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Searching for up to 100 curated homologs for WP_011913710.1 NCBI__GCF_000013785.1:WP_011913710.1 (476 a.a.)

Found high-coverage hits (≥70%) to 60 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YjiR / b4340 fused putative DNA-binding transcriptional regulator/putative aminotransferase YjiR from Escherichia coli K-12 substr. MG1655 (see 5 papers)
yjiR / RF|NP_418760 uncharacterized HTH-type transcriptional regulator yjiR from Escherichia coli K12 (see 2 papers)
    40% identity, 97% coverage of query (370 bits)

DVU0030 / VIMSS8508254 DVU0030 regulator of Amino acid transport from Desulfovibrio salexigens DSM 2638
    41% identity, 97% coverage of query (367 bits)

DVU0030 / VIMSS7650531 DVU0030 regulator of Amino acid transport from Desulfovibrio magneticus RS-1
    39% identity, 99% coverage of query (347 bits)

DVU0030 / VIMSS7454265 DVU0030 regulator of Amino acid transport from Desulfohalobium retbaense DSM 5692
    40% identity, 97% coverage of query (343 bits)

DVU0030 / VIMSS7533539 DVU0030 regulator of Amino acid transport from Desulfomicrobium baculatum DSM 4028
    41% identity, 99% coverage of query (342 bits)

DVU0030 / VIMSS8501445 DVU0030 regulator of Amino acid transport from Desulfovibrio vulgaris str. Miyazaki F
    38% identity, 98% coverage of query (337 bits)

DVU0030 / VIMSS393253 DVU0030 regulator of Amino acid transport from Desulfovibrio desulfuricans G20
    38% identity, 98% coverage of query (324 bits)

YdcR / b1439 fused putative DNA-binding transcriptional regulator/putative aminotransferase YdcR from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydcR / MB|P77730 uncharacterized HTH-type transcriptional regulator ydcR from Escherichia coli K12 (see 3 papers)
    38% identity, 97% coverage of query (322 bits)

DVU0030 / VIMSS408289 DVU0030 regulator of Amino acid transport from Desulfovibrio vulgaris Hildenborough
    38% identity, 98% coverage of query (306 bits)

3aovA / O57946 Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with plp
    31% identity, 77% coverage of query (201 bits)

O57946 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Pyrococcus horikoshii (see paper)
    31% identity, 77% coverage of query (201 bits)

3wx9A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, gla, 4ad, 2og, glu and kya
    31% identity, 77% coverage of query (201 bits)

3av7A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, kyn as substrates and kya as products
    31% identity, 77% coverage of query (201 bits)

3aowC Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with akg
    31% identity, 77% coverage of query (201 bits)

YdfD/YisV / VIMSS6924547 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Paenibacillus sp. JDR-2
    30% identity, 93% coverage of query (198 bits)

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp. (see paper)
    30% identity, 83% coverage of query (193 bits)

ARAT1_THELN / H3ZPL1 Aromatic-amino-acid aminotransferase 1; ARAT-I; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
    31% identity, 79% coverage of query (193 bits)

BWI76_RS24235 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Klebsiella michiganensis M5al
    30% identity, 75% coverage of query (174 bits)

1wstA / Q9V2W5 Crystal structure of multiple substrate aminotransferase (msat) from thermococcus profundus
    30% identity, 80% coverage of query (172 bits)

Build an alignment

Build an alignment for WP_011913710.1 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

YdfD/YisV / VIMSS822665 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Bacillus clausii KSM-K16
    27% identity, 97% coverage of query (167 bits)

YdfD/YisV / VIMSS63013 YdfD/YisV regulator of Metabolite transport (activator/repressor) from Bacillus halodurans C-125
    26% identity, 98% coverage of query (159 bits)

2zc0A / Q9C4M4 Crystal structure of an archaeal alanine:glyoxylate aminotransferase (see paper)
    30% identity, 78% coverage of query (154 bits)

NORG_STAA8 / Q2G1P1 HTH-type transcriptional regulator NorG from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
    25% identity, 92% coverage of query (152 bits)

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
    31% identity, 74% coverage of query (152 bits)

AZOBR_RS06555 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Azospirillum brasilense Sp245
    28% identity, 77% coverage of query (149 bits)

3cbfA Crystal structure of lysn, alpha-aminoadipate aminotransferase, from thermus thermophilus hb27
    29% identity, 79% coverage of query (147 bits)

2egyA Crystal structure of lysn, alpha-aminoadipate aminotransferase (substrate free form), from thermus thermophilus hb27
    29% identity, 79% coverage of query (147 bits)

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus (see paper)
2zyjA / Q72LL6 Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-glutamate), from thermus thermophilus hb27 (see paper)
    29% identity, 79% coverage of query (146 bits)

lysN / Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    29% identity, 79% coverage of query (146 bits)

2z1yA Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with n-(5'-phosphopyridoxyl)-l-leucine), from thermus thermophilus hb27
    29% identity, 79% coverage of query (140 bits)

8tn3A / Q643B9 Structure of s. Hygroscopicus aminotransferase mppq complexed with pyridoxamine 5'-phosphate (pmp) (see paper)
    33% identity, 71% coverage of query (133 bits)

Ac3H11_1015 Aromatic-amino-acid aminotransferase (EC 2.6.1.57) from Acidovorax sp. GW101-3H11
    26% identity, 79% coverage of query (132 bits)

TAUR_RHOCB / D5AKX9 HTH-type transcriptional regulator TauR from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
    29% identity, 91% coverage of query (127 bits)

1vp4A / Q9X0L5 Crystal structure of a putative aminotransferase (tm1131) from thermotoga maritima msb8 at 1.82 a resolution
    23% identity, 80% coverage of query (124 bits)

AADAT_MOUSE / Q9WVM8 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Mus musculus (Mouse) (see paper)
Q9WVM8 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Mus musculus (see paper)
    27% identity, 78% coverage of query (123 bits)

Desal_3745 / VIMSS8508801 Desal_3745 regulator of Metabolite transport from Desulfovibrio salexigens DSM 2638
    25% identity, 89% coverage of query (119 bits)

PdxR / VIMSS5804477 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus equi subsp. zooepidemicus MGCS10565
    26% identity, 87% coverage of query (118 bits)

GABR_BACSU / P94426 HTH-type transcriptional regulatory protein GabR from Bacillus subtilis (strain 168) (see 2 papers)
    28% identity, 81% coverage of query (118 bits)

Aadat / Q64602 α-aminoadipate aminotransferase subunit (EC 2.6.1.39) from Rattus norvegicus (see paper)
AADAT_RAT / Q64602 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Rattus norvegicus (Rat) (see paper)
Q64602 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Rattus norvegicus (see 2 papers)
    29% identity, 71% coverage of query (117 bits)

PdxR / VIMSS10395811 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus gallolyticus UCN34
    24% identity, 79% coverage of query (112 bits)

PdxR / VIMSS295699 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus mutans UA159
    25% identity, 94% coverage of query (108 bits)

PDXR_CORGL / Q8NS92 HTH-type pyridoxine biosynthesis transcriptional regulator PdxR from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
    29% identity, 74% coverage of query (107 bits)

tdiD / A7XRY8 L-tryptophan:phenylpyruvate aminotransferase (EC 2.6.1.28) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (see 3 papers)
TDID_EMENI / A7XRY8 Aminotransferase tdiD; Terrequinone biosynthesis protein D; EC 2.6.1.28 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 5 papers)
A7XRY8 tryptophan-phenylpyruvate transaminase (EC 2.6.1.28) from Aspergillus nidulans (see 2 papers)
    26% identity, 71% coverage of query (102 bits)

PdxR / VIMSS101492 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus pyogenes M1 GAS
    26% identity, 77% coverage of query (101 bits)

tdiD putative aminotransferase from Emericella nidulans (see paper)
    26% identity, 71% coverage of query (98.6 bits)

7zlaB / Q5WKW3 Cryo-em structure of holo-pdxr from bacillus clausii bound to its target DNA in the half-closed conformation (see paper)
    24% identity, 81% coverage of query (93.2 bits)

PdxR / VIMSS3789276 PdxR regulator of Pyridoxine biosynthesis, effector Pyridoxal-5-phosphate from Streptococcus gordonii str. Challis substr. CH1
    24% identity, 78% coverage of query (90.9 bits)

7zn5B / Q5WKW3 Cryo-em structure of holo-pdxr from bacillus clausii bound to its target DNA in the closed conformation, c2 symmetry. (see paper)
    24% identity, 81% coverage of query (90.1 bits)

AAPAT_THET8 / Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 5 papers)
Q56232 aspartate-prephenate aminotransferase (EC 2.6.1.78) from Thermus thermophilus (see paper)
aspC / RF|YP_143312.1 aspartate transaminase; EC 2.6.1.1 from Thermus thermophilus HB8 (see 2 papers)
    26% identity, 78% coverage of query (81.3 bits)

1b5oA / Q56232 Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
    26% identity, 74% coverage of query (80.9 bits)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate
    26% identity, 74% coverage of query (80.9 bits)

1bjwA Aspartate aminotransferase from thermus thermophilus
    26% identity, 74% coverage of query (80.9 bits)

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate
    26% identity, 74% coverage of query (79.7 bits)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan
    26% identity, 74% coverage of query (79.7 bits)

6s8wB / Q4X0F7 Aromatic aminotransferase aroh (aro8) form aspergillus fumigatus in complex with plp (internal aldimine)
    25% identity, 71% coverage of query (74.3 bits)

6s8wC / Q4X0F7 Aromatic aminotransferase aroh (aro8) form aspergillus fumigatus in complex with plp (internal aldimine)
    25% identity, 71% coverage of query (74.3 bits)

6l1oB Product bound bacf structure from bacillus subtillis
    23% identity, 72% coverage of query (69.7 bits)

6l1lB / P39643 Apo-bacf structure from bacillus subtillis (see paper)
    23% identity, 72% coverage of query (69.7 bits)

8wkjA / A0A130QXX8 The crystal structure of aspartate aminotransferases lpg0070 from legionella pneumophila (see paper)
    24% identity, 71% coverage of query (52.8 bits)

2o0rA / P9WPZ5 The three-dimensional structure of n-succinyldiaminopimelate aminotransferase from mycobacterium tuberculosis (see paper)
    23% identity, 79% coverage of query (49.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory