Searching for up to 100 curated homologs for WP_012469463.1 NCBI__GCF_000020385.1:WP_012469463.1 (665 a.a.)

Found high-coverage hits (≥70%) to 11 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 2.A.21.7.5 / D5APM1 Acetate permease ActP-2/ActP2/ActP3 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
    43% identity, 88% coverage of query (439 bits)

AZOBR_RS02940 large component of pyruvate transporter (actP-like) from Azospirillum brasilense Sp245
    42% identity, 89% coverage of query (436 bits)

MCTC_CORGL / Q8NS49 Monocarboxylic acid transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
TC 2.A.21.7.3 / Q8NS49 Pyruvate/acetate/propionate: H+ symporter, MctC (DhlC; cg0953) from Corynebacterium glutamicum (see paper)
    44% identity, 90% coverage of query (415 bits)

PS417_08865 large component of pyruvate transporter (actP-like) from Pseudomonas simiae WCS417
    40% identity, 89% coverage of query (415 bits)

Pf1N1B4_3673 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N1B4
    40% identity, 89% coverage of query (412 bits)

Pf6N2E2_5849 large component of pyruvate transporter (actP-like) from Pseudomonas fluorescens FW300-N2E2
    40% identity, 89% coverage of query (410 bits)

YjcG / b4067 acetate/glycolate:cation symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
actP / P32705 acetate/glycolate:cation symporter from Escherichia coli (strain K12) (see 5 papers)
ACTP_ECOLI / P32705 Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.21.7.2 / P32705 Acetate/glyoxylate permease, ActP from Escherichia coli (see 6 papers)
    38% identity, 94% coverage of query (396 bits)

TC 2.A.21.7.1 / O50471 Phenylacetate permease, Ppa from Pseudomonas putida (see paper)
    39% identity, 88% coverage of query (390 bits)

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Build an alignment for WP_012469463.1 and 8 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Psest_3078 L-proline:Na+ symporter from Pseudomonas stutzeri RCH2
    25% identity, 75% coverage of query (94.4 bits)

TC 2.A.21.2.3 / Q9I5F5 L-proline uptake porter, PutP from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    24% identity, 78% coverage of query (94.0 bits)

SGLT_VIBPH / P96169 Sodium/glucose cotransporter; Na(+)/glucose symporter from Vibrio parahaemolyticus (see paper)
TC 2.A.21.3.2 / P96169 Glucose or galactose:Na+ symporter, SglS or SglT of 543 aas and 14 TMSs (Turk et al. 2006). The 3.0 Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined (see 3 papers)
AAF80602.1 Na+/galactose cotransporter SGLT from Vibrio parahaemolyticus (see paper)
    23% identity, 81% coverage of query (66.6 bits)

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