Sites on a Tree

 

Searching for up to 100 curated homologs for WP_012277979.1 NCBI__GCF_000019185.1:WP_012277979.1 (535 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Sama_1361 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) from Shewanella amazonensis SB2B
    88% identity, 100% coverage of query (994 bits)

Pf6N2E2_2192 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N2E2
    72% identity, 100% coverage of query (805 bits)

AO356_01585 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N2C3
    72% identity, 100% coverage of query (799 bits)

Psest_1083 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) from Pseudomonas stutzeri RCH2
    70% identity, 100% coverage of query (793 bits)

liuB / Q9I297 methylcrotonyl-CoA carboxylase β-subunit (EC 6.4.1.4) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I297 methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) from Pseudomonas aeruginosa (see paper)
    70% identity, 100% coverage of query (770 bits)

3u9sF / Q9I297 Crystal structure of p. Aeruginosa 3-methylcrotonyl-coa carboxylase (mcc) 750 kd holoenzyme, coa complex (see paper)
    70% identity, 100% coverage of query (770 bits)

SM_b21122 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) from Sinorhizobium meliloti 1021
    67% identity, 100% coverage of query (763 bits)

8j4zJ / Q9HCC0 Human 3-methylcrotonyl-coa carboxylase in bccp-cts state with substrate
    68% identity, 100% coverage of query (754 bits)

8k2vG 3-methylcrotonyl-coa carboxylase in mccd state with acetyl coa
    68% identity, 100% coverage of query (754 bits)

MCCC2 / Q9HCC0 3-methylcrotonyl-CoA carboxylase β subunit (EC 6.4.1.4) from Homo sapiens (see 4 papers)
MCCB_HUMAN / Q9HCC0 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; MCCase subunit beta; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; EC 6.4.1.4 from Homo sapiens (Human) (see 14 papers)
    68% identity, 100% coverage of query (753 bits)

MCCB_DROME / Q9V9A7 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; MCCase subunit beta; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; EC 6.4.1.4 from Drosophila melanogaster (Fruit fly) (see paper)
    66% identity, 99% coverage of query (745 bits)

Caur_2034 / A9WEI4 propionyl-CoA carboxylase α subunit (EC 6.4.1.3) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    66% identity, 100% coverage of query (726 bits)

ACCD1_MYCTU / I6YDK7 Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase beta1 subunit; 3-methylcrotonyl-CoA carboxylase; MCC; EC 2.1.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    66% identity, 96% coverage of query (718 bits)

8jxmC / Q9HCC0 Human 3-methylcrotonyl-coa carboxylase in bccp-h2 state with mcoa
    64% identity, 100% coverage of query (704 bits)

Q9LDD8 methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) from Arabidopsis thaliana (see 2 papers)
    60% identity, 99% coverage of query (671 bits)

mccB non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase; EC 6.4.1.4 from Emericella nidulans (see paper)
mccB / AAR23111.1 non-biotin containing subunit of 3-methylcrotonyl CoA carboxylase from Aspergillus nidulans (see paper)
    60% identity, 100% coverage of query (642 bits)

8rthF / Q385A6 Trypanosoma brucei 3-methylcrotonyl-coa carboxylase (see paper)
    62% identity, 96% coverage of query (624 bits)

8f3dA / A0A640KGP9 3-methylcrotonyl-coa carboxylase in filament, beta-subunit centered (see paper)
    59% identity, 96% coverage of query (622 bits)

ACCD2_MYCTU / O86318 Probable biotin-dependent acyl-coenzyme A carboxylase beta2 subunit; EC 2.1.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    50% identity, 99% coverage of query (504 bits)

atuC / Q9HZV9 cis-geranyl-CoA carboxylase β-subunit (EC 6.4.1.5) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9HZV9 geranoyl-CoA carboxylase (EC 6.4.1.5) from Pseudomonas aeruginosa (see paper)
    42% identity, 100% coverage of query (432 bits)

mmdA / Q8GBW6 methylmalonyl-CoA carboxyltransferase 12S subunit (EC 2.1.3.1) from Propionibacterium freudenreichii subsp. shermanii (see 3 papers)
12S_PROFR / Q8GBW6 Methylmalonyl-CoA carboxyltransferase 12S subunit; Transcarboxylase 12S subunit; EC 2.1.3.1 from Propionibacterium freudenreichii subsp. shermanii (see 2 papers)
12S / CAD59919.1 Methylmalonyl-CoA carboxyltransferase 12S subunit from Propionibacterium freudenreichii subsp. shermanii (see paper)
    37% identity, 92% coverage of query (290 bits)

1on3E / Q8GBW6 Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) (see paper)
    37% identity, 92% coverage of query (290 bits)

1vrgA / Q9WZH5 Crystal structure of propionyl-coa carboxylase, beta subunit (tm0716) from thermotoga maritima at 2.30 a resolution
    36% identity, 92% coverage of query (286 bits)

1on3C Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound)
    37% identity, 92% coverage of query (286 bits)

pccB / Q5UWC0 propionyl-CoA carboxylase (EC 6.4.1.3) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see paper)
    34% identity, 90% coverage of query (281 bits)

PCCB_HALMT / I3R7F1 Propionyl-CoA carboxylase, carboxyltransferase subunit; PCC; EC 6.4.1.3 from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) (see paper)
I3R7F1 propionyl-CoA carboxylase (subunit 2/3) (EC 6.4.1.3) from Haloferax mediterranei (see paper)
    34% identity, 92% coverage of query (271 bits)

Dsui_0517 Propionyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.3) from Dechlorosoma suillum PS
    35% identity, 93% coverage of query (262 bits)

mmdA / Q57079 (S)-methylmalonyl-CoA decarboxylase α subunit (EC 7.2.4.3) from Veillonella parvula (see 5 papers)
MMDA_VEIPA / Q57079 Methylmalonyl-CoA decarboxylase subunit alpha; Carboxyltransferase; EC 7.2.4.3 from Veillonella parvula (Staphylococcus parvulus) (see 8 papers)
TC 3.B.1.1.2 / Q57079 Alpha-subunit,methylmalonyl-CoA decarboxylase, component of Na+-transporting methylmalonyl-CoA decarboxylase from Veillonella parvula (see paper)
AAC36820.1 methylmalonyl-CoA decarboxylase alpha-subunit from Veillonella parvula (see paper)
CAA80872.1 alpha-subunit,methylmalonyl-CoA decarboxylase from Veillonella parvula (see paper)
    33% identity, 93% coverage of query (261 bits)

MMDA_PROMO / O54028 Methylmalonyl-CoA decarboxylase subunit alpha; EC 7.2.4.3 from Propionigenium modestum (see paper)
    32% identity, 91% coverage of query (256 bits)

pccB / Q3J4E3 propionyl-CoA carboxylase β subunit (EC 6.4.1.3) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (see paper)
PCCB_CERS4 / Q3J4E3 Propionyl-CoA carboxylase beta chain; PCCase; Propanoyl-CoA:carbon dioxide ligase; EC 6.4.1.3 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
    34% identity, 94% coverage of query (256 bits)

mmdA / CAA05137.1 methylmalonyl-CoA decarboxylase, alpha-subunit, partial from Propionigenium modestum (see paper)
    32% identity, 91% coverage of query (256 bits)

pccB / Q877I3 acyl CoA carboxylase carboxyltransferase subunit (EC 2.1.3.15; EC 6.4.1.3; EC 6.3.4.14) from Acidianus brierleyi (see 2 papers)
Q877I3 acetyl-CoA carboxylase (subunit 1/3) (EC 6.4.1.2); propionyl-CoA carboxylase (subunit 2/3) (EC 6.4.1.3) from Acidianus brierleyi (see paper)
pccB / BAC55869.1 carboxyltransferase subunit of acetyl-CoA carboxylase from Acidianus brierleyi (see paper)
    33% identity, 94% coverage of query (254 bits)

ACCD5_MYCTU / P9WQH7 Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit; Acetyl-CoA carboxylase; ACC; Propionyl-CoA carboxylase; PCC; EC 2.1.3.15; EC 2.1.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 6 papers)
    34% identity, 97% coverage of query (254 bits)

Caur_3435 / A9WKJ2 propionyl-CoA carboxylase β subunit (EC 6.4.1.3) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
    33% identity, 88% coverage of query (253 bits)

3ib9A / Q9X4K7 Propionyl-coa carboxylase beta subunit, d422l (see paper)
    32% identity, 90% coverage of query (253 bits)

PCCB_ROSDO / Q168G2 Propionyl-CoA carboxylase beta chain; EC 6.4.1.3 from Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans) (see paper)
    33% identity, 94% coverage of query (252 bits)

1xnyA Biotin and propionyl-coa bound to acyl-coa carboxylase beta subunit from s. Coelicolor (pccb)
    32% identity, 90% coverage of query (252 bits)

Q9X4K7 propionyl-CoA carboxylase (EC 6.4.1.3) from Streptomyces coelicolor (see 2 papers)
    32% identity, 90% coverage of query (251 bits)

Msed_1375 / A4YGI1 acyl CoA carboxylase carboxyltransferase subunit from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
Q8J2Z5 acetyl-CoA carboxylase (EC 6.4.1.2) from Metallosphaera sedula (see paper)
    32% identity, 94% coverage of query (250 bits)

Dshi_0718 Propionyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.3) from Dinoroseobacter shibae DFL-12
    34% identity, 91% coverage of query (250 bits)

3n6rB / Q168G2 Crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) (see paper)
    34% identity, 92% coverage of query (249 bits)

8pn7A / C5AP75 Engineered glycolyl-coa carboxylase (g20r variant) with bound coa (see paper)
    33% identity, 94% coverage of query (248 bits)

Q20676 propionyl-CoA carboxylase (subunit 1/2) (EC 6.4.1.3) from Caenorhabditis elegans (see paper)
    34% identity, 89% coverage of query (246 bits)

PCCB_SACEN / P53003 Propionyl-CoA carboxylase beta chain; PCCase; Propanoyl-CoA:carbon dioxide ligase; EC 6.4.1.3 from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see paper)
    32% identity, 92% coverage of query (241 bits)

PCCB_PIG / P79384 Propionyl-CoA carboxylase beta chain, mitochondrial; PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta; EC 6.4.1.3 from Sus scrofa (Pig) (see paper)
    35% identity, 91% coverage of query (241 bits)

Pccb / P07633 propionyl-CoA carboxylase β subunit (EC 6.4.1.3) from Rattus norvegicus (see 2 papers)
    34% identity, 88% coverage of query (236 bits)

PCCB / P05166 propionyl-CoA carboxylase β chain, mitochondrial (EC 6.4.1.3) from Homo sapiens (see 4 papers)
PCCB_HUMAN / P05166 Propionyl-CoA carboxylase beta chain, mitochondrial; PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta; EC 6.4.1.3 from Homo sapiens (Human) (see 11 papers)
P05166 propionyl-CoA carboxylase (subunit 2/2) (EC 6.4.1.3) from Homo sapiens (see paper)
    34% identity, 91% coverage of query (236 bits)

7ybuP / P05166 Human propionyl-coenzyme a carboxylase
    34% identity, 91% coverage of query (235 bits)

PCCB_MOUSE / Q99MN9 Propionyl-CoA carboxylase beta chain, mitochondrial; PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta; EC 6.4.1.3 from Mus musculus (Mouse) (see paper)
Q99MN9 propionyl-CoA carboxylase (EC 6.4.1.3) from Mus musculus (see paper)
    34% identity, 88% coverage of query (233 bits)

5iniF / A0ACI9 Structural basis for acyl-coa carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics (see paper)
    31% identity, 90% coverage of query (231 bits)

AAA25676.1 methylmalonyl-CoA carboxyltransferase subunit 12S monomer from Propionibacterium freudenreichii subsp. shermanii (see paper)
    34% identity, 92% coverage of query (230 bits)

8sgxE / A0A640KR17 Leishmania tarentolae propionyl-coa carboxylase (alpha-4-beta-6) (see paper)
    31% identity, 87% coverage of query (217 bits)

ACCD4_MYCTU / O53578 Biotin-dependent long chain acyl-coenzyme A carboxylase beta4 subunit; EC 2.1.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    30% identity, 91% coverage of query (217 bits)

ACCD6_MYCTU / P9WQH5 Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit; Acetyl-CoA carboxylase; ACC; Propionyl-CoA carboxylase; PCC; EC 2.1.3.15; EC 2.1.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    31% identity, 87% coverage of query (188 bits)

Build an alignment

Build an alignment for WP_012277979.1 and 54 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

3gmaB / B7TVP1 Glutaconyl-coa decarboxylase a subunit from clostridium symbiosum co- crystallized with glutaryl-coa (see paper)
    26% identity, 90% coverage of query (182 bits)

B7TVP1 glutaconyl-CoA decarboxylase (EC 7.2.4.5) from [Clostridium] symbiosum (see paper)
    25% identity, 90% coverage of query (182 bits)

3gf3A Glutaconyl-coa decarboxylase a subunit from clostridium symbiosum co- crystallized with glutaconyl-coa
    26% identity, 90% coverage of query (182 bits)

gcdA / Q06700 GcdA (EC 7.2.4.5) from Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) (see 2 papers)
Q06700 glutaconyl-CoA decarboxylase (subunit 4/4) (EC 7.2.4.5) from Acidaminococcus fermentans (see 2 papers)
TC 3.B.1.1.3 / Q06700 GcdA, component of Na+-transporting glutaconyl-CoA decarboxylase from Acidaminococcus fermentans (see 4 papers)
    26% identity, 89% coverage of query (174 bits)

4g2rB / P9WQH5 Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor haloxyfop from mycobacterium tuberculosis (see paper)
    30% identity, 85% coverage of query (167 bits)

6tzvA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor phenyl-cyclodiaone from mycobacterium tuberculosis
    28% identity, 85% coverage of query (149 bits)

6prwA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
    28% identity, 85% coverage of query (149 bits)

6pk2A Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
    28% identity, 85% coverage of query (149 bits)

6p7uA Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p from mycobacterium tuberculosis
    28% identity, 85% coverage of query (149 bits)

6p7uC / P9WQH5 Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p from mycobacterium tuberculosis
    28% identity, 85% coverage of query (147 bits)

6tzvC Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor phenyl-cyclodiaone from mycobacterium tuberculosis
    28% identity, 85% coverage of query (147 bits)

6prwC Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
    28% identity, 85% coverage of query (147 bits)

6pk2C Crystal structure of the carboxyltransferase subunit of acc (accd6) in complex with inhibitor quizalofop-p derivative from mycobacterium tuberculosis
    28% identity, 85% coverage of query (147 bits)

ACC1 / Q13085 acetyl-CoA carboxylase 1 (EC 2.1.3.15; EC 6.4.1.2; EC 6.3.4.14) from Homo sapiens (see 6 papers)
ACACA_HUMAN / Q13085 Acetyl-CoA carboxylase 1; ACC1; Acetyl-Coenzyme A carboxylase alpha; ACC-alpha; EC 6.4.1.2 from Homo sapiens (Human) (see 8 papers)
Q13085 acetyl-CoA carboxylase (EC 6.4.1.2) from Homo sapiens (see 13 papers)
    21% identity, 71% coverage of query (45.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory