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Searching for up to 100 curated homologs for WP_012409829.1 NCBI__GCF_000020025.1:WP_012409829.1 (485 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MYCA_BACIU / Q9R9J1 Mycosubtilin synthase subunit A; EC 2.3.1.- from Bacillus subtilis (see paper)
    51% identity, 95% coverage of query (470 bits)

bmyA / CAE11250.1 BmyA protein from Bacillus amyloliquefaciens (see paper)
    51% identity, 96% coverage of query (468 bits)

6kfuA / Q9R9J1 A acp-amt fusion protein of hybrid polyketide/non-ribosomal peptide synthetase
    51% identity, 93% coverage of query (466 bits)

6kfrA Amino-transferase (amt) domain - arg complex of hybrid polyketide/non- ribosomal peptide synthetase
    51% identity, 93% coverage of query (464 bits)

gdnH / K4JEW9 guadinomine polyketide synthase module 4 from Streptomyces sp. K01-0509 (see paper)
    49% identity, 93% coverage of query (436 bits)

Gsa / b0154 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Escherichia coli K-12 substr. MG1655 (see 20 papers)
hemL / P23893 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Escherichia coli (strain K12) (see 19 papers)
GSA_ECOLI / P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see 3 papers)
    35% identity, 81% coverage of query (222 bits)

hemL / P0CL07 glutamate-1-semialdehyde 2,1-aminomutase subunit (EC 5.4.3.8) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    34% identity, 81% coverage of query (218 bits)

3bs8A / P30949 Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
    35% identity, 83% coverage of query (218 bits)

P30949 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Bacillus subtilis (see paper)
hemL / AAA22515.1 glutamate-1-semialdehyde 2,1-aminotransferase from Bacillus subtilis (see 2 papers)
    35% identity, 83% coverage of query (216 bits)

GSA_SACS2 / Q980U5 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q980U5 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Saccharolobus solfataricus (see paper)
    35% identity, 82% coverage of query (209 bits)

hemL / CAD48149.1 glutamate-1-semialdehyde 2,1-aminotransferase from Bacillus megaterium (see paper)
    34% identity, 82% coverage of query (209 bits)

6w80A / B2FT35 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
    36% identity, 79% coverage of query (206 bits)

GSA1 / P42799 glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) from Arabidopsis thaliana (see paper)
GSA1_ARATH / P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
P42799 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Arabidopsis thaliana (see paper)
    34% identity, 81% coverage of query (206 bits)

GSA2_ARATH / Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    33% identity, 82% coverage of query (205 bits)

5hdmA / P42799 Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
    34% identity, 81% coverage of query (204 bits)

2e7uA / Q5SJS4 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
    33% identity, 81% coverage of query (204 bits)

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase
    34% identity, 81% coverage of query (204 bits)

5i92F / P48247 Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
    33% identity, 81% coverage of query (203 bits)

3fqaA Gabaculien complex of gabaculine resistant gsam version
    35% identity, 82% coverage of query (201 bits)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
    34% identity, 82% coverage of query (200 bits)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
    34% identity, 82% coverage of query (200 bits)

3fq7A / P24630 Gabaculine complex of gsam (see paper)
    34% identity, 82% coverage of query (199 bits)

P24630 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Synechococcus sp. (see 2 papers)
    34% identity, 82% coverage of query (199 bits)

3usfA Crystal structure of dava-4
    34% identity, 82% coverage of query (199 bits)

2hp2A Inter-subunit signaling in gsam
    34% identity, 82% coverage of query (199 bits)

2hp1A Inter-subunit signaling in gsam
    34% identity, 82% coverage of query (199 bits)

2hozA Inter-subunit signaling in gsam
    34% identity, 82% coverage of query (199 bits)

3k28A / Q81LD0 Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
    34% identity, 79% coverage of query (196 bits)

3usfB / Q31QJ2 Crystal structure of dava-4
    33% identity, 82% coverage of query (183 bits)

BFAT_VARPD / H8WR05 Beta-phenylalanine transaminase; Aromatic beta-amino acid aminotransferase; Beta-phenylalanine aminotransferase; VpAT; EC 2.6.1.- from Variovorax paradoxus (see paper)
H8WR05 tyrosine transaminase (EC 2.6.1.5) from Variovorax paradoxus (see paper)
    34% identity, 81% coverage of query (182 bits)

4ao9A / H8WR05 Biochemical properties and crystal structure of a novel beta- phenylalanine aminotransferase from variovorax paradoxus (see paper)
    34% identity, 81% coverage of query (182 bits)

4aoaA Biochemical properties and crystal structure of a novel beta- phenylalanine aminotransferase from variovorax paradoxus
    34% identity, 81% coverage of query (182 bits)

2hp1B Inter-subunit signaling in gsam
    33% identity, 82% coverage of query (181 bits)

D1C218 beta-alanine-pyruvate transaminase (EC 2.6.1.18) from Sphaerobacter thermophilus (see paper)
    32% identity, 83% coverage of query (179 bits)

6k8hB / D1C218 Crystal structure of an omega-transaminase from sphaerobacter thermophilus (see paper)
    32% identity, 83% coverage of query (179 bits)

2cfbA / Q8DLK8 Glutamate-1-semialdehyde 2,1-aminomutase from thermosynechococcus elongatus (see paper)
    33% identity, 82% coverage of query (175 bits)

4zm4B / A8R0K5 Complex structure of pctv k276r mutant with pmp and 3-dehydroshkimate (see paper)
    30% identity, 87% coverage of query (174 bits)

Q8NT73 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Corynebacterium glutamicum (see paper)
    33% identity, 80% coverage of query (169 bits)

6ssdA Transaminase with plp bound (see paper)
    30% identity, 82% coverage of query (165 bits)

6ssgA Transaminase with dcs bound
    30% identity, 82% coverage of query (165 bits)

6ssfA Transaminase with lcs bound
    30% identity, 82% coverage of query (165 bits)

6sseA Transaminase with pmp bound
    30% identity, 82% coverage of query (165 bits)

2ykuA / A3EYF7 Structural determinants of the beta-selectivity of a bacterial aminotransferase (see paper)
    30% identity, 83% coverage of query (164 bits)

4ao4A Structural determinants of the beta-selectivity of a bacterial aminotransferase
    30% identity, 83% coverage of query (164 bits)

2ykyA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    30% identity, 83% coverage of query (164 bits)

2ykxA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    30% identity, 83% coverage of query (164 bits)

2ykvA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    30% identity, 83% coverage of query (164 bits)

hemL / BAA21914.1 glutamate 1-semialdehyde 2,1-aminomutase from Propionibacterium freudenreichii (see 2 papers)
    31% identity, 83% coverage of query (162 bits)

mxcL / Q9F631 myxocheline aldehyde aminotransferase from Stigmatella aurantiaca (see 2 papers)
    30% identity, 82% coverage of query (152 bits)

KAT_CLOAI / B0VH76 3-aminobutyryl-CoA aminotransferase; HemL-like protein; EC 2.6.1.111 from Cloacimonas acidaminovorans (strain Evry) (see paper)
B0VH76 3-aminobutanoyl-CoA transaminase (EC 2.6.1.111) from Candidatus Cloacimonas acidaminovorans (see paper)
    30% identity, 83% coverage of query (151 bits)

davT / Q9I6M4 5-aminovalerate aminotransferase (EC 2.6.1.48) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
DAVT_PSEAE / Q9I6M4 5-aminovalerate aminotransferase DavT; 5-aminovalerate transaminase; Delta-aminovalerate aminotransferase; EC 2.6.1.48 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6M4 5-aminovalerate transaminase (EC 2.6.1.48) from Pseudomonas aeruginosa (see paper)
    31% identity, 78% coverage of query (136 bits)

Build an alignment

Build an alignment for WP_012409829.1 and 51 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

YC7B_SCHPO / O94492 Uncharacterized aminotransferase C417.11c; EC 2.6.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    28% identity, 82% coverage of query (132 bits)

A0A5B8KQ12 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Agrobacterium tumefaciens (see paper)
    30% identity, 82% coverage of query (131 bits)

BARAC_PYRHO / O57878 Broad substrate specificity amino-acid racemase; BAR; EC 5.1.1.10 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 2 papers)
O57878 amino-acid racemase (EC 5.1.1.10) from Pyrococcus horikoshii (see 2 papers)
    29% identity, 74% coverage of query (129 bits)

Pf6N2E2_4013 5-aminovalerate transaminase (EC 2.6.1.48) from Pseudomonas fluorescens FW300-N2E2
    32% identity, 71% coverage of query (128 bits)

gabT / Q4KKA1 4-aminobutyrate transaminase subunit (EC 2.6.1.19) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    32% identity, 71% coverage of query (127 bits)

AO353_11510 5-aminovalerate transaminase (EC 2.6.1.48) from Pseudomonas fluorescens FW300-N2E3
    32% identity, 71% coverage of query (127 bits)

Q9HWU0 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Pseudomonas aeruginosa (see paper)
    27% identity, 76% coverage of query (125 bits)

5yktA / Q9HWU0 Crystal structure of a glutamate-1-semialdehyde-aminomutase (k286a) from pseudomonas aeruginosa pao1 in complex with pmp (see paper)
    27% identity, 76% coverage of query (123 bits)

2ordA / Q9X2A5 Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
    31% identity, 74% coverage of query (123 bits)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
    31% identity, 74% coverage of query (123 bits)

1sf2A / P22256 Structure of e. Coli gamma-aminobutyrate aminotransferase (see paper)
    29% identity, 78% coverage of query (122 bits)

GabT / b2662 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19; EC 2.6.1.48; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655 (see 29 papers)
gabT / P22256 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19; EC 2.6.1.48; EC 2.6.1.11) from Escherichia coli (strain K12) (see 28 papers)
GABT_ECOLI / P22256 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 from Escherichia coli (strain K12) (see 6 papers)
    29% identity, 78% coverage of query (122 bits)

1szkA The structure of gamma-aminobutyrate aminotransferase mutant: e211s
    29% identity, 78% coverage of query (122 bits)

1sffA Structure of gamma-aminobutyrate aminotransferase complex with aminooxyacetate
    29% identity, 78% coverage of query (122 bits)

5e3kA Crystal structure of the ornithine aminotransferase from toxoplasma gondii me49 in a complex with (s)-4-amino-5-fluoropentanoic acid
    26% identity, 75% coverage of query (100 bits)

5eqcA / S8EY38 Structure of the ornithine aminotransferase from toxoplasma gondii crystallized in presence of oxidized glutathione reveals partial occupancy of plp at the protein active site
    26% identity, 75% coverage of query (100 bits)

5e3kB Crystal structure of the ornithine aminotransferase from toxoplasma gondii me49 in a complex with (s)-4-amino-5-fluoropentanoic acid
    26% identity, 75% coverage of query (100 bits)

5e5iA Structure of the ornithine aminotransferase from toxoplasma gondii in complex with inactivator
    26% identity, 75% coverage of query (100 bits)

5dj9A Crystal structure of the ornithine aminotransferase from toxoplasma gondii me49 in a complex with gabaculine
    26% identity, 75% coverage of query (100 bits)

7lldB Crystal structure of genb4 in complex with external aldimine of plp- sisomicin
    26% identity, 88% coverage of query (94.4 bits)

7lleA Crystal structure of genb4 in complex with plp
    26% identity, 88% coverage of query (94.4 bits)

7lldA / Q6QVT7 Crystal structure of genb4 in complex with external aldimine of plp- sisomicin
    26% identity, 88% coverage of query (94.4 bits)

ORNAT_PYRHO / O50131 Ornithine aminotransferase; Orn-AT; Ornithine delta-aminotransferase; EC 2.6.1.13 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
    29% identity, 77% coverage of query (90.1 bits)

7vo1A Structure of aminotransferase-substrate complex
    29% identity, 77% coverage of query (90.1 bits)

7vntA Structure of aminotransferase-substrate complex
    29% identity, 77% coverage of query (90.1 bits)

7vnoA / O50131 Structure of aminotransferase (see paper)
    29% identity, 77% coverage of query (90.1 bits)

5g2qA The crystal structure of a s-selective transaminase from arthrobacter sp. With alanine bound
    24% identity, 78% coverage of query (86.3 bits)

7lm0A / Q2MG50 Crystal structure of genb3 in complex with plp
    26% identity, 86% coverage of query (77.0 bits)

2byjA / P04181 Ornithine aminotransferase mutant y85i (see paper)
    26% identity, 73% coverage of query (74.3 bits)

7lomC Ornithine aminotransferase (oat) soaked with its inactivator - (1s, 3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    26% identity, 73% coverage of query (73.9 bits)

7lomA Ornithine aminotransferase (oat) soaked with its inactivator - (1s, 3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    26% identity, 73% coverage of query (73.9 bits)

7lonA Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    26% identity, 73% coverage of query (73.9 bits)

8v9mA Human ornithine aminotransferase cocrystallized with its inhibitor, (r)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid.
    26% identity, 73% coverage of query (73.6 bits)

7tedA Human ornithine aminotransferase cocrystallized with its inhibitor, (s,e)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate
    26% identity, 73% coverage of query (73.6 bits)

7ta1A Human ornithine aminotransferase (hoat) soaked with gamma-aminobutyric acid
    26% identity, 73% coverage of query (73.6 bits)

7lnmB Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid
    26% identity, 73% coverage of query (73.6 bits)

7lk1A Ornithine aminotransferase (oat) with its potent inhibitor - (s)-3- amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148) - 1 hour soaking
    26% identity, 73% coverage of query (73.6 bits)

6v8cA Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
    26% identity, 73% coverage of query (73.6 bits)

6oiaA (1s,3s)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase
    26% identity, 73% coverage of query (73.6 bits)

5vwoA Ornithine aminotransferase inactivated by (1r,3s,4s)-3-amino-4- fluorocyclopentane-1-carboxylic acid (fcp)
    26% identity, 73% coverage of query (73.6 bits)

2oatA Ornithine aminotransferase complexed with 5-fluoromethylornithine
    26% identity, 73% coverage of query (73.6 bits)

7ta0A Human ornithine aminotransferase (hoat) soaked with 5-aminovaleric acid
    26% identity, 73% coverage of query (73.6 bits)

8ez1B Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid
    26% identity, 73% coverage of query (73.2 bits)

8ez1A Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid
    26% identity, 73% coverage of query (73.2 bits)

7tfpC Human ornithine aminotransferase cocrystallized with its inhibitor, (1s,3s)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid.
    26% identity, 73% coverage of query (73.2 bits)

7lk0A Ornithine aminotransferase (oat) cocrystallized with its potent inhibitor - (s)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148)
    26% identity, 73% coverage of query (73.2 bits)

7jx9A The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1s,3s)-3-amino-4- (hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid.
    26% identity, 73% coverage of query (73.2 bits)

6v8dA Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
    26% identity, 73% coverage of query (73.2 bits)

2canA Human ornithine aminotransferase complexed with l-canaline
    26% identity, 73% coverage of query (73.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory