitrate dehydrogenase in complex with a designed inhibitor
28% identity, 89% coverage of query (121 bits)
3ty3A / O14104 Crystal structure of homoisocitrate dehydrogenase from schizosaccharomyces pombe bound to glycyl-glycyl-glycine (see paper)
26% identity, 88% coverage of query (114 bits)
LYS12_SCHPO / O14104 Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.87 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 88% coverage of query (113 bits)
aksF / Q58991 NAD-dependent threo-isocitrate dehydrogenase (EC 1.1.1.87) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
AKSF_METJA / Q58991 Homoisocitrate dehydrogenase; HICDH; Homo(2)-isocitrate/homo(3)-isocitrate dehydrogenase; Isohomocitrate dehydrogenase; IHDH; NAD-dependent threo-isohomocitrate dehydrogenase; EC 1.1.1.87; EC 1.1.1.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
Q58991 methanogen homoaconitase (EC 4.2.1.114) from Methanocaldococcus jannaschii (see paper)
24% identity, 71% coverage of query (97.1 bits)
Or start over
Lawrence Berkeley National Laboratory