Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011781406.1 NCBI__GCF_000015305.1:WP_011781406.1 (254 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3ppiA / A0A0H3A4S5 Crystal structure of 3-hydroxyacyl-coa dehydrogenase type-2 from mycobacterium avium (see paper)
    56% identity, 100% coverage of query (264 bits)

HCD2_DROME / O18404 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxyacyl-CoA dehydrogenase type II; Hydroxysteroid dehydrogenase; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Scully protein; Type II HADH; EC 1.1.1.35; EC 1.1.1.51; EC 1.1.1.62; EC 1.1.1.-; EC 1.1.1.53 from Drosophila melanogaster (Fruit fly) (see 7 papers)
    46% identity, 99% coverage of query (216 bits)

1e3wD / O70351 Rat brain 3-hydroxyacyl-coa dehydrogenase binary complex with nadh and 3-keto butyrate (see paper)
    45% identity, 99% coverage of query (211 bits)

O70351 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-estradiol 17-dehydrogenase; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; MHBD; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH; EC 1.1.1.35; EC 1.1.1.62; EC 1.1.1.239; EC 1.1.1.178; EC 1.1.1.53; EC 1.1.1.159 from Rattus norvegicus (Rat)
    45% identity, 99% coverage of query (211 bits)

6ujkA / P9WGQ7 Crystal structure of a probable short-chain type dehydrogenase/reductase (rv1144) from mycobacterium tuberculosis with bound NAD
    48% identity, 100% coverage of query (210 bits)

4xgnA / Q2T0K5 Crystal structure of 3-hydroxyacyl-coa dehydrogenase in complex with NAD from burkholderia thailandensis
    50% identity, 100% coverage of query (209 bits)

HSD17B10 / Q99714 3-hydroxy-2-methylbutyryl-CoA dehydrogenase subunit (EC 1.1.1.35; EC 1.1.1.178; EC 1.1.1.239) from Homo sapiens (see 3 papers)
HCD2_HUMAN / Q99714 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-estradiol 17-dehydrogenase; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; MHBD; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH; EC 1.1.1.35; EC 1.1.1.62; EC 1.1.1.239; EC 1.1.1.178; EC 1.1.1.53; EC 1.1.1.159 from Homo sapiens (Human) (see 22 papers)
Q99714 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC 1.1.1.178) from Homo sapiens (see 2 papers)
    44% identity, 99% coverage of query (207 bits)

8cbkC Structure of human mitochondrial rnase p in complex with mitochondrial pre-tRNA-his(5,ser) (see paper)
    44% identity, 99% coverage of query (207 bits)

1u7tA Crystal structure of abad/hsd10 with a bound inhibitor
    44% identity, 99% coverage of query (207 bits)

1e6wC Rat brain 3-hydroxyacyl-coa dehydrogenase binary complex with nadh and estradiol
    45% identity, 99% coverage of query (205 bits)

HCD2_MOUSE / O08756 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-estradiol 17-dehydrogenase; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; MHBD; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH; EC 1.1.1.35; EC 1.1.1.62; EC 1.1.1.239; EC 1.1.1.178; EC 1.1.1.53; EC 1.1.1.159 from Mus musculus (Mouse) (see paper)
    44% identity, 99% coverage of query (204 bits)

4o5oB / A0A0H3G6B0 X-ray crystal structure of a 3-hydroxyacyl-coa dehydrogenase from brucella suis
    45% identity, 100% coverage of query (189 bits)

fadB2x / Q88KS5 3-hydroxy-2-methylbutyryl-CoA dehydrogenase subunit (EC 1.1.1.178) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 3 papers)
    45% identity, 100% coverage of query (182 bits)

1uayA / Q7SIA1 Crystal structure of type ii 3-hydroxyacyl-coa dehydrogenase from thermus thermophilus hb8
    46% identity, 98% coverage of query (182 bits)

7n09A / F1L0H2 Structural basis for branched substrate selectivity in a ketoreductase from ascaris suum
    42% identity, 98% coverage of query (174 bits)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
    33% identity, 95% coverage of query (121 bits)

IDOLDH / G5DGA8 ipsdienol dehydrogenase (EC 1.1.1.386) from Ips pini (see paper)
IDLDH_IPSPI / G5DGA8 Ipsdienol dehydrogenase; EC 1.1.1.386 from Ips pini (Pine engraver beetle) (see paper)
G5DGA8 ipsdienol dehydrogenase (EC 1.1.1.386) from Ips pini (see 2 papers)
    33% identity, 98% coverage of query (119 bits)

FABG_AQUAE / O67610 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Aquifex aeolicus (strain VF5)
    30% identity, 98% coverage of query (101 bits)

SO1683 3-hydroxy-2-methylbutyryl-CoA dehydrogenase IvdG (EC:1.1.1.178) from Shewanella oneidensis MR-1
    34% identity, 88% coverage of query (100 bits)

LINC_SPHIU / D4YYG1 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase; 2,5-DDOL dehydrogenase; EC 1.1.1.- from Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S) (Sphingobium japonicum) (see paper)
    32% identity, 97% coverage of query (98.2 bits)

1nffA / P9WGT1 Crystal structure of rv2002 gene product from mycobacterium tuberculosis (see paper)
    32% identity, 97% coverage of query (95.5 bits)

1nfqA Rv2002 gene product from mycobacterium tuberculosis
    32% identity, 97% coverage of query (95.5 bits)

HSD_MYCTU / P9WGT1 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase; NADH-dependent 3alpha, 20beta-hydroxysteroid dehydrogenase; EC 1.1.1.53 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
GI|3261591 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase; EC 1.1.1.53 from Mycobacterium tuberculosis H37Rv (see paper)
    32% identity, 97% coverage of query (95.1 bits)

4nbtA / A9NFJ2 Crystal structure of fabg from acholeplasma laidlawii (see paper)
    31% identity, 98% coverage of query (91.3 bits)

phbB / AAA90983.1 acetoacetyl CoA reductase from Sinorhizobium meliloti (see 2 papers)
    32% identity, 96% coverage of query (88.2 bits)

5h5xC / Q9KYM4 Crystal structure of nadh bound carbonyl reductase from streptomyces coelicolor
    35% identity, 97% coverage of query (87.8 bits)

Build an alignment

Build an alignment for WP_011781406.1 and 26 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q4UN54 acetoacetyl-CoA reductase (EC 1.1.1.36) from Rickettsia felis (see paper)
    29% identity, 94% coverage of query (87.8 bits)

budC / Q48436 acetoin reductase subunit (EC 1.1.1.304) from Klebsiella pneumoniae (see 4 papers)
BUDC_KLEPN / Q48436 Diacetyl reductase [(S)-acetoin forming]; Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase; EC 1.1.1.304 from Klebsiella pneumoniae (see paper)
Q48436 diacetyl reductase [(S)-acetoin forming] (EC 1.1.1.304); (S,S)-butanediol dehydrogenase (EC 1.1.1.76) from Klebsiella pneumoniae (see 2 papers)
budC / GB|AAC78679.1 diacetyl reductase ((S)-acetoin forming); EC 1.1.1.304 from Klebsiella pneumoniae (see 3 papers)
    30% identity, 96% coverage of query (87.8 bits)

7tzpG / A0A332H2K8 Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
    30% identity, 98% coverage of query (87.4 bits)

PHAB_SYNY3 / P73826 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    33% identity, 94% coverage of query (87.0 bits)

1gegE / Q48436 Cryatal structure analysis of meso-2,3-butanediol dehydrogenase (see paper)
    30% identity, 96% coverage of query (87.0 bits)

ABA4_BOTFB / A0A384JQF5 Short-chain dehydrogenase/reductase aba4; Abscisic acid biosynthesis cluster protein 4; EC 1.1.1.- from Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) (see 3 papers)
    29% identity, 95% coverage of query (85.9 bits)

Q7XZH5 xanthoxin dehydrogenase (EC 1.1.1.288) from Oryza sativa (see paper)
    32% identity, 80% coverage of query (85.9 bits)

LINX_SPHIU / D4Z260 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase LinX; 2,5-DDOL dehydrogenase; EC 1.1.1.- from Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S) (Sphingobium japonicum) (see paper)
    31% identity, 97% coverage of query (85.1 bits)

Q93Y47 3beta-hydroxy-DELTA5-steroid dehydrogenase (EC 1.1.1.145); 3(or 17)beta-hydroxysteroid dehydrogenase (EC 1.1.1.51) from Digitalis lanata (see 2 papers)
3bhsd / CAC93667.1 3-beta-hydroxysteroiddehydrogenase from Digitalis lanata (see paper)
    30% identity, 97% coverage of query (84.3 bits)

phbB / P23238 acetoacetyl-CoA reductase subunit (EC 1.1.1.36) from Shinella zoogloeoides (see 2 papers)
PHAB_SHIZO / P23238 Acetoacetyl-CoA reductase; EC 1.1.1.36 from Shinella zoogloeoides (Crabtreella saccharophila) (see paper)
    31% identity, 96% coverage of query (84.3 bits)

BWI76_RS23705 2-deoxy-D-ribonyl-CoA 3-dehydrogenase from Klebsiella michiganensis M5al
    30% identity, 98% coverage of query (84.3 bits)

BBSD_THAAR / Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
    30% identity, 97% coverage of query (83.6 bits)

SRDC_NEUCR / Q7SHI4 Short-chain dehydrogenase srdC; Sordarial biosynthesis cluster protein srdC; EC 1.1.1.- from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 3 papers)
    30% identity, 97% coverage of query (83.2 bits)

A0A0G2SJM3 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Fimbriaphyllia ancora (see paper)
    29% identity, 78% coverage of query (82.8 bits)

lvr / Q9LBG2 levodione reductase monomer from Leifsonia aquatica (see 3 papers)
lvr / BAA95121.1 levodione reductase from Leifsonia aquatica (see paper)
    33% identity, 94% coverage of query (82.4 bits)

1iy8A / Q9LBG2 Crystal structure of levodione reductase (see paper)
    33% identity, 94% coverage of query (82.4 bits)

7pcsB / Q9KJF1 Structure of the heterotetrameric sdr family member bbscd (see paper)
    30% identity, 96% coverage of query (82.4 bits)

Q9LBG2 Levodione reductase; (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase; EC 1.1.1.- from Leifsonia aquatica (Corynebacterium aquaticum)
    33% identity, 94% coverage of query (82.4 bits)

gutD / CAA05517.1 glucitol-6-phosphate dehydrogenase from Clostridium beijerinckii (see paper)
    30% identity, 76% coverage of query (82.0 bits)

ABA4_BOTFU / Q14RS1 Short-chain dehydrogenase/reductase aba4; Abscisic acid biosynthesis cluster protein 4; EC 1.1.1.- from Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) (see 3 papers)
    29% identity, 95% coverage of query (82.0 bits)

4wecA / A0QVJ7 Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
    30% identity, 98% coverage of query (82.0 bits)

6zt2A 17beta-hydroxysteroid dehydrogenase type 14 variant s205 in complex with 3-chloro-2,6-difluorophenol
    32% identity, 71% coverage of query (82.0 bits)

6zdiA 17beta-hydroxysteroid dehydrogenase type 14 variant s205 in complex with 2-fluoro-5-nitrophenol
    32% identity, 71% coverage of query (82.0 bits)

6zdeA 17beta-hydroxysteroid dehydrogenase type 14 variant s205 in complex with pentafluorophenol
    32% identity, 71% coverage of query (82.0 bits)

5o72A 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal quinoline based inhibitor
    32% identity, 71% coverage of query (82.0 bits)

5o6oA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal 2,6-pyridinketone inhibitor
    32% identity, 71% coverage of query (82.0 bits)

5o42A 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal 2,6-pyridinketone inhibitor.
    32% identity, 71% coverage of query (82.0 bits)

5o6xA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal quinoline based inhibitor
    32% identity, 71% coverage of query (82.0 bits)

5l7yA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal inhibitor.
    32% identity, 71% coverage of query (82.0 bits)

5l7tA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal inhibitor.
    32% identity, 71% coverage of query (82.0 bits)

5o43A 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal 2,6-pyridinketone inhibitor.
    32% identity, 71% coverage of query (82.0 bits)

5icmA 17beta-hydroxysteroid dehydrogenase type 14 in complex with a non- steroidal inhibitor
    32% identity, 71% coverage of query (82.0 bits)

5en4A Complex of 17-beta-hydroxysteroid dehydrogenase type 14 with inhibitor.
    32% identity, 71% coverage of query (82.0 bits)

6gtbA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with fb211
    32% identity, 71% coverage of query (82.0 bits)

5o7cA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal quinoline based inhibitor
    32% identity, 71% coverage of query (82.0 bits)

5o6zA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal quinoline based inhibitor
    32% identity, 71% coverage of query (82.0 bits)

6emmA / Q9BPX1 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with salicylic acid
    32% identity, 71% coverage of query (81.6 bits)

DHB14_HUMAN / Q9BPX1 17-beta-hydroxysteroid dehydrogenase 14; 17-beta-HSD 14; 17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1; EC 1.1.1.62 from Homo sapiens (Human) (see 2 papers)
Q9BPX1 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) from Homo sapiens (see 2 papers)
    32% identity, 71% coverage of query (81.6 bits)

GAME25 / Q9LEG3 3β-hydroxysteroid dehydrogenase/ Δ5,4 isomerase (EC 1.1.1.270) from Solanum lycopersicum (see 5 papers)
    31% identity, 98% coverage of query (81.6 bits)

5hs6A Human 17beta-hydroxysteroid dehydrogenase type 14 in complex with estrone
    32% identity, 71% coverage of query (81.6 bits)

6qckA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with fb262
    32% identity, 71% coverage of query (81.6 bits)

5l7wA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal inhibitor.
    32% identity, 71% coverage of query (81.6 bits)

6gtuA 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with fragment j6
    32% identity, 71% coverage of query (81.6 bits)

W5VJT8 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens var. hirtella (see paper)
    32% identity, 76% coverage of query (81.3 bits)

phaB / BAC45231.1 3-keto-acyl-CoA reductase from Bacillus sp. INT005 (see paper)
    30% identity, 98% coverage of query (80.9 bits)

3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
    31% identity, 98% coverage of query (80.5 bits)

C7RM91 acetoacetyl-CoA reductase (EC 1.1.1.36) from Candidatus Accumulibacter phosphatis (see 2 papers)
    31% identity, 96% coverage of query (80.5 bits)

8jfgA Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori (see paper)
    30% identity, 98% coverage of query (80.1 bits)

A0A5P1R8U8 acetoacetyl-CoA reductase (subunit 2/2) (EC 1.1.1.36) from Neptunomonas concharum (see paper)
    28% identity, 77% coverage of query (79.7 bits)

4k6fB / B4EAU4 X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
    31% identity, 94% coverage of query (79.7 bits)

3ijrF / A0A6L8PL20 2.05 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD+
    29% identity, 98% coverage of query (79.3 bits)

3i3oA 2.06 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD-acetone
    29% identity, 98% coverage of query (79.0 bits)

ISPD_MENPI / Q5C9I9 (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial; EC 1.1.1.223; EC 1.1.1.243 from Mentha piperita (Peppermint) (Mentha aquatica x Mentha spicata) (see 2 papers)
    30% identity, 99% coverage of query (78.2 bits)

cpnA / Q8GAV9 cyclopentanol dehydrogenase (EC 1.1.1.163) from Comamonas sp. (strain NCIMB 9872) (see 2 papers)
CPNA_COMS9 / Q8GAV9 Cyclopentanol dehydrogenase; Cyclohexanol dehydrogenase; EC 1.1.1.163; EC 1.1.1.245 from Comamonas sp. (strain NCIMB 9872) (see paper)
CPNA_COMTE / Q937L4 Cyclopentanol dehydrogenase; Cyclohexanol dehydrogenase; EC 1.1.1.163; EC 1.1.1.245 from Comamonas testosteroni (Pseudomonas testosteroni) (see paper)
cpmB / CAD10799.1 cyclohexanol dehydrogenase from Comamonas testosteroni (see paper)
    28% identity, 94% coverage of query (78.2 bits)

4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
    28% identity, 98% coverage of query (78.2 bits)

W5VJJ6 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens (see paper)
    30% identity, 86% coverage of query (78.2 bits)

fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
    25% identity, 96% coverage of query (78.2 bits)

4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
    31% identity, 98% coverage of query (77.4 bits)

2d1yA Crystal structure of tt0321 from thermus thermophilus hb8
    29% identity, 97% coverage of query (76.3 bits)

baiA2 / P19337 3α-hydroxysteroid dehydrogenase 2 (EC 1.1.1.395) from Clostridium scindens (strain JCM 10418 / VPI 12708) (see 4 papers)
BAIA2_CLOSV / P19337 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2; 3alpha-hydroxysteroid dehydrogenase 2; 3alpha-HSDH 2; Bile acid-inducible protein BaiA2; EC 1.1.1.395 from Clostridium scindens (strain JCM 10418 / VPI 12708) (see paper)
P19337 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase (EC 1.1.1.395) from [Clostridium] scindens (see paper)
    29% identity, 95% coverage of query (75.9 bits)

4is3C / P19337 Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (baia2) associated with secondary bile acid synthesis from clostridium scindens vpi12708 in complex with a putative NAD(+)-oh- adduct at 2.0 a resolution
    29% identity, 95% coverage of query (75.9 bits)

5vt6A / Q3JJT1 Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b complexed with NADP
    28% identity, 96% coverage of query (75.5 bits)

FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
    28% identity, 96% coverage of query (75.5 bits)

6zyzA Structure of the borneol dehydrogenases of salvia rosmarinus with NAD+ (see paper)
    33% identity, 74% coverage of query (75.1 bits)

7caxD / A0A1K1L6W4 Crystal structure of bacterial reductase
    29% identity, 95% coverage of query (75.1 bits)

2rh4B / P16544 Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
    29% identity, 80% coverage of query (75.1 bits)

4iinA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from helicobacter pylori 26695 complexed with NAD+
    29% identity, 98% coverage of query (75.1 bits)

ACT3_STRCO / P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
    29% identity, 80% coverage of query (75.1 bits)

SDR / F1SWA0 zerumbone synthase (EC 1.1.1.326) from Zingiber zerumbet (see paper)
ZERSY_ZINZE / F1SWA0 Zerumbone synthase; EC 1.1.1.326 from Zingiber zerumbet (Shampoo ginger) (Amomum zerumbet) (see paper)
F1SWA0 zerumbone synthase (EC 1.1.1.326) from Zingiber zerumbet (see 2 papers)
    31% identity, 77% coverage of query (75.1 bits)

1w4zA Structure of actinorhodin polyketide (actiii) reductase
    29% identity, 80% coverage of query (75.1 bits)

2rh4A Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin
    29% identity, 80% coverage of query (74.7 bits)

1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound
    29% identity, 80% coverage of query (74.7 bits)

CBR4 / Q8N4T8 carbonyl reductase family member 4 (EC 1.1.1.100) from Homo sapiens (see 2 papers)
CBR4_HUMAN / Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; Carbonyl reductase family member 4; CBR4; Quinone reductase CBR4; Short chain dehydrogenase/reductase family 45C member 1; EC 1.1.1.100; EC 1.6.5.10 from Homo sapiens (Human) (see 3 papers)
    25% identity, 95% coverage of query (74.3 bits)

2hsdA The refined three-dimensional structure of 3alpha,20beta- hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases
    32% identity, 99% coverage of query (74.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory