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Searching for up to 100 curated homologs for WP_012170620.1 NCBI__GCF_000010525.1:WP_012170620.1 (359 a.a.)

Found high-coverage hits (≥70%) to 38 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YdcT / b1441 putative ABC transporter ATP-binding protein YdcT from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ydcT / P77795 putative ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see 3 papers)
YDCT_ECOLI / P77795 Uncharacterized ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see paper)
    46% identity, 88% coverage of query (254 bits)

PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
    43% identity, 83% coverage of query (244 bits)

PS417_27115 putrescine ABC transporter, ATPase component from Pseudomonas simiae WCS417
    42% identity, 84% coverage of query (243 bits)

TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
    39% identity, 96% coverage of query (242 bits)

Q8YM92 ABC-type polyamine transporter (subunit 3/3) (EC 7.6.2.11) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    40% identity, 85% coverage of query (242 bits)

PHNT_SALTY / P96063 Putative 2-aminoethylphosphonate import ATP-binding protein PhnT from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 3.A.1.11.5 / P96063 PhnT aka STM0428, component of 2-aminoethyl phosphonate porter from Salmonella typhimurium (see 2 papers)
    44% identity, 84% coverage of query (238 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    39% identity, 87% coverage of query (237 bits)

MSIK_STRCO / Q9L0Q1 Diacetylchitobiose uptake system ATP-binding protein MsiK; EC 7.5.2.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
TC 3.A.1.1.33 / TC 3.A.1.1.36 / Q9L0Q1 ABC transporter ATP-binding protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces coelicolor (see paper)
    43% identity, 80% coverage of query (236 bits)

2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
    42% identity, 77% coverage of query (235 bits)

MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
    40% identity, 88% coverage of query (234 bits)

1g291 / Q9YGA6 Malk (see paper)
    40% identity, 88% coverage of query (234 bits)

TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
    46% identity, 74% coverage of query (233 bits)

TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    42% identity, 74% coverage of query (232 bits)

TC 3.A.1.1.34 / O32151 Uncharacterized ABC transporter ATP-binding protein YurJ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (strain 168)
    42% identity, 78% coverage of query (231 bits)

Pf1N1B4_5115 sucrose ABC transporter, ATPase component from Pseudomonas fluorescens FW300-N1B4
    44% identity, 78% coverage of query (230 bits)

TC 3.A.1.11.7 / Q97Q42 Spermidine/putrescine import ATP-binding protein PotA, component of The spermidine/putrescine uptake porter, PotABCD from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    42% identity, 77% coverage of query (230 bits)

A0A142UTH4 ABC-type polyamine transporter (subunit 4/4) (EC 7.6.2.11) from Streptococcus suis (see paper)
    43% identity, 77% coverage of query (229 bits)

PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
    40% identity, 84% coverage of query (229 bits)

TC 3.A.1.6.5 / Q8U4K3 WtpC, component of Tungsten (KM=20pM)/molybdate (KM=10nM) porter from Pyrococcus furiosus (see paper)
    41% identity, 84% coverage of query (221 bits)

TC 3.A.1.1.28 / Q00752 MsmK aka SMU.882, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    38% identity, 84% coverage of query (220 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    41% identity, 77% coverage of query (219 bits)

TC 3.A.1.1.27 / Q8DT25 MalK, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) from Streptococcus mutans (see paper)
    38% identity, 77% coverage of query (219 bits)

Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
    42% identity, 72% coverage of query (218 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    43% identity, 78% coverage of query (216 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    40% identity, 78% coverage of query (214 bits)

2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    40% identity, 78% coverage of query (208 bits)

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
    40% identity, 78% coverage of query (208 bits)

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
    40% identity, 78% coverage of query (208 bits)

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
    40% identity, 78% coverage of query (208 bits)

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
    40% identity, 78% coverage of query (208 bits)

MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
    40% identity, 78% coverage of query (207 bits)

1q12A Crystal structure of the atp-bound e. Coli malk
    39% identity, 78% coverage of query (206 bits)

2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    37% identity, 78% coverage of query (184 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    44% identity, 72% coverage of query (178 bits)

2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
    34% identity, 78% coverage of query (147 bits)

Build an alignment

Build an alignment for WP_012170620.1 and 35 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

8wooA Structure of the wild-type arabidopsis abcb19 in the brassinolide and amp-pnp bound state
    29% identity, 75% coverage of query (89.7 bits)

8womA / Q9LJX0 Structure of the wild-type arabidopsis abcb19 in the brassinolide- bound state (see paper)
    29% identity, 75% coverage of query (89.7 bits)

8wp0A Structure of the arabidopsis e529q/e1174q abcb19 in the atp bound state
    29% identity, 75% coverage of query (88.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory