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Searching for up to 100 curated homologs for WP_011802516.1 NCBI__GCF_000015505.1:WP_011802516.1 (212 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    74% identity, 100% coverage of query (324 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    74% identity, 100% coverage of query (324 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    74% identity, 100% coverage of query (324 bits)

SO1671 Maleylacetoacetate isomerase (EC 5.2.1.2) from Shewanella oneidensis MR-1
    47% identity, 100% coverage of query (187 bits)

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    48% identity, 99% coverage of query (184 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    47% identity, 99% coverage of query (181 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    46% identity, 99% coverage of query (181 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    47% identity, 99% coverage of query (180 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    45% identity, 99% coverage of query (172 bits)

Psest_3511 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas stutzeri RCH2
    44% identity, 100% coverage of query (170 bits)

Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
    39% identity, 99% coverage of query (158 bits)

2cz2A / Q9WVL0 Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
    39% identity, 99% coverage of query (157 bits)

1fw1A / O43708 Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
    41% identity, 99% coverage of query (157 bits)

MAAI_RAT / P57113 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Rattus norvegicus (Rat) (see paper)
    40% identity, 99% coverage of query (157 bits)

GSTZ1 / O43708 maleylacetoacetate isomerase/glutathione transferase ζ monomer (EC 2.5.1.18; EC 5.2.1.2) from Homo sapiens (see 11 papers)
MAAI_HUMAN / O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 3 papers)
O43708 glutathione transferase (EC 2.5.1.18); maleylacetoacetate isomerase (EC 5.2.1.2) from Homo sapiens (see 8 papers)
    42% identity, 99% coverage of query (155 bits)

4kdyA / B8J605 Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
    43% identity, 100% coverage of query (150 bits)

4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
    43% identity, 100% coverage of query (149 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    39% identity, 99% coverage of query (142 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    35% identity, 99% coverage of query (140 bits)

GSTZ1_ARATH / Q9ZVQ3 Glutathione S-transferase Z1; AtGSTZ1; GST class-zeta member 1; Glutathione S-transferase 18; Maleylacetone isomerase; MAI; EC 2.5.1.18; EC 5.2.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    39% identity, 100% coverage of query (135 bits)

MAIA_ASPFU / Q4WHT7 Maleylacetoacetate isomerase maiA; EC 5.2.1.2 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
    38% identity, 99% coverage of query (118 bits)

3n5oA / D2YW48 Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione (see paper)
    39% identity, 87% coverage of query (112 bits)

D2YW48 Probable glutathione S-transferase; EC 2.5.1.18 from Coccidioides immitis (strain RS) (Valley fever fungus)
    39% identity, 87% coverage of query (112 bits)

4pxoA / C5ATQ9 Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
    35% identity, 100% coverage of query (111 bits)

O04437 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    35% identity, 99% coverage of query (110 bits)

maiA / O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see paper)
MAAI_EMENI / O43123 Maleylacetoacetate isomerase; MAAI; EC 5.2.1.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
O43123 maleylacetoacetate isomerase (EC 5.2.1.2) from Aspergillus nidulans (see paper)
GI|2832725 maleylacetoacetate isomerase; EC 5.2.1.2 from Emericella nidulans (see paper)
maiA / CAA05041.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
maiA / CAA05044.1 maleylacetoacetate isomerase from Aspergillus nidulans (see paper)
    35% identity, 95% coverage of query (102 bits)

B3VQJ6 glutathione transferase (EC 2.5.1.18) from Phanerodontia chrysosporium (see paper)
    31% identity, 75% coverage of query (63.5 bits)

6srbB / A0A1M2V359 Crystal structure of glutathione transferase omega 3c from trametes versicolor (see paper)
    32% identity, 75% coverage of query (61.2 bits)

GSTF3_MAIZE / P04907 Glutathione S-transferase 3; GST class-phi member 3; GST-III; EC 2.5.1.18 from Zea mays (Maize) (see 2 papers)
    32% identity, 83% coverage of query (60.8 bits)

A1ZB72 glutathione transferase (EC 2.5.1.18) from Drosophila melanogaster (see paper)
4pngB / A1ZB72 Glutathione s-transferase from drosophila melanogaster - isozyme e7 (see paper)
    31% identity, 82% coverage of query (58.9 bits)

Build an alignment

Build an alignment for WP_011802516.1 and 30 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

3uarA / Q60CN1 Crystal structure of glutathione transferase (target efi-501774) from methylococcus capsulatus str. Bath with gsh bound
    28% identity, 89% coverage of query (58.5 bits)

gst3b / CAB38119.1 Glutathione transferase III(b) from Zea mays (see paper)
    31% identity, 77% coverage of query (55.1 bits)

2gdrA / Q59721 Crystal structure of a bacterial glutathione transferase (see paper)
    23% identity, 96% coverage of query (54.3 bits)

2dsaA Ternary complex of bphk, a bacterial gst
    23% identity, 96% coverage of query (54.3 bits)

GSTD7_DROME / Q9VG93 Glutathione S-transferase D7; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    25% identity, 88% coverage of query (53.9 bits)

Q59721 4-chlorobenzoate dehalogenase (EC 3.8.1.6) from Burkholderia sp. (see paper)
bphK / CAA54033.1 glutathione S-transferase from Paraburkholderia xenovorans LB400 (see paper)
    23% identity, 96% coverage of query (53.5 bits)

gst3a / CAB38118.1 Glutathione transferase III(a) from Zea mays (see paper)
    30% identity, 77% coverage of query (53.1 bits)

Q8GTB8 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    30% identity, 77% coverage of query (53.1 bits)

4pnfB / Q7JZM3 Glutathione s-transferase from drosophila melanogaster - isozyme e6 (see paper)
    27% identity, 89% coverage of query (53.1 bits)

1f2eA / O33705 Structure of sphingomonad, glutathione s-transferase complexed with glutathione
GST / AAC46031.1 glutathione S-transferase from Sphingomonas paucimobilis (see paper)
    26% identity, 85% coverage of query (52.8 bits)

3ublA / Q8F2Y8 Crystal structure of glutathione transferase (target efi-501770) from leptospira interrogans with gsh bound
    28% identity, 77% coverage of query (52.4 bits)

7rkaA / A0A1P8PEY0 Crystal structure analysis of colorado potato beetle glutathione-s transferase ldgstu1 (see paper)
    25% identity, 98% coverage of query (50.4 bits)

GSTD4_DROME / Q9VG96 Glutathione S-transferase D4; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    24% identity, 89% coverage of query (50.4 bits)

L7QHV5 glutathione transferase (EC 2.5.1.18) from Oncorhynchus kisutch (see paper)
    22% identity, 90% coverage of query (49.7 bits)

4pqiA Crystal structure of glutathione transferase lambda3 from populus trichocarpa (see paper)
    27% identity, 86% coverage of query (49.7 bits)

3vwxC / Q9U795 Structural analysis of an epsilon-class glutathione s-transferase from housefly, musca domestica (see paper)
    25% identity, 81% coverage of query (49.3 bits)

5ft3B / Q5PY77 Aedes aegypti gste2
    24% identity, 87% coverage of query (48.9 bits)

Q9FQE8 glutathione transferase (EC 2.5.1.18) from Glycine max (see paper)
    27% identity, 79% coverage of query (48.9 bits)

4agsA / A4I8P2 Leishmania tdr1 - a unique trimeric glutathione transferase (see paper)
    27% identity, 80% coverage of query (48.9 bits)

4chsA Crystal structure of a tau class glutathione transferase 10 from glycine max
    27% identity, 79% coverage of query (48.9 bits)

6m1tA / O30347 Bacterial beta class sphingomonas chungbukensis glutathione s- transferase
    25% identity, 85% coverage of query (48.5 bits)

3m3mA / Q4K8I0 Crystal structure of glutathione s-transferase from pseudomonas fluorescens [pf-5]
    24% identity, 89% coverage of query (47.4 bits)

4topA Glycine max glutathione transferase
    26% identity, 79% coverage of query (46.6 bits)

1jlvA / Q7KIF2 Anopheles dirus species b glutathione s-transferases 1-3 (see paper)
    26% identity, 84% coverage of query (46.2 bits)

1r5aA / Q9GQG7 Glutathione s-transferase (see paper)
    24% identity, 81% coverage of query (45.8 bits)

4yquA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-31
    21% identity, 85% coverage of query (45.8 bits)

6mhbA Glutathione s-transferase omega 1 bound to covalent inhibitor 18
    21% identity, 85% coverage of query (45.8 bits)

4gf0A Crystal structure of glutahtione transferase homolog from sulfitobacter, target efi-501084, with bound glutathione
    25% identity, 76% coverage of query (45.8 bits)

3vlnA Human glutathione transferase o1-1 c32s mutant in complex with ascorbic acid
    21% identity, 85% coverage of query (45.8 bits)

5a4wA Atgstf2 from arabidopsis thaliana in complex with quercetrin
    24% identity, 81% coverage of query (45.4 bits)

5a4vA Atgstf2 from arabidopsis thaliana in complex with quercetin
    24% identity, 81% coverage of query (45.4 bits)

5a4uA / P46422 Atgstf2 from arabidopsis thaliana in complex with indole-3-aldehyde (see paper)
    24% identity, 81% coverage of query (45.4 bits)

5a5kA Atgstf2 from arabidopsis thaliana in complex with camalexin
    24% identity, 81% coverage of query (45.4 bits)

1gnwA Structure of glutathione s-transferase
    24% identity, 81% coverage of query (45.4 bits)

1bx9A Glutathione s-transferase in complex with herbicide
    24% identity, 81% coverage of query (45.4 bits)

4is0A Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of the non-catalytic ligandin site.
    21% identity, 85% coverage of query (44.7 bits)

5agyA / I1MJ34 Crystal structure of a tau class gst mutant from glycine (see paper)
    27% identity, 79% coverage of query (43.9 bits)

GST1D_ANOGA / Q93113 Glutathione S-transferase 1, isoform D; AgGst1-alpha; Aggst1-1; Aggst1-6; Aggst2-1; DDT-dehydrochlorinase; GST class-theta; EC 2.5.1.18; EC 4.5.1.1 from Anopheles gambiae (African malaria mosquito) (see 3 papers)
1pn9A / Q93113 Crystal structure of an insect delta-class glutathione s-transferase from a ddt-resistant strain of the malaria vector anopheles gambiae (see paper)
GSTd1-6 / CAB03593.1 GSTD1-6 protein, partial from Anopheles gambiae (see 2 papers)
    26% identity, 87% coverage of query (43.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory