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Searching for up to 100 curated homologs for WP_012067330.1 NCBI__GCF_000017145.1:WP_012067330.1 (351 a.a.)

Found high-coverage hits (≥70%) to 65 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PP_0967 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Pseudomonas putida KT2440
    61% identity, 99% coverage of query (433 bits)

HP15_2427 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Marinobacter adhaerens HP15
    59% identity, 100% coverage of query (426 bits)

Pf6N2E2_3251 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Pseudomonas fluorescens FW300-N2E2
    59% identity, 100% coverage of query (421 bits)

Psest_3297 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Pseudomonas stutzeri RCH2
    59% identity, 99% coverage of query (410 bits)

PGA1_c25240 histidinol-phosphate aminotransferase [EC:2.6.1.9] from Phaeobacter inhibens BS107
    34% identity, 93% coverage of query (164 bits)

HIS8_CALS4 / Q8R5Q4 Histidinol-phosphate aminotransferase; Histidine transaminase; Imidazole acetol-phosphate transaminase; EC 2.6.1.9; EC 2.6.1.38 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
Q8R5Q4 histidine transaminase (EC 2.6.1.38) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
    32% identity, 92% coverage of query (164 bits)

BPHYT_RS14905 Aromatic-amino-acid transaminase (EC 2.6.1.57) from Burkholderia phytofirmans PsJN
    35% identity, 100% coverage of query (159 bits)

hisH / AAC41445.1 imidazole acetol phosphate aminotransferase from Zymomonas mobilis (see paper)
    33% identity, 98% coverage of query (158 bits)

HIS8_ZYMMO / P34037 Histidinol-phosphate aminotransferase; Imidazole acetol phosphate aminotransferase; IAP aminotransferase; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
    32% identity, 98% coverage of query (157 bits)

DvMF_0908 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Desulfovibrio vulgaris Miyazaki F
    34% identity, 98% coverage of query (154 bits)

AZOBR_RS20485 histidinol-phosphate aminotransferase [EC:2.6.1.9] from Azospirillum brasilense Sp245
    32% identity, 98% coverage of query (152 bits)

DVU1029 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Desulfovibrio vulgaris Hildenborough JW710
    32% identity, 98% coverage of query (146 bits)

hisC / P17731 histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous) (EC 2.6.1.1; EC 2.6.1.9) from Bacillus subtilis (strain 168) (see 4 papers)
    32% identity, 97% coverage of query (142 bits)

HIS6A_ARATH / B9DHD3 Histidinol-phosphate aminotransferase 1, chloroplastic; Gene duplicate 1-B protein; Imidazole acetol-phosphate transaminase; Protein EMBRYO DEFECTIVE 2196; Protein HISTIDINE BIOSYNTHESIS 6A; EC 2.6.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 97% coverage of query (142 bits)

2f8jA / Q9X0D0 Crystal structure of histidinol-phosphate aminotransferase (ec 2.6.1.9) (imidazole acetol-phosphate transferase) (tm1040) from thermotoga maritima at 2.40 a resolution
    31% identity, 96% coverage of query (141 bits)

HIS8_THEMA / Q9X0D0 Histidinol-phosphate aminotransferase; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    32% identity, 94% coverage of query (141 bits)

1uu0A Histidinol-phosphate aminotransferase (hisc) from thermotoga maritima (apo-form)
    31% identity, 96% coverage of query (141 bits)

1uu1A Complex of histidinol-phosphate aminotransferase (hisc) from thermotoga maritima (apo-form)
    31% identity, 96% coverage of query (141 bits)

1h1cA Histidinol-phosphate aminotransferase (hisc) from thermotoga maritima
    31% identity, 96% coverage of query (141 bits)

Build an alignment

Build an alignment for WP_012067330.1 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

8bj3A / A0A072U7F9 Crystal structure of medicago truncatula histidinol-phosphate aminotransferase (hisn6) in complex with histidinol-phosphate (see paper)
    29% identity, 95% coverage of query (137 bits)

HIS8_NICPL / Q9FEW2 Histidinol-phosphate aminotransferase, chloroplastic; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco) (see paper)
    30% identity, 98% coverage of query (137 bits)

HIS8_TOBAC / O82030 Histidinol-phosphate aminotransferase, chloroplastic; Imidazole acetol-phosphate transaminase; EC 2.6.1.9 from Nicotiana tabacum (Common tobacco) (see paper)
O82030 histidinol-phosphate transaminase (EC 2.6.1.9) from Nicotiana tabacum (see paper)
    30% identity, 98% coverage of query (135 bits)

3cq5B / Q9KJU4 Histidinol-phosphate aminotransferase from corynebacterium glutamicum in complex with pmp (see paper)
    32% identity, 94% coverage of query (119 bits)

3cq6A Histidinol-phosphate aminotransferase from corynebacterium glutamicum holo-form (plp covalently bound )
    32% identity, 94% coverage of query (119 bits)

his3 / GI|1174375 histidinol-phosphate aminotransferase imidazole acetol phosphate transaminase His3; EC 2.6.1.9 from Schizosaccharomyces pombe (see 2 papers)
    29% identity, 93% coverage of query (115 bits)

4r8dA / P9WML7 Crystal structure of rv1600 encoded aminotransferase in complex with plp-mes from mycobacterium tuberculosis
    30% identity, 95% coverage of query (112 bits)

P9WML7 histidinol-phosphate transaminase (EC 2.6.1.9) from Mycobacterium tuberculosis (see 3 papers)
    30% identity, 95% coverage of query (112 bits)

BT0202 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Bacteroides thetaiotaomicron VPI-5482
    28% identity, 97% coverage of query (112 bits)

C1437_CAMJE / Q0P8H7 Dihydroxyacetone phosphate transaminase Cj1437c; Capsule polysaccharide biosynthesis protein Cj1437c; PLP-dependent transaminase Cj1437; EC 2.6.1.- from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    26% identity, 97% coverage of query (110 bits)

orf2651 / A0A0D3RBW0 tryptophan—pyruvate aminotransferase (EC 2.6.1.99) from Streptomyces griseus (see 2 papers)
    30% identity, 98% coverage of query (110 bits)

4r2nA / P9WML5 Crystal structure of rv3772 in complex with its substrate (see paper)
    29% identity, 95% coverage of query (110 bits)

4r5zA Crystal structure of rv3772 encoded aminotransferase
    29% identity, 95% coverage of query (110 bits)

7szpA / A6TBC4 Crystal structure of histidinol-phosphate aminotransferase from klebsiella pneumoniae subsp. Pneumoniae (strain hs11286)
    31% identity, 97% coverage of query (108 bits)

ptaA / Q9I0V2 pyoverdine aminotransferase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
    30% identity, 92% coverage of query (105 bits)

3ly1D / Q6D4Z0 Crystal structure of putative histidinol-phosphate aminotransferase (yp_050345.1) from erwinia carotovora atroseptica scri1043 at 1.80 a resolution
    27% identity, 94% coverage of query (104 bits)

4wbtA / Q92R63 Crystal structure of histidinol-phosphate aminotransferase from sinorhizobium meliloti in complex with pyridoxal-5'-phosphate
    27% identity, 92% coverage of query (99.8 bits)

HisC / b2021 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
hisC / P06986 histidinol-phosphate aminotransferase (EC 2.6.1.9) from Escherichia coli (strain K12) (see 5 papers)
HIS8_ECOLI / P06986 Histidinol-phosphate aminotransferase; Imidazole acetol-phosphate transaminase; HPAT; HspAT; EC 2.6.1.9 from Escherichia coli (strain K12) (see 3 papers)
    27% identity, 97% coverage of query (98.6 bits)

1fg3A / P06986 Crystal structure of l-histidinol phosphate aminotransferase complexed with l-histidinol (see paper)
    27% identity, 97% coverage of query (98.6 bits)

1geyA Crystal structure of histidinol-phosphate aminotransferase complexed with n-(5'-phosphopyridoxyl)-l-glutamate
    27% identity, 91% coverage of query (98.6 bits)

1fg7A Crystal structure of l-histidinol phosphate aminotransferase with pyridoxal-5'-phosphate
    27% identity, 97% coverage of query (98.6 bits)

MmCobD / Q8PVB1 MmCobD (EC 4.1.1.81; EC 2.7.1.177) from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (see 2 papers)
Q8PVB1 threonine-phosphate decarboxylase (EC 4.1.1.81) from Methanosarcina mazei (see paper)
    26% identity, 91% coverage of query (79.0 bits)

S1544_SULMK / P0DV65 L-serine phosphate decarboxylase; CobD homolog SMUL_1544; SmCobD; L-serine O-phosphate decarboxylase; L-Ser-P decarboxylase; Norcobamide biosynthesis protein SMUL_1544; Threonine phosphate decarboxylase-like enzyme; EC 4.1.1.- from Sulfurospirillum multivorans (strain DM 12446 / JCM 15788 / NBRC 109480) (see 2 papers)
    27% identity, 82% coverage of query (76.6 bits)

1gd9A / O59096 Crystall structure of pyrococcus protein-a1 (see paper)
    27% identity, 79% coverage of query (75.5 bits)

O59096 aromatic-amino-acid transaminase (EC 2.6.1.57) from Pyrococcus horikoshii (see paper)
    27% identity, 79% coverage of query (75.5 bits)

1gdeA Crystal structure of pyrococcus protein a-1 e-form
    27% identity, 79% coverage of query (75.5 bits)

Y1178_MYCTU / O50434 Probable aminotransferase Rv1178; EC 2.6.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    28% identity, 77% coverage of query (68.2 bits)

C1436_CAMJE / Q0P8H8 L-serine phosphate decarboxylase Cj1436c; Capsule polysaccharide biosynthesis protein Cj1436c; PLP-dependent decarboxylase Cj1436; EC 4.1.1.- from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
    22% identity, 85% coverage of query (67.8 bits)

Q8TQ40 LL-diaminopimelate aminotransferase (EC 2.6.1.83) from Methanosarcina acetivorans (see paper)
    28% identity, 72% coverage of query (66.6 bits)

Q3MDN5 LL-diaminopimelate aminotransferase (EC 2.6.1.83) from Trichormus variabilis (see paper)
    26% identity, 72% coverage of query (65.1 bits)

1b5oA / Q56232 Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
    29% identity, 77% coverage of query (63.9 bits)

AAPAT_THET8 / Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 5 papers)
Q56232 aspartate-prephenate aminotransferase (EC 2.6.1.78) from Thermus thermophilus (see paper)
aspC / RF|YP_143312.1 aspartate transaminase; EC 2.6.1.1 from Thermus thermophilus HB8 (see 2 papers)
    29% identity, 77% coverage of query (63.9 bits)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate
    29% identity, 77% coverage of query (63.9 bits)

1bjwA Aspartate aminotransferase from thermus thermophilus
    29% identity, 77% coverage of query (63.9 bits)

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate
    29% identity, 77% coverage of query (63.5 bits)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan
    29% identity, 77% coverage of query (63.5 bits)

1o4sB / Q9X0Y2 Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
    25% identity, 87% coverage of query (63.2 bits)

AAT_THEMA / Q9X0Y2 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    25% identity, 87% coverage of query (63.2 bits)

oxyQ / L8EVF8 4-dedimethylamino-4-oxo-anhydrotetracycline transaminase from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see 2 papers)
OXYQ_STRRM / Q3S8P9 4-dedimethylamino-4-oxo-anhydrotetracycline transaminase OxyQ; PLP-dependent aminotransferase OxyQ; Reductive transaminase oxyQ; EC 2.6.1.- from Streptomyces rimosus (see paper)
    26% identity, 78% coverage of query (62.0 bits)

5yhvB Crystal structure of an aminotransferase from mycobacterium tuberculosis
    27% identity, 82% coverage of query (60.8 bits)

5yhvA / P96847 Crystal structure of an aminotransferase from mycobacterium tuberculosis
    27% identity, 82% coverage of query (60.8 bits)

AVTA_MYCTU / P96847 Valine--pyruvate aminotransferase; Alanine--valine transaminase; EC 2.6.1.66 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    27% identity, 82% coverage of query (60.8 bits)

P14909 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
    23% identity, 85% coverage of query (59.3 bits)

8wkjA / A0A130QXX8 The crystal structure of aspartate aminotransferases lpg0070 from legionella pneumophila (see paper)
    22% identity, 77% coverage of query (49.3 bits)

1v2fA Crystal structure of t.Th hb8 glutamine aminotransferase complex with 3-phenylpropionate
    26% identity, 79% coverage of query (46.6 bits)

1v2eA / Q75WK2 Crystal structure of t.Th hb8 glutamine aminotransferase complex with a-keto-g-methylthiobutyrate (see paper)
    26% identity, 79% coverage of query (46.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory