Searching for up to 100 curated homologs for WP_012465900.1 NCBI__GCF_000020465.1:WP_012465900.1 (366 a.a.)
Found high-coverage hits (≥70%) to 54 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Q3M4V2 3-dehydroquinate synthase (EC 4.2.3.4) from Trichormus variabilis (see paper)
41% identity, 96% coverage of query (253 bits)
Q5NFS1 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
44% identity, 80% coverage of query (242 bits)
aroB / CAA05722.1 3-dehydroquinate synthetase from Neisseria gonorrhoeae (see paper)
40% identity, 96% coverage of query (237 bits)
DHQS_SOLLC / Q8RU74 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
38% identity, 88% coverage of query (231 bits)
Q9KNV2 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
38% identity, 95% coverage of query (229 bits)
5hvnA / Q5NFS1 3.0 angstrom crystal structure of 3-dehydroquinate synthase (arob) from francisella tularensis in complex with NAD.
44% identity, 80% coverage of query (228 bits)
3zokA / U3KRF2 Structure of 3-dehydroquinate synthase from actinidia chinensis in complex with NAD (see paper)
38% identity, 89% coverage of query (228 bits)
AroB / b3389 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
aroB / P07639 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli (strain K12) (see 8 papers)
AROB_ECOLI / P07639 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Escherichia coli (strain K12) (see paper)
P07639 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli (see paper)
42% identity, 83% coverage of query (227 bits)
DHQS_ACTCC / U3KRF2 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Actinidia chinensis var. chinensis (Chinese soft-hair kiwi) (see paper)
38% identity, 89% coverage of query (227 bits)
3okfA / Q9KNV2 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase (arob) from vibrio cholerae
38% identity, 95% coverage of query (226 bits)
6llaB Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+ and NAD (see paper)
39% identity, 93% coverage of query (224 bits)
5eksA / V5V8R5 Structure of 3-dehydroquinate synthase from acinetobacter baumannii in complex with NAD
39% identity, 90% coverage of query (224 bits)
6lk2A Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+, NAD and chlorogenic acid
38% identity, 93% coverage of query (214 bits)
6c5cA / Q5AME2 Crystal structure of the 3-dehydroquinate synthase (dhqs) domain of aro1 from candida albicans sc5314 in complex with nadh (see paper)
39% identity, 79% coverage of query (189 bits)
P9WPX9 3-dehydroquinate synthase (EC 4.2.3.4) from Mycobacterium tuberculosis (see 3 papers)
40% identity, 79% coverage of query (188 bits)
P9WPX9 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
40% identity, 79% coverage of query (188 bits)
6hqvA / G0S061 Pentafunctional arom complex from chaetomium thermophilum (see paper)
38% identity, 88% coverage of query (186 bits)
AROB_HELPY / P56081 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
35% identity, 91% coverage of query (186 bits)
3qbeA / P9WPX9 Crystal structure of the 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis
39% identity, 79% coverage of query (182 bits)
Q8U0A8 3-dehydroquinate synthase (EC 4.2.3.4) from Pyrococcus furiosus (see paper)
35% identity, 90% coverage of query (177 bits)
ARO1 / P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
34% identity, 87% coverage of query (176 bits)
3qbdA 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis in complex with NAD
37% identity, 79% coverage of query (174 bits)
EVS_STIAD / Q08VU0 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Stigmatella aurantiaca (strain DW4/3-1) (see paper)
Q08VU0 2-epi-valiolone synthase (EC 4.2.3.155) from Stigmatella aurantiaca (see paper)
38% identity, 73% coverage of query (172 bits)
Q6GGU4 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Staphylococcus aureus (strain MRSA252)
32% identity, 91% coverage of query (171 bits)
3clhA / P56081 Crystal structure of 3-dehydroquinate synthase (dhqs)from helicobacter pylori (see paper)
37% identity, 75% coverage of query (169 bits)
1dqsA Crystal structure of dehydroquinate synthase (dhqs) complexed with carbaphosphonate, NAD+ and zn2+
39% identity, 82% coverage of query (169 bits)
1xagA / Q6GGU4 Crystal structure of staphlyococcus aureus 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD+ and carbaphosphonate (see paper)
32% identity, 91% coverage of query (167 bits)
ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans (see paper)
aromA pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans (see 4 papers)
38% identity, 82% coverage of query (167 bits)
1nr5A / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD and carbaphosphonate (see paper)
38% identity, 82% coverage of query (166 bits)
1nr5B / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD and carbaphosphonate (see paper)
38% identity, 82% coverage of query (166 bits)
1nvbB / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and carbaphosphonate (see paper)
38% identity, 82% coverage of query (166 bits)
Amir_2000 / C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) (see paper)
EVS_ACTMD / C6WFL3 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101) (see paper)
C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum (see paper)
36% identity, 90% coverage of query (162 bits)
1nrxA / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and NAD (see paper)
36% identity, 82% coverage of query (158 bits)
1nrxB / P07547 Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and NAD (see paper)
36% identity, 82% coverage of query (157 bits)
1nvaA Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and adp
36% identity, 82% coverage of query (155 bits)
DOIS_STRRI / Q4R0W3 2-deoxy-scyllo-inosose synthase; DOI synthase; DOIS; EC 4.2.3.124 from Streptomyces ribosidificus (see paper)
34% identity, 87% coverage of query (147 bits)
rifG / G0FS62 aminodehydroquinate synthase from Amycolatopsis mediterranei (strain S699) (see 2 papers)
RIFG_AMYMS / G0FS62 Putative aminodehydroquinate synthase; aDHQS; EC 4.2.3.- from Amycolatopsis mediterranei (strain S699) (Nocardia mediterranei) (see paper)
36% identity, 73% coverage of query (145 bits)
4p53A / H2K887 Vala (2-epi-5-epi-valiolone synthase) from streptomyces hygroscopicus subsp. Jinggangensis 5008 with NAD+ and zn2+ bound (see paper)
32% identity, 75% coverage of query (138 bits)
neoC / Q53U19 2-deoxy-scyllo-inosose synthase (EC 4.2.3.124) from Streptomyces fradiae (see 2 papers)
DOIS_STRFR / Q53U19 2-deoxy-scyllo-inosose synthase; DOI synthase; DOIS; EC 4.2.3.124 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
34% identity, 87% coverage of query (137 bits)
EEVS_STIAD / E3FKM2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Stigmatella aurantiaca (strain DW4/3-1) (see paper)
32% identity, 88% coverage of query (136 bits)
kanC / Q6L738 2-deoxy-scyllo-inosose synthase (EC 4.2.3.124) from Streptomyces kanamyceticus (see 2 papers)
DOIS_STRKN / Q6L738 2-deoxy-scyllo-inosose synthase; DOI synthase; DOIS; EC 4.2.3.124 from Streptomyces kanamyceticus (see paper)
kanA / CAE46939.1 2-deoxy-scyllo-inosose synthase from Streptomyces kanamyceticus (see paper)
33% identity, 84% coverage of query (135 bits)
valA / H2K887 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) (see 3 papers)
VALA_STRHJ / H2K887 2-epi-5-epi-valiolone synthase; EEVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.152 from Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) (see 2 papers)
H2K887 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces hygroscopicus (see paper)
valA / AAW88569.1 ValA from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
valA / ABA41506.1 2-epi-5-epi-valiolone synthase from Streptomyces hygroscopicus subsp. jinggangensis (see paper)
32% identity, 74% coverage of query (131 bits)
DOIS_MICEC / Q70KD0 2-deoxy-scyllo-inosose synthase; DOI synthase; DOIS; EC 4.2.3.124 from Micromonospora echinospora (Micromonospora purpurea) (see paper)
gtmA / CAE06511.1 2-deoxy-scyllo-inosose synthase from Micromonospora echinospora (see paper)
35% identity, 73% coverage of query (130 bits)
2gruA / Q9S5E2 Crystal structure of 2-deoxy-scyllo-inosose synthase complexed with carbaglucose-6-phosphate, NAD+ and co2+ (see paper)
30% identity, 77% coverage of query (126 bits)
btrC / Q9S5E2 2-deoxy-scyllo-inosose synthase (EC 4.2.3.124) from Niallia circulans (see 9 papers)
DOIS_NIACI / Q9S5E2 2-deoxy-scyllo-inosose synthase; DOI synthase; DOIS; EC 4.2.3.124 from Niallia circulans (Bacillus circulans) (see 5 papers)
Q9S5E2 2-deoxy-scyllo-inosose synthase (EC 4.2.3.124) from Niallia circulans (see 14 papers)
30% identity, 77% coverage of query (126 bits)
Build an alignment for WP_012465900.1 and 45 homologs with ≥ 30% identity
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2gruB Crystal structure of 2-deoxy-scyllo-inosose synthase complexed with carbaglucose-6-phosphate, NAD+ and co2+
29% identity, 77% coverage of query (124 bits)
eevs / E7EXW6 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Danio rerio (see paper)
29% identity, 72% coverage of query (118 bits)
Nos2 / B2J6X9 desmethyl-4-deoxygadusol synthase (EC 4.2.3.154) from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see 2 papers)
DDGS_NOSP7 / B2J6X9 Demethyl-4-deoxygadusol synthase; DDGS; EC 4.2.3.154 from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see 2 papers)
27% identity, 89% coverage of query (113 bits)
SALQ_STRA4 / A8D7K2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858) (see paper)
A8D7K2 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Streptomyces albus (see paper)
31% identity, 74% coverage of query (111 bits)
CETA_ACTSX / A1YPR2 2-epi-5-epi-valiolone synthase; EEVS; EC 4.2.3.152 from Actinomyces sp. (see paper)
A1YPR2 2-epi-5-epi-valiolone synthase (EC 4.2.3.152) from Actinomyces sp. (see paper)
cetA / ABL74381.1 2-epi-5-epi-valiolone synthase from Actinomyces sp. Lu 9419 (see paper)
27% identity, 77% coverage of query (111 bits)
5tprA / Q3M6C3 Desmethyl-4-deoxygadusol synthase from anabaena variabilis (ava_3858) with NAD+ and zn2+ bound (see paper)
29% identity, 72% coverage of query (110 bits)
DDGS_TRIV2 / Q3M6C3 Demethyl-4-deoxygadusol synthase; DDGS; EC 4.2.3.154 from Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis) (see 2 papers)
Q3M6C3 demethyl-4-deoxygadusol synthase (EC 4.2.3.154) from Trichormus variabilis (see paper)
29% identity, 72% coverage of query (110 bits)
hygC / Q2MFR5 2-deoxy-scyllo-inosose synthase (EC 4.2.3.124) from Streptomyces hygroscopicus subsp. hygroscopicus (see paper)
29% identity, 78% coverage of query (107 bits)
4mcaA Crystal structure of glycerol dehydrogenase from serratia to 1.9a
24% identity, 73% coverage of query (47.8 bits)
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