Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011781667.1 NCBI__GCF_000015305.1:WP_011781667.1 (354 a.a.)

Found high-coverage hits (≥70%) to 36 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

DAPE_MYCS2 / A0R2G4 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    85% identity, 99% coverage of query (585 bits)

P9WHS9 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Mycobacterium tuberculosis (see 2 papers)
    78% identity, 100% coverage of query (560 bits)

Q59284 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Corynebacterium glutamicum (see paper)
    58% identity, 99% coverage of query (392 bits)

Build an alignment

Build an alignment for WP_011781667.1 and 3 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

BT3549 N-succinylcitrulline desuccinylase (EC 3.5.1.-) from Bacteroides thetaiotaomicron VPI-5482
    27% identity, 95% coverage of query (97.8 bits)

7t1qA / A3M8H2 Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
    28% identity, 81% coverage of query (84.7 bits)

lysK / Q8VUS5 [L-2-aminoadipate carrier protein]-L-lysine lysine-hydrolase monomer (EC 3.5.1.130) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
LYSK_THET2 / Q8VUS5 [LysW]-lysine hydrolase; EC 3.5.1.130 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
Q8VUS5 [amino group carrier protein]-lysine hydrolase (EC 3.5.1.130) from Thermus thermophilus (see 3 papers)
    28% identity, 97% coverage of query (81.6 bits)

dapE / P44514 N-succinyl-L,L-diaminopimelate desuccinylase subunit (EC 3.5.1.18) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
DAPE_HAEIN / P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 7 papers)
P44514 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Haemophilus influenzae (see 3 papers)
    26% identity, 97% coverage of query (80.1 bits)

5vo3A / P44514 Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
    26% identity, 97% coverage of query (79.7 bits)

5xoyA / Q8VUS5 Crystal structure of lysk from thermus thermophilus in complex with lysine (see paper)
    28% identity, 97% coverage of query (76.6 bits)

DAPE_VIBCH / Q9KQ52 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KQ52 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Vibrio cholerae (see paper)
    29% identity, 92% coverage of query (76.6 bits)

Echvi_3851 N-succinylcitrulline desuccinylase (EC 3.5.1.-) from Echinicola vietnamensis KMM 6221, DSM 17526
    26% identity, 96% coverage of query (75.9 bits)

dapE / CAA08876.1 DapE from Bordetella pertussis (see paper)
    28% identity, 90% coverage of query (73.9 bits)

Q92Y75 acetylornithine deacetylase (EC 3.5.1.16) from Sinorhizobium meliloti (see paper)
    29% identity, 80% coverage of query (73.6 bits)

DAPE_SALTY / Q8ZN75 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; Aspartyl peptidase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    27% identity, 97% coverage of query (73.6 bits)

DAPE_NEIMB / Q9JYL2 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Neisseria meningitidis serogroup B (strain MC58) (see paper)
Q9JYL2 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Neisseria meningitidis (see paper)
    28% identity, 82% coverage of query (72.4 bits)

4o23A / Q9JYL2 Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
    28% identity, 82% coverage of query (71.2 bits)

4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril
    28% identity, 82% coverage of query (71.2 bits)

CA265_RS18500 N-succinylcitrulline desuccinylase (EC 3.5.1.-) from Pedobacter sp. GW460-11-11-14-LB5
    27% identity, 99% coverage of query (69.3 bits)

7lgpB / P0AED8 Dape enzyme from shigella flexneri
    27% identity, 83% coverage of query (69.3 bits)

MsgB / b2472 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
dapE / P0AED7 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Escherichia coli (strain K12) (see paper)
DAPE_ECOLI / P0AED7 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Escherichia coli (strain K12) (see paper)
dapE / RF|NP_416967 succinyl-diaminopimelate desuccinylase; EC 3.5.1.18 from Escherichia coli K12 (see 7 papers)
    27% identity, 83% coverage of query (68.9 bits)

7uoiA / A0A1S8KJG1 Crystallographic structure of dape from enterococcus faecium (see paper)
    25% identity, 97% coverage of query (67.0 bits)

argE / CAB95019.1 acetylornithinase (n2-acetyl-l-ornithine amidohydrolase) from Moritella abyssi (see paper)
    24% identity, 90% coverage of query (65.9 bits)

DAPE_HELPY / O25002 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
O25002 succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) from Helicobacter pylori (see paper)
    23% identity, 83% coverage of query (63.9 bits)

8uw6B / P23908 Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
    28% identity, 86% coverage of query (63.2 bits)

ArgE / b3957 acetylornithine deacetylase (EC 3.5.1.16) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
argE / P23908 acetylornithine deacetylase (EC 3.5.1.16) from Escherichia coli (strain K12) (see 5 papers)
ARGE_ECOLI / P23908 Acetylornithine deacetylase; AO; Acetylornithinase; N-acetylornithinase; NAO; EC 3.5.1.16 from Escherichia coli (strain K12) (see 2 papers)
    28% identity, 82% coverage of query (62.4 bits)

2f7vA / Q8P8J5 Structure of acetylcitrulline deacetylase complexed with one co (see paper)
    27% identity, 90% coverage of query (60.8 bits)

argE / Q8P8J5 acetylcitrulline deacetylase subunit (EC 3.5.1.16) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
ACDAS_XANCP / Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 3 papers)
    27% identity, 90% coverage of query (59.7 bits)

ABZR86_RS08710 N-acetylcitrulline deacetylase (EC 3.5.1.-) from Dyella japonica UNC79MFTsu3.2
    27% identity, 89% coverage of query (59.3 bits)

FAPD_BACSU / O31724 N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase; Formylaminopyrimidine deformylase; Amidohydrolase YlmB; EC 3.5.1.- from Bacillus subtilis (strain 168) (see paper)
    24% identity, 85% coverage of query (56.6 bits)

1cg2A / P06621 Carboxypeptidase g2 (see paper)
    26% identity, 87% coverage of query (54.7 bits)

YgeY / b2872 putative peptidase YgeY from Escherichia coli K-12 substr. MG1655 (see 3 papers)
    22% identity, 97% coverage of query (54.7 bits)

CBPG_PSES6 / P06621 Carboxypeptidase G2; CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; EC 3.4.17.11 from Pseudomonas sp. (strain RS-16) (see paper)
P06621 glutamate carboxypeptidase (EC 3.4.17.11) from Pseudomonas sp. (see 2 papers)
cpg / AAA62842.1 carboxypeptidase G2 precursor from Variovorax paradoxus (see 2 papers)
    26% identity, 87% coverage of query (54.3 bits)

7m6uB / P06621 Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase g2 (see paper)
    26% identity, 83% coverage of query (50.8 bits)

P37111 N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) from Sus scrofa (see 6 papers)
    23% identity, 82% coverage of query (50.4 bits)

P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig)
    23% identity, 82% coverage of query (50.4 bits)

lysK / Q4JAP7 [amino group carrier protein]-lysine/ornithine hydrolase (EC 3.5.1.130; EC 3.5.1.132) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
    22% identity, 91% coverage of query (47.4 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory