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Searching for up to 100 curated homologs for WP_012335778.1 NCBI__GCF_000019365.1:WP_012335778.1 (417 a.a.)

Found high-coverage hits (≥70%) to 26 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

argG / CAA88926.1 argininosuccinate synthetase from Streptomyces clavuligerus (see 3 papers)
    33% identity, 83% coverage of query (142 bits)

ASSY_SYNY3 / P77973 Argininosuccinate synthase; Argininosuccinate synthetase; Citrulline--aspartate ligase; SyArgG; EC 6.3.4.5 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    30% identity, 83% coverage of query (126 bits)

Build an alignment

Build an alignment for WP_012335778.1 and 2 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

4xfjB / G7CBN9 Crystal structure of argininosuccinate synthase from mycobacterium thermoresistibile in complex with amppnp and arginine
    29% identity, 82% coverage of query (120 bits)

7k5zA / Q5ZY78 Crystal structure of argininosuccinate synthase from legionella pneumophila philadelphia 1 in complex with anppnp and a substrate analogue arginine
    28% identity, 84% coverage of query (114 bits)

H9BG20 argininosuccinate synthase (EC 6.3.4.5) from Leishmania donovani (see 2 papers)
    27% identity, 88% coverage of query (102 bits)

A4I066 argininosuccinate synthase (EC 6.3.4.5) from Leishmania infantum (see paper)
    27% identity, 88% coverage of query (101 bits)

argG / CAB95023.1 argininosuccinate synthetase from Moritella abyssi (see paper)
    27% identity, 78% coverage of query (95.5 bits)

ASSY_THEMA / Q9X2A1 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
    29% identity, 87% coverage of query (94.4 bits)

S4V5K7 argininosuccinate synthase (EC 6.3.4.5) from Protopterus annectens (see paper)
    27% identity, 90% coverage of query (93.6 bits)

ASSY_THET8 / P59846 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
    29% identity, 82% coverage of query (91.7 bits)

1kh3A Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with inhibitor
    29% identity, 82% coverage of query (88.6 bits)

1j1zA / P59846 Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with substrate (see paper)
    29% identity, 82% coverage of query (88.2 bits)

1j20A Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with product
    29% identity, 82% coverage of query (88.2 bits)

ABZR86_RS08715 arginosuccinate synthetase (EC 6.3.4.5) from Dyella japonica UNC79MFTsu3.2
    29% identity, 76% coverage of query (80.5 bits)

2nz2A / P00966 Crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline (see paper)
    27% identity, 83% coverage of query (77.8 bits)

Q2Z0F6 argininosuccinate synthase (EC 6.3.4.5) from Agaricus bisporus (see paper)
    30% identity, 71% coverage of query (77.8 bits)

ASSY_BOVIN / P14568 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Bos taurus (Bovine) (see paper)
    26% identity, 89% coverage of query (77.8 bits)

ASSY_RAT / P09034 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Rattus norvegicus (Rat) (see paper)
    26% identity, 83% coverage of query (75.9 bits)

BT3760 arginosuccinate synthetase (EC 6.3.4.5) from Bacteroides thetaiotaomicron VPI-5482
    25% identity, 79% coverage of query (75.1 bits)

ASSY_MOUSE / P16460 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Mus musculus (Mouse) (see 3 papers)
P16460 argininosuccinate synthase (EC 6.3.4.5) from Mus musculus (see 4 papers)
    26% identity, 83% coverage of query (74.7 bits)

ARG1 argininosuccinate synthase; EC 6.3.4.5 from Candida albicans (see paper)
    28% identity, 82% coverage of query (74.7 bits)

ASS1 / P00966 Argininosuccinate synthase (EC 6.3.4.5) from Homo sapiens (see 7 papers)
ASSY_HUMAN / P00966 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Homo sapiens (Human) (see 21 papers)
P00966 argininosuccinate synthase (EC 6.3.4.5) from Homo sapiens (see 9 papers)
    27% identity, 83% coverage of query (73.6 bits)

ASSY_SCHPO / O94354 Argininosuccinate synthase; Citrulline--aspartate ligase; EC 6.3.4.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
arg12 / RF|NP_595183.1 argininosuccinate synthase (predicted); EC 6.3.4.5 from Schizosaccharomyces pombe (see 2 papers)
    28% identity, 73% coverage of query (72.0 bits)

5us8A / Q7VTJ9 2.15 angstrom resolution crystal structure of argininosuccinate synthase from bordetella pertussis
    26% identity, 82% coverage of query (52.0 bits)

6e5yA 1.50 angstrom resolution crystal structure of argininosuccinate synthase from bordetella pertussis in complex with amp.
    26% identity, 82% coverage of query (52.0 bits)

argG / BAC65286.1 argininosuccinate synthase from Burkholderia multivorans (see paper)
    24% identity, 90% coverage of query (46.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory