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Searching for up to 100 curated homologs for WP_012334742.1 NCBI__GCF_000019365.1:WP_012334742.1 (315 a.a.)

Found high-coverage hits (≥70%) to 24 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SMc01801 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Sinorhizobium meliloti 1021
    50% identity, 97% coverage of query (294 bits)

argC / CAC29374.1 acetylglutamylphosphate reductase from Rhizobium etli (see paper)
    49% identity, 97% coverage of query (280 bits)

Ga0059261_0351 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Sphingomonas koreensis DSMZ 15582
    53% identity, 96% coverage of query (276 bits)

ARGC_ORYSJ / Q6AV34 Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Oryza sativa subsp. japonica (Rice) (see paper)
    34% identity, 84% coverage of query (112 bits)

ARG56_SCHPO / P31318 Protein arg11, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
arg11 / GI|1204210 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe (see 2 papers)
    35% identity, 81% coverage of query (103 bits)

ARGC_ARATH / Q93Z70 Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Arabidopsis thaliana (Mouse-ear cress)
    33% identity, 84% coverage of query (102 bits)

Build an alignment

Build an alignment for WP_012334742.1 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ARG5,6 arginine biosynthetic enzyme activities from Candida albicans (see 3 papers)
    29% identity, 81% coverage of query (90.9 bits)

argC / CAB95020.1 n-acetylglutamate 5-semialdehyde dehydrogenase from Moritella abyssi (see paper)
    31% identity, 84% coverage of query (90.9 bits)

Echvi_3847 N-succinylglutamylphosphate reductase (EC 1.2.1.-) from Echinicola vietnamensis KMM 6221, DSM 17526
    31% identity, 82% coverage of query (87.4 bits)

ABZR86_RS08700 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Dyella japonica UNC79MFTsu3.2
    35% identity, 80% coverage of query (87.4 bits)

ARGC_GEOSE / Q07906 N-acetyl-gamma-glutamyl-phosphate reductase; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
    28% identity, 82% coverage of query (83.6 bits)

ArgC / b3958 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
argC / P11446 N-acetylglutamylphosphate reductase (EC 1.2.1.38) from Escherichia coli (strain K12) (see 4 papers)
ARGC_ECOLI / P11446 N-acetyl-gamma-glutamyl-phosphate reductase; AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase; EC 1.2.1.38 from Escherichia coli (strain K12) (see paper)
P11446 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) from Escherichia coli (see paper)
    32% identity, 81% coverage of query (82.8 bits)

argC / CAB82479.1 N-acetyl-gamma-glutamyl-phosphate reductase from Streptomyces clavuligerus (see 3 papers)
    32% identity, 85% coverage of query (82.8 bits)

CA265_RS18540 N-succinylglutamylphosphate reductase (EC 1.2.1.38) from Pedobacter sp. GW460-11-11-14-LB5
    27% identity, 82% coverage of query (77.8 bits)

BT3759 N-succinylglutamylphosphate reductase (EC 1.2.1.-) from Bacteroides thetaiotaomicron VPI-5482
    25% identity, 73% coverage of query (75.5 bits)

ARG56_YEAST / Q01217 Protein ARG5,6, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Q01217 acetylglutamate kinase (EC 2.7.2.8) from Saccharomyces cerevisiae (see paper)
ARG5,6 / CAA40336.1 acetylglutamate kinase from Saccharomyces cerevisiae (see paper)
    30% identity, 81% coverage of query (74.7 bits)

2i3gA / P9WPZ9 Crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase (rv1652) from mycobacterium tuberculosis in complex with NADP+. (see paper)
    31% identity, 87% coverage of query (72.0 bits)

P9WPZ9 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) from Mycobacterium tuberculosis (see paper)
    31% identity, 87% coverage of query (72.0 bits)

7npjB Crystal structure of mycobacterium tuberculosis argc in complex with 6-phenoxy-3-pyridinamine
    31% identity, 87% coverage of query (72.0 bits)

7nphC Crystal structure of mycobacterium tuberculosis argc in complex with 5-methoxy-1,3-benzoxazole-2-carboxylic acid
    31% identity, 87% coverage of query (72.0 bits)

7notA Crystal structure of mycobacterium tuberculosis argc in complex with nicotinamide adenine dinucleotide phosphate (NADP+) and 5-methoxy-3- indoleacetic acid
    31% identity, 87% coverage of query (72.0 bits)

7nnrA Crystal structure of mycobacterium tuberculosis argc in complex with xanthene-9-carboxylic acid
    31% identity, 87% coverage of query (72.0 bits)

Q5JFW1 [amino-group carrier protein]-5-phospho-L-glutamate reductase (EC 1.2.1.106) from Thermococcus kodakarensis (see paper)
    25% identity, 82% coverage of query (63.9 bits)

lysY / O50146 [amino-group carrier protein]-L-2-aminoadipate 6-phosphate reductase (EC 1.2.1.103) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
LYSY_THET2 / O50146 [LysW]-L-2-aminoadipate 6-phosphate reductase; EC 1.2.1.103 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
O50146 [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase (EC 1.2.1.103); [amino-group carrier protein]-5-phospho-L-glutamate reductase (EC 1.2.1.106) from Thermus thermophilus (see paper)
    24% identity, 88% coverage of query (51.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory