Searching for up to 100 curated homologs for WP_012066786.1 NCBI__GCF_000017145.1:WP_012066786.1 (192 a.a.)

Found high-coverage hits (≥70%) to 33 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

CCNA_03103 shikimate kinase (EC 2.7.1.71) from Caulobacter crescentus NA1000
    42% identity, 94% coverage of query (149 bits)

A0A0M3KL09 shikimate kinase (EC 2.7.1.71) from Acinetobacter baumannii (see paper)
4y0aA / A0A0M3KL09 Shikimate kinase from acinetobacter baumannii in complex with shikimate (see paper)
    37% identity, 87% coverage of query (110 bits)

AroK / b3390 shikimate kinase 1 (EC 2.7.1.71) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
aroK / P0A6D7 shikimate kinase 1 (EC 2.7.1.71) from Escherichia coli (strain K12) (see 30 papers)
AROK_ECOLI / P0A6D7 Shikimate kinase 1; SK 1; Shikimate kinase I; SKI; EC 2.7.1.71 from Escherichia coli (strain K12) (see 3 papers)
P0A6D7 shikimate kinase (EC 2.7.1.71) from Escherichia coli (see paper)
aroK / AAB59099.1 shikimic acid kinase I from Escherichia coli (see paper)
    36% identity, 84% coverage of query (102 bits)

SK_SOLLC / Q00497 Shikimate kinase, chloroplastic; EC 2.7.1.71 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
    37% identity, 79% coverage of query (91.7 bits)

Q6GGG1 shikimate kinase (EC 2.7.1.71) from Staphylococcus aureus (see paper)
    32% identity, 74% coverage of query (90.5 bits)

SK1_ORYSJ / Q5NTH4 Shikimate kinase 1, chloroplastic; OsSK1; EC 2.7.1.71 from Oryza sativa subsp. japonica (Rice) (see paper)
Q5NTH4 shikimate kinase (EC 2.7.1.71) from Oryza sativa (see paper)
    37% identity, 78% coverage of query (88.2 bits)

SK3_ORYSJ / Q7X7H9 Shikimate kinase 3, chloroplastic; OsSK3; EC 2.7.1.71 from Oryza sativa subsp. japonica (Rice) (see paper)
Q7X7H9 shikimate kinase (EC 2.7.1.71) from Oryza sativa (see paper)
    35% identity, 78% coverage of query (85.5 bits)

SK2 / Q8GY88 shikimate kinase (EC 2.7.1.71) from Arabidopsis thaliana (see 3 papers)
SK2_ARATH / Q8GY88 Shikimate kinase 2, chloroplastic; AtSK2; EC 2.7.1.71 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q8GY88 shikimate kinase (EC 2.7.1.71) from Arabidopsis thaliana (see paper)
    36% identity, 71% coverage of query (84.3 bits)

SK2_ORYSJ / Q5NTH3 Shikimate kinase 2, chloroplastic; OsSK2; EC 2.7.1.71 from Oryza sativa subsp. japonica (Rice) (see paper)
Q5NTH3 shikimate kinase (EC 2.7.1.71) from Oryza sativa (see paper)
    36% identity, 78% coverage of query (84.0 bits)

AROK_MYCTU / P9WPY3 Shikimate kinase; SK; EC 2.7.1.71 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 7 papers)
P9WPY3 shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis (see 8 papers)
    38% identity, 71% coverage of query (81.6 bits)

2iyvA / P9WPY3 Shikimate kinase from mycobacterium tuberculosis in complex with adp, open lid (conf. B) (see paper)
    38% identity, 71% coverage of query (81.6 bits)

2iywA Shikimate kinase from mycobacterium tuberculosis in complex with mgatp, open lid (conf. B)
    38% identity, 71% coverage of query (81.6 bits)

3bafA Crystal structure of shikimate kinase from mycobacterium tuberculosis in complex with amp-pnp
    38% identity, 71% coverage of query (81.6 bits)

2dfnA Structure of shikimate kinase from mycobacterium tuberculosis complexed with adp and shikimate at 1.9 angstrons of resolution
    38% identity, 71% coverage of query (81.6 bits)

1we2A Crystal structure of shikimate kinase from mycobacterium tuberculosis in complex with mgadp and shikimic acid
    38% identity, 71% coverage of query (81.6 bits)

4bqsA Crystal structure of mycobacterium tuberculosis shikimate kinase in complex with adp and a shikimic acid derivative.
    38% identity, 71% coverage of query (81.3 bits)

2iyyA Shikimate kinase from mycobacterium tuberculosis in complex with shikimate-3-phosphate and so4
    38% identity, 71% coverage of query (81.3 bits)

1zyuA Crystal structure of mycobacterium tuberculosis shikimate kinase in complex with shikimate and amppcp at 2.85 angstrom resolution
    38% identity, 71% coverage of query (81.3 bits)

Build an alignment

Build an alignment for WP_012066786.1 and 18 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

bzdR / AAQ08805.1 BzdR from Azoarcus sp. CIB (see paper)
    29% identity, 81% coverage of query (77.4 bits)

1u8aA Crystal structure of mycobacterium tuberculosis shikimate kinase in complex with shikimate and adp at 2.15 angstrom resolution
    38% identity, 71% coverage of query (77.4 bits)

1zuiA Structural basis for shikimate-binding specificity of helicobacter pylori shikimate kinase
    34% identity, 72% coverage of query (75.9 bits)

AROL_DICCH / P10880 Shikimate kinase 2; SK 2; Shikimate kinase II; SKII; EC 2.7.1.71 from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) (see 4 papers)
    31% identity, 83% coverage of query (74.7 bits)

1e6cA / P10880 K15m mutant of shikimate kinase from erwinia chrysanthemi (see paper)
    30% identity, 83% coverage of query (72.0 bits)

AROK_HELPY / P56073 Shikimate kinase; SK; EC 2.7.1.71 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
    34% identity, 72% coverage of query (71.2 bits)

3mufA Shikimate kinase from helicobacter pylori in complex with shikimate-3- phosphate and adp
    34% identity, 72% coverage of query (71.2 bits)

3n2eA / P56073 Crystal structure of helicobactor pylori shikimate kinase in complex with nsc162535 (see paper)
    33% identity, 72% coverage of query (70.1 bits)

2shkB The three-dimensional structure of shikimate kinase from erwinia chrysanthemi complexed with adp
    31% identity, 83% coverage of query (70.1 bits)

1shkA The three-dimensional structure of shikimate kinase from erwinia chrysanthemi
    30% identity, 83% coverage of query (67.4 bits)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans (see paper)
aromA pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans (see 4 papers)
    31% identity, 90% coverage of query (67.0 bits)

AroL / b0388 shikimate kinase 2 (EC 2.7.1.71) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
aroL / P0A6E1 shikimate kinase 2 (EC 2.7.1.71) from Escherichia coli (strain K12) (see 8 papers)
AROL_ECOLI / P0A6E1 Shikimate kinase 2; SK 2; Shikimate kinase II; SKII; EC 2.7.1.71 from Escherichia coli (strain K12) (see 5 papers)
    27% identity, 85% coverage of query (66.2 bits)

DvMF_0971 Homoserine kinase (EC:2.7.1.39) from Desulfovibrio vulgaris Miyazaki F
thrB / B8DPL9 homoserine kinase (EC 2.7.1.39) from Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F) (see paper)
    32% identity, 70% coverage of query (60.5 bits)

6hqvA / G0S061 Pentafunctional arom complex from chaetomium thermophilum (see paper)
    31% identity, 74% coverage of query (60.5 bits)

ARO1 / P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    28% identity, 71% coverage of query (53.9 bits)

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