Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011813374.1 NCBI__GCF_000015585.1:WP_011813374.1 (444 a.a.)

Found high-coverage hits (≥70%) to 72 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3slhD / Q83E11 1.70 angstrom resolution structure of 3-phosphoshikimate 1- carboxyvinyltransferase (aroa) from coxiella burnetii in complex with shikimate-3-phosphate and glyphosate
    56% identity, 97% coverage of query (465 bits)

AROA_COXBU / Q83E11 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Q83E11 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Coxiella burnetii (see paper)
    56% identity, 97% coverage of query (465 bits)

4egrA 2.50 angstrom resolution structure of 3-phosphoshikimate 1- carboxyvinyltransferase (aroa) from coxiella burnetii in complex with phosphoenolpyruvate
    55% identity, 97% coverage of query (456 bits)

AROA1_HALH5 / Q9KCA6 3-phosphoshikimate 1-carboxyvinyltransferase 1; 5-enolpyruvylshikimate-3-phosphate synthase 1; EPSP synthase 1; EPSPS 1; EC 2.5.1.19 from Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
    53% identity, 96% coverage of query (405 bits)

aroE / P20691 5-enolpyruvoylshikimate-3-phosphate synthase (EC 2.5.1.19) from Bacillus subtilis (strain 168) (see 3 papers)
    49% identity, 94% coverage of query (403 bits)

F5A7Q0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Bacillus cereus (see paper)
    50% identity, 94% coverage of query (394 bits)

B8CWX4 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Halothermothrix orenii (see paper)
    49% identity, 95% coverage of query (388 bits)

A6TL04 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Alkaliphilus metalliredigens (see paper)
    50% identity, 93% coverage of query (380 bits)

A0A139XBW5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Scytonema hofmannii (see paper)
    52% identity, 95% coverage of query (379 bits)

B1XM36 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus sp. (see paper)
    51% identity, 95% coverage of query (373 bits)

K9QNN0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc sp. (see paper)
    51% identity, 94% coverage of query (373 bits)

Q31RQ5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus elongatus (see paper)
Q5N2J9 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus elongatus (see paper)
    51% identity, 96% coverage of query (371 bits)

A0A0P4UM05 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Leptolyngbya boryana (see paper)
    52% identity, 95% coverage of query (370 bits)

K9RIB8 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Rivularia sp. PCC 7116 (see paper)
    51% identity, 93% coverage of query (368 bits)

A0A0D6KU47 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Tolypothrix sp. (see paper)
    51% identity, 94% coverage of query (367 bits)

K9TX81 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Chroococcidiopsis thermalis (see paper)
    51% identity, 95% coverage of query (365 bits)

A6WUV8 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Brucella anthropi (see paper)
    49% identity, 95% coverage of query (363 bits)

1rf4A / Q9S400 Structural studies of streptococcus pneumoniae epsp synthase, tetrahedral intermediate bound state (see paper)
    47% identity, 94% coverage of query (362 bits)

AROA_STRPN / Q9S400 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see 2 papers)
Q9S400 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Streptococcus pneumoniae (see paper)
    47% identity, 94% coverage of query (362 bits)

1rf6A Structural studies of streptococcus pneumoniae epsp synthase in s3p- glp bound state
    47% identity, 94% coverage of query (362 bits)

B4VHX1 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Coleofasciculus chthonoplastes (see paper)
    50% identity, 94% coverage of query (358 bits)

I4GHG6 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Microcystis aeruginosa (see paper)
    51% identity, 94% coverage of query (358 bits)

K9VBD9 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Oscillatoria sp. (see paper)
    51% identity, 95% coverage of query (355 bits)

C3MC80 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Sinorhizobium fredii (see paper)
    48% identity, 95% coverage of query (353 bits)

2gg6A / Q9R4E4 Cp4 epsp synthase liganded with s3p (see paper)
    48% identity, 95% coverage of query (350 bits)

AROA_AGRSC / Q9R4E4 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; CP4 EPSP synthase; EC 2.5.1.19 from Agrobacterium sp. (strain CP4) (see 2 papers)
Q9R4E4 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Agrobacterium sp. (see paper)
    48% identity, 95% coverage of query (350 bits)

2pqcA Cp4 epsps liganded with (r)-phosphonate tetrahedral reaction intermediate analog
    48% identity, 95% coverage of query (350 bits)

2pqbA Cp4 epsps liganded with (r)-difluoromethyl tetrahedral intermediate analog
    48% identity, 95% coverage of query (350 bits)

2ggaA Cp4 epsp synthase liganded with s3p and glyphosate
    48% identity, 95% coverage of query (350 bits)

K9TRT1 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Oscillatoria sp. (see paper)
    50% identity, 95% coverage of query (349 bits)

B4WHQ7 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus sp. (see paper)
    50% identity, 89% coverage of query (315 bits)

aroA / AAA71897.1 3-phosphoshikimate-1-carboxyvinyltransferase from Staphylococcus aureus (see paper)
    42% identity, 94% coverage of query (282 bits)

C9EGX2 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Rahnella aquatilis (see paper)
    30% identity, 95% coverage of query (154 bits)

AROA_VIBCH / Q9KRB0 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KRB0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Vibrio cholerae serotype O1 (see paper)
3nvsA / Q9KRB0 1.02 angstrom resolution crystal structure of 3-phosphoshikimate 1- carboxyvinyltransferase from vibrio cholerae in complex with shikimate-3-phosphate (partially photolyzed) and glyphosate
    31% identity, 96% coverage of query (145 bits)

Build an alignment

Build an alignment for WP_011813374.1 and 34 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q482G5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Colwellia psychrerythraea (see paper)
    28% identity, 96% coverage of query (141 bits)

6hqvA / G0S061 Pentafunctional arom complex from chaetomium thermophilum (see paper)
    31% identity, 98% coverage of query (140 bits)

7tm5B / A0A0H3GV01 Crystal structure of shikimate-3-phosphate bound 3-phosphoshikimate 1- carboxyvinyltransferase from klebsiella pneumoniae
    30% identity, 96% coverage of query (139 bits)

7tm6A Crystal structure of shikimate-3-phosphate and glyphosate bound 3- phosphoshikimate 1-carboxyvinyltransferase from klebsiella pneumoniae
    30% identity, 96% coverage of query (138 bits)

AroA / b0908 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
aroA / P0A6D3 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Escherichia coli (strain K12) (see 14 papers)
AROA_ECOLI / P0A6D3 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Escherichia coli (strain K12) (see 9 papers)
P0A6D3 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Escherichia coli (see 12 papers)
2aa9A / P0A6D3 Epsp synthase liganded with shikimate (see paper)
    30% identity, 96% coverage of query (137 bits)

2pq9A E. Coli epsps liganded with (r)-difluoromethyl tetrahedral reaction intermediate analog
    30% identity, 96% coverage of query (137 bits)

1x8tA Epsps liganded with the (r)-phosphonate analog of the tetrahedral reaction intermediate
    30% identity, 96% coverage of query (137 bits)

1x8rA Epsps liganded with the (s)-phosphonate analog of the tetrahedral reaction intermediate
    30% identity, 96% coverage of query (137 bits)

1g6tA Structure of epsp synthase liganded with shikimate-3-phosphate
    30% identity, 96% coverage of query (137 bits)

1g6sA Structure of epsp synthase liganded with shikimate-3-phosphate and glyphosate
    30% identity, 96% coverage of query (137 bits)

mycA4 / H9TE88 shimimate dehydratase/3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate--CoA ligase from Streptomyces flaveolus (see 3 papers)
    31% identity, 95% coverage of query (136 bits)

AROA_KLEPN / P24497 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Klebsiella pneumoniae (see paper)
    31% identity, 96% coverage of query (135 bits)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans (see paper)
aromA pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans (see 4 papers)
    31% identity, 92% coverage of query (134 bits)

3fjzA E. Coli epsp synthase (t97i) liganded with s3p and glyphosate
    30% identity, 96% coverage of query (134 bits)

aroA / CAH19218.1 3-phosphoshikimate 1-carboxyvinyltransferase from Pseudomonas putida (see paper)
    29% identity, 94% coverage of query (131 bits)

1q36A Epsp synthase (asp313ala) liganded with tetrahedral reaction intermediate
    30% identity, 96% coverage of query (131 bits)

AROA_PETHY / P11043 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EC 2.5.1.19 from Petunia hybrida (Petunia) (see 5 papers)
    30% identity, 95% coverage of query (124 bits)

7tbuA / Q5AME2 Crystal structure of the 5-enolpyruvate-shikimate-3-phosphate synthase (epsps) domain of aro1 from candida albicans in complex with shikimate-3-phosphate (see paper)
    29% identity, 94% coverage of query (122 bits)

A2T9R8 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Dunaliella salina (see paper)
    29% identity, 94% coverage of query (119 bits)

Q93VK6 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Oryza sativa (see paper)
    30% identity, 93% coverage of query (114 bits)

ARO1 / P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    27% identity, 94% coverage of query (113 bits)

A1Z0H6 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Pseudomonas fluorescens (see paper)
    28% identity, 95% coverage of query (110 bits)

epsps-S / CAD01096.1 5-enolpyruvylshikimate-3-phosphate synthase, partial from Eleusine indica (see paper)
    30% identity, 94% coverage of query (110 bits)

epsps-R / CAD01095.1 5-enolpyruvylshikimate-3-phosphate synthase, partial from Eleusine indica (see paper)
    30% identity, 94% coverage of query (110 bits)

7m0oA / B5HND8 Dgt-28 epsps (see paper)
    30% identity, 93% coverage of query (102 bits)

Q3MAV9 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc sp. (see paper)
    26% identity, 93% coverage of query (98.6 bits)

A3TGI7 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Janibacter sp. (see paper)
    29% identity, 97% coverage of query (97.1 bits)

K9PSG5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Calothrix sp. (see paper)
    27% identity, 89% coverage of query (96.3 bits)

Q8YMB5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc sp. (see paper)
    27% identity, 86% coverage of query (95.9 bits)

B2IYE4 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc punctiforme (see paper)
    27% identity, 86% coverage of query (90.9 bits)

A0A2K1XRJ2 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Populus trichocarpa (see paper)
    28% identity, 83% coverage of query (87.8 bits)

2o0bA / P9WPY5 Mycobacterium tuberculosis epsp synthase in complex with s3p (partially photolyzed)
    30% identity, 91% coverage of query (76.6 bits)

AROA_MYCTU / P9WPY5 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WPY5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Mycobacterium tuberculosis (see paper)
    30% identity, 91% coverage of query (76.6 bits)

2o0zA Mycobacterium tuberculosis epsp synthase in complex with product (eps)
    30% identity, 91% coverage of query (76.6 bits)

2o0xA Mycobacterium tuberculosis epsp synthase in complex with intermediate
    30% identity, 91% coverage of query (76.6 bits)

2o0eA Mycobacterium tuberculosis epsp synthase in complex with s3p and pep
    30% identity, 91% coverage of query (76.6 bits)

5wi5A / Q97NQ4 2.0 angstrom resolution crystal structure of udp-n-acetylglucosamine 1-carboxyvinyltransferase from streptococcus pneumoniae in complex with uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2r)- 2-(phosphonooxy)propanoic acid and magnesium.
    27% identity, 71% coverage of query (51.6 bits)

5bq2A / Q9HVW7 Crystal structure of udp-n-acetylglucosamine 1-carboxyvinyltransferase (udp-n-acetylglucosamine enolpyruvyl transferase, ept) from pseudomonas aeruginosa
    26% identity, 95% coverage of query (48.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory