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Searching for up to 100 curated homologs for WP_012061729.1 NCBI__GCF_000017145.1:WP_012061729.1 (166 a.a.)

Found high-coverage hits (≥70%) to 60 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

B2RGM6 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Porphyromonas gingivalis (see paper)
    43% identity, 86% coverage of query (105 bits)

fdtC / Q6T1W7 dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose 3-N-acetyltransferase (EC 2.3.1.197) from Aneurinibacillus thermoaerophilus (see 2 papers)
FDTC_ANETH / Q6T1W7 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase; dTDP-D-Fucp3N acetylase; EC 2.3.1.197 from Aneurinibacillus thermoaerophilus (see paper)
Q6T1W7 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase (EC 2.3.1.197) from Aneurinibacillus thermoaerophilus (see paper)
    42% identity, 77% coverage of query (99.0 bits)

wbpD / G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase monomer (EC 2.3.1.201) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
WBPD_PSEAE / G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase; UDP-D-GlcNAc3NA N-acetyltransferase; UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronic acid 3-N-acetyltransferase; EC 2.3.1.201 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Pseudomonas aeruginosa (see paper)
    41% identity, 80% coverage of query (95.9 bits)

7s3uA Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-amino-3,6-dideoxy-d-glucose (see paper)
    42% identity, 72% coverage of query (95.1 bits)

7s42A Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-acetamido-3,6-dideoxy-d- galactose
    42% identity, 72% coverage of query (95.1 bits)

7s41A Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-acetamido-3,6-dideoxy-d- glucose
    42% identity, 72% coverage of query (95.1 bits)

7s3wA Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-amino-3,6-dideoxy-d- galactose
    42% identity, 72% coverage of query (95.1 bits)

7s45A Crystal structure of an n-acetyltransferase, c80t mutant, from helicobacter pullorum in the presence of acetyl coenzyme a and dtdp
    42% identity, 72% coverage of query (94.0 bits)

fdtD / Q12KT8 bifunctional ketoisomerase / N-acetyltransferase FdtD subunit (EC 5.3.2.3; EC 2.3.1.197) from Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) (see paper)
    38% identity, 83% coverage of query (91.3 bits)

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans
    37% identity, 83% coverage of query (91.3 bits)

4mzuF / Q12KT8 Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
    37% identity, 83% coverage of query (90.9 bits)

A9IH93 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase (EC 2.3.1.201) from Bordetella petrii (see paper)
    43% identity, 78% coverage of query (86.3 bits)

3mqgC / A9IH93 Crystal structure of the 3-n-acetyl transferase wlbb from bordetella petrii in complex with acetyl-coa (see paper)
    43% identity, 78% coverage of query (86.3 bits)

3mqhA Crystal structure of the 3-n-acetyl transferase wlbb from bordetella petrii in complex with coa and udp-3-amino-2-acetamido-2,3-dideoxy glucuronic acid
    43% identity, 78% coverage of query (86.3 bits)

qdtC / Q6TFC6 dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose:acetyl-CoA acetyltransferase from Thermoanaerobacterium thermosaccharolyticum (see paper)
    37% identity, 75% coverage of query (70.1 bits)

3fsbA / Q6TFC6 Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
    37% identity, 75% coverage of query (70.1 bits)

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose
    37% identity, 75% coverage of query (70.1 bits)

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa
    37% identity, 75% coverage of query (70.1 bits)

RF|NP_435661.1 nodulation protein L from Sinorhizobium meliloti (see paper)
    35% identity, 72% coverage of query (60.5 bits)

GB|CAA68625.1 nodulation protein L from Rhizobium leguminosarum bv. viciae (see paper)
    34% identity, 84% coverage of query (60.5 bits)

Build an alignment

Build an alignment for WP_012061729.1 and 20 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

cpsI polysaccharide capsule synthesis protein CpsI from Streptococcus iniae (see paper)
    29% identity, 77% coverage of query (60.5 bits)

3gvdI / A0A2U2H3H7 Crystal structure of serine acetyltransferase cyse from yersinia pestis
    29% identity, 80% coverage of query (56.6 bits)

LacA / b0342 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
lacA / P07464 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli (strain K12) (see 19 papers)
THGA_ECOLI / P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 5 papers)
P07464 galactoside O-acetyltransferase (EC 2.3.1.18) from Escherichia coli (see paper)
    28% identity, 89% coverage of query (54.7 bits)

1kruA / P07464 Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
    28% identity, 89% coverage of query (54.7 bits)

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal
    28% identity, 89% coverage of query (54.7 bits)

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a
    28% identity, 89% coverage of query (54.7 bits)

Q0ZB96 serine O-acetyltransferase (EC 2.3.1.30) from Klebsiella pneumoniae (see paper)
    28% identity, 70% coverage of query (53.9 bits)

CYSE_MYCTU / P95231 Serine acetyltransferase; SAT; EC 2.3.1.30 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P95231 serine O-acetyltransferase (EC 2.3.1.30) from Mycobacterium tuberculosis (see 2 papers)
    36% identity, 77% coverage of query (53.9 bits)

wbiO / A0A0A8J6G1 acetyl-CoA:α-L-Fuc-(1→2)-β-D-Gal-(1→3)-α-D-GalNAc-(1→3)-α-D-GalNAc-PP-Und 3/4-OIVacetyltransferase from Escherichia coli (see 2 papers)
wzxO127 / A0A0A8J6G1 Escherichia coli O:127 antigen repeat unit flippase from Escherichia coli (see 8 papers)
    28% identity, 89% coverage of query (53.1 bits)

Q6F4D7 serine O-acetyltransferase (EC 2.3.1.30) from Thermus thermophilus HB8 (see paper)
    32% identity, 82% coverage of query (53.1 bits)

sat / AAN77593.1 streptogramin acetyl transferase from Yersinia enterocolitica (see paper)
    29% identity, 75% coverage of query (52.8 bits)

7kr9A Bifunctional enzyme glmu bound to zn(ii)
    32% identity, 73% coverage of query (52.4 bits)

GLMU_STRPN / Q97R46 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see 2 papers)
    32% identity, 73% coverage of query (52.0 bits)

1hm8A / Q97R46 Crystal structure of s.Pneumoniae n-acetylglucosamine-1-phosphate uridyltransferase, glmu, bound to acetyl coenzyme a (see paper)
    32% identity, 73% coverage of query (52.0 bits)

4ac3A S.Pneumoniae glmu in complex with an antibacterial inhibitor
    32% identity, 73% coverage of query (52.0 bits)

1g97A S.Pneumoniae glmu complexed with udp-n-acetylglucosamine and mg2+
    32% identity, 73% coverage of query (52.0 bits)

4aawA S.Pneumoniae glmu in complex with an antibacterial inhibitor
    32% identity, 73% coverage of query (52.0 bits)

1hm9A Crystal structure of s.Pneumoniae n-acetylglucosamine-1-phosphate uridyltransferase, glmu, bound to acetyl coenzyme a and udp-n- acetylglucosamine
    32% identity, 73% coverage of query (52.0 bits)

DAPH_BACSU / O34981 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Tetrahydrodipicolinate N-acetyltransferase; THP acetyltransferase; Tetrahydropicolinate acetylase; EC 2.3.1.89 from Bacillus subtilis (strain 168) (see 2 papers)
    32% identity, 91% coverage of query (49.7 bits)

CYSE_BACSU / Q06750 Serine acetyltransferase; SAT; EC 2.3.1.30 from Bacillus subtilis (strain 168) (see paper)
    31% identity, 75% coverage of query (49.7 bits)

3igjC / A0A6L7H2S4 Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
    29% identity, 86% coverage of query (48.9 bits)

GLMU_MYCTU / P9WMN3 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
A5U161 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Mycobacterium tuberculosis (see 2 papers)
P9WMN3 glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) from Mycobacterium tuberculosis (see 13 papers)
    32% identity, 77% coverage of query (46.6 bits)

4k6rA Crystal structure of glmu in complex with atp
    32% identity, 77% coverage of query (46.2 bits)

6ge9A Structure of mycobacterium tuberculosis glmu bound to glc-1p and ac- coa
    32% identity, 77% coverage of query (46.2 bits)

3sptA Crystal structure of glmu from mycobacterium tuberculosis in complex with acetyl coenzyme a and uridine-diphosphate-n-acetylglucosamine
    32% identity, 77% coverage of query (46.2 bits)

3st8A Crystal structure of glmu from mycobacterium tuberculosis in complex with coenzyme a, glucosamine 1-phosphate and uridine-diphosphate-n- acetylglucosamine
    32% identity, 77% coverage of query (46.2 bits)

3r8yA / Q81MQ2 Structure of the bacillus anthracis tetrahydropicolinate succinyltransferase
    31% identity, 92% coverage of query (45.8 bits)

7l82AAA Putative acetyl transferase protein
    31% identity, 76% coverage of query (45.4 bits)

7l81AAA Putative acetyl transferase protein
    31% identity, 76% coverage of query (45.4 bits)

7l7zAAA Putative acetyl transferase protein
    31% identity, 76% coverage of query (45.4 bits)

7l7yAAA / Q1QD33 7l7yAAA (see paper)
    31% identity, 76% coverage of query (45.4 bits)

3d8vA / P9WMN3 Crystal structure of glmu from mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine (see paper)
    32% identity, 77% coverage of query (44.7 bits)

EPSM_BACSU / P71063 UDP-N-acetylbacillosamine N-acetyltransferase; EC 2.3.1.203 from Bacillus subtilis (strain 168) (see 3 papers)
    28% identity, 86% coverage of query (44.7 bits)

Q8Z9S7 Bifunctional protein GlmU; EC 2.7.7.23; EC 2.3.1.157 from Yersinia pestis
    30% identity, 72% coverage of query (43.5 bits)

4fceA / Q8Z9S7 Crystal structure of yersinia pestis glmu in complex with alpha-d- glucosamine 1-phosphate (gp1)
    30% identity, 72% coverage of query (43.5 bits)

4g3pA Crystal structure of glmu from mycobacterium tuberculosis snapshot 3
    31% identity, 77% coverage of query (43.1 bits)

3dj4A Crystal structure of glmu from mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine.
    31% identity, 77% coverage of query (43.1 bits)

4ea9A X-ray structure of gdp-perosamine n-acetyltransferase in complex with transition state analog at 0.9 angstrom resolution
    24% identity, 92% coverage of query (43.1 bits)

4ea8A X-ray crystal structure of perb from caulobacter crescentus in complex with coenzyme a and gdp-n-acetylperosamine at 1 angstrom resolution
    24% identity, 92% coverage of query (43.1 bits)

3foqA / P9WMN3 Crystal structure of n-acetylglucosamine-1-phosphate uridyltransferase (glmu) from mycobacterium tuberculosis in a cubic space group. (see paper)
    31% identity, 77% coverage of query (42.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory