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Searching for up to 100 curated homologs for WP_011913322.1 NCBI__GCF_000013785.1:WP_011913322.1 (277 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.1.49 / O30493 MtlG, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    87% identity, 100% coverage of query (491 bits)

PS417_12705 ABC transporter for D-Mannitol and D-Sorbitol, permease component 1 from Pseudomonas simiae WCS417
    86% identity, 100% coverage of query (490 bits)

Pf6N2E2_1961 ABC transporter for D-sorbitol, permease component 2 from Pseudomonas fluorescens FW300-N2E2
    87% identity, 100% coverage of query (488 bits)

AO356_00015 ABC transporter for D-Sorbitol, permease component 1 from Pseudomonas fluorescens FW300-N2C3
    87% identity, 100% coverage of query (488 bits)

mtlG / Q4KC55 polyol ABC-type transporter permease component MtlG from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    85% identity, 100% coverage of query (484 bits)

BPHYT_RS16105 ABC transporter for D-Sorbitol, permease component 1 from Burkholderia phytofirmans PsJN
    67% identity, 95% coverage of query (348 bits)

PGA1_c13190 ABC transporter for D-Sorbitol, permease component 1 from Phaeobacter inhibens BS107
    67% identity, 94% coverage of query (346 bits)

TC 3.A.1.1.5 / O30833 SmoG, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
    61% identity, 99% coverage of query (332 bits)

Ac3H11_2942 ABC transporter for D-Sorbitol, permease component 1 from Acidovorax sp. GW101-3H11
    63% identity, 97% coverage of query (328 bits)

Dshi_0549 ABC transporter for Xylitol, permease component 2 from Dinoroseobacter shibae DFL-12
    40% identity, 90% coverage of query (196 bits)

HSERO_RS17010 ABC transporter for D-sorbitol/xylitol, permease component 2 from Herbaspirillum seropedicae SmR1
    34% identity, 87% coverage of query (137 bits)

TC 3.A.1.1.25 / Q72H66 Maltose transport system permease protein malG aka TT_C1629, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    33% identity, 90% coverage of query (136 bits)

SM_b21105 ABC transporter for L-Fucose, permease component 2 from Sinorhizobium meliloti 1021
    30% identity, 92% coverage of query (132 bits)

Build an alignment

Build an alignment for WP_011913322.1 and 13 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

TC 3.A.1.1.41 / G4FGN6 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    28% identity, 99% coverage of query (126 bits)

Ac3H11_794 ABC transporter for Glycerol, permease component 2 from Acidovorax sp. GW101-3H11
    30% identity, 92% coverage of query (125 bits)

Pf1N1B4_5114 sucrose ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N1B4
    32% identity, 90% coverage of query (125 bits)

smoH / Q7CS31 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    31% identity, 90% coverage of query (123 bits)

TC 3.A.1.1.44 / Q9KZ08 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    28% identity, 92% coverage of query (112 bits)

TC 3.A.1.1.33 / Q8KN17 Putative sugar transporter integral membrane protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    30% identity, 93% coverage of query (111 bits)

SM_b20327 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 2 (ThuG) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q5 ThuG aka RB0313 aka SMB20327, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    31% identity, 92% coverage of query (109 bits)

DASC_STRCO / Q9K489 Diacetylchitobiose uptake system permease protein DasC from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    28% identity, 91% coverage of query (105 bits)

MALG_THELN / Q7LYX6 Trehalose/maltose transport system permease protein MalG from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
TC 3.A.1.1.7 / O51925 MalG aka PF1741, component of Maltose/trehalose porter (see paper)
    29% identity, 96% coverage of query (105 bits)

sugB / P9WG01 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGB_MYCTU / P9WG01 Trehalose transport system permease protein SugB from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50453 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 3 papers)
    32% identity, 97% coverage of query (100 bits)

NGCG_STRCO / O50501 Diacetylchitobiose uptake system permease protein NgcG from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    29% identity, 79% coverage of query (100 bits)

ARAQ_BACSU / P94530 Arabinooligosaccharides transport system permease protein AraQ from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94530 L-arabinose transport system permease protein AraQ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 5 papers)
    29% identity, 94% coverage of query (99.0 bits)

TC 3.A.1.1.12 / Q9AI66 PalG, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    29% identity, 98% coverage of query (98.2 bits)

SM_b21219 ABC transporter for D-Glucosamine, permease component 1 from Sinorhizobium meliloti 1021
    31% identity, 92% coverage of query (97.8 bits)

YcjP / b1312 putative ABC transporter membrane subunit YcjP from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P77716 Inner membrane ABC transporter permease protein YcjP, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    30% identity, 90% coverage of query (96.7 bits)

TC 3.A.1.1.35 / G3LHZ1 GlpQ, component of Glycerol uptake porter, GlpSTPQV from Rhizobium leguminosarum bv. viciae
    26% identity, 91% coverage of query (96.3 bits)

MELC_BACSU / O34518 Melibiose/raffinose/stachyose import permease protein MelC from Bacillus subtilis (strain 168) (see paper)
    26% identity, 99% coverage of query (95.9 bits)

TC 3.A.1.1.20 / Q7WWQ8 Transmembrane permease MsmG, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmG / GI|33149340 transmembrane permease MsmG from Lactobacillus acidophilus (see paper)
    26% identity, 98% coverage of query (95.1 bits)

TC 3.A.1.1.6 / Q48397 CymG, component of Cyclodextrin porter from Klebsiella oxytoca (see paper)
    28% identity, 97% coverage of query (94.7 bits)

TC 3.A.1.1.18 / Q8RJU8 NgcG, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    26% identity, 99% coverage of query (93.6 bits)

SMc04257 ABC transporter for D-Cellobiose and D-Salicin, permease component 1 from Sinorhizobium meliloti 1021
    27% identity, 98% coverage of query (92.0 bits)

TC 3.A.1.1.26 / O06991 MalG aka yvdI, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    27% identity, 98% coverage of query (90.9 bits)

PGA1_c27950 N-Acetyl-D-glucosamine ABC transport system, permease component 2 from Phaeobacter inhibens BS107
    26% identity, 92% coverage of query (90.5 bits)

Psest_0865 maltose ABC transporter, permease component 2 (MalG) from Pseudomonas stutzeri RCH2
    31% identity, 100% coverage of query (87.8 bits)

TC 3.A.1.1.24 / Q72KX4 Sugar transport system permease protein aka TT_C0326, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    27% identity, 75% coverage of query (87.4 bits)

TC 3.A.1.1.39 / Q9WYR1 Alpha-1,4-digalacturonate porter (Nanavati et al., 2006). Regulated by pectin utilization regulon UxaR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    27% identity, 90% coverage of query (87.0 bits)

SMc02871 ABC transporter for N-Acetyl-D-glucosamine, permease protein 2 from Sinorhizobium meliloti 1021
    28% identity, 93% coverage of query (87.0 bits)

G9MB86 ABC-type glycerol 3-phosphate transporter (subunit 1/3) (EC 7.6.2.10) from Thermus thermophilus (see paper)
    28% identity, 87% coverage of query (85.5 bits)

BWI76_RS01820 maltose ABC transporter, permease component 2 (MalG) from Klebsiella michiganensis M5al
    34% identity, 74% coverage of query (81.6 bits)

MalG / b4032 maltose ABC transporter membrane subunit MalG (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
MalG / P68183 maltose ABC transporter membrane subunit MalG (EC 7.5.2.1) from Escherichia coli (strain K12) (see 6 papers)
MALG_ECOLI / P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 5 papers)
P68183 ABC-type maltose transporter (subunit 2/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68183 Maltose transport system permease protein MalG aka B4032, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 13 papers)
malG / RF|NP_418456 maltose transport system permease protein malG from Escherichia coli K12 (see 15 papers)
    34% identity, 74% coverage of query (81.3 bits)

TC 3.A.1.1.4 / P29824 LacG, component of Lactose porter from Agrobacterium radiobacter (see paper)
    26% identity, 100% coverage of query (80.5 bits)

TC 3.A.1.1.27 / Q8DT26 MalG, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) from Streptococcus mutans (see paper)
    27% identity, 90% coverage of query (79.7 bits)

PfGW456L13_1896 ABC transporter for D-Galactose and D-Glucose, permease component 2 from Pseudomonas fluorescens GW456-L13
    26% identity, 90% coverage of query (78.6 bits)

GGTD_SYNY3 / Q55473 Osmoprotective compounds uptake permease protein GgtD from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
TC 3.A.1.1.32 / Q55473 Membrane bound sugar transport protein, component of The glucosylglycerol uptake transporter (functions in osmoprotection and also transports sucrose and trehalose (Mikkat and Hagemann, 2000) (most similar to 3.A.1.1.8) from Synechocystis sp. (strain PCC 6803) (see paper)
    25% identity, 92% coverage of query (77.0 bits)

TC 3.A.1.1.50 / Q5SLB5 Sugar ABC transporter, permease protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    26% identity, 80% coverage of query (75.9 bits)

SM_b21654 ABC transporter for Lactose, permease component 2 from Sinorhizobium meliloti 1021
    24% identity, 92% coverage of query (74.7 bits)

TC 3.A.1.1.11 / Q93KB9 TogN, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    24% identity, 93% coverage of query (74.3 bits)

TC 3.A.1.1.16 / Q8TZQ0 MalG, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    30% identity, 77% coverage of query (72.0 bits)

Dshi_1650 glucose/maltose/trehalose/sucrose ABC transporter, permease component 2 from Dinoroseobacter shibae DFL-12
    27% identity, 83% coverage of query (71.2 bits)

TC 3.A.1.1.23 / Q9X9R5 CBP protein aka CebG, component of The cellobiose/cellotriose (and possibly higher cellooligosaccharides), CebEFGMsiK [MsiK functions to energize several ABC transporters including those for maltose/maltotriose and trehalose] from Streptomyces reticuli (see paper)
    27% identity, 92% coverage of query (70.9 bits)

TC 3.A.1.1.13 / Q97UY9 GlcU, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see paper)
    26% identity, 88% coverage of query (70.5 bits)

TC 3.A.1.1.10 / Q9KWT7 AlgM2, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
    26% identity, 97% coverage of query (70.1 bits)

PS417_22135 glucose/xylose ABC transporter, permease component 1 from Pseudomonas simiae WCS417
    25% identity, 76% coverage of query (69.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory