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Searching for up to 100 curated homologs for WP_012282203.1 NCBI__GCF_000019165.1:WP_012282203.1 (293 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.4.10 / Q8DQI0 ABC transporter membrane-spanning permease-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    38% identity, 99% coverage of query (205 bits)

AZOBR_RS08235 L-proline and D-alanine ABC transporter, permease component 1 from Azospirillum brasilense Sp245
    36% identity, 99% coverage of query (175 bits)

braD / CAB75549.1 integral membrane protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    36% identity, 99% coverage of query (169 bits)

HSERO_RS00885 L-proline ABC transporter, permease component 1 from Herbaspirillum seropedicae SmR1
    37% identity, 99% coverage of query (169 bits)

TC 3.A.1.4.8 / P21627 High-affinity branched-chain amino acid transport system permease protein BraD, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    37% identity, 99% coverage of query (166 bits)

Ac3H11_1695 ABC transporter for glutamine/isoleucine/leucine/phenylalanine/proline/serine/tyrosine, permease component 1 from Acidovorax sp. GW101-3H11
    35% identity, 99% coverage of query (162 bits)

Pf6N2E2_2923 ABC transporter for L-leucine/L-phenylalanine/D-alanine, permease component 1 LivH from Pseudomonas fluorescens FW300-N2E2
    36% identity, 99% coverage of query (162 bits)

LivH / b3457 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
LivH / P0AEX7 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH (EC 7.4.2.2) from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.4.1 / P0AEX7 High-affinity branched-chain amino acid transport system permease protein LivH aka B3457, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 6 papers)
livH high-affinity branched-chain amino acid ABC transporter, permease protein LivH from Escherichia coli K12 (see 6 papers)
    34% identity, 100% coverage of query (147 bits)

Build an alignment

Build an alignment for WP_012282203.1 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

TC 3.A.1.4.3 / Q8VM85 BraD aka Bra2D, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
    29% identity, 98% coverage of query (130 bits)

TC 3.A.1.4.5 / Q8NRW0 UrtA, component of The high affinity urea/thiourea/hydroxyurea porter from Corynebacterium glutamicum (see paper)
    31% identity, 99% coverage of query (112 bits)

TC 3.A.1.4.2 / P74318 NatD aka LivH aka SLR0949, component of Leucine/proline/alanine/serine/glycine (and possibly histidine) porter, NatABCDE (see paper)
    30% identity, 81% coverage of query (98.6 bits)

TC 3.A.1.4.9 / Q0S718 ABC amino acid transporter, permease component, component of Uptake transporter, CamABCD of cholate (steroid) metabolites, 1β(2'-propanoate)-3aα-H-4α(3"(R)-hydroxy-3"-propanoate)-7aβ-methylhexahydro-5-indanone and a desaturated analog from Rhodococcus sp. (strain RHA1)
    30% identity, 97% coverage of query (95.5 bits)

TC 3.A.1.4.6 / Q8YXD0 NatD, component of The neutral amino acid permease, N-1 (transports pro, phe, leu, gly, ala, ser, gln and his, but gln and his are not transported via NatB) (see paper)
    27% identity, 80% coverage of query (92.0 bits)

braE / CAB75550.1 integral membrane protein from Rhizobium leguminosarum bv. viciae (see 2 papers)
    28% identity, 98% coverage of query (74.7 bits)

LivM / b3456 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
LivM / P22729 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2) from Escherichia coli (strain K12) (see 5 papers)
LIVM_ECOLI / P22729 High-affinity branched-chain amino acid transport system permease protein LivM; LIV-I protein M from Escherichia coli (strain K12) (see paper)
TC 3.A.1.4.1 / P22729 LivM aka B3456, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli (see 5 papers)
    28% identity, 94% coverage of query (71.2 bits)

TC 3.A.1.2.16 / Q1M4Q8 Erythritol permease, component of ABC transporter, component of The erythritol uptake permease, EryEFG (Yost et al., 2006) (probably orthologous to 3.A.1.2.11) from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    28% identity, 95% coverage of query (69.7 bits)

TC 3.A.1.4.11 / Q6N8W1 Putative branched-chain amino acid transport system ATP-binding protein, component of The phenylpropeneoid uptake porter, CouPSTW from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    26% identity, 89% coverage of query (67.4 bits)

HSERO_RS00890 L-proline ABC transporter, permease component 2 from Herbaspirillum seropedicae SmR1
    27% identity, 81% coverage of query (63.5 bits)

Psest_0566 urea ABC transporter, permease component from Pseudomonas stutzeri RCH2
    24% identity, 76% coverage of query (63.5 bits)

TC 3.A.1.4.7 / Q92TN1 ABC transporter, permease, component of The protocatechuate (3,4-dihydroxybenzoate) uptake porter, PcaMNVWX from Rhizobium meliloti (strain 1021)
    25% identity, 83% coverage of query (61.6 bits)

AZOBR_RS08240 L-proline and D-alanine ABC transporter, permease component 2 from Azospirillum brasilense Sp245
    26% identity, 94% coverage of query (61.6 bits)

DVU0549 proline/arginine ABC transporter, permease component from Desulfovibrio vulgaris Hildenborough JW710
    24% identity, 100% coverage of query (61.6 bits)

TC 3.A.1.4.3 / Q8VM84 BraE aka Bra2E, component of General L- (and D-)amino acid uptake porter (transports acidic, basic, polar, semipolar and hydrophobic amino acids). The amino and carboxyl groups do not need to be α since γ-aminobutyric acid (GABA) is a substrate. The system may function with additional binding proteins since L-alanine uptake is not dependent on BraC from Rhizobium leguminosarum (biovar viciae) (see paper)
    24% identity, 94% coverage of query (61.2 bits)

PGA1_c12660 D-lactate transporter, permease component 2 from Phaeobacter inhibens BS107
    29% identity, 97% coverage of query (58.9 bits)

Pf6N2E2_2924 ABC transporter for L-leucine/L-isoleucine/L-phenylalanine/D-alanine, permease component 2 LivM from Pseudomonas fluorescens FW300-N2E2
    25% identity, 92% coverage of query (57.0 bits)

PS417_11895 Inositol transport system permease protein from Pseudomonas simiae WCS417
    25% identity, 92% coverage of query (56.2 bits)

TC 3.A.1.4.4 / Q9L3S5 UrtB aka ALL1950, component of The high-affinity (<1 μM) urea porter (see 2 papers)
    22% identity, 84% coverage of query (54.7 bits)

AO353_21390 m-Inositol ABC transporter, permease component (iatP) from Pseudomonas fluorescens FW300-N2E3
    26% identity, 92% coverage of query (54.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory