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Searching for up to 100 curated homologs for WP_011842723.1 NCBI__GCF_000015985.1:WP_011842723.1 (576 a.a.)

Found high-coverage hits (≥70%) to 26 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 2.A.21.7.5 / D5APM1 Acetate permease ActP-2/ActP2/ActP3 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    80% identity, 100% coverage of query (895 bits)

PS417_08865 large component of pyruvate transporter (actP-like) from Pseudomonas simiae WCS417
    64% identity, 99% coverage of query (701 bits)

Pf6N2E2_5849 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N2E2
    66% identity, 95% coverage of query (700 bits)

Pf1N1B4_3673 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N1B4
    65% identity, 99% coverage of query (698 bits)

YjcG / b4067 acetate/glycolate:cation symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
actP / P32705 acetate/glycolate:cation symporter from Escherichia coli (strain K12) (see 5 papers)
ACTP_ECOLI / P32705 Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.21.7.2 / P32705 Acetate/glyoxylate permease, ActP from Escherichia coli (see 6 papers)
    63% identity, 99% coverage of query (682 bits)

AZOBR_RS02940 large component of pyruvate transporter (actP-like) from Azospirillum brasilense Sp245
    60% identity, 100% coverage of query (654 bits)

TC 2.A.21.7.1 / O50471 Phenylacetate permease, Ppa from Pseudomonas putida (see paper)
    61% identity, 93% coverage of query (634 bits)

TC 2.A.21.7.4 / D5AU53 Acetate uptake permease, ActP1; also takes up tellurite from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    62% identity, 95% coverage of query (625 bits)

MCTC_CORGL / Q8NS49 Monocarboxylic acid transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
TC 2.A.21.7.3 / Q8NS49 Pyruvate/acetate/propionate: H+ symporter, MctC (DhlC; cg0953) from Corynebacterium glutamicum (see paper)
    45% identity, 93% coverage of query (371 bits)

Build an alignment

Build an alignment for WP_011842723.1 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Shew_2371 actP-like component of L-lactate and L-malate uptake system from Shewanella loihica PV-4
    28% identity, 77% coverage of query (147 bits)

OPUE_BACSU / O06493 Osmoregulated proline transporter OpuE; Osmoprotectant uptake; Proline uptake system from Bacillus subtilis (strain 168) (see 2 papers)
TC 2.A.21.2.5 / M1TZ79 Proline uptake porter, OpuE (YerK) from Bacillus subtilis subsp. subtilis 6051-HGW
opuE / AAB72182.1 OpuE from Bacillus subtilis (see paper)
    24% identity, 84% coverage of query (97.8 bits)

Psest_3078 L-proline:Na+ symporter from Pseudomonas stutzeri RCH2
    26% identity, 76% coverage of query (95.9 bits)

PUTP_BACSU / P94392 High-affinity proline transporter PutP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.21.2.4 / J7JIE8 The high affinity nutritional proline uptake porter, PutP from Bacillus subtilis QB928
    24% identity, 76% coverage of query (95.9 bits)

TC 2.A.21.2.3 / Q9I5F5 L-proline uptake porter, PutP from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    26% identity, 89% coverage of query (95.5 bits)

PUTP_SALTY / P10502 Sodium/proline symporter; Proline permease from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    25% identity, 76% coverage of query (85.5 bits)

PutC / b1015 proline:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
putP / P07117 proline:Na+ symporter from Escherichia coli (strain K12) (see 12 papers)
PUTP_ECOLI / P07117 Sodium/proline symporter; Proline carrier; Proline permease; Propionate transporter from Escherichia coli (strain K12) (see 9 papers)
TC 2.A.21.2.1 / P07117 Proline:Na+ symporter, PutP from Escherichia coli (see 12 papers)
    24% identity, 76% coverage of query (78.6 bits)

TC 2.A.21.2.6 / O24896 High affinity proline-specific Na+:proline symporter, PutP (Rivera-Ordaz et al. 2013).  Proline is a preferred source of energy for this microaerophilic bacterium.  PutP is efficiently inhibited by the proline analogs, 3,4-dehydro-D,L-proline and L-azetidine-2-carboxylic acid from Helicobacter pylori (strain ATCC 700392 / 26695)
    22% identity, 77% coverage of query (74.7 bits)

putP / AAA79365.1 proline permease homolog from Staphylococcus aureus (see paper)
    22% identity, 81% coverage of query (73.2 bits)

PUTP_STAA8 / Q2FWY7 Sodium/proline symporter; Proline permease from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
TC 2.A.21.2.2 / Q7A4Q7 Sodium/proline symporter (Proline permease) from Staphylococcus aureus (strain N315) (see paper)
    23% identity, 81% coverage of query (72.0 bits)

NANT_ALIF1 / Q5E733 Sodium/sialic acid symporter NanT; N-acetylneuraminate transporter from Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri) (see paper)
    21% identity, 79% coverage of query (55.8 bits)

TC 2.A.21.3.14 / P53794 Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) from Homo sapiens (see 3 papers)
    21% identity, 78% coverage of query (50.8 bits)

SC5A3_HUMAN / P53794 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Homo sapiens (Human) (see 4 papers)
    21% identity, 78% coverage of query (50.8 bits)

SC5A3_CANLF / P31637 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Canis lupus familiaris (Dog) (Canis familiaris) (see 2 papers)
TC 2.A.21.3.5 / P31637 Myoinositol:Na+ symporter, SMIT1 from Canis familiaris (Dog) (see paper)
    21% identity, 78% coverage of query (50.1 bits)

SC5A2_HUMAN / P31639 Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 from Homo sapiens (Human) (see 4 papers)
TC 2.A.21.3.16 / P31639 Sodium/glucose cotransporter 2 (Na+/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2) of 672 aas and 14 TMSs from Homo sapiens (see 2 papers)
    21% identity, 70% coverage of query (50.1 bits)

SC5A3_MOUSE / Q9JKZ2 Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 from Mus musculus (Mouse) (see 3 papers)
    20% identity, 81% coverage of query (49.7 bits)

SC5A4_RAT / D3ZIS0 Solute carrier family 5 member 4 from Rattus norvegicus (Rat) (see paper)
    19% identity, 87% coverage of query (48.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory