Sites on a Tree

 

Searching for up to 100 curated homologs for WP_011841981.1 NCBI__GCF_000015985.1:WP_011841981.1 (310 a.a.)

Found high-coverage hits (≥70%) to 16 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.4.4 / Q9L3S4 UrtC, component of The high-affinity (<1 μM) urea porter (see paper)
    31% identity, 98% coverage of query (108 bits)

DVU0549 proline/arginine ABC transporter, permease component from Desulfovibrio vulgaris Hildenborough JW710
    32% identity, 96% coverage of query (101 bits)

TC 3.A.1.4.3 / Q8VM84 BraE aka Bra2E, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
    32% identity, 93% coverage of query (101 bits)

PGA1_c12650 D-lactate transporter, permease component 1 from Phaeobacter inhibens BS107
    31% identity, 79% coverage of query (89.7 bits)

TC 3.A.1.4.7 / Q92TN2 ABC transporter, permease, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
    30% identity, 96% coverage of query (88.6 bits)

AZOBR_RS08240 L-proline and D-alanine ABC transporter, permease component 2 from Azospirillum brasilense Sp245
    33% identity, 83% coverage of query (84.0 bits)

Build an alignment

Build an alignment for WP_011841981.1 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

braE / CAB75550.1 integral membrane protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    29% identity, 91% coverage of query (82.4 bits)

TC 3.A.1.4.11 / Q6N8W1 Putative branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    32% identity, 75% coverage of query (76.3 bits)

LivM / b3456 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
LivM / P22729 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
LIVM_ECOLI / P22729 High-affinity branched-chain amino acid transport system permease protein LivM; LIV-I protein M from Escherichia coli (strain K12) (see paper)
TC 3.A.1.4.1 / P22729 LivM aka B3456, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 5 papers)
    30% identity, 85% coverage of query (73.9 bits)

TC 3.A.1.4.8 / P21628 High-affinity branched-chain amino acid transport system permease protein BraE, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    31% identity, 88% coverage of query (72.0 bits)

Pf6N2E2_2924 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, permease component 2 LivM from Pseudomonas fluorescens FW300-N2E2
    29% identity, 89% coverage of query (72.0 bits)

TC 3.A.1.4.10 / Q8DQH9 ABC transporter membrane-spanning permease-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    28% identity, 84% coverage of query (69.3 bits)

HSERO_RS00890 L-proline ABC transporter, permease component 2 from Herbaspirillum seropedicae SmR1
    28% identity, 79% coverage of query (69.3 bits)

Ac3H11_1694 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, permease component 2 from Acidovorax sp. GW101-3H11
    27% identity, 82% coverage of query (68.9 bits)

TC 3.A.1.4.5 / Q8NRV9 UrtC, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
    27% identity, 93% coverage of query (67.8 bits)

TC 3.A.1.4.9 / Q0S719 ABC amino acid transporter, ATP-binding, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
    27% identity, 75% coverage of query (51.6 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory