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Searching for up to 100 curated homologs for WP_012385491.1 NCBI__GCF_000019845.1:WP_012385491.1 (394 a.a.)

Found high-coverage hits (≥70%) to 71 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

fkbE / Q9KIE9 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) from Streptomyces hygroscopicus subsp. ascomyceticus (see paper)
    55% identity, 94% coverage of query (387 bits)

act / B9U6P4 acyl-CoA:3-sulfinopropionate CoA-transferase from Variovorax paradoxus (see paper)
    38% identity, 85% coverage of query (229 bits)

AO356_10845 succinyl-CoA-glutarate CoA-transferase (EC 2.8.3.13) from Pseudomonas fluorescens FW300-N2C3
    37% identity, 95% coverage of query (224 bits)

gcdG / Q88RH1 succinyl-CoA-glutarate CoA-transferase (EC 2.8.3.13) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    35% identity, 97% coverage of query (220 bits)

acuN / C8YX88 AcuN from Halomonas sp. HTNK1 (see paper)
    35% identity, 95% coverage of query (214 bits)

9br7C / Q9HAC7 9br7C (see paper)
    32% identity, 95% coverage of query (209 bits)

SUCHY_HUMAN / Q9HAC7 Succinate--hydroxymethylglutarate CoA-transferase; Dermal papilla-derived protein 13; SuccinylCoA:glutarate-CoA transferase; EC 2.8.3.13 from Homo sapiens (Human) (see 3 papers)
    32% identity, 95% coverage of query (209 bits)

SUGCT / Q9HAC7 succinyl-CoA-glutarate CoA-transferase (EC 2.8.3.13) from Homo sapiens (see 3 papers)
Q9HAC7 succinate-hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) from Homo sapiens (see paper)
    32% identity, 95% coverage of query (209 bits)

caiB / Q7CXU0 succinate—lglutarate CoA-transferase (EC 2.8.3.13) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SGCOT_AGRFC / Q7CXU0 Succinate--glutarate CoA-transferase; EC 2.8.3.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    34% identity, 96% coverage of query (208 bits)

FDB20_FUSPC / K3VD64 Acyl-CoA transferase FPSE_08120; Fusarium detoxification of benzoxazolinone cluster protein FPSE_08120; FDB cluster protein FPSE_08120; EC 2.8.3.- from Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot fungus) (see 3 papers)
    35% identity, 96% coverage of query (204 bits)

YfdE / b2371 acetyl-CoA:oxalate CoA-transferase (EC 2.8.3.19) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
yfdE / P76518 acetyl-CoA:oxalate CoA-transferase (EC 2.8.3.19) from Escherichia coli (strain K12) (see paper)
ACOCT_ECOLI / P76518 Acetyl-CoA:oxalate CoA-transferase; ACOCT; Acetyl-coenzyme A transferase; CoA:oxalate CoA-transferase; EC 2.8.3.19 from Escherichia coli (strain K12) (see 3 papers)
P76518 CoA:oxalate CoA-transferase (EC 2.8.3.19) from Escherichia coli (see paper)
    32% identity, 95% coverage of query (192 bits)

ACOCT_ACEAC / A9X6P9 Acetyl-CoA:oxalate CoA-transferase; ACOCT; Acetyl-coenzyme A transferase; CoA:oxalate CoA-transferase; CoAT3; EC 2.8.3.19 from Acetobacter aceti (see paper)
    33% identity, 95% coverage of query (190 bits)

gbuC / A0A415DZ14 γ-butyrobetaine CoA transferase GbuC component from Emergencia timonensis (see paper)
    31% identity, 97% coverage of query (188 bits)

A0A1G7S280 formyl-CoA transferase (EC 2.8.3.16) from Pseudomonas abietaniphila (see paper)
    32% identity, 98% coverage of query (184 bits)

act / CAG29276.1 beta-alanine CoA-transferase from Anaerotignum propionicum (see paper)
    37% identity, 71% coverage of query (179 bits)

MCT_HALHT / G0HQ31 Succinyl-CoA:mesaconate CoA-transferase; Mesaconate CoA-transferase; EC 2.8.3.26 from Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755) (see paper)
G0HQ31 succinyl-CoA:mesaconate CoA transferase (EC 2.8.3.26) from Haloarcula hispanica (see paper)
    33% identity, 97% coverage of query (174 bits)

mct / Q5V468 succinyl-CoA:mesaconate CoA transferase (EC 2.8.3.26) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see paper)
MCT_HALMA / Q5V468 Succinyl-CoA:mesaconate CoA-transferase; EC 2.8.3.26 from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) (see paper)
    32% identity, 97% coverage of query (170 bits)

Q46S66 formyl-CoA transferase (EC 2.8.3.16) from Cupriavidus necator (see paper)
    31% identity, 96% coverage of query (165 bits)

Q13RQ4 formyl-CoA transferase (EC 2.8.3.16) from Paraburkholderia xenovorans (see paper)
    30% identity, 96% coverage of query (163 bits)

Build an alignment

Build an alignment for WP_012385491.1 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q0K0H8 formyl-CoA transferase (EC 2.8.3.16) from Cupriavidus necator (see paper)
    29% identity, 98% coverage of query (160 bits)

1p5rA / O06644 Formyl-coa transferase in complex with coenzyme a (see paper)
    29% identity, 98% coverage of query (159 bits)

frc / O06644 formyl-coenzyme A transferase monomer (EC 2.8.3.16) from Oxalobacter formigenes (see 3 papers)
FCTA_OXAFO / O06644 Formyl-CoA:oxalate CoA-transferase; FCOCT; Formyl-coenzyme A transferase; EC 2.8.3.16 from Oxalobacter formigenes (see 6 papers)
O06644 formyl-CoA transferase (EC 2.8.3.16) from Oxalobacter formigenes (see 7 papers)
    29% identity, 98% coverage of query (159 bits)

2vjoA Formyl-coa transferase mutant variant q17a with aspartyl-coa thioester intermediates and oxalate
    29% identity, 98% coverage of query (159 bits)

2vjkA Formyl-coa transferase with aspartyl-coa thioester intermediate derived from oxalyl-coa
    29% identity, 98% coverage of query (159 bits)

1t4cA Formyl-coa transferase in complex with oxalyl-coa
    29% identity, 98% coverage of query (159 bits)

Q46S72 formyl-CoA transferase (EC 2.8.3.16) from Cupriavidus necator (see paper)
    29% identity, 98% coverage of query (158 bits)

A6T0J2 formyl-CoA transferase (EC 2.8.3.16) from Janthinobacterium sp. Marseille (see paper)
    31% identity, 97% coverage of query (157 bits)

1t3zA Formyl-coa tranferase mutant asp169 to ser
    29% identity, 98% coverage of query (157 bits)

YfdW / b2374 formyl-CoA transferase (EC 2.8.3.16) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
frc / P69902 formyl-CoA transferase (EC 2.8.3.16) from Escherichia coli (strain K12) (see 5 papers)
FCTA_ECOLI / P69902 Formyl-CoA:oxalate CoA-transferase; FCOCT; Formyl-coenzyme A transferase; Formyl-CoA transferase; EC 2.8.3.16 from Escherichia coli (strain K12) (see 5 papers)
P69902 formyl-CoA transferase (EC 2.8.3.16) from Escherichia coli (see paper)
P69903 formyl-CoA transferase (EC 2.8.3.16) from Shigella flexneri (see paper)
frc / GB|AAC75433.1 formyl-coenzyme A transferase; EC 2.8.3.16 from Escherichia coli K12 (see 4 papers)
    31% identity, 96% coverage of query (156 bits)

1pt5A Crystal structure of gene yfdw of e. Coli
    31% identity, 96% coverage of query (156 bits)

1q6yA / P69902 Hypothetical protein yfdw from e. Coli bound to coenzyme a (see paper)
    31% identity, 96% coverage of query (155 bits)

Q82M40 formyl-CoA transferase (EC 2.8.3.16) from Streptomyces avermitilis (see paper)
    30% identity, 96% coverage of query (152 bits)

A9X6P7 formyl-CoA transferase (EC 2.8.3.16) from Acetobacter aceti (see paper)
    28% identity, 96% coverage of query (152 bits)

3ubmB / A9X6P7 Formyl-coa:oxalate coa-transferase from acetobacter aceti (see paper)
    28% identity, 96% coverage of query (151 bits)

O87838 formyl-CoA transferase (EC 2.8.3.16) from Streptomyces coelicolor (see paper)
    29% identity, 96% coverage of query (150 bits)

A7ICK2 formyl-CoA transferase (EC 2.8.3.16) from Xanthobacter autotrophicus (see paper)
    30% identity, 96% coverage of query (147 bits)

Q89QH2 formyl-CoA transferase (EC 2.8.3.16) from Bradyrhizobium japonicum (see paper)
    28% identity, 96% coverage of query (146 bits)

SMTB_CHLAU / Q1KLK0 Succinyl-CoA--L-malate CoA-transferase beta subunit; EC 2.8.3.22 from Chloroflexus aurantiacus (see paper)
    29% identity, 95% coverage of query (146 bits)

SMTA_CHLAU / Q1KLK1 Succinyl-CoA--L-malate CoA-transferase alpha subunit; EC 2.8.3.22 from Chloroflexus aurantiacus (see paper)
    28% identity, 98% coverage of query (146 bits)

A5EGD7 formyl-CoA transferase (EC 2.8.3.16) from Bradyrhizobium sp. (see paper)
    28% identity, 96% coverage of query (145 bits)

A4G241 formyl-CoA transferase (EC 2.8.3.16) from Herminiimonas arsenicoxydans (see paper)
    28% identity, 96% coverage of query (145 bits)

COATR_MYCTU / P96877 Probable fatty acyl-CoA transferase Rv3272; EC 2.8.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    32% identity, 96% coverage of query (144 bits)

1q7eA Crystal structure of yfdw protein from e. Coli
    30% identity, 96% coverage of query (144 bits)

5yx6A / P96877 Crystal structure of rv3272 from m. Tuberculosis orthorhombic form (see paper)
    31% identity, 95% coverage of query (142 bits)

Q6N8F8 formyl-CoA transferase (EC 2.8.3.16) from Rhodopseudomonas palustris (see paper)
    29% identity, 95% coverage of query (142 bits)

A4G242 formyl-CoA transferase (EC 2.8.3.16) from Herminiimonas arsenicoxydans (see paper)
    29% identity, 96% coverage of query (141 bits)

gbuB / A0A415DZ12 γ-butyrobetaine CoA transferase GbuB component from Emergencia timonensis (see paper)
    28% identity, 96% coverage of query (135 bits)

Y1866_MYCTU / P95149 Probable CoA-transferase Rv1866; EC 2.8.3.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    29% identity, 98% coverage of query (126 bits)

IAAL_AROAE / Q5P5Z3 Phenylsuccinyl-CoA transferase; EC 2.8.3.28 from Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) (see paper)
    29% identity, 80% coverage of query (123 bits)

AMACR / Q9UHK6 α-methylacyl-CoA racemase (EC 5.1.99.4) from Homo sapiens (see 16 papers)
AMACR_HUMAN / Q9UHK6 Alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; EC 5.1.99.4 from Homo sapiens (Human) (see 5 papers)
Q9UHK6 alpha-methylacyl-CoA racemase (EC 5.1.99.4) from Homo sapiens (see 9 papers)
    30% identity, 96% coverage of query (112 bits)

hadA / GI|54781347 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); EC 1.2.4.4 from Clostridium difficile (see 2 papers)
    25% identity, 95% coverage of query (105 bits)

hadA / Q188I3 isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase (EC 2.8.3.24) from Clostridioides difficile (strain 630) (see 2 papers)
    25% identity, 95% coverage of query (105 bits)

CAIB_PROSL / Q8GB19 L-carnitine CoA-transferase; Crotonobetainyl-CoA:carnitine CoA-transferase; EC 2.8.3.21 from Proteus sp. (strain LE138) (see paper)
Q8GB19 L-carnitine CoA-transferase (EC 2.8.3.21) from Proteus sp. (see 2 papers)
caiB / CAD48580.1 betainyl-CoA transferase from Proteus sp. LE138 (see paper)
    26% identity, 96% coverage of query (101 bits)

AMACR_MOUSE / O09174 Alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; EC 5.1.99.4 from Mus musculus (Mouse) (see paper)
    27% identity, 98% coverage of query (98.2 bits)

mcr / O06543 α-methylacyl-CoA racemase (EC 5.1.99.4) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
AMACR_MYCTU / O06543 Alpha-methylacyl-CoA racemase; AMACR; MtMCR; EC 5.1.99.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 6 papers)
    27% identity, 87% coverage of query (97.4 bits)

fldA / Q93AM1 cinnamoyl-CoA:phenyllactate CoA-transferase monomer (EC 2.8.3.17) from Clostridium sporogenes (see 2 papers)
FLDA_CLOSG / Q93AM1 Cinnamoyl-CoA:phenyllactate CoA-transferase; (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase; (R)-phenyllactate CoA-transferase; EC 2.8.3.17 from Clostridium sporogenes (see 2 papers)
fldA cinnamoyl-CoA:phenyllactate CoA-transferase; EC 2.8.3.17 from Clostridium sporogenes (see paper)
fldA / GI|16417587 cinnamoyl-CoA:phenyllactate CoA-transferase, large subunit; EC 2.8.3.17 from Clostridium sporogenes (see paper)
    25% identity, 96% coverage of query (96.7 bits)

2gd6A The 1,1-proton transfer reaction mechanism by alpha-methylacyl-coa racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
    26% identity, 87% coverage of query (96.3 bits)

2gd2A The 1,1-proton transfer reaction mechanism by alpha-methylacyl-coa racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
    26% identity, 87% coverage of query (96.3 bits)

2gd0A The 1,1-proton transfer reaction mechanism by alpha-methylacyl-coa racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
    26% identity, 87% coverage of query (96.3 bits)

2gciA The 1,1-proton transfer reaction mechanism by alpha-methylacyl-coa racemase is catalyzed by an asparte/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
    26% identity, 87% coverage of query (96.3 bits)

2gceA The 1,1-proton transfer reaction mechanism by alpha-methylacyl-coa racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
    26% identity, 87% coverage of query (96.3 bits)

2yimA / O06543 The enolisation chemistry of a thioester-dependent racemase: the 1.4 a crystal structure of a complex with a planar reaction intermediate analogue (see paper)
    26% identity, 87% coverage of query (95.9 bits)

bbsE / Q9KJF0 succinyl-CoA:benzylsuccinate CoA-transferase BbsE subunit (EC 2.8.3.15) from Thauera aromatica (see 2 papers)
BBSE_THAAR / Q9KJF0 Succinyl-CoA:(R)-benzylsuccinate CoA-transferase subunit BbsE; EC 2.8.3.15 from Thauera aromatica (see 2 papers)
    27% identity, 92% coverage of query (95.1 bits)

bbsF / Q9KJE9 succinyl-CoA:benzylsuccinate CoA-transferase BbsF subunit (EC 2.8.3.15) from Thauera aromatica (see 2 papers)
BBSF_THAAR / Q9KJE9 Succinyl-CoA:(R)-benzylsuccinate CoA-transferase subunit BbsF; EC 2.8.3.15 from Thauera aromatica (see 2 papers)
    27% identity, 95% coverage of query (94.4 bits)

Amacr / P70473 α-methylacyl-CoA racemase (EC 5.1.99.4) from Rattus norvegicus (see 4 papers)
AMACR_RAT / P70473 Alpha-methylacyl-CoA racemase; 2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase; EC 5.1.99.4 from Rattus norvegicus (Rat) (see 4 papers)
    27% identity, 98% coverage of query (89.0 bits)

1xvtA / P31572 Crystal structure of native caib in complex with coenzyme a (see paper)
    26% identity, 96% coverage of query (87.8 bits)

YaaN / b0038 γ-butyrobetainyl-CoA:carnitine CoA transferase (EC 2.8.3.21) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
caiB / P31572 γ-butyrobetainyl-CoA:carnitine CoA transferase (EC 2.8.3.21) from Escherichia coli (strain K12) (see 5 papers)
CAIB_ECOLI / P31572 L-carnitine CoA-transferase; Crotonobetainyl-CoA:carnitine CoA-transferase; EC 2.8.3.21 from Escherichia coli (strain K12) (see 2 papers)
P31572 L-carnitine CoA-transferase (EC 2.8.3.21) from Escherichia coli (see 3 papers)
    26% identity, 96% coverage of query (87.8 bits)

1xvvA Crystal structure of caib mutant d169a in complex with carnitinyl-coa
    26% identity, 96% coverage of query (84.7 bits)

8apqA / A9WC36 Camct - mesaconyl-coa c1:c4 coa transferase of chloroflexus aurantiacus (see paper)
    27% identity, 98% coverage of query (84.3 bits)

mct / A9WC36 mesaconyl-C1-CoA-C4-CoA transferase monomer (EC 5.4.1.3) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
MCT_CHLAA / A9WC36 2-methylfumaryl-CoA isomerase; EC 5.4.1.3 from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
A9WC36 2-methylfumaryl-CoA isomerase (EC 5.4.1.3) from Chloroflexus aurantiacus (see paper)
    27% identity, 98% coverage of query (84.3 bits)

8apqB Camct - mesaconyl-coa c1:c4 coa transferase of chloroflexus aurantiacus
    27% identity, 98% coverage of query (84.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory