Searching for up to 100 curated homologs for WP_012469685.1 NCBI__GCF_000020385.1:WP_012469685.1 (377 a.a.)
Found high-coverage hits (≥70%) to 47 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
KORA_METTM / P80904 2-oxoglutarate synthase subunit KorA; 2-ketoglutarate oxidoreductase alpha chain; KOR; 2-oxoglutarate-ferredoxin oxidoreductase subunit alpha; EC 1.2.7.3 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
48% identity, 98% coverage of query (358 bits)
korA / Q6M1B3 2-oxoglutarate ferredoxin oxidoreductase α subunit (EC 1.2.7.3) from Methanococcus maripaludis (strain S2 / LL) (see 2 papers)
48% identity, 98% coverage of query (337 bits)
oorA / O25311 2-oxoglutarate-acceptor oxidoreductase subunit OorA (EC 1.2.7.3) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
44% identity, 97% coverage of query (303 bits)
VORB_METTM / P80908 Ketoisovalerate oxidoreductase subunit VorB; VOR; 2-oxoisovalerate ferredoxin reductase subunit beta; 2-oxoisovalerate oxidoreductase beta chain; EC 1.2.7.7 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
37% identity, 98% coverage of query (217 bits)
A0L8G4 2-oxoglutarate synthase (subunit 2/2) (EC 1.2.7.3) from Magnetococcus marinus (see paper)
36% identity, 99% coverage of query (210 bits)
6n2nA / A0L8G4 Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus (see paper)
36% identity, 99% coverage of query (210 bits)
6n2oC 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound
36% identity, 99% coverage of query (210 bits)
6n2oA 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound
36% identity, 99% coverage of query (210 bits)
korA / Q9AJM0 2-oxoglutarate:ferredoxin oxidoreductase α subunit (EC 1.2.7.3) from Hydrogenobacter thermophilus (see paper)
Q9AJM0 2-oxoglutarate synthase (subunit 2/2) (EC 1.2.7.3) from Hydrogenobacter thermophilus (see 3 papers)
33% identity, 99% coverage of query (196 bits)
O87870 2-oxoglutarate synthase (subunit 2/2) (EC 1.2.7.3) from Thauera aromatica (see paper)
31% identity, 99% coverage of query (181 bits)
porA / B0R4X6 pyruvate—ferredoxin oxidoreductaseα subunit (EC 1.2.7.1) from Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) (see 10 papers)
31% identity, 98% coverage of query (171 bits)
korA / B0R3G0 2-oxoglutarate--ferredoxin oxidoreductase α subunit (EC 1.2.7.3) from Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) (see 2 papers)
39% identity, 74% coverage of query (162 bits)
OFOA_SACSO / A0A0E3JT70 2-oxoacid:ferredoxin oxidoreductase subunit alpha; OFOR; EC 1.2.7.11 from Saccharolobus solfataricus (Sulfolobus solfataricus) (see paper)
31% identity, 98% coverage of query (156 bits)
OFOA1_AERPE / Q9YA13 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha; OFOR1; EC 1.2.7.11 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
31% identity, 97% coverage of query (153 bits)
OFOA2_AERPE / Q9YBX7 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha; OFOR2; EC 1.2.7.11 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
30% identity, 97% coverage of query (148 bits)
Q4J6I9 2-oxoacid oxidoreductase (ferredoxin) (subunit 2/2) (EC 1.2.7.11) from Sulfolobus acidocaldarius (see paper)
30% identity, 98% coverage of query (143 bits)
Build an alignment for WP_012469685.1 and 16 homologs with ≥ 30% identity
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OFOA2_SULTO / Q96XT2 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha; OFOR2; EC 1.2.7.11 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q96XT2 2-oxoacid oxidoreductase (ferredoxin) (subunit 2/2) (EC 1.2.7.11) from Sulfurisphaera tokodaii (see paper)
29% identity, 98% coverage of query (142 bits)
5b46A / Q96XT2 2-oxoacid:ferredoxin oxidoreductase 2 from sulfolobus tokodai - ligand free form (see paper)
29% identity, 98% coverage of query (142 bits)
5b47A 2-oxoacid:ferredoxin oxidoreductase 2 from sulfolobus tokodai - pyruvate complex
29% identity, 98% coverage of query (142 bits)
OFOA1_SULTO / Q96Y66 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha; OFOR1; EC 1.2.7.11 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 2 papers)
Q96Y66 2-oxoacid oxidoreductase (ferredoxin) (subunit 2/2) (EC 1.2.7.11) from Sulfurisphaera tokodaii (see paper)
29% identity, 98% coverage of query (137 bits)
ST2300 / P72578 2-oxoacid:ferredoxin oxidoreductase α subunit (EC 1.2.7.11; EC 1.2.7.1; EC 1.2.7.3; EC 1.2.7.7) from Sulfolobus sp. (see 2 papers)
OFOA_SULSP / P72578 2-oxoacid:ferredoxin oxidoreductase subunit alpha; OFOR; EC 1.2.7.11 from Sulfolobus sp. (see 3 papers)
P72578 2-oxoacid oxidoreductase (ferredoxin) (subunit 2/2) (EC 1.2.7.11) from Sulfolobus sp. (see 2 papers)
29% identity, 98% coverage of query (136 bits)
5b48A / Q96Y66 2-oxoacid:ferredoxin oxidoreductase 1 from sulfolobus tokodai (see paper)
28% identity, 98% coverage of query (133 bits)
korA / O53182 2-oxoglutarate:ferredoxin oxidoreductase α/γ subunit (EC 1.2.7.3) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
KORA_MYCTU / O53182 2-oxoglutarate oxidoreductase subunit KorA; Alpha-ketoglutarate oxidoreductase subunit alpha/gamma; KG oxidoreductase subunit alpha/gamma; KGO subunit alpha/gamma; KOR subunit alpha/gamma; EC 1.2.7.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
30% identity, 88% coverage of query (126 bits)
padG / Q8L3B1 phenylglyoxylate dehydrogenase (acylating) subunit PadG (EC 1.2.1.58) from Aromatoleum evansii (see 2 papers)
PADG_AROEV / Q8L3B1 NADH-dependent phenylglyoxylate dehydrogenase subunit alpha; Phenylglyoxylate:NAD oxidoreductase; Phenylglyoxylate:acceptor oxidoreductase; EC 1.2.1.58 from Aromatoleum evansii (Azoarcus evansii) (see paper)
31% identity, 89% coverage of query (110 bits)
P80521 pyruvate synthase (subunit 4/4) (EC 1.2.7.1) from Methanosarcina barkeri (see paper)
27% identity, 90% coverage of query (96.3 bits)
W8CQR1 pyruvate synthase (subunit 4/4) (EC 1.2.7.1); pyruvate decarboxylase (subunit 4/4) (EC 4.1.1.1) from Thermococcus guaymasensis (see paper)
29% identity, 82% coverage of query (95.9 bits)
porA / Q9LBF9 pyruvate:ferredoxin oxidoreductase α subunit (EC 1.2.7.1) from Hydrogenobacter thermophilus (see 2 papers)
D3DJK0 pyruvate synthase (subunit 2/2) (EC 1.2.7.1) from Hydrogenobacter thermophilus (see paper)
porA / BAA95605.1 pyruvate:ferredoxin oxidoreductase alpha subunit from Hydrogenobacter thermophilus (see paper)
27% identity, 97% coverage of query (95.1 bits)
PORA_METTM / P80900 Pyruvate synthase subunit PorA; Pyruvate oxidoreductase alpha chain; POR; Pyruvic-ferredoxin oxidoreductase subunit alpha; EC 1.2.7.1 from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) (see paper)
25% identity, 98% coverage of query (94.0 bits)
Q5JIJ7 pyruvate synthase (subunit 2/3) (EC 1.2.7.1) from Thermococcus kodakarensis (see paper)
28% identity, 82% coverage of query (93.6 bits)
porA / P56810 pyruvate synthase subunit α (EC 1.2.7.1) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see 7 papers)
26% identity, 97% coverage of query (93.6 bits)
Q93RA3 2-oxoglutarate synthase (subunit 2/2) (EC 1.2.7.3) from Hydrogenobacter thermophilus (see paper)
D3DIA1 2-oxoglutarate synthase (subunit 5/5) (EC 1.2.7.3) from Hydrogenobacter thermophilus (see 2 papers)
27% identity, 98% coverage of query (92.8 bits)
porA / O05651 pyruvate:ferredoxin oxidoreductase α subunit (EC 1.2.7.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 7 papers)
O05651 pyruvate synthase (subunit 4/4) (EC 1.2.7.1) from Thermotoga maritima (see 2 papers)
30% identity, 86% coverage of query (85.1 bits)
Q9P9E5 pyruvate synthase (subunit 5/5) (EC 1.2.7.1) from Methanococcus maripaludis (see paper)
26% identity, 92% coverage of query (76.3 bits)
Q51804 pyruvate synthase (subunit 4/4) (EC 1.2.7.1) from Pyrococcus furiosus (see 2 papers)
27% identity, 83% coverage of query (75.1 bits)
5c4iA / Q2RI41 Structure of an oxalate oxidoreductase (see paper)
23% identity, 89% coverage of query (67.8 bits)
OORA_MOOTA / Q2RI41 Oxalate oxidoreductase subunit alpha; OOR subunit alpha; EC 1.2.7.10 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
Q2RI41 oxalate oxidoreductase (EC 1.2.7.10) from Moorella thermoacetica (see paper)
23% identity, 89% coverage of query (67.8 bits)
5exeA Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-tpp adduct
23% identity, 89% coverage of query (67.8 bits)
5exdD Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate
23% identity, 89% coverage of query (67.8 bits)
Q8RCI3 pyruvate synthase (EC 1.2.7.1) from Caldanaerobacter subterraneus subsp. tengcongensis (see paper)
27% identity, 85% coverage of query (67.4 bits)
PFOR_MOOTA / Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see 3 papers)
Q2RMD6 pyruvate synthase (EC 1.2.7.1) from Moorella thermoacetica (see paper)
28% identity, 86% coverage of query (66.6 bits)
6cinB / Q2RMD6 Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
28% identity, 86% coverage of query (66.6 bits)
6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound
28% identity, 86% coverage of query (66.6 bits)
6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound
28% identity, 86% coverage of query (66.6 bits)
6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound
28% identity, 86% coverage of query (66.6 bits)
I3VRD9 pyruvate synthase (EC 1.2.7.1) from Thermoanaerobacterium saccharolyticum (see paper)
28% identity, 85% coverage of query (66.2 bits)
pfoA / Q97GY6 pyruvate:ferredoxin oxidoreductase subunit (EC 1.2.7.1) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 7 papers)
27% identity, 83% coverage of query (65.1 bits)
A0A097APA2 pyruvate synthase (EC 1.2.7.1) from Thermoanaerobacter kivui (see paper)
27% identity, 85% coverage of query (64.7 bits)
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Lawrence Berkeley National Laboratory