Searching for up to 100 curated homologs for WP_011781545.1 NCBI__GCF_000015305.1:WP_011781545.1 (337 a.a.)
Found high-coverage hits (≥70%) to 48 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
cmtG / Q51983 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
cmtG / AAB62295.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see 3 papers)
64% identity, 99% coverage of query (437 bits)
8ih7A / Q9KWS0 Amng-amnh complex
64% identity, 99% coverage of query (437 bits)
HOA_PSESP / Q9KWS0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (see paper)
64% identity, 99% coverage of query (436 bits)
carE / BAC41556.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas resinovorans (see 9 papers)
67% identity, 99% coverage of query (435 bits)
MhpE / b0352 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
mhpE / P51020 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (strain K12) (see 3 papers)
HOA_ECOLI / P51020 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Escherichia coli (strain K12) (see 2 papers)
mhpE / GB|BAA13057.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Escherichia coli K12 (see 4 papers)
66% identity, 98% coverage of query (435 bits)
todH / P51018 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
66% identity, 97% coverage of query (430 bits)
xylK / P51019 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see 5 papers)
66% identity, 99% coverage of query (430 bits)
dmpG / P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (strain CF600) (see paper)
HOA_PSEUF / P51016 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Pseudomonas sp. (strain CF600) (see 3 papers)
P51016 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp. (see paper)
dmpG / CAA43227.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas sp. CF600 (see paper)
65% identity, 99% coverage of query (427 bits)
1nvmA / P51016 Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate (see paper)
65% identity, 99% coverage of query (427 bits)
todH / AAA61944.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
66% identity, 97% coverage of query (424 bits)
P51017 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas putida (see paper)
nahM / AAA89107.1 4-hydroxy-2-oxovalerate aldolase from Pseudomonas putida (see paper)
53% identity, 98% coverage of query (363 bits)
nahM / BAE92172.1 4-hydroxy-2-oxovalerate aldolase NahM from Pseudomonas putida (see 2 papers)
53% identity, 98% coverage of query (360 bits)
HOA4_PARXL / P51015 4-hydroxy-2-oxovalerate aldolase 4; HOA 4; 4-hydroxy-2-keto-pentanoic acid aldolase 4; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase 4; EC 4.1.3.39; EC 4.1.3.43 from Paraburkholderia xenovorans (strain LB400) (see 3 papers)
P51015 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39); 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Paraburkholderia xenovorans LB400 (see 2 papers)
bphI / GB|ABE37049.1 4-hydroxy-2-oxovalerate aldolase; EC 4.1.3.39 from Burkholderia xenovorans LB400 (see paper)
55% identity, 98% coverage of query (357 bits)
bphI / CAA54036.1 4-hydroxy-2-oxovalerate aldolase from Paraburkholderia xenovorans LB400 (see paper)
54% identity, 98% coverage of query (355 bits)
tesG / Q83VZ3 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Comamonas testosteroni (see 2 papers)
54% identity, 97% coverage of query (353 bits)
hsaF / Q0S815 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Rhodococcus jostii (strain RHA1) (see paper)
49% identity, 98% coverage of query (311 bits)
4jn6C / P9WMK5 Crystal structure of the aldolase-dehydrogenase complex from mycobacterium tuberculosis hrv37 (see paper)
50% identity, 98% coverage of query (308 bits)
hsaF / P9WMK5 4-hydroxy-2-oxohexanoate aldolase monomer (EC 4.1.3.43) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HOA_MYCTU / P9WMK5 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.43; EC 4.1.3.39 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WMK5 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Mycobacterium tuberculosis (see paper)
50% identity, 98% coverage of query (308 bits)
HOA_THET8 / Q53WI0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39; EC 4.1.3.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q53WI0 4-hydroxy-2-oxohexanoate aldolase (EC 4.1.3.43) from Thermus thermophilus (see paper)
50% identity, 97% coverage of query (303 bits)
4lrsA / D1A3K8 Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
48% identity, 98% coverage of query (290 bits)
HOA_STRTE / Q9X9Q0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39 from Streptomyces tendae (see paper)
41% identity, 98% coverage of query (207 bits)
OAADC_MYCTU / O06334 Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.1.112 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
31% identity, 91% coverage of query (133 bits)
rhiG / D4HRI4 rhiG aldolase subunit from Bacillus subtilis subsp. spizizenii ATCC 6633 (see paper)
30% identity, 84% coverage of query (117 bits)
Build an alignment for WP_011781545.1 and 23 homologs with ≥ 30% identity
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LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis (see 2 papers)
27% identity, 82% coverage of query (73.6 bits)
3rmjB / Q9JZG1 Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
27% identity, 82% coverage of query (72.8 bits)
LeuA / b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655 (see 7 papers)
leuA / P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12) (see 15 papers)
30% identity, 71% coverage of query (72.4 bits)
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
28% identity, 71% coverage of query (70.9 bits)
CA265_RS15855 2-isopropylmalate synthase (EC 2.3.3.13) from Pedobacter sp. GW460-11-11-14-LB5
26% identity, 71% coverage of query (69.7 bits)
cimA / Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii (see 2 papers)
27% identity, 80% coverage of query (65.1 bits)
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii (see paper)
28% identity, 72% coverage of query (59.3 bits)
PYCB_METJA / Q58628 Pyruvate carboxylase subunit B; Pyruvic carboxylase B; EC 6.4.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
23% identity, 77% coverage of query (59.3 bits)
A0A0S6UXF5 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. DOA9 (see paper)
29% identity, 75% coverage of query (57.8 bits)
pycB / Q6M0D1 pyruvate carboxylase subunit B (EC 6.4.1.1) from Methanococcus maripaludis (strain S2 / LL) (see paper)
23% identity, 76% coverage of query (57.0 bits)
A0A1Y6KBA1 homocitrate synthase (EC 2.3.3.14) from Bradyrhizobium sp. ORS 285 (see 2 papers)
30% identity, 75% coverage of query (55.5 bits)
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
25% identity, 75% coverage of query (53.5 bits)
Q9KUH1 oxaloacetate decarboxylase (EC 4.1.1.112) from Vibrio cholerae (see paper)
23% identity, 93% coverage of query (49.3 bits)
pycB / O27179 pyruvate carboxylase subunit B (EC 6.4.1.1) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see paper)
22% identity, 75% coverage of query (48.9 bits)
nifV / P05342 homocitrate synthase monomer (EC 2.3.3.14) from Azotobacter vinelandii (see paper)
NIFV_AZOVI / P05342 Homocitrate synthase; EC 2.3.3.14 from Azotobacter vinelandii (see paper)
27% identity, 74% coverage of query (48.9 bits)
B0K6M2 (R)-citramalate synthase (EC 2.3.3.21) from Thermoanaerobacter sp. (see paper)
23% identity, 73% coverage of query (48.9 bits)
HOSA_SULTO / Q971S5 Homocitrate synthase; HCS; EC 2.3.3.14 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
25% identity, 74% coverage of query (48.5 bits)
5ks8D / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
26% identity, 75% coverage of query (47.4 bits)
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
22% identity, 77% coverage of query (47.4 bits)
5ks8C / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
26% identity, 75% coverage of query (47.4 bits)
Q1H157 pyruvate carboxylase (EC 6.4.1.1) from Methylobacillus flagellatus (see paper)
26% identity, 75% coverage of query (47.0 bits)
2nx9B / Q6A1F6 Crystal structure of the carboxyltransferase domain of the oxaloacetate decarboxylase na+ pump from vibrio cholerae (see paper)
24% identity, 76% coverage of query (47.0 bits)
Q6A1F6 oxaloacetate decarboxylase (EC 4.1.1.112) from Vibrio cholerae (see paper)
TC 3.B.1.1.6 / Q6A1F6 Oxaloacetate decarboxylase, component of Na+-exporting oxaloacetate decarboxylase with three subunits, OadA (α), OadB (β) and OadG (γ) of 599 aas and 0 TMSs, 433 aas and 11 TMSs, and 90 aas and 1 TMS, respectively from Vibrio cholerae
24% identity, 76% coverage of query (46.6 bits)
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
25% identity, 72% coverage of query (46.2 bits)
5ks8F / Q1H157 Crystal structure of two-subunit pyruvate carboxylase from methylobacillus flagellatus (see paper)
25% identity, 75% coverage of query (44.3 bits)
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