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Searching for up to 100 curated homologs for WP_011937928.1 NCBI__GCF_000016745.1:WP_011937928.1 (931 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1dgjA / Q9REC4 Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
    66% identity, 97% coverage of query (1252 bits)

Q46509 aldehyde dehydrogenase (FAD-independent) (EC 1.2.99.7) from Megalodesulfovibrio gigas (see 4 papers)
4c7yA / Q46509 Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
    66% identity, 97% coverage of query (1225 bits)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde
    66% identity, 97% coverage of query (1225 bits)

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde
    66% identity, 97% coverage of query (1225 bits)

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde
    66% identity, 97% coverage of query (1225 bits)

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas
    66% identity, 97% coverage of query (1225 bits)

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas
    66% identity, 97% coverage of query (1225 bits)

1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]-
    66% identity, 97% coverage of query (1225 bits)

Q46509 Aldehyde oxidoreductase; Molybdenum iron sulfur protein; EC 1.2.99.7 from Megalodesulfovibrio gigas (Desulfovibrio gigas)
    66% identity, 97% coverage of query (1225 bits)

Build an alignment

Build an alignment for WP_011937928.1 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3ax7A / P80457 Bovine xanthine oxidase, protease cleaved form (see paper)
    29% identity, 76% coverage of query (224 bits)

2e1qA / P47989 Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
    29% identity, 77% coverage of query (224 bits)

XDH / P47989 xanthine dehydrogenase monomer (EC 1.17.1.4) from Homo sapiens (see 14 papers)
XDH_HUMAN / P47989 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Homo sapiens (Human) (see 6 papers)
P47989 xanthine oxidase (EC 1.17.3.2) from Homo sapiens (see paper)
    29% identity, 77% coverage of query (224 bits)

2ckjA / P47989 Human milk xanthine oxidoreductase
    29% identity, 77% coverage of query (224 bits)

1fo4A / P80457 Crystal structure of xanthine dehydrogenase isolated from bovine milk (see paper)
    29% identity, 76% coverage of query (223 bits)

3nrzL / P80457 Crystal structure of bovine xanthine oxidase in complex with hypoxanthine (see paper)
    29% identity, 76% coverage of query (223 bits)

XDH_BOVIN / P80457 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Bos taurus (Bovine) (see 6 papers)
P80457 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Bos taurus (see 15 papers)
    29% identity, 76% coverage of query (223 bits)

3nrzC / P80457 Crystal structure of bovine xanthine oxidase in complex with hypoxanthine (see paper)
    29% identity, 76% coverage of query (223 bits)

3bdjA Crystal structure of bovine milk xanthine dehydrogenase with a covalently bound oxipurinol inhibitor
    29% identity, 76% coverage of query (223 bits)

1vdvA Bovine milk xanthine dehydrogenase y-700 bound form
    29% identity, 76% coverage of query (223 bits)

1v97A Crystal structure of bovine milk xanthine dehydrogenase fyx-051 bound form
    29% identity, 76% coverage of query (223 bits)

3b9jC Structure of xanthine oxidase with 2-hydroxy-6-methylpurine
    29% identity, 76% coverage of query (223 bits)

1n5xA Xanthine dehydrogenase from bovine milk with inhibitor tei-6720 bound
    29% identity, 76% coverage of query (223 bits)

3unaA Crystal structure of bovine milk xanthine dehydrogenase with NAD bound
    29% identity, 76% coverage of query (223 bits)

3sr6C Crystal structure of reduced bovine xanthine oxidase in complex with arsenite
    29% identity, 76% coverage of query (223 bits)

3nvzC Crystal structure of bovine xanthine oxidase in complex with indole-3- aldehyde
    29% identity, 76% coverage of query (223 bits)

3nvvC Crystal structure of bovine xanthine oxidase in complex with arsenite
    29% identity, 76% coverage of query (223 bits)

3ns1C Crystal structure of bovine xanthine oxidase in complex with 6- mercaptopurine
    29% identity, 76% coverage of query (223 bits)

3etrC Crystal structure of xanthine oxidase in complex with lumazine
    29% identity, 76% coverage of query (223 bits)

3amzA Bovine xanthine oxidoreductase urate bound form
    29% identity, 76% coverage of query (223 bits)

3am9A Complex of bovine xanthine dehydrogenase and trihydroxy fyx-051
    29% identity, 76% coverage of query (223 bits)

3nvyC Crystal structure of bovine xanthine oxidase in complex with quercetin
    29% identity, 76% coverage of query (223 bits)

3nvwC Crystal structure of bovine xanthine oxidase in complex with guanine
    29% identity, 76% coverage of query (223 bits)

3eub4 Crystal structure of desulfo-xanthine oxidase with xanthine
    29% identity, 76% coverage of query (223 bits)

F1S3Y7 xanthine oxidase (EC 1.17.3.2) from Sus scrofa (see paper)
    29% identity, 77% coverage of query (222 bits)

Xdh / Q00519 xanthine oxidase monomer (EC 1.17.1.4; EC 1.17.3.2) from Mus musculus (see 4 papers)
XDH_MOUSE / Q00519 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Mus musculus (Mouse) (see paper)
    29% identity, 73% coverage of query (219 bits)

XDH_CHICK / P47990 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Gallus gallus (Chicken) (see 2 papers)
    28% identity, 73% coverage of query (217 bits)

XDHD_BACSU / O32144 Probable xanthine dehydrogenase subunit D; XDHase subunit D; EC 1.17.1.4 from Bacillus subtilis (strain 168) (see paper)
pucD / GB|CAB15238.1 xanthine dehydrogenase subunit D; EC 1.17.1.4 from Bacillus subtilis (see paper)
    28% identity, 78% coverage of query (217 bits)

Xdh / P22985 xanthine oxidoreductase subunit (EC 1.17.1.4; EC 1.17.3.2) from Rattus norvegicus (see paper)
XDH_RAT / P22985 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Rattus norvegicus (Rat) (see 4 papers)
P22985 xanthine dehydrogenase (EC 1.17.1.4); xanthine oxidase (EC 1.17.3.2) from Rattus norvegicus (see 4 papers)
    28% identity, 77% coverage of query (211 bits)

2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l)
    28% identity, 77% coverage of query (211 bits)

6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
    28% identity, 77% coverage of query (211 bits)

4yswA Structure of rat xanthine oxidoreductase, c-terminal deletion protein variant, nadh bound form
    28% identity, 77% coverage of query (211 bits)

6a7xB Rat xanthine oxidoreductase, d428a variant, NAD bound form
    28% identity, 77% coverage of query (211 bits)

YgeS / b2866 putative xanthine dehydrogenase molybdenum-binding subunit XdhA (EC 1.17.1.4) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
xdhA / Q46799 putative xanthine dehydrogenase molybdenum-binding subunit XdhA (EC 1.17.1.4) from Escherichia coli (strain K12) (see 2 papers)
XDHA_ECOLI / Q46799 Putative xanthine dehydrogenase molybdenum-binding subunit XdhA; EC 1.17.1.4 from Escherichia coli (strain K12) (see paper)
Q46799 xanthine dehydrogenase (subunit 2/2) (EC 1.17.1.4) from Escherichia coli (see paper)
xdhA xanthine dehydrogenase; EC 1.17.1.4 from Escherichia coli K12 (see paper)
    25% identity, 77% coverage of query (210 bits)

YgfN / b2881 fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
xdhD / Q46814 fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit from Escherichia coli (strain K12) (see 5 papers)
XDHD_ECOLI / Q46814 Probable hypoxanthine oxidase XdhD; EC 1.-.-.- from Escherichia coli (strain K12) (see paper)
    25% identity, 93% coverage of query (206 bits)

hcrA / O33819 4-hydroxybenzoyl-CoA reductase α subunit (EC 1.1.7.1) from Thauera aromatica (see paper)
HCRA_THAAR / O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see 3 papers)
hcrA / CAA05038.1 4-Hydroxybenzoyl-CoA reductase alpha-subunit from Thauera aromatica (see paper)
    26% identity, 80% coverage of query (191 bits)

picA1 / A0A1X9WE62 picolinate 6-hydroxylase α subunit from Alcaligenes faecalis (see paper)
    25% identity, 79% coverage of query (191 bits)

1rm6A / O33819 Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
    26% identity, 79% coverage of query (190 bits)

A0A1S4G2F8 xanthine dehydrogenase (EC 1.17.1.4) from Aedes aegypti (see paper)
    26% identity, 74% coverage of query (189 bits)

A0A1S4F2J6 xanthine dehydrogenase (EC 1.17.1.4) from Aedes aegypti (see paper)
    26% identity, 76% coverage of query (187 bits)

Q5QE79 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    27% identity, 74% coverage of query (182 bits)

BPHYT_RS03870 xanthine dehydrogenase, molybdopterin binding subunit (EC 1.17.1.4) from Burkholderia phytofirmans PsJN
    26% identity, 79% coverage of query (182 bits)

AOXD_MOUSE / Q3TYQ9 Aldehyde oxidase 4; Aldehyde oxidase homolog 2; Azaheterocycle hydroxylase 4; Retinal oxidase; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 2 papers)
Q3TYQ9 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 2 papers)
    27% identity, 76% coverage of query (182 bits)

Q148T8 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    27% identity, 76% coverage of query (181 bits)

1jroB / O54051 Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
    27% identity, 78% coverage of query (176 bits)

2w54B Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde
    27% identity, 78% coverage of query (176 bits)

2w3sB Crystal structure of xanthine dehydrogenase (desulfo form) from rhodobacter capsulatus in complex with xanthine
    27% identity, 78% coverage of query (176 bits)

2w3rB Crystal structure of xanthine dehydrogenase (desulfo form) from rhodobacter capsulatus in complex with hypoxanthine
    27% identity, 78% coverage of query (176 bits)

1jrpB Crystal structure of xanthine dehydrogenase inhibited by alloxanthine from rhodobacter capsulatus
    27% identity, 78% coverage of query (176 bits)

hcrA / Q5P3F3 4-hydroxybenzoyl-CoA reductase, α subunit (EC 1.1.7.1) from Aromatoleum aromaticum (strain EbN1) (see 3 papers)
    25% identity, 79% coverage of query (174 bits)

Q2QB49 aldehyde oxidase (EC 1.2.3.1) from Gallus gallus (see 2 papers)
    27% identity, 71% coverage of query (174 bits)

AOXB_CAVPO / H9TB19 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see paper)
    28% identity, 71% coverage of query (173 bits)

XDH1 / Q8GUQ8 xanthine dehydrogenase monomer (EC 1.17.1.4) from Arabidopsis thaliana (see paper)
XDH1_ARATH / Q8GUQ8 Xanthine dehydrogenase 1; AtXDH1; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
    26% identity, 77% coverage of query (173 bits)

Dshi_2959 Xanthine dehydrogenase (EC 1.17.1.4) from Dinoroseobacter shibae DFL-12
    25% identity, 78% coverage of query (172 bits)

Q17209 xanthine dehydrogenase (EC 1.17.1.4); aldehyde oxidase (EC 1.2.3.1) from Bombyx mori (see paper)
    25% identity, 72% coverage of query (171 bits)

Q96XN5 glyceraldehyde dehydrogenase (FAD-containing) (subunit 3/3) (EC 1.2.99.8) from Sulfurisphaera tokodaii (see paper)
    26% identity, 77% coverage of query (171 bits)

AOXB_MOUSE / Q5SGK3 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 2 papers)
Q5SGK3 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 4 papers)
    26% identity, 71% coverage of query (170 bits)

Q2QB47 aldehyde oxidase (EC 1.2.3.1) from Canis lupus familiaris (see 2 papers)
    26% identity, 71% coverage of query (169 bits)

O54051 xanthine dehydrogenase (subunit 1/2) (EC 1.17.1.4) from Rhodobacter capsulatus (see 2 papers)
xdhB / CAA04470.2 xanthine dehydrogenase from Rhodobacter capsulatus (see paper)
    27% identity, 78% coverage of query (169 bits)

kdhC / Q933N0 ketone dehydrogenase large subunit (EC 1.5.99.14) from Paenarthrobacter nicotinovorans (see paper)
KDHC_PAENI / Q933N0 6-hydroxypseudooxynicotine dehydrogenase complex subunit gamma; Ketone dehydrogenase large molybdopterin subunit; EC 1.5.99.14 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 2 papers)
AAK64253.1 kdhL from Paenarthrobacter nicotinovorans (see paper)
kdhL / CAC37487.1 ketone dehydrogenase large subunit from Paenarthrobacter nicotinovorans (see paper)
    27% identity, 73% coverage of query (168 bits)

7dqxD / Q933N0 Crystal structure of xanthine dehydrogenase family protein
    27% identity, 73% coverage of query (167 bits)

XDH_DROME / P10351 Xanthine dehydrogenase; XD; Protein rosy locus; EC 1.17.1.4 from Drosophila melanogaster (Fruit fly) (see paper)
    26% identity, 74% coverage of query (167 bits)

3zyvB / G3X982 Crystal structure of the mouse liver aldehyde oxidase 3 (maox3) (see paper)
    27% identity, 76% coverage of query (166 bits)

XDH_EMENI / Q12553 Xanthine dehydrogenase; Purine hydroxylase I; EC 1.17.1.4 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
hxA xanthine dehydrogenase (purine hydroxylase I); EC 1.17.1.4 from Emericella nidulans (see 2 papers)
    26% identity, 77% coverage of query (165 bits)

XDH2_ARATH / F4JLI5 Xanthine dehydrogenase 2; AtXDH2; EC 1.17.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    26% identity, 73% coverage of query (165 bits)

Q2QB48 aldehyde oxidase (EC 1.2.3.1) from Canis lupus familiaris (see 2 papers)
    25% identity, 76% coverage of query (164 bits)

AOXD_CAVPO / H9TB18 Aldehyde oxidase 4; Aldehyde oxidase homolog 2; Azaheterocycle hydroxylase 4; Retinal oxidase; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see paper)
    26% identity, 78% coverage of query (164 bits)

AOXB_MACFA / C4NYZ3 Aldehyde oxidase 2; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2; EC 1.2.3.1; EC 1.17.3.- from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
    25% identity, 71% coverage of query (163 bits)

atcA / A0A127F6U7 1-testosterone hydratase/dehydrogenase α subunit (EC 1.17.99.11) from Steroidobacter denitrificans (see 2 papers)
A0A127F6U7 3-oxo-DELTA1-steroid hydratase/dehydrogenase (subunit 3/3) (EC 1.17.99.11) from Steroidobacter denitrificans (see paper)
    25% identity, 79% coverage of query (161 bits)

AOXC_MOUSE / G3X982 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Mus musculus (Mouse) (see 5 papers)
G3X982 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see 4 papers)
    27% identity, 76% coverage of query (158 bits)

hbaC / Q6NC04 4-hydroxybenzoyl-CoA reductase HbaC subunit (EC 1.1.7.1) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) (see 7 papers)
    26% identity, 77% coverage of query (158 bits)

AOXA_BOVIN / P48034 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Bos taurus (Bovine) (see paper)
P48034 aldehyde oxidase (EC 1.2.3.1) from Bos taurus (see 3 papers)
    26% identity, 73% coverage of query (158 bits)

NDHL_PAENI / Q93NH5 Nicotine 6-hydroxylase large subunit; Nicotine dehydrogenase large subunit; Nicotine dehydrogenase subunit C; NDH C; EC 1.5.99.4 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 2 papers)
AAK64263.1 ndhL from Paenarthrobacter nicotinovorans (see paper)
    25% identity, 79% coverage of query (157 bits)

AOXA_CAVPO / H9TB17 Aldehyde oxidase 1; Azaheterocycle hydroxylase 1; EC 1.2.3.1; EC 1.17.3.- from Cavia porcellus (Guinea pig) (see 2 papers)
    25% identity, 73% coverage of query (157 bits)

O61198 aldehyde oxidase (EC 1.2.3.1) from Caenorhabditis elegans (see paper)
    25% identity, 77% coverage of query (157 bits)

8uemA / O53708 The cryoem structure of the high affinity carbon monoxide dehydrogenase from mycobacterium smegmatis (see paper)
    26% identity, 77% coverage of query (157 bits)

8emtA / Q06278 Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
    25% identity, 73% coverage of query (155 bits)

GAD3_CAEEL / Q960A1 Probable aldehyde oxidase gad-3; EC 1.2.3.1 from Caenorhabditis elegans (see paper)
Q960A1 aldehyde oxidase (EC 1.2.3.1) from Caenorhabditis elegans (see paper)
    25% identity, 73% coverage of query (154 bits)

AOX1 / Q06278 aldehyde oxidase monomer (EC 1.2.3.1) from Homo sapiens (see 5 papers)
AOXA_HUMAN / Q06278 Aldehyde oxidase; Aldehyde oxidase 1; Azaheterocycle hydroxylase; EC 1.2.3.1; EC 1.17.3.- from Homo sapiens (Human) (see 14 papers)
Q06278 aldehyde oxidase (EC 1.2.3.1) from Homo sapiens (see 5 papers)
    25% identity, 73% coverage of query (153 bits)

7orcB / Q06278 Human aldehyde oxidase in complex with raloxifene (see paper)
    25% identity, 73% coverage of query (153 bits)

4uhxA Human aldehyde oxidase in complex with phthalazine and thioridazine
    25% identity, 73% coverage of query (153 bits)

AOXC_RAT / Q5QE80 Aldehyde oxidase 3; Aldehyde oxidase homolog 1; Azaheterocycle hydroxylase 3; EC 1.2.3.1; EC 1.17.3.- from Rattus norvegicus (Rat) (see 2 papers)
Q5QE80 aldehyde oxidase (EC 1.2.3.1) from Rattus norvegicus (see paper)
    25% identity, 79% coverage of query (152 bits)

Q6V956 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    27% identity, 76% coverage of query (151 bits)

spmA / F8G0N9 3-succinoylpyridine monooxygenase oxygenase subunit from Pseudomonas putida (strain DSM 28022 / S16) (see paper)
    26% identity, 78% coverage of query (150 bits)

PS417_20890 Xanthine dehydrogenase (EC 1.17.1.4) from Pseudomonas simiae WCS417
    25% identity, 73% coverage of query (149 bits)

ndhC / Q59129 NdhC (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 2 papers)
Q59129 nicotine dehydrogenase (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 2 papers)
    25% identity, 79% coverage of query (149 bits)

8emtB / Q06278 Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
    25% identity, 73% coverage of query (148 bits)

A0A336UZ51 aldehyde oxidase (EC 1.2.3.1) from Penaeus japonicus (see paper)
    26% identity, 76% coverage of query (148 bits)

Q8R387 aldehyde oxidase (EC 1.2.3.1) from Mus musculus (see paper)
    26% identity, 73% coverage of query (148 bits)

HXNS_EMENI / A0A1U8QNG8 Nicotinate hydroxylase hnxS; Nicotinate catabolism cluster protein hxnS; Purine hydroxylase II; PHII; Xanthine dehydrogenase II; EC 1.-.-.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 3 papers)
    25% identity, 77% coverage of query (147 bits)

CDHA_PSEU3 / D7REY3 Caffeine dehydrogenase subunit alpha; Caffeine dehydrogenase large subunit; EC 1.17.5.2 from Pseudomonas sp. (strain CBB1) (see paper)
    25% identity, 79% coverage of query (147 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory