Searching for up to 100 curated homologs for WP_011782448.1 NCBI__GCF_000015305.1:WP_011782448.1 (295 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
hsaD / P9WNH5 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase monomer (EC 3.7.1.17) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
HSAD_MYCTU / P9WNH5 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase; EC 3.7.1.17; EC 3.7.1.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
P9WNH5 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Mycobacterium tuberculosis (see paper)
77% identity, 96% coverage of query (464 bits)
5jz9A / P9WNH5 Crystal structure of hsad bound to 3,5-dichloro-4- hydroxybenzenesulphonic acid (see paper)
77% identity, 96% coverage of query (461 bits)
7zm4A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc31
77% identity, 96% coverage of query (461 bits)
7zm3A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclipostin-like inhibitor cyc17
77% identity, 96% coverage of query (461 bits)
7zm2A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc8b
77% identity, 96% coverage of query (461 bits)
7zm1A Crystal structure of hsad from mycobacterium tuberculosis in complex with cyclophostin-like inhibitor cyc7b
77% identity, 96% coverage of query (461 bits)
5jzsB Hsad bound to 3,5-dichloro-4-hydroxybenzoic acid
77% identity, 96% coverage of query (461 bits)
2wugA Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopda
77% identity, 95% coverage of query (458 bits)
5jzbA Crystal structure of hsad bound to 3,5-dichlorobenzene sulphonamide
77% identity, 95% coverage of query (457 bits)
2wufB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with 4,9dsha
77% identity, 95% coverage of query (456 bits)
2wueB Crystal structure of s114a mutant of hsad from mycobacterium tuberculosis in complex with hopoda
77% identity, 95% coverage of query (456 bits)
hsaD / Q9KWQ6 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase monomer (EC 3.7.1.17) from Rhodococcus jostii (strain RHA1) (see paper)
HSAD_RHOJR / Q9KWQ6 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase; Meta-cleavage product hydrolase; MCP hydrolase; EC 3.7.1.17 from Rhodococcus jostii (strain RHA1) (see 2 papers)
77% identity, 96% coverage of query (447 bits)
B5SU85 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Dyella ginsengisoli (see paper)
44% identity, 95% coverage of query (225 bits)
AGH13449.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
41% identity, 95% coverage of query (223 bits)
BPHD_PSEPU / Q52036 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
45% identity, 95% coverage of query (221 bits)
BPHD_PSEFK / Q52011 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Pseudomonas furukawaii (see paper)
bphD / BAA12881.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase from Pseudomonas oleovorans (see paper)
44% identity, 95% coverage of query (217 bits)
2og1A / P47229 Crystal structure of bphd, a c-c hydrolase from burkholderia xenovorans lb400 (see paper)
44% identity, 95% coverage of query (216 bits)
BPHD_PARXL / P47229 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Paraburkholderia xenovorans (strain LB400) (see 2 papers)
P47229 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) from Paraburkholderia xenovorans (see 2 papers)
BphD / CAA46911.1 2-hydroxy-6-oxo-6-phenylhexa-2, 4-dienoate hydrolase from Pseudomonas sp (see paper)
44% identity, 95% coverage of query (216 bits)
2rhwA Crystal structure of the s112a mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with 3,10-di-fluoro hopda
44% identity, 95% coverage of query (215 bits)
2rhtA Crystal structure of the s112a mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with 3-cl hopda
44% identity, 95% coverage of query (215 bits)
2puhA Crystal structure of the s112a mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with its substrate hopda
44% identity, 95% coverage of query (215 bits)
MHPC_COMTE / Q8KZP5 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase; 2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; EC 3.7.1.14 from Comamonas testosteroni (Pseudomonas testosteroni) (see paper)
42% identity, 96% coverage of query (212 bits)
2pujA Crystal structure of the s112a/h265a double mutant of a c-c hydrolase, bphd from burkholderia xenovorans lb400, in complex with its substrate hopda
43% identity, 95% coverage of query (211 bits)
hbpD / O06648 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoate hydrolase [multifunctional] (EC 3.7.1.8) from Pseudomonas nitroreducens (see 2 papers)
42% identity, 95% coverage of query (208 bits)
BPHD_PSES1 / P17548 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase; EC 3.7.1.8 from Pseudomonas sp. (strain KKS102) (see paper)
42% identity, 96% coverage of query (203 bits)
MhpC / b0349 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (EC 3.7.1.14) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpC / P77044 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase (EC 3.7.1.14) from Escherichia coli (strain K12) (see 10 papers)
MHPC_ECOLI / P77044 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase; 2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase; 2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase; EC 3.7.1.14 from Escherichia coli (strain K12) (see 4 papers)
P77044 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC 3.7.1.14) from Escherichia coli (see 4 papers)
38% identity, 95% coverage of query (191 bits)
cbzF / AAX50133.1 CbzF from Pseudomonas putida (see paper)
41% identity, 84% coverage of query (182 bits)
bphD / BAA25612.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus erythropolis (see paper)
39% identity, 90% coverage of query (179 bits)
bpdF / AAB17100.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus sp. M5 (see paper)
38% identity, 90% coverage of query (178 bits)
bphD / BAM76235.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Janibacter sp. TYM3221 (see paper)
38% identity, 89% coverage of query (172 bits)
P96965 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas fluorescens (see 2 papers)
cumD / BAA12150.1 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase from Pseudomonas fluorescens (see paper)
36% identity, 88% coverage of query (163 bits)
1iunB / P96965 Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant hexagonal (see paper)
35% identity, 88% coverage of query (162 bits)
2d0dA Crystal structure of a meta-cleavage product hydrolase (cumd) a129v mutant
36% identity, 88% coverage of query (162 bits)
1ukaA Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with (s)-2-methylbutyrate
35% identity, 88% coverage of query (162 bits)
1uk9A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with isovalerate
35% identity, 88% coverage of query (162 bits)
1uk8A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-valerate
35% identity, 88% coverage of query (162 bits)
1uk7A Crystal structure of a meta-cleavage product hydrolase (cumd) complexed with n-butyrate
35% identity, 88% coverage of query (162 bits)
1iupA Meta-cleavage product hydrolase from pseudomonas fluorescens ip01 (cumd) s103a mutant complexed with isobutyrates
35% identity, 88% coverage of query (162 bits)
cmpF / CAB06612.1 2-hydroxymuconic semialdehyde hydrolase from Sphingomonas sp (see 2 papers)
33% identity, 89% coverage of query (153 bits)
G3KFX4 2-hydroxymuconate-6-semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas sp. (see paper)
33% identity, 89% coverage of query (151 bits)
bphD / Q75WN8 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (EC 3.7.1.8) from Rhodococcus jostii (strain RHA1) (see 2 papers)
etbD / BAA18939.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus sp (see 2 papers)
34% identity, 88% coverage of query (147 bits)
todF / P23133 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase (EC 3.7.1.25) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
TODF_PSEP1 / P23133 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase; HOHH; EC 3.7.1.25 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see 2 papers)
34% identity, 89% coverage of query (144 bits)
hppC / AAB81313.1 2-hydroxy-6-ketonona-2,4-dienoate hydrolase from Rhodococcus globerulus (see paper)
35% identity, 88% coverage of query (141 bits)
AGH13447.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
33% identity, 88% coverage of query (139 bits)
nahN / BAE92169.1 2-hydroxymuconic semialdehyde hydrolase NahN from Pseudomonas putida (see 2 papers)
35% identity, 85% coverage of query (139 bits)
tesD / Q83VZ6 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17) from Comamonas testosteroni (see 3 papers)
34% identity, 90% coverage of query (134 bits)
xylF / P23106 2-hydroxymuconic semialdehyde hydrolase (EC 3.7.1.9) from Pseudomonas putida (see paper)
XYLF_PSEPU / P23106 2-hydroxymuconate semialdehyde hydrolase; HMSH; 2-hydroxymuconic semialdehyde hydrolase; EC 3.7.1.9 from Pseudomonas putida (Arthrobacter siderocapsulatus)
33% identity, 89% coverage of query (130 bits)
Build an alignment for WP_011782448.1 and 47 homologs with ≥ 30% identity
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AGH13448.1 hybrid C-C meta-cleavage hydrolase-carboxylesterase from Cycloclasticus zancles (see paper)
29% identity, 87% coverage of query (129 bits)
EstN1 / K0IAM1 pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) from Nitrososphaera gargensis (strain Ga9.2) (see paper)
33% identity, 88% coverage of query (121 bits)
4lxhA Crystal structure of the s105a mutant of a carbon-carbon bond hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with 3- cl hopda (see paper)
31% identity, 93% coverage of query (114 bits)
4lyeA Crystal structure of the s105a mutant of a c-c hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with substrate hopda
31% identity, 93% coverage of query (114 bits)
4lxiA Crystal structure of the s105a mutant of a carbon-carbon bond hydrolase, dxnb2 from sphingomonas wittichii rw1, in complex with 5, 8-dif hopda
31% identity, 93% coverage of query (114 bits)
flnE / BAC75995.1 meta cleavage compound hydrolase from Terrabacter sp. DBF63 (see paper)
32% identity, 99% coverage of query (112 bits)
cmtE / Q51980 HOMODA hydrolase from Pseudomonas putida (see 2 papers)
cmtE / AAB62292.1 HOMODA hydrolase from Pseudomonas putida (see 3 papers)
30% identity, 96% coverage of query (98.6 bits)
Q84II3 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Janthinobacterium sp. J3 (see paper)
29% identity, 88% coverage of query (87.8 bits)
carC / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase monomer (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
CARC_PSERE / Q9AQM4 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase; HOPDA; EC 3.7.1.13 from Pseudomonas resinovorans (see 3 papers)
Q9AQM4 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase (EC 3.7.1.13) from Pseudomonas resinovorans (see paper)
carC / BAC41548.1 meta cleavage compound hydrolase from Pseudomonas resinovorans (see 9 papers)
29% identity, 88% coverage of query (86.3 bits)
acoC / AAA21950.1 FMP from Cupriavidus necator (see paper)
26% identity, 91% coverage of query (85.5 bits)
6i8wB / Q9KJG6 Crystal structure of a membrane phospholipase a, a novel bacterial virulence factor (see paper)
26% identity, 91% coverage of query (77.4 bits)
Q9KJG6 triacylglycerol lipase (EC 3.1.1.3) from Pseudomonas aeruginosa (see paper)
26% identity, 91% coverage of query (77.4 bits)
estRB8 / CAE54381.1 carboxylesterase, partial from Oleispira antarctica (see paper)
estRB8 / CAE54384.1 carboxylesterase from Oleispira antarctica (see paper)
26% identity, 91% coverage of query (70.9 bits)
ABHD6_HUMAN / Q9BV23 Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6; EC 3.1.1.23 from Homo sapiens (Human) (see 2 papers)
25% identity, 92% coverage of query (69.3 bits)
YBFK_BACSU / O31452 Carboxylesterase YbfK; EC 3.1.1.1 from Bacillus subtilis (strain 168) (see paper)
25% identity, 95% coverage of query (68.9 bits)
ABHD6_MOUSE / Q8R2Y0 Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6; EC 3.1.1.23 from Mus musculus (Mouse) (see 4 papers)
25% identity, 93% coverage of query (67.8 bits)
4ccwA / Q59248 Crystal structure of naproxen esterase (carboxylesterase np) from bacillus subtilis (see paper)
26% identity, 95% coverage of query (65.5 bits)
D0EPY0 carboxylesterase (EC 3.1.1.1) from Bacillus subtilis (see paper)
26% identity, 95% coverage of query (63.2 bits)
bioH / BAB39459.1 BioH from Kurthia sp. 538-KA26 (see paper)
24% identity, 91% coverage of query (63.2 bits)
pydB / Q5IH18 4-formamido-2-oxobut-3-enoate deformylase from Rhizobium sp. TAL1145 (see 2 papers)
23% identity, 86% coverage of query (62.8 bits)
5alsA Ligand complex structure of soluble epoxide hydrolase
24% identity, 92% coverage of query (61.6 bits)
5h3hB Esterase (eaest) from exiguobacterium antarcticum (see paper)
24% identity, 92% coverage of query (61.2 bits)
NAP_BACSU / P96688 Uncharacterized carboxylesterase nap; EC 3.1.1.1 from Bacillus subtilis (strain 168)
23% identity, 95% coverage of query (61.2 bits)
6eb3B Structural and enzymatic characterization of an esterase from a metagenomic library
26% identity, 92% coverage of query (60.8 bits)
CEEH1_CAEEL / G5EBI4 Epoxide hydrolase 1; CEEH1; EC 3.3.2.10 from Caenorhabditis elegans (see paper)
23% identity, 93% coverage of query (60.8 bits)
3pdcA Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor
24% identity, 92% coverage of query (60.8 bits)
5fp0A Ligand complex structure of soluble epoxide hydrolase
23% identity, 92% coverage of query (60.8 bits)
7a7gA Soluble epoxide hydrolase in complex with tk90
24% identity, 92% coverage of query (60.8 bits)
8qn0A Soluble epoxide hydrolase in complex with rk3
24% identity, 92% coverage of query (60.8 bits)
4c4zA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with a8
24% identity, 92% coverage of query (60.5 bits)
4c4yA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with a4
24% identity, 92% coverage of query (60.5 bits)
6i5gA X-ray structure of human soluble epoxide hydrolasE C-terminal domain (hseh ctd)in complex with 15d-pgj2
24% identity, 92% coverage of query (60.5 bits)
4x6yA Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative
24% identity, 92% coverage of query (60.5 bits)
4x6xA Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative
24% identity, 92% coverage of query (60.5 bits)
8qzdA Soluble epoxide hydrolase in complex with epoxykinin
24% identity, 92% coverage of query (60.5 bits)
8qmzA Soluble epoxide hydrolase in complex with rk4
24% identity, 92% coverage of query (60.5 bits)
7ebaA Co-crystal of kurarinone with seh
24% identity, 92% coverage of query (60.5 bits)
6yl4A Soluble epoxide hydrolase in complex with 3-((r)-3-(1-hydroxyureido) but-1-yn-1-yl)-n-((s)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl) benzamide
24% identity, 92% coverage of query (60.5 bits)
6hgxA Soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl) morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea
24% identity, 92% coverage of query (60.5 bits)
6hgwA Soluble epoxide hydrolase in complex with 2-(4-fluorophenyl)-n-(4- phenoxybenzyl)ethanamine
24% identity, 92% coverage of query (60.5 bits)
6hgvA Soluble epoxide hydrolase in complex with talinolol
24% identity, 92% coverage of query (60.5 bits)
6fr2A Soluble epoxide hydrolase in complex with lk864
24% identity, 92% coverage of query (60.5 bits)
3antA Human soluble epoxide hydrolase in complex with a synthetic inhibitor
24% identity, 92% coverage of query (60.5 bits)
3ansA Human soluble epoxide hydrolase in complex with a synthetic inhibitor
24% identity, 92% coverage of query (60.5 bits)
4jncA Soluble epoxide hydrolase complexed with a carboxamide inhibitor
24% identity, 92% coverage of query (60.5 bits)
4c4xA Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with c9
24% identity, 92% coverage of query (60.5 bits)
HYES_HUMAN / P34913 Bifunctional epoxide hydrolase 2; EC 3.3.2.10; EC 3.1.3.76 from Homo sapiens (Human) (see 12 papers)
P34913 2-lysophosphatidate phosphatase (EC 3.1.3.106); soluble epoxide hydrolase (EC 3.3.2.10) from Homo sapiens (see 47 papers)
24% identity, 92% coverage of query (60.1 bits)
6eb3A Structural and enzymatic characterization of an esterase from a metagenomic library
26% identity, 92% coverage of query (60.1 bits)
7p4kA Soluble epoxide hydrolase in complex with fl217
24% identity, 92% coverage of query (60.1 bits)
5ak6A Ligand complex structure of soluble epoxide hydrolase
24% identity, 92% coverage of query (60.1 bits)
5ai8A Ligand complex structure of soluble epoxide hydrolase
24% identity, 92% coverage of query (60.1 bits)
5am2A Ligand complex structure of soluble epoxide hydrolase
23% identity, 92% coverage of query (60.1 bits)
5akiA Ligand complex structure of soluble epoxide hydrolase
24% identity, 92% coverage of query (60.1 bits)
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