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Searching for up to 100 curated homologs for WP_012471169.1 NCBI__GCF_000020385.1:WP_012471169.1 (428 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Gsa / b0154 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Escherichia coli K-12 substr. MG1655 (see 20 papers)
hemL / P23893 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Escherichia coli (strain K12) (see 19 papers)
GSA_ECOLI / P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see 3 papers)
    62% identity, 98% coverage of query (537 bits)

hemL / P0CL07 glutamate-1-semialdehyde 2,1-aminomutase subunit (EC 5.4.3.8) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    61% identity, 98% coverage of query (534 bits)

3bs8A / P30949 Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
    62% identity, 100% coverage of query (530 bits)

5i92F / P48247 Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
    60% identity, 98% coverage of query (528 bits)

P30949 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Bacillus subtilis (see paper)
hemL / AAA22515.1 glutamate-1-semialdehyde 2,1-aminotransferase from Bacillus subtilis (see 2 papers)
    61% identity, 100% coverage of query (526 bits)

hemL / CAD48149.1 glutamate-1-semialdehyde 2,1-aminotransferase from Bacillus megaterium (see paper)
    59% identity, 100% coverage of query (516 bits)

P24630 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Synechococcus sp. (see 2 papers)
    59% identity, 97% coverage of query (513 bits)

GSA2_ARATH / Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    58% identity, 99% coverage of query (513 bits)

GSA1 / P42799 glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) from Arabidopsis thaliana (see paper)
GSA1_ARATH / P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
P42799 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Arabidopsis thaliana (see paper)
    57% identity, 99% coverage of query (508 bits)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
    58% identity, 97% coverage of query (508 bits)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
    58% identity, 97% coverage of query (508 bits)

3fq7A / P24630 Gabaculine complex of gsam (see paper)
    58% identity, 97% coverage of query (507 bits)

3usfA Crystal structure of dava-4
    58% identity, 97% coverage of query (507 bits)

2hp2A Inter-subunit signaling in gsam
    58% identity, 97% coverage of query (507 bits)

2hp1A Inter-subunit signaling in gsam
    58% identity, 97% coverage of query (507 bits)

2hozA Inter-subunit signaling in gsam
    58% identity, 97% coverage of query (507 bits)

5hdmA / P42799 Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
    57% identity, 99% coverage of query (506 bits)

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase
    57% identity, 99% coverage of query (506 bits)

3fqaA Gabaculien complex of gabaculine resistant gsam version
    58% identity, 97% coverage of query (506 bits)

6w80A / B2FT35 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
    58% identity, 97% coverage of query (499 bits)

3k28A / Q81LD0 Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
    60% identity, 95% coverage of query (493 bits)

3usfB / Q31QJ2 Crystal structure of dava-4
    54% identity, 97% coverage of query (463 bits)

2hp1B Inter-subunit signaling in gsam
    54% identity, 97% coverage of query (458 bits)

2e7uA / Q5SJS4 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
    52% identity, 99% coverage of query (454 bits)

2cfbA / Q8DLK8 Glutamate-1-semialdehyde 2,1-aminomutase from thermosynechococcus elongatus (see paper)
    52% identity, 91% coverage of query (397 bits)

Q8NT73 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Corynebacterium glutamicum (see paper)
    48% identity, 96% coverage of query (382 bits)

hemL / BAA21914.1 glutamate 1-semialdehyde 2,1-aminomutase from Propionibacterium freudenreichii (see 2 papers)
    47% identity, 98% coverage of query (370 bits)

GSA_SACS2 / Q980U5 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q980U5 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Saccharolobus solfataricus (see paper)
    46% identity, 98% coverage of query (349 bits)

2zsmA / Q9Y9I9 Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from aeropyrum pernix, hexagonal form
    42% identity, 99% coverage of query (332 bits)

D1C218 beta-alanine-pyruvate transaminase (EC 2.6.1.18) from Sphaerobacter thermophilus (see paper)
    37% identity, 91% coverage of query (263 bits)

6k8hB / D1C218 Crystal structure of an omega-transaminase from sphaerobacter thermophilus (see paper)
    37% identity, 91% coverage of query (263 bits)

4zm4B / A8R0K5 Complex structure of pctv k276r mutant with pmp and 3-dehydroshkimate (see paper)
    34% identity, 97% coverage of query (245 bits)

4zm4D / A8R0K5 Complex structure of pctv k276r mutant with pmp and 3-dehydroshkimate (see paper)
    36% identity, 93% coverage of query (233 bits)

KAT_CLOAI / B0VH76 3-aminobutyryl-CoA aminotransferase; HemL-like protein; EC 2.6.1.111 from Cloacimonas acidaminovorans (strain Evry) (see paper)
B0VH76 3-aminobutanoyl-CoA transaminase (EC 2.6.1.111) from Candidatus Cloacimonas acidaminovorans (see paper)
    31% identity, 99% coverage of query (219 bits)

4ao9A / H8WR05 Biochemical properties and crystal structure of a novel beta- phenylalanine aminotransferase from variovorax paradoxus (see paper)
    33% identity, 97% coverage of query (212 bits)

BFAT_VARPD / H8WR05 Beta-phenylalanine transaminase; Aromatic beta-amino acid aminotransferase; Beta-phenylalanine aminotransferase; VpAT; EC 2.6.1.- from Variovorax paradoxus (see paper)
H8WR05 tyrosine transaminase (EC 2.6.1.5) from Variovorax paradoxus (see paper)
    33% identity, 97% coverage of query (212 bits)

4aoaA Biochemical properties and crystal structure of a novel beta- phenylalanine aminotransferase from variovorax paradoxus
    33% identity, 97% coverage of query (212 bits)

2ykuA / A3EYF7 Structural determinants of the beta-selectivity of a bacterial aminotransferase (see paper)
    34% identity, 90% coverage of query (211 bits)

4ao4A Structural determinants of the beta-selectivity of a bacterial aminotransferase
    34% identity, 90% coverage of query (211 bits)

2ykyA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    34% identity, 90% coverage of query (211 bits)

2ykxA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    34% identity, 90% coverage of query (211 bits)

2ykvA Structural determinants of the beta-selectivity of a bacterial aminotransferase
    34% identity, 90% coverage of query (211 bits)

6ssdA Transaminase with plp bound (see paper)
    32% identity, 93% coverage of query (209 bits)

6ssgA Transaminase with dcs bound
    32% identity, 93% coverage of query (209 bits)

6ssfA Transaminase with lcs bound
    32% identity, 93% coverage of query (209 bits)

6sseA Transaminase with pmp bound
    32% identity, 93% coverage of query (209 bits)

bmyA / CAE11250.1 BmyA protein from Bacillus amyloliquefaciens (see paper)
    32% identity, 95% coverage of query (194 bits)

6kfuA / Q9R9J1 A acp-amt fusion protein of hybrid polyketide/non-ribosomal peptide synthetase
    31% identity, 95% coverage of query (189 bits)

MYCA_BACIU / Q9R9J1 Mycosubtilin synthase subunit A; EC 2.3.1.- from Bacillus subtilis (see paper)
    31% identity, 95% coverage of query (188 bits)

6kfrA Amino-transferase (amt) domain - arg complex of hybrid polyketide/non- ribosomal peptide synthetase
    31% identity, 95% coverage of query (188 bits)

gdnH / K4JEW9 guadinomine polyketide synthase module 4 from Streptomyces sp. K01-0509 (see paper)
    31% identity, 92% coverage of query (184 bits)

dpgA / Q6VY99 D-phenylglycine aminotransferase monomer (EC 2.6.1.72) from Stutzerimonas stutzeri (see 7 papers)
Q6VY99 D-4-hydroxyphenylglycine transaminase (EC 2.6.1.72) from Pseudomonas stutzeri (see 2 papers)
    32% identity, 95% coverage of query (176 bits)

Build an alignment

Build an alignment for WP_012471169.1 and 52 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

mxcL / Q9F631 myxocheline aldehyde aminotransferase from Stigmatella aurantiaca (see 2 papers)
    29% identity, 99% coverage of query (175 bits)

6hbvA / D2D3B2 Structure of plp internal aldimine form of sphingopyxis sp. Mta144 fumi protein
    27% identity, 99% coverage of query (167 bits)

fumI / D2D3B2 aminopentol aminotransferase from Sphingopyxis macrogoltabida (see paper)
FUMI_SPHMC / D2D3B2 Aminopentol aminotransferase; EC 2.6.1.- from Sphingopyxis macrogoltabida (Sphingomonas macrogoltabidus) (see 2 papers)
    27% identity, 99% coverage of query (166 bits)

YC7B_SCHPO / O94492 Uncharacterized aminotransferase C417.11c; EC 2.6.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    31% identity, 89% coverage of query (166 bits)

Q9HWU0 glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) from Pseudomonas aeruginosa (see paper)
    29% identity, 99% coverage of query (146 bits)

1sf2A / P22256 Structure of e. Coli gamma-aminobutyrate aminotransferase (see paper)
    30% identity, 71% coverage of query (144 bits)

GabT / b2662 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19; EC 2.6.1.48; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655 (see 29 papers)
gabT / P22256 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19; EC 2.6.1.48; EC 2.6.1.11) from Escherichia coli (strain K12) (see 28 papers)
GABT_ECOLI / P22256 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 from Escherichia coli (strain K12) (see 6 papers)
    30% identity, 71% coverage of query (144 bits)

5yktA / Q9HWU0 Crystal structure of a glutamate-1-semialdehyde-aminomutase (k286a) from pseudomonas aeruginosa pao1 in complex with pmp (see paper)
    28% identity, 99% coverage of query (144 bits)

1szkA The structure of gamma-aminobutyrate aminotransferase mutant: e211s
    30% identity, 71% coverage of query (144 bits)

1sffA Structure of gamma-aminobutyrate aminotransferase complex with aminooxyacetate
    30% identity, 71% coverage of query (144 bits)

davT / Q9I6M4 5-aminovalerate aminotransferase (EC 2.6.1.48) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
DAVT_PSEAE / Q9I6M4 5-aminovalerate aminotransferase DavT; 5-aminovalerate transaminase; Delta-aminovalerate aminotransferase; EC 2.6.1.48 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6M4 5-aminovalerate transaminase (EC 2.6.1.48) from Pseudomonas aeruginosa (see paper)
    32% identity, 71% coverage of query (143 bits)

ASTC_SALTY / Q8ZPV2 Succinylornithine transaminase; SOAT; Succinylornithine aminotransferase; EC 2.6.1.81 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    33% identity, 71% coverage of query (139 bits)

4adbB / P77581 Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
    32% identity, 71% coverage of query (139 bits)

A0A140N9B6 succinylornithine transaminase (EC 2.6.1.81) from Escherichia coli (see paper)
    32% identity, 71% coverage of query (138 bits)

AstC / b1748 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
astC / P77581 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli (strain K12) (see 6 papers)
ASTC_ECOLI / P77581 Succinylornithine transaminase; SOAT; Carbon starvation protein C; Succinylornithine aminotransferase; EC 2.6.1.81 from Escherichia coli (strain K12) (see paper)
astC / RF|NP_416262.1 succinylornithine transaminase; EC 2.6.1.81 from Escherichia coli K12 (see 5 papers)
    32% identity, 71% coverage of query (138 bits)

4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli
    32% identity, 71% coverage of query (138 bits)

kacL / Q6L741 glutamate--6'-dehydroparomanine aminotransferase (EC 2.6.1.94; EC 2.6.1.93) from Streptomyces kanamyceticus (see 2 papers)
KACL_STRKN / Q6L741 2'-deamino-2'-hydroxyneamine transaminase; Kanamycin biosynthesis protein B; Neamine transaminase KanB; EC 2.6.1.94; EC 2.6.1.93 from Streptomyces kanamyceticus (see paper)
    27% identity, 91% coverage of query (137 bits)

4jevB / P40732 N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
    31% identity, 73% coverage of query (132 bits)

4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
    31% identity, 73% coverage of query (131 bits)

ARGD_SALTY / P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    31% identity, 73% coverage of query (130 bits)

2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding
    31% identity, 73% coverage of query (129 bits)

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
    29% identity, 91% coverage of query (124 bits)

GoaG / b1302 4-aminobutyrate aminotransferase PuuE (EC 2.6.1.19; EC 2.6.1.48) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
puuE / P50457 4-aminobutyrate aminotransferase PuuE (EC 2.6.1.19; EC 2.6.1.48) from Escherichia coli (strain K12) (see 11 papers)
PUUE_ECOLI / P50457 4-aminobutyrate aminotransferase PuuE; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; EC 2.6.1.19 from Escherichia coli (strain K12) (see 2 papers)
puuE / BAD88710.1 gamma-aminobutyrate aminotransferase from Escherichia coli K-12 (see paper)
    29% identity, 84% coverage of query (122 bits)

1dgdA An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase
    28% identity, 71% coverage of query (120 bits)

1d7vA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with nma
    28% identity, 71% coverage of query (120 bits)

1d7uA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with lcs
    28% identity, 71% coverage of query (120 bits)

1d7sA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with dcs
    28% identity, 71% coverage of query (120 bits)

1d7rA / P16932 Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with 5pa (see paper)
    28% identity, 71% coverage of query (120 bits)

2eh6A / O66442 Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
    29% identity, 71% coverage of query (120 bits)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
    29% identity, 71% coverage of query (119 bits)

1zobA Crystal structure of dialkylglycine decarboxylases bound with calcium ion
    28% identity, 71% coverage of query (119 bits)

1zc9A The crystal structure of dialkylglycine decarboxylase complex with pyridoxamine 5-phosphate
    28% identity, 71% coverage of query (119 bits)

1m0qA Structure of dialkylglycine decarboxylase complexed with s-1- aminoethanephosphonate
    28% identity, 71% coverage of query (119 bits)

1m0pA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- phenylethanephosphonate
    28% identity, 71% coverage of query (119 bits)

1m0oA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- methylpropanephosphonate
    28% identity, 71% coverage of query (119 bits)

1m0nA Structure of dialkylglycine decarboxylase complexed with 1- aminocyclopentanephosphonate
    28% identity, 71% coverage of query (119 bits)

slr1022 / P73133 bifunctional acetylornithine transaminase/4-aminobutyrate—2-oxoglutarate transaminase (EC 2.6.1.19; EC 2.6.1.11) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 4 papers)
ARGD_SYNY3 / P73133 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
P73133 acetylornithine transaminase (EC 2.6.1.11); 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Synechococcus sp. PCC 6803 (see paper)
    29% identity, 77% coverage of query (119 bits)

P9WPZ7 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    30% identity, 83% coverage of query (116 bits)

7nncC Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal-5'-phosphate and 6-methoxyquinoline-3-carboxylic acid
    30% identity, 83% coverage of query (116 bits)

7nn4A / P9WPZ7 Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal 5'-phosphate and 3-hydroxy-2-naphthoic acid.
    30% identity, 83% coverage of query (116 bits)

4uoyA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate
    29% identity, 71% coverage of query (112 bits)

4uoxA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate and putrescine
    29% identity, 71% coverage of query (112 bits)

8cplC / P38507,P42588 Yzw2 a scaffold for cryo-em of small proteins of interest
    29% identity, 71% coverage of query (112 bits)

PatA / b3073 putrescine aminotransferase (EC 2.6.1.29) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
patA / P42588 putrescine aminotransferase (EC 2.6.1.82; EC 2.6.1.29) from Escherichia coli (strain K12) (see 15 papers)
PAT_ECOLI / P42588 Putrescine aminotransferase; PAT; PATase; Cadaverine transaminase; Diamine transaminase; Putrescine transaminase; Putrescine--2-oxoglutaric acid transaminase; Putrescine:2-OG aminotransferase; EC 2.6.1.82; EC 2.6.1.29 from Escherichia coli (strain K12) (see 8 papers)
P42588 putrescine-2-oxoglutarate transaminase (EC 2.6.1.82) from Escherichia coli (see 4 papers)
    29% identity, 71% coverage of query (112 bits)

3q8nC / A0QQ04 Crystal structure of 4-aminobutyrate transaminase from mycobacterium smegmatis (see paper)
    30% identity, 78% coverage of query (110 bits)

5e3kB Crystal structure of the ornithine aminotransferase from toxoplasma gondii me49 in a complex with (s)-4-amino-5-fluoropentanoic acid
    25% identity, 70% coverage of query (107 bits)

5eqcA / S8EY38 Structure of the ornithine aminotransferase from toxoplasma gondii crystallized in presence of oxidized glutathione reveals partial occupancy of plp at the protein active site
    25% identity, 70% coverage of query (107 bits)

7lonA Ornithine aminotransferase (oat) cocrystallized with its inactivator - (1s,3s)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
    27% identity, 80% coverage of query (107 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory